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The map label for this gene is hemH [H]

Identifier: 161525807

GI number: 161525807

Start: 2873100

End: 2874167

Strand: Reverse

Name: hemH [H]

Synonym: Bmul_2638

Alternate gene names: 161525807

Gene position: 2874167-2873100 (Counterclockwise)

Preceding gene: 161525808

Following gene: 161525806

Centisome position: 83.35

GC content: 69.66

Gene sequence:

>1068_bases
ATGCGTTTCGACCTTGAGCCGCCTTCGAGTGTCGCGGCTGCCCACCGCGTCGGCGTGCTGCTGATCAATCTCGGCACGCC
CGACGCGCCGACGCCGCGTGCGGTGCGGCGCTACCTCGCCGAATTCCTGTCCGATCCGCGTGTCGTCGAAATCCCTCAGC
CCGTCTGGCAGGTGCTGCTGCGCACGCTGATCCTGCCGCTGCGCGGCCGGGCATCCGCGAAGAAGTACGCGGCGGTCTGG
ATGCCCGAGGGCTCGCCGCTGCGCGTGTACACCGAGCGTCAGACCGAGGGCGTGCGGCATCTGCTCGCCTCGAACGACTA
TCACGTGCTGGTCGACTACGCGATGCGCTACGGCAGCCCCGGCATCGCGCAGGCGCTCGCGCAGTTCAAGCGCGCGGGCG
TCGAGCGCGTGCTGCTGATGCCGATGTACCCGCAGTATTCGGCATCGACGACGGCCACCGCGTTCGACGCCGCCTTCGCG
GCGCTCGCGCGCATGCGCAACCAGCCGGAAGTGCGCACGGTGCGCCACTATGCCGACCACCCGGCCTACATCCACGCGCT
CGCCGAGCAGGTGCGCCACTACTGGGCGCAGCACGGCCGGCCCGATTTCGCGGCCGGCGACAAGCTCGTGCTGAGCTTTC
ACGGCGTGCCGAAGCGCACGCTCGATCTCGGCGATCCGTATCACGACCAGTGCCAGCAGACGGGCGCGCTGCTGATGGCC
GCGCTCGGGCTCTCGACGATCGAATGCCGCGTGACGTTCCAGTCGCGCTTCGGCAAGGCCGAATGGCTGCAGCCGTACAC
GGCGCCGACGCTGCGCGAGCTCGGCGAGGCCGGCGTGCGGCGCGCCGACGTGTTTTGCCCTGGTTTCACGGCCGACTGCC
TCGAGACGATCGAGGAGATCGGCATGGAAGTGCGCGACGAGTTCATCGCGGGCGGCGGCCAGTCGTTCCACCGGATTCCG
TGCCTGAACGGCGCGCCGGCGTGGATCGGCGCGCTCGGCGAAATCGTCGCGGAGAATCTGCAGGGCTGGCCCGTGCGGAC
CGCCCAACCCGAAACGGTGAACGGATGA

Upstream 100 bases:

>100_bases
CGCCGGCCGGTCTTCCGCGGTCGGGCCTTCGCGGCCCCACCTCCGCACCCCGCTATAATTGAAAGCCATCCGGTTTCGTG
CCTCGAGCACGCTCTTGCCC

Downstream 100 bases:

>100_bases
ACTACAGGATTTCGACGGAGCCCGGCGCGAAGCTGCGCATCGACAAATGGCTGTGGGCCGCGCGGTTCTTCAAGACGCGT
TCGCTCGCGAGCGATGCGGT

Product: ferrochelatase

Products: NA

Alternate protein names: Heme synthase; Protoheme ferro-lyase [H]

Number of amino acids: Translated: 355; Mature: 355

Protein sequence:

>355_residues
MRFDLEPPSSVAAAHRVGVLLINLGTPDAPTPRAVRRYLAEFLSDPRVVEIPQPVWQVLLRTLILPLRGRASAKKYAAVW
MPEGSPLRVYTERQTEGVRHLLASNDYHVLVDYAMRYGSPGIAQALAQFKRAGVERVLLMPMYPQYSASTTATAFDAAFA
ALARMRNQPEVRTVRHYADHPAYIHALAEQVRHYWAQHGRPDFAAGDKLVLSFHGVPKRTLDLGDPYHDQCQQTGALLMA
ALGLSTIECRVTFQSRFGKAEWLQPYTAPTLRELGEAGVRRADVFCPGFTADCLETIEEIGMEVRDEFIAGGGQSFHRIP
CLNGAPAWIGALGEIVAENLQGWPVRTAQPETVNG

Sequences:

>Translated_355_residues
MRFDLEPPSSVAAAHRVGVLLINLGTPDAPTPRAVRRYLAEFLSDPRVVEIPQPVWQVLLRTLILPLRGRASAKKYAAVW
MPEGSPLRVYTERQTEGVRHLLASNDYHVLVDYAMRYGSPGIAQALAQFKRAGVERVLLMPMYPQYSASTTATAFDAAFA
ALARMRNQPEVRTVRHYADHPAYIHALAEQVRHYWAQHGRPDFAAGDKLVLSFHGVPKRTLDLGDPYHDQCQQTGALLMA
ALGLSTIECRVTFQSRFGKAEWLQPYTAPTLRELGEAGVRRADVFCPGFTADCLETIEEIGMEVRDEFIAGGGQSFHRIP
CLNGAPAWIGALGEIVAENLQGWPVRTAQPETVNG
>Mature_355_residues
MRFDLEPPSSVAAAHRVGVLLINLGTPDAPTPRAVRRYLAEFLSDPRVVEIPQPVWQVLLRTLILPLRGRASAKKYAAVW
MPEGSPLRVYTERQTEGVRHLLASNDYHVLVDYAMRYGSPGIAQALAQFKRAGVERVLLMPMYPQYSASTTATAFDAAFA
ALARMRNQPEVRTVRHYADHPAYIHALAEQVRHYWAQHGRPDFAAGDKLVLSFHGVPKRTLDLGDPYHDQCQQTGALLMA
ALGLSTIECRVTFQSRFGKAEWLQPYTAPTLRELGEAGVRRADVFCPGFTADCLETIEEIGMEVRDEFIAGGGQSFHRIP
CLNGAPAWIGALGEIVAENLQGWPVRTAQPETVNG

Specific function: Catalyzes the ferrous insertion into protoporphyrin IX [H]

COG id: COG0276

COG function: function code H; Protoheme ferro-lyase (ferrochelatase)

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ferrochelatase family [H]

Homologues:

Organism=Homo sapiens, GI60499021, Length=269, Percent_Identity=26.7657992565056, Blast_Score=105, Evalue=5e-23,
Organism=Homo sapiens, GI60499025, Length=269, Percent_Identity=26.7657992565056, Blast_Score=105, Evalue=6e-23,
Organism=Escherichia coli, GI1786681, Length=322, Percent_Identity=45.9627329192547, Blast_Score=280, Evalue=1e-76,
Organism=Saccharomyces cerevisiae, GI6324750, Length=347, Percent_Identity=24.7838616714697, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI17864156, Length=341, Percent_Identity=25.5131964809384, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24651774, Length=270, Percent_Identity=25.5555555555556, Blast_Score=77, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001015
- InterPro:   IPR019772 [H]

Pfam domain/function: PF00762 Ferrochelatase [H]

EC number: =4.99.1.1 [H]

Molecular weight: Translated: 39311; Mature: 39311

Theoretical pI: Translated: 7.64; Mature: 7.64

Prosite motif: PS00534 FERROCHELATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRFDLEPPSSVAAAHRVGVLLINLGTPDAPTPRAVRRYLAEFLSDPRVVEIPQPVWQVLL
CCCCCCCCHHHHHHHHEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEECCHHHHHHHH
RTLILPLRGRASAKKYAAVWMPEGSPLRVYTERQTEGVRHLLASNDYHVLVDYAMRYGSP
HHHHHHCCCCCCCCCEEEEECCCCCCEEEEECHHHHHHHHHHHCCCCEEHHHHHHHCCCC
GIAQALAQFKRAGVERVLLMPMYPQYSASTTATAFDAAFAALARMRNQPEVRTVRHYADH
HHHHHHHHHHHCCHHEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCC
PAYIHALAEQVRHYWAQHGRPDFAAGDKLVLSFHGVPKRTLDLGDPYHDQCQQTGALLMA
HHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHH
ALGLSTIECRVTFQSRFGKAEWLQPYTAPTLRELGEAGVRRADVFCPGFTADCLETIEEI
HHCCCEEEEEEEEHHHCCCHHHCCCCCCHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHH
GMEVRDEFIAGGGQSFHRIPCLNGAPAWIGALGEIVAENLQGWPVRTAQPETVNG
HHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRFDLEPPSSVAAAHRVGVLLINLGTPDAPTPRAVRRYLAEFLSDPRVVEIPQPVWQVLL
CCCCCCCCHHHHHHHHEEEEEEECCCCCCCCHHHHHHHHHHHHCCCCEEECCHHHHHHHH
RTLILPLRGRASAKKYAAVWMPEGSPLRVYTERQTEGVRHLLASNDYHVLVDYAMRYGSP
HHHHHHCCCCCCCCCEEEEECCCCCCEEEEECHHHHHHHHHHHCCCCEEHHHHHHHCCCC
GIAQALAQFKRAGVERVLLMPMYPQYSASTTATAFDAAFAALARMRNQPEVRTVRHYADH
HHHHHHHHHHHCCHHEEEEEECCCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHCC
PAYIHALAEQVRHYWAQHGRPDFAAGDKLVLSFHGVPKRTLDLGDPYHDQCQQTGALLMA
HHHHHHHHHHHHHHHHHCCCCCCCCCCEEEEEECCCCCCCCCCCCCHHHHHHHHHHHHHH
ALGLSTIECRVTFQSRFGKAEWLQPYTAPTLRELGEAGVRRADVFCPGFTADCLETIEEI
HHCCCEEEEEEEEHHHCCCHHHCCCCCCHHHHHHHHHCCCCCEEECCCCCHHHHHHHHHH
GMEVRDEFIAGGGQSFHRIPCLNGAPAWIGALGEIVAENLQGWPVRTAQPETVNG
HHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA