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The map label for this gene is degP [C]

Identifier: 161525478

GI number: 161525478

Start: 2522612

End: 2523763

Strand: Direct

Name: degP [C]

Synonym: Bmul_2308

Alternate gene names: 161525478

Gene position: 2522612-2523763 (Clockwise)

Preceding gene: 161525477

Following gene: 161525483

Centisome position: 73.15

GC content: 65.62

Gene sequence:

>1152_bases
ATGGCCTACCCCGACCCGTACCAACGTCCCGCGCCGGACCACTTCGTCCGGCGCTGGCTCTTCATCACCGCCTGTATTGC
CGCGCTCATGCTGCTGTGGCAGTTCCTGCCCGCCATCGAGGCATGGTTCAGTCCGCGCGAGGCGGCAGAGCGCACCGTGA
CGGCGCGCGGCGACTTGGCGGCGGACGAAAAGGCCACCATCGAACTGTTCGAAAAATCGCGCGCCTCGGTGGTCTACATC
ACTACCGCACAATTGGTACGCGATGTCTGGACGCGCAACGTCTTCTCCGTGCCGCGCGGCACTGGTTCGGGCTTCATCTG
GGACGACGCCGGCCATGTCGTGACCAATTTCCACGTCATCCAGGGCGCGTCGGAGGCCACCGTCAAACTCGCCGACGGAC
GCGACTACCAGGCCGCGCTGGTAGGGGCGAGCCCTGCGCACGACATCGCTGTGCTCAAGATCGGCGTCGGTTTCAAGCGC
CCGCCGGCTGTGCCGGTCGGCACCAGTGCCGACCTCAAGGTGGGTCAGAAGGTGTTCGCTATCGGCAACCCCTTCGGCCT
GGACTGGACGCTCACCACCGGCATCGTCTCCGCGCTCGACCGCTCGTTACCCGGAGAAGCGGGCGGCCCGGCCATCGATC
ACCTGATCCAGACCGACGCCGCCATCAACCCTGGCAACTCCGGTGGGCCGCTGCTCGATTCGGCCGGGCGGCTTATCGGC
ATCAACACGGCGATCTACAGCCCCTCCGGCGCCTCGGCCGGGATTGGTTTCGCCGTGCCGGTGGACACCGTCATGCGCGT
AGTCCCGCAACTCATCAAGACCGGTAAGTACATCCGTCCGGCGCTGGGCATTGAGGTGGACGAACAGCTCAATCAGCGCC
TGCTGGCGCTGACTGGAAGCAAGGGCGTGTTCGTGTTGCGTGTTACCCCTGGTTCGGCAGCGCACAAGGCCGGCCTCGCG
GGTGTCGAAGTCACGCCGCAAGGCATCGTGCCGGGCGACCGCATCATCGATGTTGATGGCAAGGCGACGGACGATGTGGC
CAAGCTGCTCGCGCGGCTAGACGACAGGAAGGTCGGCGATGTGGTGGTCTTGTCAGTGGAACGGGCCGGCAAATCGCGCG
AGGTGCGTGTGGAGCTGCAACCGGGAATTTGA

Upstream 100 bases:

>100_bases
CGCGCCCCATTTCTTGCCGGAATCTGCTGTGACGCCGCGCCCGCCGCGCTGGCGCCCGAGCGGGCTATGGCGCTGATTGC
CTATCAACAGGAGACTTCTC

Downstream 100 bases:

>100_bases
TCGAGGCGACCCGGTCTATCAGGCGGCGCGGAGCAGGCAAGTCGCCTCGGCCTCTCGCCGCGTGACAAGCCCCGGCAGTA
CCTTGCCACCGCCATACACC

Product: 2-alkenal reductase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 383; Mature: 382

Protein sequence:

>383_residues
MAYPDPYQRPAPDHFVRRWLFITACIAALMLLWQFLPAIEAWFSPREAAERTVTARGDLAADEKATIELFEKSRASVVYI
TTAQLVRDVWTRNVFSVPRGTGSGFIWDDAGHVVTNFHVIQGASEATVKLADGRDYQAALVGASPAHDIAVLKIGVGFKR
PPAVPVGTSADLKVGQKVFAIGNPFGLDWTLTTGIVSALDRSLPGEAGGPAIDHLIQTDAAINPGNSGGPLLDSAGRLIG
INTAIYSPSGASAGIGFAVPVDTVMRVVPQLIKTGKYIRPALGIEVDEQLNQRLLALTGSKGVFVLRVTPGSAAHKAGLA
GVEVTPQGIVPGDRIIDVDGKATDDVAKLLARLDDRKVGDVVVLSVERAGKSREVRVELQPGI

Sequences:

>Translated_383_residues
MAYPDPYQRPAPDHFVRRWLFITACIAALMLLWQFLPAIEAWFSPREAAERTVTARGDLAADEKATIELFEKSRASVVYI
TTAQLVRDVWTRNVFSVPRGTGSGFIWDDAGHVVTNFHVIQGASEATVKLADGRDYQAALVGASPAHDIAVLKIGVGFKR
PPAVPVGTSADLKVGQKVFAIGNPFGLDWTLTTGIVSALDRSLPGEAGGPAIDHLIQTDAAINPGNSGGPLLDSAGRLIG
INTAIYSPSGASAGIGFAVPVDTVMRVVPQLIKTGKYIRPALGIEVDEQLNQRLLALTGSKGVFVLRVTPGSAAHKAGLA
GVEVTPQGIVPGDRIIDVDGKATDDVAKLLARLDDRKVGDVVVLSVERAGKSREVRVELQPGI
>Mature_382_residues
AYPDPYQRPAPDHFVRRWLFITACIAALMLLWQFLPAIEAWFSPREAAERTVTARGDLAADEKATIELFEKSRASVVYIT
TAQLVRDVWTRNVFSVPRGTGSGFIWDDAGHVVTNFHVIQGASEATVKLADGRDYQAALVGASPAHDIAVLKIGVGFKRP
PAVPVGTSADLKVGQKVFAIGNPFGLDWTLTTGIVSALDRSLPGEAGGPAIDHLIQTDAAINPGNSGGPLLDSAGRLIGI
NTAIYSPSGASAGIGFAVPVDTVMRVVPQLIKTGKYIRPALGIEVDEQLNQRLLALTGSKGVFVLRVTPGSAAHKAGLAG
VEVTPQGIVPGDRIIDVDGKATDDVAKLLARLDDRKVGDVVVLSVERAGKSREVRVELQPGI

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=304, Percent_Identity=36.5131578947368, Blast_Score=127, Evalue=2e-29,
Organism=Homo sapiens, GI4506141, Length=310, Percent_Identity=33.5483870967742, Blast_Score=124, Evalue=2e-28,
Organism=Homo sapiens, GI7019477, Length=275, Percent_Identity=35.2727272727273, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI24308541, Length=302, Percent_Identity=32.4503311258278, Blast_Score=111, Evalue=1e-24,
Organism=Escherichia coli, GI1786356, Length=284, Percent_Identity=43.3098591549296, Blast_Score=187, Evalue=9e-49,
Organism=Escherichia coli, GI1789629, Length=287, Percent_Identity=41.1149825783972, Blast_Score=175, Evalue=4e-45,
Organism=Escherichia coli, GI1789630, Length=290, Percent_Identity=36.2068965517241, Blast_Score=141, Evalue=9e-35,
Organism=Drosophila melanogaster, GI24646839, Length=316, Percent_Identity=32.2784810126582, Blast_Score=114, Evalue=1e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 40558; Mature: 40427

Theoretical pI: Translated: 7.17; Mature: 7.17

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.3 %Cys     (Translated Protein)
0.8 %Met     (Translated Protein)
1.0 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.5 %Met     (Mature Protein)
0.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAYPDPYQRPAPDHFVRRWLFITACIAALMLLWQFLPAIEAWFSPREAAERTVTARGDLA
CCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHEEECCCCCC
ADEKATIELFEKSRASVVYITTAQLVRDVWTRNVFSVPRGTGSGFIWDDAGHVVTNFHVI
CCCHHHHHHHHCCCCCEEEEEHHHHHHHHHHCCCEECCCCCCCEEEECCCCCEEEEEEEE
QGASEATVKLADGRDYQAALVGASPAHDIAVLKIGVGFKRPPAVPVGTSADLKVGQKVFA
ECCCCCEEEEECCCCEEEEEECCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHCCCEEEE
IGNPFGLDWTLTTGIVSALDRSLPGEAGGPAIDHLIQTDAAINPGNSGGPLLDSAGRLIG
ECCCCCCCEEHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHCCCCEEE
INTAIYSPSGASAGIGFAVPVDTVMRVVPQLIKTGKYIRPALGIEVDEQLNQRLLALTGS
EEEEEECCCCCCCCCEEECCHHHHHHHHHHHHHCCCCCCHHCCCCHHHHHCCEEEEEECC
KGVFVLRVTPGSAAHKAGLAGVEVTPQGIVPGDRIIDVDGKATDDVAKLLARLDDRKVGD
CCEEEEEECCCCHHHHCCCCCCEECCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCC
VVVLSVERAGKSREVRVELQPGI
EEEEEEECCCCCCEEEEEECCCC
>Mature Secondary Structure 
AYPDPYQRPAPDHFVRRWLFITACIAALMLLWQFLPAIEAWFSPREAAERTVTARGDLA
CCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHEEECCCCCC
ADEKATIELFEKSRASVVYITTAQLVRDVWTRNVFSVPRGTGSGFIWDDAGHVVTNFHVI
CCCHHHHHHHHCCCCCEEEEEHHHHHHHHHHCCCEECCCCCCCEEEECCCCCEEEEEEEE
QGASEATVKLADGRDYQAALVGASPAHDIAVLKIGVGFKRPPAVPVGTSADLKVGQKVFA
ECCCCCEEEEECCCCEEEEEECCCCCCCEEEEEECCCCCCCCCCCCCCCCCHHCCCEEEE
IGNPFGLDWTLTTGIVSALDRSLPGEAGGPAIDHLIQTDAAINPGNSGGPLLDSAGRLIG
ECCCCCCCEEHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCCCCCCCCCCCCHHCCCCEEE
INTAIYSPSGASAGIGFAVPVDTVMRVVPQLIKTGKYIRPALGIEVDEQLNQRLLALTGS
EEEEEECCCCCCCCCEEECCHHHHHHHHHHHHHCCCCCCHHCCCCHHHHHCCEEEEEECC
KGVFVLRVTPGSAAHKAGLAGVEVTPQGIVPGDRIIDVDGKATDDVAKLLARLDDRKVGD
CCEEEEEECCCCHHHHCCCCCCEECCCCCCCCCEEEECCCCCHHHHHHHHHHHCCCCCCC
VVVLSVERAGKSREVRVELQPGI
EEEEEEECCCCCCEEEEEECCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]