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The map label for this gene is guaD [H]

Identifier: 161525547

GI number: 161525547

Start: 2590111

End: 2591430

Strand: Direct

Name: guaD [H]

Synonym: Bmul_2377

Alternate gene names: 161525547

Gene position: 2590111-2591430 (Clockwise)

Preceding gene: 161525546

Following gene: 161525548

Centisome position: 75.11

GC content: 69.24

Gene sequence:

>1320_bases
ATGACGCAAACCGCTTTTCGCTCCCAGTTGCTGACCTTCAACGGCGACCCCGCACAATCGAGCCAGGCCGCGATTCACGA
GACCGACGGTCTGCTGATCGTCGACGACGGCAAGGTCGTCGCGGCGGGCCCCTATGCGCGCATCGCGCCGATGCTCGCGC
GCGACGCAGTCGTGCACGACCTGCGCGGCAAGCTGATCGTGCCGGGCTTCATCGACACGCACATCCACTACCCGCAGACG
GACATGATCGCGTCGCCGGCGCCCGGCCTGCTGCCCTGGCTCGACACGTACACGTTCCCGACCGAGCGGCGGTTCGGCGA
CCCCGAGCATGCGCGCGAAGTCGCGGATTTCTTCGTCGACGAACTGCTCGCCTGCGGCACGACGAGCGCGCTCGTCTACT
GCACGGTGCACAAGCAGTCGGCCGACGCGCTGTTCGCGGCGAGTGAAGCGCGCGACCTGCGGATGATCGCGGGCAAGGTG
CTGATGGATCGCAACTGCCCCGAGTTCCTGCGCGACACCGCGCAGTCCGGCTACGACGACACGGCCGAGCTGATCGCGCG
CTGGCACGGCCGCGGCCGGCAGATGTACGTGATCACGCCGCGCTTTGCGCCGACCTCGACCGAAGCGCAACTCGAAGCCT
GCGGCGAGCTCGCGCGCCGCCATCCGGACGTGTTCGTGCAGAGCCACGTCGCCGAAAACGTCGACGAGGTGAAATGGGCG
GCCGAACTGTTCCCCGGCCATCGCAGCTATCTCGACATCTACGATCGCTACGGGCTGCTGCGGCCGCGCGCCGTGTACGG
CCACTGCATCCATCTCGACGACGAGGACCGCCGCCGCATGGCCGAGACGCGCACGGTCGTCGCGCACTGCCCGACGTCGA
ACTTCTTCCTCGGCAGCGGCTTGTTCGATTTCGACAAGGCCGGCGAATACGGCGTGCCGGTCACGCTCGCGACCGACGTC
GGCGGCGGCACGTCGTTCTCGATGCTGCAGACGATGAACGAGGCGCACAAGGTCGCGCGGCTGTCGGGCCATCATCTGAG
CGCGACGCGGATGTTCTGGCTCGCGACGGCGGGCGCCGCACAGGCGCTCGATCTCGCCGATACGATCGGCACGCTCGCGC
CGCGCACCGAGGCCGACTTCGTCGTGCTCGATCCGCAGGCCACGCCGCTGCTCGCGCGGCGCACGCAGCGCGCGGAATCG
CTCGAGGAACTGCTGTTCGCGTTCGCGCTGCTCGGCGACGACCGCGCGGTCTATCGCACCTATGCGGCCGGCCGCCTCGT
GCACGAGCGCGGCGCCGCACGCCGCGTCGCGGCGAACTGA

Upstream 100 bases:

>100_bases
GCCGCTGCGCCGATACGCGCACGGTTTCGTCGACGCCTTCGCCGCTGCGGCGCCGGCCGTTTTCTTCTGTCTGTCTTACC
TTGATGCAGGACCCTTCGTC

Downstream 100 bases:

>100_bases
CGACGCCCCGCGCCGGCACGTAGCACGCGCGGGCTGGCAGCCGAGCGCCATTCGATGCGCGCGCAACGCGCGTTTGCACG
TTGCGCGCGCCATGCTAGAA

Product: guanine deaminase

Products: NA

Alternate protein names: Guanase; Guanine aminase; Guanine aminohydrolase; GAH [H]

Number of amino acids: Translated: 439; Mature: 438

Protein sequence:

>439_residues
MTQTAFRSQLLTFNGDPAQSSQAAIHETDGLLIVDDGKVVAAGPYARIAPMLARDAVVHDLRGKLIVPGFIDTHIHYPQT
DMIASPAPGLLPWLDTYTFPTERRFGDPEHAREVADFFVDELLACGTTSALVYCTVHKQSADALFAASEARDLRMIAGKV
LMDRNCPEFLRDTAQSGYDDTAELIARWHGRGRQMYVITPRFAPTSTEAQLEACGELARRHPDVFVQSHVAENVDEVKWA
AELFPGHRSYLDIYDRYGLLRPRAVYGHCIHLDDEDRRRMAETRTVVAHCPTSNFFLGSGLFDFDKAGEYGVPVTLATDV
GGGTSFSMLQTMNEAHKVARLSGHHLSATRMFWLATAGAAQALDLADTIGTLAPRTEADFVVLDPQATPLLARRTQRAES
LEELLFAFALLGDDRAVYRTYAAGRLVHERGAARRVAAN

Sequences:

>Translated_439_residues
MTQTAFRSQLLTFNGDPAQSSQAAIHETDGLLIVDDGKVVAAGPYARIAPMLARDAVVHDLRGKLIVPGFIDTHIHYPQT
DMIASPAPGLLPWLDTYTFPTERRFGDPEHAREVADFFVDELLACGTTSALVYCTVHKQSADALFAASEARDLRMIAGKV
LMDRNCPEFLRDTAQSGYDDTAELIARWHGRGRQMYVITPRFAPTSTEAQLEACGELARRHPDVFVQSHVAENVDEVKWA
AELFPGHRSYLDIYDRYGLLRPRAVYGHCIHLDDEDRRRMAETRTVVAHCPTSNFFLGSGLFDFDKAGEYGVPVTLATDV
GGGTSFSMLQTMNEAHKVARLSGHHLSATRMFWLATAGAAQALDLADTIGTLAPRTEADFVVLDPQATPLLARRTQRAES
LEELLFAFALLGDDRAVYRTYAAGRLVHERGAARRVAAN
>Mature_438_residues
TQTAFRSQLLTFNGDPAQSSQAAIHETDGLLIVDDGKVVAAGPYARIAPMLARDAVVHDLRGKLIVPGFIDTHIHYPQTD
MIASPAPGLLPWLDTYTFPTERRFGDPEHAREVADFFVDELLACGTTSALVYCTVHKQSADALFAASEARDLRMIAGKVL
MDRNCPEFLRDTAQSGYDDTAELIARWHGRGRQMYVITPRFAPTSTEAQLEACGELARRHPDVFVQSHVAENVDEVKWAA
ELFPGHRSYLDIYDRYGLLRPRAVYGHCIHLDDEDRRRMAETRTVVAHCPTSNFFLGSGLFDFDKAGEYGVPVTLATDVG
GGTSFSMLQTMNEAHKVARLSGHHLSATRMFWLATAGAAQALDLADTIGTLAPRTEADFVVLDPQATPLLARRTQRAESL
EELLFAFALLGDDRAVYRTYAAGRLVHERGAARRVAAN

Specific function: Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia [H]

COG id: COG0402

COG function: function code FR; Cytosine deaminase and related metal-dependent hydrolases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATZ/TRZ family [H]

Homologues:

Organism=Homo sapiens, GI4758426, Length=380, Percent_Identity=32.6315789473684, Blast_Score=196, Evalue=3e-50,
Organism=Escherichia coli, GI1789249, Length=416, Percent_Identity=50.4807692307692, Blast_Score=449, Evalue=1e-127,
Organism=Saccharomyces cerevisiae, GI6319963, Length=430, Percent_Identity=30.6976744186047, Blast_Score=199, Evalue=5e-52,
Organism=Drosophila melanogaster, GI24643849, Length=432, Percent_Identity=33.1018518518519, Blast_Score=207, Evalue=1e-53,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006680
- InterPro:   IPR014311
- InterPro:   IPR011059 [H]

Pfam domain/function: PF01979 Amidohydro_1 [H]

EC number: =3.5.4.3 [H]

Molecular weight: Translated: 48418; Mature: 48287

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQTAFRSQLLTFNGDPAQSSQAAIHETDGLLIVDDGKVVAAGPYARIAPMLARDAVVHD
CCCHHHHHHHEEECCCCCCCCCCEEEECCCEEEEECCEEEEECCHHHHHHHHHHHHHHHH
LRGKLIVPGFIDTHIHYPQTDMIASPAPGLLPWLDTYTFPTERRFGDPEHAREVADFFVD
CCCCEEECCHHHCCCCCCCCCCCCCCCCCCCHHHHCCCCCCHHCCCCHHHHHHHHHHHHH
ELLACGTTSALVYCTVHKQSADALFAASEARDLRMIAGKVLMDRNCPEFLRDTAQSGYDD
HHHHCCCCCEEEEEEEECCCCCHHEEHHCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCH
TAELIARWHGRGRQMYVITPRFAPTSTEAQLEACGELARRHPDVFVQSHVAENVDEVKWA
HHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHH
AELFPGHRSYLDIYDRYGLLRPRAVYGHCIHLDDEDRRRMAETRTVVAHCPTSNFFLGSG
HHHCCCCHHHHHHHHHCCCCCCHHHEEEEEECCCHHHHHHHHHCEEEEECCCCCEEECCC
LFDFDKAGEYGVPVTLATDVGGGTSFSMLQTMNEAHKVARLSGHHLSATRMFWLATAGAA
CCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHEEEEEEECCCH
QALDLADTIGTLAPRTEADFVVLDPQATPLLARRTQRAESLEELLFAFALLGDDRAVYRT
HHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
YAAGRLVHERGAARRVAAN
HHHHHHHHHCCCCHHCCCC
>Mature Secondary Structure 
TQTAFRSQLLTFNGDPAQSSQAAIHETDGLLIVDDGKVVAAGPYARIAPMLARDAVVHD
CCHHHHHHHEEECCCCCCCCCCEEEECCCEEEEECCEEEEECCHHHHHHHHHHHHHHHH
LRGKLIVPGFIDTHIHYPQTDMIASPAPGLLPWLDTYTFPTERRFGDPEHAREVADFFVD
CCCCEEECCHHHCCCCCCCCCCCCCCCCCCCHHHHCCCCCCHHCCCCHHHHHHHHHHHHH
ELLACGTTSALVYCTVHKQSADALFAASEARDLRMIAGKVLMDRNCPEFLRDTAQSGYDD
HHHHCCCCCEEEEEEEECCCCCHHEEHHCHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCH
TAELIARWHGRGRQMYVITPRFAPTSTEAQLEACGELARRHPDVFVQSHVAENVDEVKWA
HHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHHHHHHHCCCCHHHHHHHHCCHHHHHHH
AELFPGHRSYLDIYDRYGLLRPRAVYGHCIHLDDEDRRRMAETRTVVAHCPTSNFFLGSG
HHHCCCCHHHHHHHHHCCCCCCHHHEEEEEECCCHHHHHHHHHCEEEEECCCCCEEECCC
LFDFDKAGEYGVPVTLATDVGGGTSFSMLQTMNEAHKVARLSGHHLSATRMFWLATAGAA
CCCCCCCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHCCCCCCHHEEEEEEECCCH
QALDLADTIGTLAPRTEADFVVLDPQATPLLARRTQRAESLEELLFAFALLGDDRAVYRT
HHHHHHHHHHHCCCCCCCCEEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHH
YAAGRLVHERGAARRVAAN
HHHHHHHHHCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9278503; 10913105 [H]