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The map label for this gene is hemL [H]

Identifier: 161525606

GI number: 161525606

Start: 2651597

End: 2652880

Strand: Direct

Name: hemL [H]

Synonym: Bmul_2436

Alternate gene names: 161525606

Gene position: 2651597-2652880 (Clockwise)

Preceding gene: 161525605

Following gene: 161525607

Centisome position: 76.89

GC content: 69.24

Gene sequence:

>1284_bases
ATGTCCAACAATCAGATCCTCTTCGAACGCGCCCAGAAGACCATTCCCGGCGGCGTCAACTCGCCGGTTCGCGCGTTCCG
TTCGGTCGGCGGCACCCCGCGCTTCGTCGCGCGCGCGCAAGGCCCGTACTTCTGGGATGCCGACGGCAAGCAGTACATCG
ACTACATCGGCTCGTGGGGCCCGATGATCGTCGGCCACGTGCACCCCGAGGTGCTCGACGCCGTGCAGAAGGTGCTCGCC
GACGGCTTCTCGTTCGGCGCGCCGACCGAGGCCGAGATCGAGATCGCCGAAGAGATCTGCAAGCTCGTGCCGTCGATCGA
GCAAGTGCGGATGGTGTCGAGCGGCACCGAAGCGACGATGAGCGCGCTGCGGCTCGCACGCGGCTTCACCGGCCGCAGCC
GCATCGTCAAATTCGAAGGCTGCTACCACGGTCACGCGGACAGCCTGCTCGTGAAGGCCGGCTCCGGCCTGCTGACGTTC
GGCAATCCGACCTCGGCCGGCGTGCCCGCCGACATCGCGAAACACACGACCGTCCTCGAATACAACAACGTCGCCGCGCT
CGAAGAAGCGTTCGGCGCGTTCGGTGACGAAATCGCGGCGGTGATCGTCGAGCCGGTCGCAGGCAACATGAACCTCGTGC
GCGGCACGCCGGAGTTCCTCAACGCACTGCGCGCGCTGTGCACGAAGCACGGCGCCGTGCTGATCTTCGACGAAGTGATG
TGCGGCTTCCGTGTCGCGCTCGGCGGCGCGCAGGCGCACTACGGGATCGCGGCCGACCTCACCTGCCTCGGCAAGGTGAT
CGGCGGCGGGATGCCGGCCGCCGCGTTCGGCGGGCGCCGCGACATCATGGCCCACCTCGCGCCGCTCGGCGGCGTGTACC
AGGCCGGCACGCTGTCGGGCAACCCGATCGCGGTCGCCGCGGGCCTGAAGACGCTGCAGCTGATCCAGGCGCCCGGCTTC
TACGAGGCGCTGACCGCGCAGACCAAGCGGCTCGCCGACGGCCTCGCGGCCGAAGCGCGCGCGGCAGGCGTGCCGTTCGC
GGCCGACTCGATCGGCGCGATGTTCGGCCTGTACTTCGCCGAGCGCGTGCCGACGAGCTTCGCCGAAGTCACGAAGAGCG
ACATCGAGCGCTTCAACCGCTTCTTCCACCTGATGCTCGACGAAGGCGTGTATTTCGCGCCGTCCGCGTACGAAGCGGGC
TTCGTGTCGAGCACGCACGACGACGCGGTGATCGACGCGACGCTCGCGGCCGCGCGCCGCGCGTTCGCGGCCCTCGCCGC
CTGA

Upstream 100 bases:

>100_bases
CGGCTGGCCGCGCGCGTCTCCGGTACAATCGGACGATCGTTCCGCCCAGGCGCCGCGGCCCGTGCACAGGCCCCGCGCCG
TTCTCTCGCAGGTTTCGCTC

Downstream 100 bases:

>100_bases
GCGGGCGCGCGCATGTTTTCGGACATCGACTTCGCCCACATGCAGCGCGCGCTCGCGCTCGCTGCACGCGGGATGTATAC
GACCACGCCGAACCCGCGCG

Product: glutamate-1-semialdehyde aminotransferase

Products: NA

Alternate protein names: GSA; Glutamate-1-semialdehyde aminotransferase; GSA-AT [H]

Number of amino acids: Translated: 427; Mature: 426

Protein sequence:

>427_residues
MSNNQILFERAQKTIPGGVNSPVRAFRSVGGTPRFVARAQGPYFWDADGKQYIDYIGSWGPMIVGHVHPEVLDAVQKVLA
DGFSFGAPTEAEIEIAEEICKLVPSIEQVRMVSSGTEATMSALRLARGFTGRSRIVKFEGCYHGHADSLLVKAGSGLLTF
GNPTSAGVPADIAKHTTVLEYNNVAALEEAFGAFGDEIAAVIVEPVAGNMNLVRGTPEFLNALRALCTKHGAVLIFDEVM
CGFRVALGGAQAHYGIAADLTCLGKVIGGGMPAAAFGGRRDIMAHLAPLGGVYQAGTLSGNPIAVAAGLKTLQLIQAPGF
YEALTAQTKRLADGLAAEARAAGVPFAADSIGAMFGLYFAERVPTSFAEVTKSDIERFNRFFHLMLDEGVYFAPSAYEAG
FVSSTHDDAVIDATLAAARRAFAALAA

Sequences:

>Translated_427_residues
MSNNQILFERAQKTIPGGVNSPVRAFRSVGGTPRFVARAQGPYFWDADGKQYIDYIGSWGPMIVGHVHPEVLDAVQKVLA
DGFSFGAPTEAEIEIAEEICKLVPSIEQVRMVSSGTEATMSALRLARGFTGRSRIVKFEGCYHGHADSLLVKAGSGLLTF
GNPTSAGVPADIAKHTTVLEYNNVAALEEAFGAFGDEIAAVIVEPVAGNMNLVRGTPEFLNALRALCTKHGAVLIFDEVM
CGFRVALGGAQAHYGIAADLTCLGKVIGGGMPAAAFGGRRDIMAHLAPLGGVYQAGTLSGNPIAVAAGLKTLQLIQAPGF
YEALTAQTKRLADGLAAEARAAGVPFAADSIGAMFGLYFAERVPTSFAEVTKSDIERFNRFFHLMLDEGVYFAPSAYEAG
FVSSTHDDAVIDATLAAARRAFAALAA
>Mature_426_residues
SNNQILFERAQKTIPGGVNSPVRAFRSVGGTPRFVARAQGPYFWDADGKQYIDYIGSWGPMIVGHVHPEVLDAVQKVLAD
GFSFGAPTEAEIEIAEEICKLVPSIEQVRMVSSGTEATMSALRLARGFTGRSRIVKFEGCYHGHADSLLVKAGSGLLTFG
NPTSAGVPADIAKHTTVLEYNNVAALEEAFGAFGDEIAAVIVEPVAGNMNLVRGTPEFLNALRALCTKHGAVLIFDEVMC
GFRVALGGAQAHYGIAADLTCLGKVIGGGMPAAAFGGRRDIMAHLAPLGGVYQAGTLSGNPIAVAAGLKTLQLIQAPGFY
EALTAQTKRLADGLAAEARAAGVPFAADSIGAMFGLYFAERVPTSFAEVTKSDIERFNRFFHLMLDEGVYFAPSAYEAGF
VSSTHDDAVIDATLAAARRAFAALAA

Specific function: Porphyrin biosynthesis by the C5 pathway; second step. [C]

COG id: COG0001

COG function: function code H; Glutamate-1-semialdehyde aminotransferase

Gene ontology:

Cell location: Cytoplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily [H]

Homologues:

Organism=Homo sapiens, GI4557809, Length=332, Percent_Identity=27.710843373494, Blast_Score=109, Evalue=4e-24,
Organism=Homo sapiens, GI284507298, Length=249, Percent_Identity=26.9076305220884, Blast_Score=74, Evalue=2e-13,
Organism=Escherichia coli, GI1786349, Length=427, Percent_Identity=60.8899297423888, Blast_Score=535, Evalue=1e-153,
Organism=Escherichia coli, GI1789016, Length=378, Percent_Identity=32.010582010582, Blast_Score=163, Evalue=2e-41,
Organism=Escherichia coli, GI1789759, Length=311, Percent_Identity=29.5819935691318, Blast_Score=135, Evalue=4e-33,
Organism=Escherichia coli, GI1788044, Length=332, Percent_Identity=32.2289156626506, Blast_Score=134, Evalue=9e-33,
Organism=Escherichia coli, GI1787560, Length=359, Percent_Identity=30.3621169916435, Blast_Score=126, Evalue=3e-30,
Organism=Escherichia coli, GI145693181, Length=341, Percent_Identity=29.3255131964809, Blast_Score=114, Evalue=9e-27,
Organism=Escherichia coli, GI1786991, Length=327, Percent_Identity=28.7461773700306, Blast_Score=97, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI25144271, Length=364, Percent_Identity=25.8241758241758, Blast_Score=105, Evalue=5e-23,
Organism=Caenorhabditis elegans, GI71992977, Length=344, Percent_Identity=25.8720930232558, Blast_Score=96, Evalue=5e-20,
Organism=Caenorhabditis elegans, GI25144274, Length=211, Percent_Identity=27.9620853080569, Blast_Score=73, Evalue=3e-13,
Organism=Saccharomyces cerevisiae, GI6323470, Length=348, Percent_Identity=27.0114942528736, Blast_Score=98, Evalue=3e-21,
Organism=Saccharomyces cerevisiae, GI6324432, Length=345, Percent_Identity=26.0869565217391, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI21357415, Length=320, Percent_Identity=25.625, Blast_Score=97, Evalue=2e-20,
Organism=Drosophila melanogaster, GI21356575, Length=327, Percent_Identity=25.3822629969419, Blast_Score=82, Evalue=6e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004639
- InterPro:   IPR005814
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00202 Aminotran_3 [H]

EC number: =5.4.3.8 [H]

Molecular weight: Translated: 44925; Mature: 44794

Theoretical pI: Translated: 6.00; Mature: 6.00

Prosite motif: PS00600 AA_TRANSFER_CLASS_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSNNQILFERAQKTIPGGVNSPVRAFRSVGGTPRFVARAQGPYFWDADGKQYIDYIGSWG
CCCCCCHHHHHHHHCCCCCCHHHHHHHHCCCCCCEEEECCCCEEECCCCHHHHHHHCCCC
PMIVGHVHPEVLDAVQKVLADGFSFGAPTEAEIEIAEEICKLVPSIEQVRMVSSGTEATM
CEEEECCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCHHHHH
SALRLARGFTGRSRIVKFEGCYHGHADSLLVKAGSGLLTFGNPTSAGVPADIAKHTTVLE
HHHHHHHCCCCCCCEEEEECCCCCCCCCEEEECCCCEEEECCCCCCCCCHHHHHCCEEEE
YNNVAALEEAFGAFGDEIAAVIVEPVAGNMNLVRGTPEFLNALRALCTKHGAVLIFDEVM
ECCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHCCCEEEEHHHH
CGFRVALGGAQAHYGIAADLTCLGKVIGGGMPAAAFGGRRDIMAHLAPLGGVYQAGTLSG
HHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHCCCCCEECCCCCC
NPIAVAAGLKTLQLIQAPGFYEALTAQTKRLADGLAAEARAAGVPFAADSIGAMFGLYFA
CCEEEECCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
ERVPTSFAEVTKSDIERFNRFFHLMLDEGVYFAPSAYEAGFVSSTHDDAVIDATLAAARR
HHCCHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHH
AFAALAA
HHHHHCC
>Mature Secondary Structure 
SNNQILFERAQKTIPGGVNSPVRAFRSVGGTPRFVARAQGPYFWDADGKQYIDYIGSWG
CCCCCHHHHHHHHCCCCCCHHHHHHHHCCCCCCEEEECCCCEEECCCCHHHHHHHCCCC
PMIVGHVHPEVLDAVQKVLADGFSFGAPTEAEIEIAEEICKLVPSIEQVRMVSSGTEATM
CEEEECCCHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCHHHHH
SALRLARGFTGRSRIVKFEGCYHGHADSLLVKAGSGLLTFGNPTSAGVPADIAKHTTVLE
HHHHHHHCCCCCCCEEEEECCCCCCCCCEEEECCCCEEEECCCCCCCCCHHHHHCCEEEE
YNNVAALEEAFGAFGDEIAAVIVEPVAGNMNLVRGTPEFLNALRALCTKHGAVLIFDEVM
ECCHHHHHHHHHHHHHHHHHHHHHCCCCCCEEECCCHHHHHHHHHHHHHCCCEEEEHHHH
CGFRVALGGAQAHYGIAADLTCLGKVIGGGMPAAAFGGRRDIMAHLAPLGGVYQAGTLSG
HHHHHHHCCCCCCCCHHHHHHHHHHHHCCCCCHHHCCCHHHHHHHHHCCCCCEECCCCCC
NPIAVAAGLKTLQLIQAPGFYEALTAQTKRLADGLAAEARAAGVPFAADSIGAMFGLYFA
CCEEEECCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHH
ERVPTSFAEVTKSDIERFNRFFHLMLDEGVYFAPSAYEAGFVSSTHDDAVIDATLAAARR
HHCCHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCHHHHHHHHHHHH
AFAALAA
HHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA