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The map label for this gene is yhfN [H]

Identifier: 161525396

GI number: 161525396

Start: 2441667

End: 2442926

Strand: Direct

Name: yhfN [H]

Synonym: Bmul_2226

Alternate gene names: 161525396

Gene position: 2441667-2442926 (Clockwise)

Preceding gene: 161525394

Following gene: 161525397

Centisome position: 70.8

GC content: 66.67

Gene sequence:

>1260_bases
ATGTCACCCTTTTCGTTCACCCTGCTGTTCGCGTGCGCCGTGCTCGCGATGGTCGTCACCAAATTGTGGCTCGCGTCGCG
GCAAATCCGCTTCGTCGCCGCGCATCGCGACCGCGTGCCCGCGCAGTTCGCCGCCAAGGTGCCGCTCGGCGCGCACCAGC
GCGCGGCCGACTATACGGTCGAGCGCACGCGCCTGACCATGCTCGAGATCGTCGTCAGCGCGGCCGTGCTGGTCGCACTC
ACGCTGCTGGGCGGCGTCGGCGCGCTCGACACGCTGCTGACCGGCTGGTTCGGGCGCGGCTACGGCCAGCAGGTCGCGCT
CGTCGCCGTCGTGCTCGCGATCACCGGCGCGATCGACGTGCCGTTCGAGTATTACCGCCAGTTCGGGATCGAGCAGCGCT
TCGGCTTCAACCGGATGACGAAGCGGCTGTTCTTCACCGACATGCTGAAGAACACGCTGCTCGGCGCCGTACTCGGGCTG
CCGCTGCTGTTCGTCGTGCTGTGGCTGATGAACCAGGCCGGCAGCCTCTGGTGGCTGTGGGCGTGGCTCGTCTGGGTCGC
GTTCCAGATGCTCGTGCTGCTGATCTATCCGACCTTCATCGCGCCGCTCTTCAACAAGTTCGAGCCGCTGACCGACGAAG
CGCTGCGCGCGCGGATCGAATCGCTGATGAAGCGCTGCGGTTTCGCCGCGAAAGGCCTGTTCGTGATGGACGGCAGCCGC
CGCTCCGCGCACGGCAACGCCTACTTCACGGGCTTCGGCGCATCGAAGCGGATCGTGTTCTTCGATACGCTGCTGGCGCG
GCTGTCCGGCCAGGAAATCGAGGCGGTGCTCGCGCACGAACTCGGCCATTTCAAGCGGCGCCACGTGATGAAGCGCATGC
TCGTGTCGTTCGTGCTGAGCCTTGCGCTGCTCGCGCTGCTCGGCTGGCTCGCGCAGCGCACGTGGTTTTACACGGGGCTC
GGCGTGATCCCGTCGCTCGACTCGAGCAATGCAGGCGTCGCGCTCGTGCTGTTCTTCCTCGCGATCCCCGTGTTCCTGTT
CTTCGCGACGCCGTTCGGCAGCCTCACGTCGCGCAAGCACGAGTTCGAGGCCGACGCGTTCGCGGCCAGCCAGACCGATG
CGCAAGACCTCGTCAGCGCGCTCGTGAAGCTGTACGAGGACAACGCGTCGACGCTGACGCCCGACCCCGTCTACACGGCC
TTCTACTACTCGCATCCGCCCGCGTCGCAGCGGATCGACCGTCTGCTGCAGCAAGCATGA

Upstream 100 bases:

>100_bases
GGCAGGCGGCGCGCGGCGCCGTCCGGACGGCCGGCCTCGCCTCTGCGGGCGCCGTCCGCAAGAACATATAATTCTCGCAT
AGAACCCTTTGGCGCCTTCG

Downstream 100 bases:

>100_bases
GCCGGCCGCCCTCCCGCAAGCCGGCCGCGCGCGCATCGGGCGCCGAACGTGTCGAAGGCCGCGTGATCGCGGCGCACGGC
CGCCACTACATCGTCGCGCC

Product: Ste24 endopeptidase

Products: NA

Alternate protein names: PSP23 [H]

Number of amino acids: Translated: 419; Mature: 418

Protein sequence:

>419_residues
MSPFSFTLLFACAVLAMVVTKLWLASRQIRFVAAHRDRVPAQFAAKVPLGAHQRAADYTVERTRLTMLEIVVSAAVLVAL
TLLGGVGALDTLLTGWFGRGYGQQVALVAVVLAITGAIDVPFEYYRQFGIEQRFGFNRMTKRLFFTDMLKNTLLGAVLGL
PLLFVVLWLMNQAGSLWWLWAWLVWVAFQMLVLLIYPTFIAPLFNKFEPLTDEALRARIESLMKRCGFAAKGLFVMDGSR
RSAHGNAYFTGFGASKRIVFFDTLLARLSGQEIEAVLAHELGHFKRRHVMKRMLVSFVLSLALLALLGWLAQRTWFYTGL
GVIPSLDSSNAGVALVLFFLAIPVFLFFATPFGSLTSRKHEFEADAFAASQTDAQDLVSALVKLYEDNASTLTPDPVYTA
FYYSHPPASQRIDRLLQQA

Sequences:

>Translated_419_residues
MSPFSFTLLFACAVLAMVVTKLWLASRQIRFVAAHRDRVPAQFAAKVPLGAHQRAADYTVERTRLTMLEIVVSAAVLVAL
TLLGGVGALDTLLTGWFGRGYGQQVALVAVVLAITGAIDVPFEYYRQFGIEQRFGFNRMTKRLFFTDMLKNTLLGAVLGL
PLLFVVLWLMNQAGSLWWLWAWLVWVAFQMLVLLIYPTFIAPLFNKFEPLTDEALRARIESLMKRCGFAAKGLFVMDGSR
RSAHGNAYFTGFGASKRIVFFDTLLARLSGQEIEAVLAHELGHFKRRHVMKRMLVSFVLSLALLALLGWLAQRTWFYTGL
GVIPSLDSSNAGVALVLFFLAIPVFLFFATPFGSLTSRKHEFEADAFAASQTDAQDLVSALVKLYEDNASTLTPDPVYTA
FYYSHPPASQRIDRLLQQA
>Mature_418_residues
SPFSFTLLFACAVLAMVVTKLWLASRQIRFVAAHRDRVPAQFAAKVPLGAHQRAADYTVERTRLTMLEIVVSAAVLVALT
LLGGVGALDTLLTGWFGRGYGQQVALVAVVLAITGAIDVPFEYYRQFGIEQRFGFNRMTKRLFFTDMLKNTLLGAVLGLP
LLFVVLWLMNQAGSLWWLWAWLVWVAFQMLVLLIYPTFIAPLFNKFEPLTDEALRARIESLMKRCGFAAKGLFVMDGSRR
SAHGNAYFTGFGASKRIVFFDTLLARLSGQEIEAVLAHELGHFKRRHVMKRMLVSFVLSLALLALLGWLAQRTWFYTGLG
VIPSLDSSNAGVALVLFFLAIPVFLFFATPFGSLTSRKHEFEADAFAASQTDAQDLVSALVKLYEDNASTLTPDPVYTAF
YYSHPPASQRIDRLLQQA

Specific function: Unknown Function. Overexpression Of A Truncated Form Of The Htpx Protein Leads To An Increase In The Degradation Of Abnormal Proteins. [C]

COG id: COG0501

COG function: function code O; Zn-dependent protease with chaperone function

Gene ontology:

Cell location: Integral Membrane Protein. Inner Membrane [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M48B family [H]

Homologues:

Organism=Homo sapiens, GI18379366, Length=461, Percent_Identity=29.0672451193059, Blast_Score=186, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI17505484, Length=436, Percent_Identity=29.3577981651376, Blast_Score=182, Evalue=3e-46,
Organism=Saccharomyces cerevisiae, GI6322577, Length=311, Percent_Identity=38.5852090032154, Blast_Score=218, Evalue=2e-57,
Organism=Drosophila melanogaster, GI19922414, Length=421, Percent_Identity=30.166270783848, Blast_Score=194, Evalue=1e-49,
Organism=Drosophila melanogaster, GI78707252, Length=411, Percent_Identity=25.3041362530414, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI78707254, Length=411, Percent_Identity=25.3041362530414, Blast_Score=120, Evalue=2e-27,
Organism=Drosophila melanogaster, GI24654305, Length=428, Percent_Identity=25.2336448598131, Blast_Score=115, Evalue=7e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001915 [H]

Pfam domain/function: PF01435 Peptidase_M48 [H]

EC number: 3.4.24.- [C]

Molecular weight: Translated: 46743; Mature: 46612

Theoretical pI: Translated: 10.05; Mature: 10.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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HHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCC
>Mature Secondary Structure 
SPFSFTLLFACAVLAMVVTKLWLASRQIRFVAAHRDRVPAQFAAKVPLGAHQRAADYTV
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCCCHHHHHHHH
ERTRLTMLEIVVSAAVLVALTLLGGVGALDTLLTGWFGRGYGQQVALVAVVLAITGAIDV
HHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCC
PFEYYRQFGIEQRFGFNRMTKRLFFTDMLKNTLLGAVLGLPLLFVVLWLMNQAGSLWWLW
CHHHHHHCCCHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHH
AWLVWVAFQMLVLLIYPTFIAPLFNKFEPLTDEALRARIESLMKRCGFAAKGLFVMDGSR
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHCCCHHCCEEEECCCC
RSAHGNAYFTGFGASKRIVFFDTLLARLSGQEIEAVLAHELGHFKRRHVMKRMLVSFVLS
CCCCCCEEEEECCCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LALLALLGWLAQRTWFYTGLGVIPSLDSSNAGVALVLFFLAIPVFLFFATPFGSLTSRKH
HHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHCCCCHHHCCHH
EFEADAFAASQTDAQDLVSALVKLYEDNASTLTPDPVYTAFYYSHPPASQRIDRLLQQA
HHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: Zn [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377; 3145906 [H]