Click here to switch to the map view.

The map label for this gene is bioA [C]

Identifier: 161525650

GI number: 161525650

Start: 2694851

End: 2696179

Strand: Reverse

Name: bioA [C]

Synonym: Bmul_2481

Alternate gene names: 161525650

Gene position: 2696179-2694851 (Counterclockwise)

Preceding gene: 161525663

Following gene: 161525645

Centisome position: 78.18

GC content: 68.1

Gene sequence:

>1329_bases
ATGACCGAATCGCCCTCGAATACGCCCGACCTGTCCGCGTTCTGGATGCCGTTTACCGCGAACCGTCAGTTCAAGGACGC
GCCGCGCTTGCTGGTATCGGCGAAGGGGATGTACTACACGTCGGACGACGGCCGACGCATTCTCGACGGCACCGCCGGGC
TCTGGTGCGTGAACGCCGGCCATTGCCGCGACGAGATCGTCGCGGCGATCGGCGCGCAGGCGGCCGAGATGGATTTCGCG
CCGACGTTCCAGATGGGGCACCCGAAGGCGTTCGAGGCCGCGACGCGCATCGCGCGTCATACGCCGGGCAATCTGAAGCA
CGTGTTCTTCACGAACTCCGGCTCCGAAGCGGTCGATACCGCGCTGAAGATCGCGCTCGCGTATCACCGCGCGCGAGGCG
AAGCGCAGCGCACGCGCTTCGTCGGCCGCGAGCGCGGCTATCACGGCGTCGGCTTCGGCGGCATCTCGGTCGGCGGCATC
GCGCCGAACCGCAAGGCGTATTCGGGCGCGCTGCTGCCGGCGGTCGATCATCTGCCGCATACGCTGAACCTCGCCGAAGC
CGCGTTTTCGAAAGGGCAGCCTGCGTGGGGCGCGCATCTCGCGGACGAACTCGAGCGAATCGTCGCGCTGCACGACGCCT
CGACGATCGCCGCGGTGATCGTCGAGCCGGTCGCCGGCTCGGCAGGCGTGCTGATTCCGCCGCAGGGCTATCTGGAGCGG
CTGCGCGCGCTATGCGACCGCTACGGCATCCTGCTGATCTTCGACGAGGTGATCACGGGCTGGGGTCGGCTCGGCGCGCC
GTTCGCCGCGCAGTTCTTCGGCGTGACGCCCGATCTGCTGACGATGGCGAAGGGCACGACGAACGCGGCGGTGCCGATGG
GCGCGGTCGCCGCGAGCGACATGATCCACGACACGATCGTCGACGGCGCGCCGGCCGGCATCGAGCTGTTCCACGGCTAT
ACGTATTCGGGGCATCCGCTCGCCGCGGCCGCTGCGTGCGCGACGCTCGACGTCTACGAGCGCGAGCAGCTGTTCGACCG
CGCGGCGCGCATGGCGCCCGTGTTCGAACGCGAGATCCACAAGCTGCGCGACGCGCGGCACGTGATCGACGTGCGCAATC
TCGGGCTCGTCGGCGGCGTCGAGCTGAAGCCGCGCGACGGCAAGCCCGGCACGCGCGCGTACGACGTGTTCGTCAGGTGT
TATAGGAAGGGCGCGATGATCCGTTATACGGGCGACATCCTCGCGTTTTCGCCGCCGCTGATCATCGATGAGGCACAGAT
CGCGGAGCTGTTTGCGATCGTCGCGGAAGCGCTGAAGGAAACGGACTAG

Upstream 100 bases:

>100_bases
TTTCGGTGCCTACACTCGATGTTCGATCCGCATCGAACGGGCGTCGGCGCACCACGCCGGCGCAGCGAACGGCCGCGCCC
GATACCGCCAAGGAGACGTC

Downstream 100 bases:

>100_bases
CGAAGGAGGGAAGCGCGGGCACGCGATGCGCGTGCCCGGCGTGCGATCGGTAGCGTGCGATCAGTAGCGCGGCACCGACG
GATCGACGTCGCGCGACCAC

Product: omega amino acid--pyruvate transaminase

Products: NA

Alternate protein names: Omega-APT; Beta-alanine--pyruvate aminotransferase [H]

Number of amino acids: Translated: 442; Mature: 441

Protein sequence:

>442_residues
MTESPSNTPDLSAFWMPFTANRQFKDAPRLLVSAKGMYYTSDDGRRILDGTAGLWCVNAGHCRDEIVAAIGAQAAEMDFA
PTFQMGHPKAFEAATRIARHTPGNLKHVFFTNSGSEAVDTALKIALAYHRARGEAQRTRFVGRERGYHGVGFGGISVGGI
APNRKAYSGALLPAVDHLPHTLNLAEAAFSKGQPAWGAHLADELERIVALHDASTIAAVIVEPVAGSAGVLIPPQGYLER
LRALCDRYGILLIFDEVITGWGRLGAPFAAQFFGVTPDLLTMAKGTTNAAVPMGAVAASDMIHDTIVDGAPAGIELFHGY
TYSGHPLAAAAACATLDVYEREQLFDRAARMAPVFEREIHKLRDARHVIDVRNLGLVGGVELKPRDGKPGTRAYDVFVRC
YRKGAMIRYTGDILAFSPPLIIDEAQIAELFAIVAEALKETD

Sequences:

>Translated_442_residues
MTESPSNTPDLSAFWMPFTANRQFKDAPRLLVSAKGMYYTSDDGRRILDGTAGLWCVNAGHCRDEIVAAIGAQAAEMDFA
PTFQMGHPKAFEAATRIARHTPGNLKHVFFTNSGSEAVDTALKIALAYHRARGEAQRTRFVGRERGYHGVGFGGISVGGI
APNRKAYSGALLPAVDHLPHTLNLAEAAFSKGQPAWGAHLADELERIVALHDASTIAAVIVEPVAGSAGVLIPPQGYLER
LRALCDRYGILLIFDEVITGWGRLGAPFAAQFFGVTPDLLTMAKGTTNAAVPMGAVAASDMIHDTIVDGAPAGIELFHGY
TYSGHPLAAAAACATLDVYEREQLFDRAARMAPVFEREIHKLRDARHVIDVRNLGLVGGVELKPRDGKPGTRAYDVFVRC
YRKGAMIRYTGDILAFSPPLIIDEAQIAELFAIVAEALKETD
>Mature_441_residues
TESPSNTPDLSAFWMPFTANRQFKDAPRLLVSAKGMYYTSDDGRRILDGTAGLWCVNAGHCRDEIVAAIGAQAAEMDFAP
TFQMGHPKAFEAATRIARHTPGNLKHVFFTNSGSEAVDTALKIALAYHRARGEAQRTRFVGRERGYHGVGFGGISVGGIA
PNRKAYSGALLPAVDHLPHTLNLAEAAFSKGQPAWGAHLADELERIVALHDASTIAAVIVEPVAGSAGVLIPPQGYLERL
RALCDRYGILLIFDEVITGWGRLGAPFAAQFFGVTPDLLTMAKGTTNAAVPMGAVAASDMIHDTIVDGAPAGIELFHGYT
YSGHPLAAAAACATLDVYEREQLFDRAARMAPVFEREIHKLRDARHVIDVRNLGLVGGVELKPRDGKPGTRAYDVFVRCY
RKGAMIRYTGDILAFSPPLIIDEAQIAELFAIVAEALKETD

Specific function: Catalyzes transamination between a variety of omega- amino acids, mono and diamines, and pyruvate. Plays a pivotal role in the metabolism of the omega amino acids [H]

COG id: COG0161

COG function: function code H; Adenosylmethionine-8-amino-7-oxononanoate aminotransferase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=419, Percent_Identity=30.0715990453461, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI284507298, Length=333, Percent_Identity=31.5315315315315, Blast_Score=134, Evalue=2e-31,
Organism=Homo sapiens, GI37574042, Length=439, Percent_Identity=27.5626423690205, Blast_Score=132, Evalue=9e-31,
Organism=Homo sapiens, GI226442705, Length=435, Percent_Identity=27.1264367816092, Blast_Score=123, Evalue=4e-28,
Organism=Homo sapiens, GI226442709, Length=399, Percent_Identity=27.8195488721804, Blast_Score=122, Evalue=5e-28,
Organism=Homo sapiens, GI13994255, Length=376, Percent_Identity=28.9893617021277, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI24119277, Length=433, Percent_Identity=27.9445727482679, Blast_Score=116, Evalue=4e-26,
Organism=Escherichia coli, GI1786991, Length=433, Percent_Identity=33.9491916859122, Blast_Score=186, Evalue=3e-48,
Organism=Escherichia coli, GI145693181, Length=303, Percent_Identity=33.6633663366337, Blast_Score=164, Evalue=1e-41,
Organism=Escherichia coli, GI1789016, Length=421, Percent_Identity=30.166270783848, Blast_Score=152, Evalue=3e-38,
Organism=Escherichia coli, GI1789759, Length=403, Percent_Identity=30.0248138957816, Blast_Score=149, Evalue=4e-37,
Organism=Escherichia coli, GI1788044, Length=408, Percent_Identity=28.921568627451, Blast_Score=141, Evalue=1e-34,
Organism=Escherichia coli, GI1787560, Length=424, Percent_Identity=30.188679245283, Blast_Score=134, Evalue=8e-33,
Organism=Escherichia coli, GI1786349, Length=320, Percent_Identity=29.6875, Blast_Score=94, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI32564660, Length=436, Percent_Identity=28.8990825688073, Blast_Score=150, Evalue=1e-36,
Organism=Caenorhabditis elegans, GI25144271, Length=427, Percent_Identity=25.9953161592506, Blast_Score=139, Evalue=3e-33,
Organism=Caenorhabditis elegans, GI71992977, Length=440, Percent_Identity=27.9545454545455, Blast_Score=127, Evalue=9e-30,
Organism=Caenorhabditis elegans, GI25144274, Length=241, Percent_Identity=31.1203319502075, Blast_Score=117, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6323470, Length=433, Percent_Identity=26.7898383371824, Blast_Score=161, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6324386, Length=491, Percent_Identity=27.6985743380855, Blast_Score=139, Evalue=1e-33,
Organism=Saccharomyces cerevisiae, GI6324432, Length=403, Percent_Identity=24.0694789081886, Blast_Score=102, Evalue=1e-22,
Organism=Drosophila melanogaster, GI21357415, Length=418, Percent_Identity=27.511961722488, Blast_Score=155, Evalue=4e-38,
Organism=Drosophila melanogaster, GI28574759, Length=443, Percent_Identity=30.4740406320542, Blast_Score=145, Evalue=6e-35,
Organism=Drosophila melanogaster, GI161085790, Length=441, Percent_Identity=30.1587301587302, Blast_Score=144, Evalue=9e-35,
Organism=Drosophila melanogaster, GI21356575, Length=433, Percent_Identity=27.2517321016166, Blast_Score=115, Evalue=4e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =2.6.1.18 [H]

Molecular weight: Translated: 47595; Mature: 47464

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTESPSNTPDLSAFWMPFTANRQFKDAPRLLVSAKGMYYTSDDGRRILDGTAGLWCVNAG
CCCCCCCCCCCEEEEEEECCCCCCCCCCHHEEEECCEEEECCCCCEEECCCCCEEEECCC
HCRDEIVAAIGAQAAEMDFAPTFQMGHPKAFEAATRIARHTPGNLKHVFFTNSGSEAVDT
CHHHHHHHHHCCHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHH
ALKIALAYHRARGEAQRTRFVGRERGYHGVGFGGISVGGIAPNRKAYSGALLPAVDHLPH
HHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCCCCCHHHHHCCC
TLNLAEAAFSKGQPAWGAHLADELERIVALHDASTIAAVIVEPVAGSAGVLIPPQGYLER
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCHHHEEHHHEECCCCCCCEEECCHHHHHH
LRALCDRYGILLIFDEVITGWGRLGAPFAAQFFGVTPDLLTMAKGTTNAAVPMGAVAASD
HHHHHHHCCEEEEEHHHHHCCCCCCCCHHHHHHCCCHHHHHHHCCCCCCCCCCHHHHHHH
MIHDTIVDGAPAGIELFHGYTYSGHPLAAAAACATLDVYEREQLFDRAARMAPVFEREIH
HHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLRDARHVIDVRNLGLVGGVELKPRDGKPGTRAYDVFVRCYRKGAMIRYTGDILAFSPPL
HHHHHHHHHHHHCCCEECCEEECCCCCCCCCHHHHHHHHHHHCCCEEEEECCEEEECCCE
IIDEAQIAELFAIVAEALKETD
EECHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TESPSNTPDLSAFWMPFTANRQFKDAPRLLVSAKGMYYTSDDGRRILDGTAGLWCVNAG
CCCCCCCCCCEEEEEEECCCCCCCCCCHHEEEECCEEEECCCCCEEECCCCCEEEECCC
HCRDEIVAAIGAQAAEMDFAPTFQMGHPKAFEAATRIARHTPGNLKHVFFTNSGSEAVDT
CHHHHHHHHHCCHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCCCEEEEEEECCCCHHHHH
ALKIALAYHRARGEAQRTRFVGRERGYHGVGFGGISVGGIAPNRKAYSGALLPAVDHLPH
HHHHHHHHHHHCCHHHHHHHHHHHCCCCCCCCCCEEECCCCCCCCCCCCCCCHHHHHCCC
TLNLAEAAFSKGQPAWGAHLADELERIVALHDASTIAAVIVEPVAGSAGVLIPPQGYLER
HHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHCHHHEEHHHEECCCCCCCEEECCHHHHHH
LRALCDRYGILLIFDEVITGWGRLGAPFAAQFFGVTPDLLTMAKGTTNAAVPMGAVAASD
HHHHHHHCCEEEEEHHHHHCCCCCCCCHHHHHHCCCHHHHHHHCCCCCCCCCCHHHHHHH
MIHDTIVDGAPAGIELFHGYTYSGHPLAAAAACATLDVYEREQLFDRAARMAPVFEREIH
HHHHHHHCCCCCCEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
KLRDARHVIDVRNLGLVGGVELKPRDGKPGTRAYDVFVRCYRKGAMIRYTGDILAFSPPL
HHHHHHHHHHHHCCCEECCEEECCCCCCCCCHHHHHHHHHHHCCCEEEEECCEEEECCCE
IIDEAQIAELFAIVAEALKETD
EECHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1618757; 6822556; 2500426 [H]