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The map label for this gene is clcA [H]

Identifier: 161525581

GI number: 161525581

Start: 2624230

End: 2625783

Strand: Direct

Name: clcA [H]

Synonym: Bmul_2411

Alternate gene names: 161525581

Gene position: 2624230-2625783 (Clockwise)

Preceding gene: 161525579

Following gene: 161525588

Centisome position: 76.1

GC content: 70.72

Gene sequence:

>1554_bases
ATGCCACGCCCCGCGCTTCCCACCCTGTTTCCCGCCCTCACCCGCCGCTCGCTGCGGATCTGGCGCCAGTACGGCGTGTT
CTGGCTCGGCGCGATCGCCGTCGGCCTCACCGCGGTGCTCTATGCGCGGCTGATCGACTGGGGCTACGAAACGTTCCGCA
CGATGCGCGCGCATGCCGTGTGGCTGCCGCTCGTGCTGACGCCCGCGATCGCGGCCGCCTCCGTGTGGACCACGCGCCGG
TTCTTTCGCGGCGCCGAAGGCAGCGGCATTCCGCAAGTGATCGCGACGCTGCACGCGCAGCCGGGTGCATTCGGCTCGCG
GCTGCTCACGCTGCGCATCCTGTTCGGCAAGATCCTGATTTCGTTTCTGGGCATCCTCGGCGGCTTCACGATCGGCCGCG
AAGGGCCGACCGTGCAGGTCGGCGCCGCGCTGATGTTCAATCTGCGGCGCCTGTATCCGCGCTCGAACGCGCAGATCGAA
CGCCAGCTCGTGCTCGCCGGCGCGGCCGCCGGCCTGTCGGCCGCGTTCAACACGCCGCTCGCGGGGATCGTGTTCGCGAT
CGAGGAACTGACGCGCAGCTTCTCCGCACGTGCGAGCGGCGTGCTGATCACCGCGATCATCCTCGCCGGCGTCGTCGCGC
TGGGCCTGAACGGCAACTACACGTATTTCGGCACGATCGACGTCGGCGCGCATTTCCCGAAGCTGCTCGCGGTCGCCGTG
CTCGTCACCGCGATCGTGACCGGCATCGCCGGCGGCCTGTTCAGCTGGCTGCTGCTCAATACCGCGCGCTGGCTGCCCGA
GCGGCTGCTCGGCCTGTACCGCGGGCGGCCGGTCGCGTTCGCCGCGCTGTGCGGCTTCGTGATCGCCGTCGTCGGCCTCG
TGTCGGGCGGCACGACGTTCGGCAGCGGCTACGCCGAAGCGCGCGGGCTGCTCGACGGCCACGAGCAATTGTCGGTCTTC
TATCCGTTCATGAAGATGGTGTCGATGGTCGCGTCGTATCTGCCCGGCATTCCGGGCGGGATCTTCGCGCCGTCGCTGTC
GATCGGCGCGGGGTTCGGCAACCTGCTGCATCTCGTGTTCGGCAACATGCCGCTGCCGTTGCTGATCGCGCTCGCGATGG
TCGGCTATCTCGCCGCCGTCACGCAGTCGCCGATCACGTCGTTCGTGATCGTGATGGAGATGATCAACGGGCATGCGCTC
GTGATTTCGCTGATGGCGACCGCGCTCGTCTCGAGCCGCGTCGCGCGCTTCTTCGCGCCGCCGCTCTGCGAGACGCTCGC
CGAGCGCTACCTCGCGCCGCCGGCGCCCGTCGCCGCCGCGCAGCCGGCACCAGCTGCAGCGGCGGCAGCGGCGGCCACCG
ACGTCGTCGCCGCGCAGGACGCGGGCACGGCGCCTGCCGATCCGCTCGATACGCTGCGCGACGAAGGCGGCGCCGAGACC
GGCCATCGCGCAGAAAGCGACGCCACGCCGGCCGGCGCGGCGCCGCAACGCGACGAGGCAGAGACGGCCGCCACGGCCGA
TGCGGCGCGCAACGGCCCGCGCGACACTCAGTAG

Upstream 100 bases:

>100_bases
TACACTTGCAACAAAATGCGTCGCGACAGTAAAAGCTTGTCGAAAGGCGCGCCGGCGGCGTTCTTTTTATAATCGAATCT
TTGCCCGCCCGGCCCCGCCG

Downstream 100 bases:

>100_bases
ATCACCACGGGCGCCGGCCGGTAGTAGACGGGCCGCGCCGGCACGACGATGCAGCCGGCGAGCGTGACGGCCACGAGCGC
GATGGCAAAGAGCGTTCGTT

Product: chloride channel core protein

Products: Cl Ion [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 517; Mature: 516

Protein sequence:

>517_residues
MPRPALPTLFPALTRRSLRIWRQYGVFWLGAIAVGLTAVLYARLIDWGYETFRTMRAHAVWLPLVLTPAIAAASVWTTRR
FFRGAEGSGIPQVIATLHAQPGAFGSRLLTLRILFGKILISFLGILGGFTIGREGPTVQVGAALMFNLRRLYPRSNAQIE
RQLVLAGAAAGLSAAFNTPLAGIVFAIEELTRSFSARASGVLITAIILAGVVALGLNGNYTYFGTIDVGAHFPKLLAVAV
LVTAIVTGIAGGLFSWLLLNTARWLPERLLGLYRGRPVAFAALCGFVIAVVGLVSGGTTFGSGYAEARGLLDGHEQLSVF
YPFMKMVSMVASYLPGIPGGIFAPSLSIGAGFGNLLHLVFGNMPLPLLIALAMVGYLAAVTQSPITSFVIVMEMINGHAL
VISLMATALVSSRVARFFAPPLCETLAERYLAPPAPVAAAQPAPAAAAAAAATDVVAAQDAGTAPADPLDTLRDEGGAET
GHRAESDATPAGAAPQRDEAETAATADAARNGPRDTQ

Sequences:

>Translated_517_residues
MPRPALPTLFPALTRRSLRIWRQYGVFWLGAIAVGLTAVLYARLIDWGYETFRTMRAHAVWLPLVLTPAIAAASVWTTRR
FFRGAEGSGIPQVIATLHAQPGAFGSRLLTLRILFGKILISFLGILGGFTIGREGPTVQVGAALMFNLRRLYPRSNAQIE
RQLVLAGAAAGLSAAFNTPLAGIVFAIEELTRSFSARASGVLITAIILAGVVALGLNGNYTYFGTIDVGAHFPKLLAVAV
LVTAIVTGIAGGLFSWLLLNTARWLPERLLGLYRGRPVAFAALCGFVIAVVGLVSGGTTFGSGYAEARGLLDGHEQLSVF
YPFMKMVSMVASYLPGIPGGIFAPSLSIGAGFGNLLHLVFGNMPLPLLIALAMVGYLAAVTQSPITSFVIVMEMINGHAL
VISLMATALVSSRVARFFAPPLCETLAERYLAPPAPVAAAQPAPAAAAAAAATDVVAAQDAGTAPADPLDTLRDEGGAET
GHRAESDATPAGAAPQRDEAETAATADAARNGPRDTQ
>Mature_516_residues
PRPALPTLFPALTRRSLRIWRQYGVFWLGAIAVGLTAVLYARLIDWGYETFRTMRAHAVWLPLVLTPAIAAASVWTTRRF
FRGAEGSGIPQVIATLHAQPGAFGSRLLTLRILFGKILISFLGILGGFTIGREGPTVQVGAALMFNLRRLYPRSNAQIER
QLVLAGAAAGLSAAFNTPLAGIVFAIEELTRSFSARASGVLITAIILAGVVALGLNGNYTYFGTIDVGAHFPKLLAVAVL
VTAIVTGIAGGLFSWLLLNTARWLPERLLGLYRGRPVAFAALCGFVIAVVGLVSGGTTFGSGYAEARGLLDGHEQLSVFY
PFMKMVSMVASYLPGIPGGIFAPSLSIGAGFGNLLHLVFGNMPLPLLIALAMVGYLAAVTQSPITSFVIVMEMINGHALV
ISLMATALVSSRVARFFAPPLCETLAERYLAPPAPVAAAQPAPAAAAAAAATDVVAAQDAGTAPADPLDTLRDEGGAETG
HRAESDATPAGAAPQRDEAETAATADAARNGPRDTQ

Specific function: Proton-coupled chloride transporter. Functions as antiport system and exchanges two chloride ions for 1 proton. Probably acts as an electrical shunt for an outwardly-directed proton pump that is linked to amino acid decarboxylation, as part of the extreme

COG id: COG0038

COG function: function code P; Chloride channel protein EriC

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the chloride channel (TC 2.A.49) family. ClcA subfamily [H]

Homologues:

Organism=Escherichia coli, GI1786350, Length=443, Percent_Identity=28.6681715575621, Blast_Score=83, Evalue=4e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014743
- InterPro:   IPR001807 [H]

Pfam domain/function: PF00654 Voltage_CLC [H]

EC number: NA

Molecular weight: Translated: 54072; Mature: 53941

Theoretical pI: Translated: 9.77; Mature: 9.77

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPRPALPTLFPALTRRSLRIWRQYGVFWLGAIAVGLTAVLYARLIDWGYETFRTMRAHAV
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WLPLVLTPAIAAASVWTTRRFFRGAEGSGIPQVIATLHAQPGAFGSRLLTLRILFGKILI
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
SFLGILGGFTIGREGPTVQVGAALMFNLRRLYPRSNAQIERQLVLAGAAAGLSAAFNTPL
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCH
AGIVFAIEELTRSFSARASGVLITAIILAGVVALGLNGNYTYFGTIDVGAHFPKLLAVAV
HHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHH
LVTAIVTGIAGGLFSWLLLNTARWLPERLLGLYRGRPVAFAALCGFVIAVVGLVSGGTTF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCC
GSGYAEARGLLDGHEQLSVFYPFMKMVSMVASYLPGIPGGIFAPSLSIGAGFGNLLHLVF
CCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCHHCCCHHHHHHHHH
GNMPLPLLIALAMVGYLAAVTQSPITSFVIVMEMINGHALVISLMATALVSSRVARFFAP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCC
PLCETLAERYLAPPAPVAAAQPAPAAAAAAAATDVVAAQDAGTAPADPLDTLRDEGGAET
HHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCC
GHRAESDATPAGAAPQRDEAETAATADAARNGPRDTQ
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
PRPALPTLFPALTRRSLRIWRQYGVFWLGAIAVGLTAVLYARLIDWGYETFRTMRAHAV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
WLPLVLTPAIAAASVWTTRRFFRGAEGSGIPQVIATLHAQPGAFGSRLLTLRILFGKILI
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHH
SFLGILGGFTIGREGPTVQVGAALMFNLRRLYPRSNAQIERQLVLAGAAAGLSAAFNTPL
HHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCH
AGIVFAIEELTRSFSARASGVLITAIILAGVVALGLNGNYTYFGTIDVGAHFPKLLAVAV
HHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCEEEEEEECCCHHHHHHHHHHH
LVTAIVTGIAGGLFSWLLLNTARWLPERLLGLYRGRPVAFAALCGFVIAVVGLVSGGTTF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCC
GSGYAEARGLLDGHEQLSVFYPFMKMVSMVASYLPGIPGGIFAPSLSIGAGFGNLLHLVF
CCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHCCCCHHCCCHHHHHHHHH
GNMPLPLLIALAMVGYLAAVTQSPITSFVIVMEMINGHALVISLMATALVSSRVARFFAP
CCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCC
PLCETLAERYLAPPAPVAAAQPAPAAAAAAAATDVVAAQDAGTAPADPLDTLRDEGGAET
HHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCCCCHHHHHHCCCCCCC
GHRAESDATPAGAAPQRDEAETAATADAARNGPRDTQ
CCCCCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Cl Ion [Periplasm] [C]

Specific reaction: Cl Ion [Periplasm] = Cl Ion [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA