Click here to switch to the map view.

The map label for this gene is zwf [H]

Identifier: 161525601

GI number: 161525601

Start: 2645283

End: 2646752

Strand: Direct

Name: zwf [H]

Synonym: Bmul_2431

Alternate gene names: 161525601

Gene position: 2645283-2646752 (Clockwise)

Preceding gene: 161525596

Following gene: 161525602

Centisome position: 76.71

GC content: 66.05

Gene sequence:

>1470_bases
ATGCATACCGATTCCAGCTTTACCTTCGTACTTTTCGGCGGCACCGGCGATCTGTCGATGCGCAAGATCCTGCCTGCGCT
GTTCGAAGCGCACCGCGCGAACATGCTCGCGCAAAGCGGCCGGATCGTTGCCGTCGCGCGGCACGAATCGGATCGGGCCG
GGTATCTCGAATGGGTCGACACGCACGTGAAGCCGCATGCGGCAAAGGCGGCGGGCAGCGCGTTCGATCAGGCCGCGTGG
CAGTCCTTCCTCGAGCGCATCGAATACGTGAAGCTCGATCTCGGCCGCGCGGAAGACTATGCGGTGCTGCGCGATGCGGT
CGAGCCGCTGCCCGGCATCCGCGTGTTCTATCTCGCGACGGGGCCGTCGCTGTTCGTGCCGATCTGCAAGGCGCTCGCAT
CGGTCGGGCTCAACGAAGGCTCGCGCATCGTGCTCGAGAAGCCGCTCGGCTACGACCTGCGCTCGTCGAACGCGATCAAC
GACGCGGTCGGCGAAATCTTCGCGGAAGACCAGATCTACCGGATCGACCACTACCTCGGCAAGGAACCCGTGCAGAACCT
GCTCGCGCTGCGCTTCGGCAACGCGCTGTTCGAGCCGCTGTGGCGCCGCGAGTGGGTCGAGAGCATCCAGATCACGATCG
CCGAGGAGCTCGGCGTCGAAGCGCGCGGCGATTTCTACGACAATACGGGCGCGCTGCGCGACATGGTGCAGAACCACCTG
CTGCAGCTGCTGTCGATCGTCGCGATGGAGCCGCCGCACTCGATGGATTCCGATTCCGTGCGCGACGAAAAGCTGCGCGT
GCTGCGCGCGCTGAAGCCGGTCGATCCGCGCGACATCGGCAAGGTCGCGGTGCGCGGCCAGTATCATGCGGGCGTGATCA
AGGGCGTGCAGGTGCCCGCCTATGCGACCGAGCCGGGCGTGAAGCCCGACAGCCAGACCGAAACGTTCGTCGCGCTGAAG
GCGGAAATCGAAAACTGGCGCTGGGCCGGCGTGCCGTTCTTCCTGCGCACCGGCAAGCGGCTCGCCGATCGCGTCGCGGA
GATCGTCGTCAATTTCCGGCCGGTCCCGCATTCGGCGCTCGGGCCGACCGCGCTGCGTCCCGGCGCGAACCGCCTCGTGA
TCCGTCTGCAGCCGAACGAGACGATTCGCCTCTACTGCCTCGCGAAGCAGCCGGGCGAAGGAATGAATCTTGCCAGCGTG
CACCTCGATCTCGCGTTCGATCAGTTCTTCAAGGAAGGACAGATGGAGGCGTATCAACGCCTGCTGCTCGACGTGATCAA
CGGTCGCCTCGCGCTGTTCGTGCGCCGCGACGAGCAGGAGGCCGCGTGGCGCTGGGTCGAGCCGATTCTCAACGAATGGG
CGCGCTCGCTGAAGCCGCCGAAGCCCTATGCGGCAGGCACGTGGGGGCCGGCCGCGTCGAGCGCGATGCTCGCGCAGCAC
GGCACGTGCTGGCTCGAAGAAGAAAACTGA

Upstream 100 bases:

>100_bases
ACCCCTTGCGGCGAATTGTAGTTAAACTACAATTCAGTGTCAAAAATATTTTTATCGCACTACGGATCGCTTCCCAGCAC
CCCCAAACCGGCGGAGACAC

Downstream 100 bases:

>100_bases
TGCGCGCGTCGCCGCGCCGCACGGCGGCCCGGCATCGCGTCGCATGAACGACACGATTTGAACAGACAAAGCAGTCCGGA
GGAGATGTGATCGAGATCCA

Product: glucose-6-phosphate 1-dehydrogenase

Products: NA

Alternate protein names: G6PD [H]

Number of amino acids: Translated: 489; Mature: 489

Protein sequence:

>489_residues
MHTDSSFTFVLFGGTGDLSMRKILPALFEAHRANMLAQSGRIVAVARHESDRAGYLEWVDTHVKPHAAKAAGSAFDQAAW
QSFLERIEYVKLDLGRAEDYAVLRDAVEPLPGIRVFYLATGPSLFVPICKALASVGLNEGSRIVLEKPLGYDLRSSNAIN
DAVGEIFAEDQIYRIDHYLGKEPVQNLLALRFGNALFEPLWRREWVESIQITIAEELGVEARGDFYDNTGALRDMVQNHL
LQLLSIVAMEPPHSMDSDSVRDEKLRVLRALKPVDPRDIGKVAVRGQYHAGVIKGVQVPAYATEPGVKPDSQTETFVALK
AEIENWRWAGVPFFLRTGKRLADRVAEIVVNFRPVPHSALGPTALRPGANRLVIRLQPNETIRLYCLAKQPGEGMNLASV
HLDLAFDQFFKEGQMEAYQRLLLDVINGRLALFVRRDEQEAAWRWVEPILNEWARSLKPPKPYAAGTWGPAASSAMLAQH
GTCWLEEEN

Sequences:

>Translated_489_residues
MHTDSSFTFVLFGGTGDLSMRKILPALFEAHRANMLAQSGRIVAVARHESDRAGYLEWVDTHVKPHAAKAAGSAFDQAAW
QSFLERIEYVKLDLGRAEDYAVLRDAVEPLPGIRVFYLATGPSLFVPICKALASVGLNEGSRIVLEKPLGYDLRSSNAIN
DAVGEIFAEDQIYRIDHYLGKEPVQNLLALRFGNALFEPLWRREWVESIQITIAEELGVEARGDFYDNTGALRDMVQNHL
LQLLSIVAMEPPHSMDSDSVRDEKLRVLRALKPVDPRDIGKVAVRGQYHAGVIKGVQVPAYATEPGVKPDSQTETFVALK
AEIENWRWAGVPFFLRTGKRLADRVAEIVVNFRPVPHSALGPTALRPGANRLVIRLQPNETIRLYCLAKQPGEGMNLASV
HLDLAFDQFFKEGQMEAYQRLLLDVINGRLALFVRRDEQEAAWRWVEPILNEWARSLKPPKPYAAGTWGPAASSAMLAQH
GTCWLEEEN
>Mature_489_residues
MHTDSSFTFVLFGGTGDLSMRKILPALFEAHRANMLAQSGRIVAVARHESDRAGYLEWVDTHVKPHAAKAAGSAFDQAAW
QSFLERIEYVKLDLGRAEDYAVLRDAVEPLPGIRVFYLATGPSLFVPICKALASVGLNEGSRIVLEKPLGYDLRSSNAIN
DAVGEIFAEDQIYRIDHYLGKEPVQNLLALRFGNALFEPLWRREWVESIQITIAEELGVEARGDFYDNTGALRDMVQNHL
LQLLSIVAMEPPHSMDSDSVRDEKLRVLRALKPVDPRDIGKVAVRGQYHAGVIKGVQVPAYATEPGVKPDSQTETFVALK
AEIENWRWAGVPFFLRTGKRLADRVAEIVVNFRPVPHSALGPTALRPGANRLVIRLQPNETIRLYCLAKQPGEGMNLASV
HLDLAFDQFFKEGQMEAYQRLLLDVINGRLALFVRRDEQEAAWRWVEPILNEWARSLKPPKPYAAGTWGPAASSAMLAQH
GTCWLEEEN

Specific function: Pentose phosphate pathway; first step. [C]

COG id: COG0364

COG function: function code G; Glucose-6-phosphate 1-dehydrogenase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glucose-6-phosphate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI108773793, Length=492, Percent_Identity=36.1788617886179, Blast_Score=303, Evalue=2e-82,
Organism=Homo sapiens, GI109389365, Length=492, Percent_Identity=36.1788617886179, Blast_Score=303, Evalue=3e-82,
Organism=Homo sapiens, GI52145310, Length=367, Percent_Identity=32.9700272479564, Blast_Score=160, Evalue=3e-39,
Organism=Escherichia coli, GI1788158, Length=491, Percent_Identity=43.5845213849287, Blast_Score=426, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI17538218, Length=496, Percent_Identity=34.6774193548387, Blast_Score=318, Evalue=4e-87,
Organism=Saccharomyces cerevisiae, GI6324088, Length=481, Percent_Identity=35.5509355509356, Blast_Score=293, Evalue=5e-80,
Organism=Drosophila melanogaster, GI24643350, Length=477, Percent_Identity=36.8972746331237, Blast_Score=300, Evalue=2e-81,
Organism=Drosophila melanogaster, GI24643352, Length=477, Percent_Identity=36.8972746331237, Blast_Score=298, Evalue=4e-81,
Organism=Drosophila melanogaster, GI221513548, Length=486, Percent_Identity=30.6584362139918, Blast_Score=210, Evalue=2e-54,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001282
- InterPro:   IPR019796
- InterPro:   IPR022675
- InterPro:   IPR022674
- InterPro:   IPR016040 [H]

Pfam domain/function: PF02781 G6PD_C; PF00479 G6PD_N [H]

EC number: =1.1.1.49 [H]

Molecular weight: Translated: 54652; Mature: 54652

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS00069 G6P_DEHYDROGENASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHTDSSFTFVLFGGTGDLSMRKILPALFEAHRANMLAQSGRIVAVARHESDRAGYLEWVD
CCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHH
THVKPHAAKAAGSAFDQAAWQSFLERIEYVKLDLGRAEDYAVLRDAVEPLPGIRVFYLAT
HCCCCCHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCEEEEEEC
GPSLFVPICKALASVGLNEGSRIVLEKPLGYDLRSSNAINDAVGEIFAEDQIYRIDHYLG
CCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHCCCEEEHHHHCC
KEPVQNLLALRFGNALFEPLWRREWVESIQITIAEELGVEARGDFYDNTGALRDMVQNHL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHCCCCCCCCCCCCCHHHHHHHHHHH
LQLLSIVAMEPPHSMDSDSVRDEKLRVLRALKPVDPRDIGKVAVRGQYHAGVIKGVQVPA
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCHHHCCCCCCC
YATEPGVKPDSQTETFVALKAEIENWRWAGVPFFLRTGKRLADRVAEIVVNFRPVPHSAL
CCCCCCCCCCCCCCEEEEEEEECCCCEECCCHHHHHCCHHHHHHHHHHHHHCCCCCCCCC
GPTALRPGANRLVIRLQPNETIRLYCLAKQPGEGMNLASVHLDLAFDQFFKEGQMEAYQR
CCCCCCCCCCEEEEEECCCCEEEEEEEECCCCCCCCEEEEEEHHHHHHHHHCCHHHHHHH
LLLDVINGRLALFVRRDEQEAAWRWVEPILNEWARSLKPPKPYAAGTWGPAASSAMLAQH
HHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHCC
GTCWLEEEN
CCEEEECCC
>Mature Secondary Structure
MHTDSSFTFVLFGGTGDLSMRKILPALFEAHRANMLAQSGRIVAVARHESDRAGYLEWVD
CCCCCCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCCHHHHHH
THVKPHAAKAAGSAFDQAAWQSFLERIEYVKLDLGRAEDYAVLRDAVEPLPGIRVFYLAT
HCCCCCHHHHHCHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCCCCEEEEEEC
GPSLFVPICKALASVGLNEGSRIVLEKPLGYDLRSSNAINDAVGEIFAEDQIYRIDHYLG
CCHHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCCCHHHHHHHHHHCCCEEEHHHHCC
KEPVQNLLALRFGNALFEPLWRREWVESIQITIAEELGVEARGDFYDNTGALRDMVQNHL
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEHHHCCCCCCCCCCCCCHHHHHHHHHHH
LQLLSIVAMEPPHSMDSDSVRDEKLRVLRALKPVDPRDIGKVAVRGQYHAGVIKGVQVPA
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCEEECCCCCCHHHCCCCCCC
YATEPGVKPDSQTETFVALKAEIENWRWAGVPFFLRTGKRLADRVAEIVVNFRPVPHSAL
CCCCCCCCCCCCCCEEEEEEEECCCCEECCCHHHHHCCHHHHHHHHHHHHHCCCCCCCCC
GPTALRPGANRLVIRLQPNETIRLYCLAKQPGEGMNLASVHLDLAFDQFFKEGQMEAYQR
CCCCCCCCCCEEEEEECCCCEEEEEEEECCCCCCCCEEEEEEHHHHHHHHHCCHHHHHHH
LLLDVINGRLALFVRRDEQEAAWRWVEPILNEWARSLKPPKPYAAGTWGPAASSAMLAQH
HHHHHHCCCEEEEEEECCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHCC
GTCWLEEEN
CCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10400573; 11481430 [H]