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The map label for this gene is paaJ [C]

Identifier: 161525632

GI number: 161525632

Start: 2676483

End: 2677649

Strand: Reverse

Name: paaJ [C]

Synonym: Bmul_2462

Alternate gene names: 161525632

Gene position: 2677649-2676483 (Counterclockwise)

Preceding gene: 161525634

Following gene: 161525631

Centisome position: 77.65

GC content: 65.55

Gene sequence:

>1167_bases
ATGACTGTTGCAATCGTGGGATGGGGGCACCTGCCATTTGGCCGACTGGACGCCCTGAGCCTGGAAGATCTCATTGTGGG
CGCGGGCCGTGCCGCGCTGAGCGATGCAGGTATGCCGGCAGATTCCGTCGATGGTATCTGGCTGGGCAATCTGAATGGCG
GTTTCGTTCCGGACATCTTTGCCGCGCCGCTCGCACTGAACTGCGATGCCGGCCTGCGCTGGAAACCGGCGGTGCGCGTC
GAAAACGCTTGCGCATCGGGCTCTGCGGCGGTCTATGCGGCATGCGATGCGATCGAGGCCGGGCGAGCCCGCATCGCGCT
CGTGATCGGCGCCGAGAAGATGACATCGGTGTCCGGCGCCGAAGTGACGCGGATTCTCGGGAATTGCGGCTACTCGGGCG
AGGCAGGCAATCCGCCCGGCGGCTTCCCCGGCATATTCGCCGAGGTCGCGCGCGACTATTTCGAACAGTACGGCGACCAC
TCCGCGACGCTCGCTGCCATCGCCGCGAAAAACCATGCGAACGGCGTCGCCAATCCGTGGGCGCATATGCGGCGGGATCT
CGGCTTCGATTTCTGCAACACCGTCTCCGAGAAGAACCCGCTGATTGCGCCGCCGTTGCGCAAAACCGACTGCTCGCTCG
TCTCGGACGGCGCCGCTGCGCTGGTTCTGGTCGCGCAAGAGCTGGCTGCGGATTTCGCAAAGGCCGTCTCGATCCGGGCG
CGCGTACAGGTCAACGACTACCTCCCGCTGGCGCAGCGTCGCGCGATCGAATTCAACGGCCCGAAGCGTGCCTGGAAGCA
TGCGCTGAGCGAGGCCGGCTGCACGATCGACGATCTTTCGTTCGCCGAAGTGCACGATTGCTTCACGATCGCCGAGCTGC
TCAGCTATGAAGCGATGGGGTTGGCACCGGCGGGGCAGGGTCATCGCTTGATCGAAGACGGAACGGTCGCCAGAGACGGG
CGTTTCCCGGTCAATGCGTCGGGCGGCCTCAAGGCGAAGGGCCATCCGATCGGCGCGACCGGCGTGTCGATGCACGTACT
CGCCGCGATGCAGCTGGCCGGCCAGGCGGGCGAGATGCAGATTCCCGACGCGACGCTGGGCGGCGTGTTCAACATGGGTG
GCGCCGCGGTGGCGAGCTACGTCAGTATTCTGGAGCGCAGCCGATGA

Upstream 100 bases:

>100_bases
TCGGCACACGAAATCAGTGACGACCCTAGCGTATTTCGACGACTGATAATCGCATCGGCACCCGCGTACATTCCGTTCAA
CACACCGAACGGAGAAGCAG

Downstream 100 bases:

>100_bases
ACATCGCGCAATTGCTTGTTCGCACGGCGTCCGCTTTCGCGGACCGCCTCGCGGTGCTGCACGGCGAGCAACCGTGGCTC
GACTACGGTTCGCTCGCGAA

Product: acetyl-CoA acetyltransferase

Products: CoA; 3-oxoacyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 388; Mature: 387

Protein sequence:

>388_residues
MTVAIVGWGHLPFGRLDALSLEDLIVGAGRAALSDAGMPADSVDGIWLGNLNGGFVPDIFAAPLALNCDAGLRWKPAVRV
ENACASGSAAVYAACDAIEAGRARIALVIGAEKMTSVSGAEVTRILGNCGYSGEAGNPPGGFPGIFAEVARDYFEQYGDH
SATLAAIAAKNHANGVANPWAHMRRDLGFDFCNTVSEKNPLIAPPLRKTDCSLVSDGAAALVLVAQELAADFAKAVSIRA
RVQVNDYLPLAQRRAIEFNGPKRAWKHALSEAGCTIDDLSFAEVHDCFTIAELLSYEAMGLAPAGQGHRLIEDGTVARDG
RFPVNASGGLKAKGHPIGATGVSMHVLAAMQLAGQAGEMQIPDATLGGVFNMGGAAVASYVSILERSR

Sequences:

>Translated_388_residues
MTVAIVGWGHLPFGRLDALSLEDLIVGAGRAALSDAGMPADSVDGIWLGNLNGGFVPDIFAAPLALNCDAGLRWKPAVRV
ENACASGSAAVYAACDAIEAGRARIALVIGAEKMTSVSGAEVTRILGNCGYSGEAGNPPGGFPGIFAEVARDYFEQYGDH
SATLAAIAAKNHANGVANPWAHMRRDLGFDFCNTVSEKNPLIAPPLRKTDCSLVSDGAAALVLVAQELAADFAKAVSIRA
RVQVNDYLPLAQRRAIEFNGPKRAWKHALSEAGCTIDDLSFAEVHDCFTIAELLSYEAMGLAPAGQGHRLIEDGTVARDG
RFPVNASGGLKAKGHPIGATGVSMHVLAAMQLAGQAGEMQIPDATLGGVFNMGGAAVASYVSILERSR
>Mature_387_residues
TVAIVGWGHLPFGRLDALSLEDLIVGAGRAALSDAGMPADSVDGIWLGNLNGGFVPDIFAAPLALNCDAGLRWKPAVRVE
NACASGSAAVYAACDAIEAGRARIALVIGAEKMTSVSGAEVTRILGNCGYSGEAGNPPGGFPGIFAEVARDYFEQYGDHS
ATLAAIAAKNHANGVANPWAHMRRDLGFDFCNTVSEKNPLIAPPLRKTDCSLVSDGAAALVLVAQELAADFAKAVSIRAR
VQVNDYLPLAQRRAIEFNGPKRAWKHALSEAGCTIDDLSFAEVHDCFTIAELLSYEAMGLAPAGQGHRLIEDGTVARDGR
FPVNASGGLKAKGHPIGATGVSMHVLAAMQLAGQAGEMQIPDATLGGVFNMGGAAVASYVSILERSR

Specific function: Thiolytic Cleavage Of Beta-Ketoadipyl-CoA To Succinate And Acetyl-CoA (By Similarity). [C]

COG id: COG0183

COG function: function code I; Acetyl-CoA acetyltransferase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: NA

Homologues:

Organism=Homo sapiens, GI19923233, Length=405, Percent_Identity=31.358024691358, Blast_Score=166, Evalue=4e-41,
Organism=Homo sapiens, GI302344760, Length=334, Percent_Identity=31.7365269461078, Blast_Score=151, Evalue=1e-36,
Organism=Homo sapiens, GI302344767, Length=329, Percent_Identity=31.9148936170213, Blast_Score=150, Evalue=2e-36,
Organism=Homo sapiens, GI302344762, Length=316, Percent_Identity=31.3291139240506, Blast_Score=132, Evalue=4e-31,
Organism=Homo sapiens, GI55956775, Length=272, Percent_Identity=31.6176470588235, Blast_Score=117, Evalue=3e-26,
Organism=Caenorhabditis elegans, GI17537653, Length=390, Percent_Identity=30.5128205128205, Blast_Score=155, Evalue=3e-38,
Organism=Drosophila melanogaster, GI24585051, Length=407, Percent_Identity=29.2383292383292, Blast_Score=142, Evalue=3e-34,
Organism=Drosophila melanogaster, GI19921506, Length=394, Percent_Identity=28.9340101522843, Blast_Score=139, Evalue=4e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002155
- InterPro:   IPR016039
- InterPro:   IPR016038
- InterPro:   IPR020617
- InterPro:   IPR020616 [H]

Pfam domain/function: PF02803 Thiolase_C; PF00108 Thiolase_N [H]

EC number: 2.3.1.16

Molecular weight: Translated: 40281; Mature: 40150

Theoretical pI: Translated: 5.59; Mature: 5.59

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.1 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
2.1 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTVAIVGWGHLPFGRLDALSLEDLIVGAGRAALSDAGMPADSVDGIWLGNLNGGFVPDIF
CEEEEEECCCCCCCCCCCCCHHHHHHCCCHHHHHCCCCCCCCCCCEEEECCCCCCCCHHH
AAPLALNCDAGLRWKPAVRVENACASGSAAVYAACDAIEAGRARIALVIGAEKMTSVSGA
HCCEEEECCCCCCCCCCCEECCCCCCCCCEEEEEHHHHHCCCEEEEEEECCHHHCCCCHH
EVTRILGNCGYSGEAGNPPGGFPGIFAEVARDYFEQYGDHSATLAAIAAKNHANGVANPW
HHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEHHHHHCCCCCCCCCHH
AHMRRDLGFDFCNTVSEKNPLIAPPLRKTDCSLVSDGAAALVLVAQELAADFAKAVSIRA
HHHHHHCCCHHHHHHCCCCCEECCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHEEE
RVQVNDYLPLAQRRAIEFNGPKRAWKHALSEAGCTIDDLSFAEVHDCFTIAELLSYEAMG
EEEECCCCCHHHHCEEECCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
LAPAGQGHRLIEDGTVARDGRFPVNASGGLKAKGHPIGATGVSMHVLAAMQLAGQAGEMQ
CCCCCCCCEEECCCCEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEE
IPDATLGGVFNMGGAAVASYVSILERSR
CCCCHHCCHHCCCHHHHHHHHHHHHCCC
>Mature Secondary Structure 
TVAIVGWGHLPFGRLDALSLEDLIVGAGRAALSDAGMPADSVDGIWLGNLNGGFVPDIF
EEEEEECCCCCCCCCCCCCHHHHHHCCCHHHHHCCCCCCCCCCCEEEECCCCCCCCHHH
AAPLALNCDAGLRWKPAVRVENACASGSAAVYAACDAIEAGRARIALVIGAEKMTSVSGA
HCCEEEECCCCCCCCCCCEECCCCCCCCCEEEEEHHHHHCCCEEEEEEECCHHHCCCCHH
EVTRILGNCGYSGEAGNPPGGFPGIFAEVARDYFEQYGDHSATLAAIAAKNHANGVANPW
HHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHCCCCCEEHHHHHCCCCCCCCCHH
AHMRRDLGFDFCNTVSEKNPLIAPPLRKTDCSLVSDGAAALVLVAQELAADFAKAVSIRA
HHHHHHCCCHHHHHHCCCCCEECCCCCCCCCCHHCCCHHHHHHHHHHHHHHHHHHHHEEE
RVQVNDYLPLAQRRAIEFNGPKRAWKHALSEAGCTIDDLSFAEVHDCFTIAELLSYEAMG
EEEECCCCCHHHHCEEECCCHHHHHHHHHHHCCCCCCCCCHHHHHHHHHHHHHHHHHHHC
LAPAGQGHRLIEDGTVARDGRFPVNASGGLKAKGHPIGATGVSMHVLAAMQLAGQAGEMQ
CCCCCCCCEEECCCCEECCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCEE
IPDATLGGVFNMGGAAVASYVSILERSR
CCCCHHCCHHCCCHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: acyl-CoA; acetyl-CoA

Specific reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9371463 [H]