Click here to switch to the map view.

The map label for this gene is clpB [H]

Identifier: 161525461

GI number: 161525461

Start: 2503708

End: 2505408

Strand: Direct

Name: clpB [H]

Synonym: Bmul_2291

Alternate gene names: 161525461

Gene position: 2503708-2505408 (Clockwise)

Preceding gene: 161525460

Following gene: 161525462

Centisome position: 72.6

GC content: 65.43

Gene sequence:

>1701_bases
GTGCACACCATCGTCGGTGCAGGCCAGGGTGGCGGCGAAGGCGGGCTGGACGTGGCCAACGTGTTCAAGCCGATGATGGC
GCGCGGCGAACTGAACCTGATCGGCGCCACCACGCTCAACGAGTATCAGAAGTACATCGAGAAGGACGCCGCGCTGGAGC
GTCGCTTCCAGCCGGTGATGGTGCCCGAGCCGACGGTAGCGCAGACCATGATGATCCTGCGCGGCTTGCGCGACACCTTC
GAGGCGCACCACAAGGTCAGCATCACCGAGGATGCGATCATCGCCGCCGCCGAGTTGTCGGACCGCTACATCACCGCGCG
CTTTTTGCCGGACAAGGCCATCGACCTGCTCGACCAGGCGGCCGCACGCGTGAAGCTGTCGGCCACGGCCCGCCCGGTGG
CGGTGCAGGAGCTGGAGTCCGAACTGCACCAGCTGCGGCGTGAGCAGGACTATGTGGCCTCGCGCAAGCAATACGACAAG
GCCGCCGAGCTGGGCAAGCACATCGAGGCCAAAGAGGCCGAACTCAAGAAGCTTGTCGAGGAATGGGAACGCGAGCGCGC
CTCGGGCAGTGCCGAAGTCAAAGCCGAGCATGTCGCGCAGATCGTCTCGCGCCTGACCGGCATTCCGGTCAACGAGCTGA
CGGTGGAAGAACGCGAGAAGCTGCTGCATCTGGAGCAACGGCTGCACGAGCGCCTCGTGGGCCAGGACGAAGCGGTGCGC
GCGGTAGCCGATGCCGTGCGGTTGTCGCGCGCGGGCCTGCGCGAAGGCAGCAAGCCGGTTGCTACTTTCCTGTTCCTCGG
GCCGACCGGCGTGGGCAAGACCGAACTCGCCAAGGCGCTGGCCGAGTCGATCTATGGCGATGAAGGTGCGCTGCTGCGCA
TCGACATGTCCGAGTACGGTGAGCGCCATACCGTGGCACGCCTGGTGGGCGCGCCTCCGGGCTATGTGGGCTATGACGAG
GGGGGGCAGCTCACCGAGAAAGTGCGGCGCAAACCCTACAGCGTGTTGTTGCTCGATGAGATCGAAAAAGCGCACCCCGA
CGTCTACAACATCCTGCTGCAGGTATTCGACGACGGGCGGCTCACCGACGGCAAGGGCCGGGTGGTGGATTTCACCAATA
CCATCATCATCGCCACCTCGAACTTGGGCTCGGACATCATCCAGCGTCGGCTGAAGGCCCGTGGCGCCGCCGGCGAGGAA
TACGAGAAGACCAAGTCCGAGGTGATGGACGTGCTGCGCGGACACTTCCGCCCCGAGTTCCTCAACCGCATCGACGAGAT
CATTGTCTTCCATGCGCTGGGCAAGGAGGAGATCCGCCATATCGTCGGCCTGCAGCTCGATCGTGTGGCGCGCAGCGCTG
CCAGCCAGGGGGTTACGCTGAGCTTCGATCAAACGCTGATCGACCACTTCGCCGAAGAAGGCTACAAGCCCGAGTTCGGC
GCGCGTGAGCTCAAGCGGCTGATCCGCAGCGAGCTGGAAACCGCTCTGGCGCGCGAGATGCTGGGTGGCGGTATCGGCAA
GGCCGATCACGCCAGCGCCCGCTGGGACGACAAGGCCGAACGGGTGGTCTTCGAGCGCCAGGAGCGACCCGCGAAGCCGG
CCGAGCCTGAGAAGCCCGATGCCGCGAACGTGGCCGAGACGCCGCCGAGCGACGCGAGCAAGCCTGCGCGCAAGAAGAAG
TCAGCGGGCGGCGAATCTTGA

Upstream 100 bases:

>100_bases
AATCCATTGACCGCGCAACACCACCTTCCAAACTGATCACGTTCGCCGAAACGCCTGATCACCATCACCGAAATCCGCAC
TGATTCTCTTCATCGACGAG

Downstream 100 bases:

>100_bases
GTCATGGGGAGGCTGTCGTGTCCGACCCCAACGGGCTGACATGGGCAGCCACCCTCGTATCGCTGGCGGTCGCTATCCCC
ACAGCGGGGCACGCGGTCAT

Product: ATPase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 566; Mature: 566

Protein sequence:

>566_residues
MHTIVGAGQGGGEGGLDVANVFKPMMARGELNLIGATTLNEYQKYIEKDAALERRFQPVMVPEPTVAQTMMILRGLRDTF
EAHHKVSITEDAIIAAAELSDRYITARFLPDKAIDLLDQAAARVKLSATARPVAVQELESELHQLRREQDYVASRKQYDK
AAELGKHIEAKEAELKKLVEEWERERASGSAEVKAEHVAQIVSRLTGIPVNELTVEEREKLLHLEQRLHERLVGQDEAVR
AVADAVRLSRAGLREGSKPVATFLFLGPTGVGKTELAKALAESIYGDEGALLRIDMSEYGERHTVARLVGAPPGYVGYDE
GGQLTEKVRRKPYSVLLLDEIEKAHPDVYNILLQVFDDGRLTDGKGRVVDFTNTIIIATSNLGSDIIQRRLKARGAAGEE
YEKTKSEVMDVLRGHFRPEFLNRIDEIIVFHALGKEEIRHIVGLQLDRVARSAASQGVTLSFDQTLIDHFAEEGYKPEFG
ARELKRLIRSELETALAREMLGGGIGKADHASARWDDKAERVVFERQERPAKPAEPEKPDAANVAETPPSDASKPARKKK
SAGGES

Sequences:

>Translated_566_residues
MHTIVGAGQGGGEGGLDVANVFKPMMARGELNLIGATTLNEYQKYIEKDAALERRFQPVMVPEPTVAQTMMILRGLRDTF
EAHHKVSITEDAIIAAAELSDRYITARFLPDKAIDLLDQAAARVKLSATARPVAVQELESELHQLRREQDYVASRKQYDK
AAELGKHIEAKEAELKKLVEEWERERASGSAEVKAEHVAQIVSRLTGIPVNELTVEEREKLLHLEQRLHERLVGQDEAVR
AVADAVRLSRAGLREGSKPVATFLFLGPTGVGKTELAKALAESIYGDEGALLRIDMSEYGERHTVARLVGAPPGYVGYDE
GGQLTEKVRRKPYSVLLLDEIEKAHPDVYNILLQVFDDGRLTDGKGRVVDFTNTIIIATSNLGSDIIQRRLKARGAAGEE
YEKTKSEVMDVLRGHFRPEFLNRIDEIIVFHALGKEEIRHIVGLQLDRVARSAASQGVTLSFDQTLIDHFAEEGYKPEFG
ARELKRLIRSELETALAREMLGGGIGKADHASARWDDKAERVVFERQERPAKPAEPEKPDAANVAETPPSDASKPARKKK
SAGGES
>Mature_566_residues
MHTIVGAGQGGGEGGLDVANVFKPMMARGELNLIGATTLNEYQKYIEKDAALERRFQPVMVPEPTVAQTMMILRGLRDTF
EAHHKVSITEDAIIAAAELSDRYITARFLPDKAIDLLDQAAARVKLSATARPVAVQELESELHQLRREQDYVASRKQYDK
AAELGKHIEAKEAELKKLVEEWERERASGSAEVKAEHVAQIVSRLTGIPVNELTVEEREKLLHLEQRLHERLVGQDEAVR
AVADAVRLSRAGLREGSKPVATFLFLGPTGVGKTELAKALAESIYGDEGALLRIDMSEYGERHTVARLVGAPPGYVGYDE
GGQLTEKVRRKPYSVLLLDEIEKAHPDVYNILLQVFDDGRLTDGKGRVVDFTNTIIIATSNLGSDIIQRRLKARGAAGEE
YEKTKSEVMDVLRGHFRPEFLNRIDEIIVFHALGKEEIRHIVGLQLDRVARSAASQGVTLSFDQTLIDHFAEEGYKPEFG
ARELKRLIRSELETALAREMLGGGIGKADHASARWDDKAERVVFERQERPAKPAEPEKPDAANVAETPPSDASKPARKKK
SAGGES

Specific function: Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase

COG id: COG0542

COG function: function code O; ATPases with chaperone activity, ATP-binding subunit

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Homo sapiens, GI13540606, Length=311, Percent_Identity=40.1929260450161, Blast_Score=218, Evalue=1e-56,
Organism=Escherichia coli, GI1788943, Length=572, Percent_Identity=45.2797202797203, Blast_Score=456, Evalue=1e-129,
Organism=Escherichia coli, GI1787109, Length=535, Percent_Identity=36.2616822429907, Blast_Score=330, Evalue=2e-91,
Organism=Saccharomyces cerevisiae, GI6320464, Length=567, Percent_Identity=41.6225749559083, Blast_Score=436, Evalue=1e-123,
Organism=Saccharomyces cerevisiae, GI6323002, Length=576, Percent_Identity=39.0625, Blast_Score=387, Evalue=1e-108,

Paralogues:

None

Copy number: 560 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR013093
- InterPro:   IPR003959
- InterPro:   IPR018368
- InterPro:   IPR001270
- InterPro:   IPR019489
- InterPro:   IPR004176
- InterPro:   IPR023150
- InterPro:   IPR001943 [H]

Pfam domain/function: PF00004 AAA; PF07724 AAA_2; PF02861 Clp_N; PF10431 ClpB_D2-small; PF02151 UVR [H]

EC number: NA

Molecular weight: Translated: 62604; Mature: 62604

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: PS00871 CLPAB_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHTIVGAGQGGGEGGLDVANVFKPMMARGELNLIGATTLNEYQKYIEKDAALERRFQPVM
CCCEEECCCCCCCCCCHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHCCCCC
VPEPTVAQTMMILRGLRDTFEAHHKVSITEDAIIAAAELSDRYITARFLPDKAIDLLDQA
CCCCHHHHHHHHHHHHHHHHHHHCCEEECHHHHHHHHHHCCCEEEEEECCHHHHHHHHHH
AARVKLSATARPVAVQELESELHQLRREQDYVASRKQYDKAAELGKHIEAKEAELKKLVE
HHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
EWERERASGSAEVKAEHVAQIVSRLTGIPVNELTVEEREKLLHLEQRLHERLVGQDEAVR
HHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
AVADAVRLSRAGLREGSKPVATFLFLGPTGVGKTELAKALAESIYGDEGALLRIDMSEYG
HHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEHHHCC
ERHTVARLVGAPPGYVGYDEGGQLTEKVRRKPYSVLLLDEIEKAHPDVYNILLQVFDDGR
CHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCEEEEHHHHHHHCCHHHHHHHHHHCCCC
LTDGKGRVVDFTNTIIIATSNLGSDIIQRRLKARGAAGEEYEKTKSEVMDVLRGHFRPEF
EECCCCCEEEECCEEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHH
LNRIDEIIVFHALGKEEIRHIVGLQLDRVARSAASQGVTLSFDQTLIDHFAEEGYKPEFG
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHCCCCCCCC
ARELKRLIRSELETALAREMLGGGIGKADHASARWDDKAERVVFERQERPAKPAEPEKPD
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCC
AANVAETPPSDASKPARKKKSAGGES
CCCCCCCCCCCCCCHHHHHHCCCCCC
>Mature Secondary Structure
MHTIVGAGQGGGEGGLDVANVFKPMMARGELNLIGATTLNEYQKYIEKDAALERRFQPVM
CCCEEECCCCCCCCCCHHHHHHHHHHHCCCCEEEECHHHHHHHHHHHHHHHHHHHCCCCC
VPEPTVAQTMMILRGLRDTFEAHHKVSITEDAIIAAAELSDRYITARFLPDKAIDLLDQA
CCCCHHHHHHHHHHHHHHHHHHHCCEEECHHHHHHHHHHCCCEEEEEECCHHHHHHHHHH
AARVKLSATARPVAVQELESELHQLRREQDYVASRKQYDKAAELGKHIEAKEAELKKLVE
HHHEEECCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHH
EWERERASGSAEVKAEHVAQIVSRLTGIPVNELTVEEREKLLHLEQRLHERLVGQDEAVR
HHHHHHCCCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHH
AVADAVRLSRAGLREGSKPVATFLFLGPTGVGKTELAKALAESIYGDEGALLRIDMSEYG
HHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCEEEEEHHHCC
ERHTVARLVGAPPGYVGYDEGGQLTEKVRRKPYSVLLLDEIEKAHPDVYNILLQVFDDGR
CHHHHHHHHCCCCCCCCCCCCCHHHHHHHHCCCEEEEHHHHHHHCCHHHHHHHHHHCCCC
LTDGKGRVVDFTNTIIIATSNLGSDIIQRRLKARGAAGEEYEKTKSEVMDVLRGHFRPEF
EECCCCCEEEECCEEEEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHCCCHHH
LNRIDEIIVFHALGKEEIRHIVGLQLDRVARSAASQGVTLSFDQTLIDHFAEEGYKPEFG
HHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHCCCCCCCC
ARELKRLIRSELETALAREMLGGGIGKADHASARWDDKAERVVFERQERPAKPAEPEKPD
HHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCC
AANVAETPPSDASKPARKKKSAGGES
CCCCCCCCCCCCCCHHHHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Hydrolase; Acting on peptide bonds (Peptidases); Serine endopeptidases [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12235376 [H]