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The map label for this gene is livM [H]

Identifier: 161525653

GI number: 161525653

Start: 2699566

End: 2700786

Strand: Direct

Name: livM [H]

Synonym: Bmul_2484

Alternate gene names: 161525653

Gene position: 2699566-2700786 (Clockwise)

Preceding gene: 161525652

Following gene: 161525654

Centisome position: 78.28

GC content: 67.9

Gene sequence:

>1221_bases
TTGCCGCCAAGGGCCGCAGCGCGGAGGCTTGACGTGACTTCCCTCACCGATTCGTTGTCGAACGCGGCCGCCGATGCGCA
GCCGCACGCGCCCGCCGCGCGCACGCTGGACGGCTTTGCACTGGGCCTGCCGCCGCGCCCGGCGCTGCTGTCGCGCCGCG
CGTGGCTCGCGCTCGTCGCGCTGTGCCTCGCGGTCGGCATCGGCGTGCCGCTCGCGGCGCTCGTCGCGCCCGAGTCGAGC
GCGTTCCATCTGTCCGCCTATGCGATGACGCTCGCCGGCAAGCTGATGTGCTATGCGATCGCCGCGCTCGCGCTCGATCT
CGTCTGGGGCTACTGCGGGATCCTGAGCCTCGGCCACGGGCTGTTCTTCGCGCTCGGCGGCTATGCGATCGGCATGTACC
TGATGCGCGAGATCGGCCGCGACGGCCAGTACGGCAGCGACCTGCCCGACTTCATGGTGTTTCTCGACTGGCATCAATTG
CCGTGGTACTGGGCCGGCACGCAGCACCTCGCGTGGGCGCTGCTGCTCGTCGTGATCGTGCCGGCCGTGCTTGCGTGGGT
GTTCGGCTTCTTCGCGTTCCGCTCGCGCGTGAAAGGCGTCTATCTGTCGATCATCACGCAAGCGCTGACGTTCGCCGCGA
TGCTGCTGTTCTATCGGAACGAGACGGGCTTCGGCGGCAACAACGGCTTCACCGATTTCAAGCGAATCGCCGGCTTCCCG
ATCACGTCGCCCGGCACGCGCACCGTGCTGTTGCTGCTCACGTTCGCGACGCTCGTGCTCGCGTTCGTCGCCGCGCGCGC
GATCGTCACGAGCAAGCTCGGCCGCGTCGTGACCGCGGTGCGCGACGGCGAGACGCGGCTGATGTTCCTCGGCTACAGCC
CGCTCGCCTACAAGCTGTTCGTGTGGACAGTCTCGGCCGTGCTCTGCGGCATCGCGGGCGCGCTGTACGTGCCGCAGGTC
GGCATCGTGAACCCCGGCGAGATGTCGCCCGGCAATTCGATCGAGATGGCGATCTGGGTCGCGGTCGGCGGACGCGGCAC
GCTGATCGGCCCGATCGTCGGCGCGTTCGCAGTGAACGGCGCGAAGAGCGTATTTACTGCCTACTTCGCCGAATACTGGC
TGTTCTTTCTCGGCCTGATCTTCGTGCTCGTGCCGCTGCTGCTGCCGCGCGGGATCATGGGCGTCGTCGAACGCGTGCTT
GCGAAAGGGGAAAGCCGATGA

Upstream 100 bases:

>100_bases
GTCGGCAAGGCGATCGAACCGTTCTGGGGCGCGGTGCTCGCCAAGATCGCCGTGCTCGTGATGATCGTGCTGTTCATCCA
GAAGCGTCCCCAGGGCATGT

Downstream 100 bases:

>100_bases
ACGGAACGGCGCTCTATCAGTTCATTCCGCCGCCGGAAGACGACCAGCTTGCGGTGAGCGGCACCGCGTCGATGGGGCGC
GTCGCGCCGACCGGCATCGA

Product: urea ABC transporter permease UrtC

Products: ADP; phosphate; L-valine [Cytoplasm]; ADP; L-iso-leucine [Cytoplasm]; L-leucine [Cytoplasm] [C]

Alternate protein names: LIV-I protein M [H]

Number of amino acids: Translated: 406; Mature: 405

Protein sequence:

>406_residues
MPPRAAARRLDVTSLTDSLSNAAADAQPHAPAARTLDGFALGLPPRPALLSRRAWLALVALCLAVGIGVPLAALVAPESS
AFHLSAYAMTLAGKLMCYAIAALALDLVWGYCGILSLGHGLFFALGGYAIGMYLMREIGRDGQYGSDLPDFMVFLDWHQL
PWYWAGTQHLAWALLLVVIVPAVLAWVFGFFAFRSRVKGVYLSIITQALTFAAMLLFYRNETGFGGNNGFTDFKRIAGFP
ITSPGTRTVLLLLTFATLVLAFVAARAIVTSKLGRVVTAVRDGETRLMFLGYSPLAYKLFVWTVSAVLCGIAGALYVPQV
GIVNPGEMSPGNSIEMAIWVAVGGRGTLIGPIVGAFAVNGAKSVFTAYFAEYWLFFLGLIFVLVPLLLPRGIMGVVERVL
AKGESR

Sequences:

>Translated_406_residues
MPPRAAARRLDVTSLTDSLSNAAADAQPHAPAARTLDGFALGLPPRPALLSRRAWLALVALCLAVGIGVPLAALVAPESS
AFHLSAYAMTLAGKLMCYAIAALALDLVWGYCGILSLGHGLFFALGGYAIGMYLMREIGRDGQYGSDLPDFMVFLDWHQL
PWYWAGTQHLAWALLLVVIVPAVLAWVFGFFAFRSRVKGVYLSIITQALTFAAMLLFYRNETGFGGNNGFTDFKRIAGFP
ITSPGTRTVLLLLTFATLVLAFVAARAIVTSKLGRVVTAVRDGETRLMFLGYSPLAYKLFVWTVSAVLCGIAGALYVPQV
GIVNPGEMSPGNSIEMAIWVAVGGRGTLIGPIVGAFAVNGAKSVFTAYFAEYWLFFLGLIFVLVPLLLPRGIMGVVERVL
AKGESR
>Mature_405_residues
PPRAAARRLDVTSLTDSLSNAAADAQPHAPAARTLDGFALGLPPRPALLSRRAWLALVALCLAVGIGVPLAALVAPESSA
FHLSAYAMTLAGKLMCYAIAALALDLVWGYCGILSLGHGLFFALGGYAIGMYLMREIGRDGQYGSDLPDFMVFLDWHQLP
WYWAGTQHLAWALLLVVIVPAVLAWVFGFFAFRSRVKGVYLSIITQALTFAAMLLFYRNETGFGGNNGFTDFKRIAGFPI
TSPGTRTVLLLLTFATLVLAFVAARAIVTSKLGRVVTAVRDGETRLMFLGYSPLAYKLFVWTVSAVLCGIAGALYVPQVG
IVNPGEMSPGNSIEMAIWVAVGGRGTLIGPIVGAFAVNGAKSVFTAYFAEYWLFFLGLIFVLVPLLLPRGIMGVVERVLA
KGESR

Specific function: Part of the binding-protein-dependent transport system for branched-chain amino acids. Probably responsible for the translocation of the substrates across the membrane [H]

COG id: COG4177

COG function: function code E; ABC-type branched-chain amino acid transport system, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the binding-protein-dependent transport system permease family. LivHM subfamily [H]

Homologues:

Organism=Escherichia coli, GI1789865, Length=352, Percent_Identity=26.7045454545455, Blast_Score=69, Evalue=7e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001851
- InterPro:   IPR021807 [H]

Pfam domain/function: PF02653 BPD_transp_2; PF11862 DUF3382 [H]

EC number: NA

Molecular weight: Translated: 43520; Mature: 43389

Theoretical pI: Translated: 9.67; Mature: 9.67

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCC
>Mature Secondary Structure 
PPRAAARRLDVTSLTDSLSNAAADAQPHAPAARTLDGFALGLPPRPALLSRRAWLALVA
CCHHHHHHCCHHHHHHHHHHHHCCCCCCCCHHHCCCCCEECCCCCHHHHHHHHHHHHHH
LCLAVGIGVPLAALVAPESSAFHLSAYAMTLAGKLMCYAIAALALDLVWGYCGILSLGHG
HHHHHHCCHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LFFALGGYAIGMYLMREIGRDGQYGSDLPDFMVFLDWHQLPWYWAGTQHLAWALLLVVIV
HHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHCCCEEECCHHHHHHHHHHHHHH
PAVLAWVFGFFAFRSRVKGVYLSIITQALTFAAMLLFYRNETGFGGNNGFTDFKRIAGFP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCHHHHHHCCCC
ITSPGTRTVLLLLTFATLVLAFVAARAIVTSKLGRVVTAVRDGETRLMFLGYSPLAYKLF
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEEEEECCHHHHHHH
VWTVSAVLCGIAGALYVPQVGIVNPGEMSPGNSIEMAIWVAVGGRGTLIGPIVGAFAVNG
HHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEEEECCCCCCHHHHHHHHHHCC
AKSVFTAYFAEYWLFFLGLIFVLVPLLLPRGIMGVVERVLAKGESR
HHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; L-valine [Periplasm]; H2O; ATP; L-iso-leucine [Periplasm]; L-leucine [Periplasm] [C]

Specific reaction: ATP + L-valine [Periplasm] + H2O = ADP + phosphate + L-valine [Cytoplasm] ATP + L-iso-leucine [Periplasm] + H2O = ADP + phosphate + L-iso-leucine [Cytoplasm] ATP + L-leucine [Periplasm] + H2O = ADP + phosphate + L-leucine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 2195019; 8041620; 9278503 [H]