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The map label for this gene is moeA [H]

Identifier: 161525366

GI number: 161525366

Start: 2412689

End: 2413981

Strand: Direct

Name: moeA [H]

Synonym: Bmul_2196

Alternate gene names: 161525366

Gene position: 2412689-2413981 (Clockwise)

Preceding gene: 161525365

Following gene: 161525367

Centisome position: 69.96

GC content: 72.7

Gene sequence:

>1293_bases
ATGATCACGCAACCCTCGCCCGCCTCCCGAGCCGCACCCGATTCCGACCTGCCGCTGTCGCTCGCCGATGCGCAGGCGCT
CGCCTGCCGTTTCGCGACGCCGGTCGCCGCCAGCGAATCCGTGCCGTTGCGCGACGCGCTCCATCGCGTGCTCGCCGCCG
ACGTGCGCGCACCGTTCGACATTCCCGCGTACGACAACTCGGCGATGGACGGCTATGCGTTCGACGGCGGCGCGTACGCG
TCGGTGCACGGCGACGTCGCGATGCGCGTCGTCGGCGCCGCATTCGCGGGCCATCCGTTCGACGGTGTCGTGCCGGCCGG
CGCGTGCGTACGCATCATGACGGGCGCGCCGATGCCGGCCGGATGCGACACCGTGATTCCGCAGGAACGCGTGCATGTCG
ACGACGACGGAATCCGCTTCGCCGCACGGGACATCGCGCGCGGCGCGAACTGCCGCAAGGCCGGCGAGGATCTCGCACGC
GGCGTATGCGCGCTCGCGGCGGGCCGCATCCTGCGCGCCGCCGACATCGGCCTGCTCGCGTCGTTCGGCATCGCCCACGT
GACGGTGCGACGCCGCGTGCGCGTCGCGGTGTTTTCGACCGGCGACGAATTGCGTGAGCCGGGCGCCGCGCTCGAACGCG
GCGCGCTCTACGACAGCAATCGCGCGATGCTGATCGCGATGCTCGAACAGCTGCACGTCGACGTGCTCGATCTCGGCATC
GTCCGCGACGATCCGGCCGCGCTCGAAGCCGCATTGCGCGACGCGGTCGCACGCGATGCCGACGCGGTGATCACGTCGGG
CGGCGTGTCGGTCGGCGAAGCGGATTTCACGCGCGACGTGATGGCACGGCTCGGCGACGTCACGTTCGCGAGCCTCGCGC
TGCGCCCGGGCCGGCCGCTCGCCGTCGGCACGCTCGCGCGCGGCGACGGCGCACCGGGCCACGCGCTGTTCTTCGGGCTG
CCCGGCAATCCCGTCGCGTCCGCGGTCACCTTCGACGCGATCGTGCGCGCGGCGCTGCTGACGCTCGCGGGCGCCTGCGT
GCCGCCGCCGGCGATGTACACCGCGTACACCACGCAAGCGCTGAAAAAGCGCGCGGGCCGCACCGAATATCTGCGCGGCA
TCGCGACGCGCGCAGCCGACGGGCGCTGGCACGTCGCGCCGGCCGGCTCTCAGAGCTCCGCATCGCTGAGCGGCCTCGCG
GCCGCTAACTGTTTCATCGTCCTGGGCCACGATGCCGCGGCAGTCGACGCGGGCGCCCCGGTCGACATCCTGCCGTTCGG
CAGCCCGATCTGA

Upstream 100 bases:

>100_bases
CCGCCGTTCCCGCGCGCCGCCCCGCCGCTCGCGACCGCGCCACGCACACTGCTCGCGCCTCCGGCCACGAACCCTGTACG
CCTTGCGGCGCAGTCCGACG

Downstream 100 bases:

>100_bases
ATCTGAATCCAACTATCGGTATTTCTCTACGGGGGCATTCTGCACATGAAGAAACAAATCTCGTCGATCGCCGCGGGGCA
GACCGCCAAAGCGCTGATCC

Product: molybdenum cofactor synthesis domain-containing protein

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 430; Mature: 430

Protein sequence:

>430_residues
MITQPSPASRAAPDSDLPLSLADAQALACRFATPVAASESVPLRDALHRVLAADVRAPFDIPAYDNSAMDGYAFDGGAYA
SVHGDVAMRVVGAAFAGHPFDGVVPAGACVRIMTGAPMPAGCDTVIPQERVHVDDDGIRFAARDIARGANCRKAGEDLAR
GVCALAAGRILRAADIGLLASFGIAHVTVRRRVRVAVFSTGDELREPGAALERGALYDSNRAMLIAMLEQLHVDVLDLGI
VRDDPAALEAALRDAVARDADAVITSGGVSVGEADFTRDVMARLGDVTFASLALRPGRPLAVGTLARGDGAPGHALFFGL
PGNPVASAVTFDAIVRAALLTLAGACVPPPAMYTAYTTQALKKRAGRTEYLRGIATRAADGRWHVAPAGSQSSASLSGLA
AANCFIVLGHDAAAVDAGAPVDILPFGSPI

Sequences:

>Translated_430_residues
MITQPSPASRAAPDSDLPLSLADAQALACRFATPVAASESVPLRDALHRVLAADVRAPFDIPAYDNSAMDGYAFDGGAYA
SVHGDVAMRVVGAAFAGHPFDGVVPAGACVRIMTGAPMPAGCDTVIPQERVHVDDDGIRFAARDIARGANCRKAGEDLAR
GVCALAAGRILRAADIGLLASFGIAHVTVRRRVRVAVFSTGDELREPGAALERGALYDSNRAMLIAMLEQLHVDVLDLGI
VRDDPAALEAALRDAVARDADAVITSGGVSVGEADFTRDVMARLGDVTFASLALRPGRPLAVGTLARGDGAPGHALFFGL
PGNPVASAVTFDAIVRAALLTLAGACVPPPAMYTAYTTQALKKRAGRTEYLRGIATRAADGRWHVAPAGSQSSASLSGLA
AANCFIVLGHDAAAVDAGAPVDILPFGSPI
>Mature_430_residues
MITQPSPASRAAPDSDLPLSLADAQALACRFATPVAASESVPLRDALHRVLAADVRAPFDIPAYDNSAMDGYAFDGGAYA
SVHGDVAMRVVGAAFAGHPFDGVVPAGACVRIMTGAPMPAGCDTVIPQERVHVDDDGIRFAARDIARGANCRKAGEDLAR
GVCALAAGRILRAADIGLLASFGIAHVTVRRRVRVAVFSTGDELREPGAALERGALYDSNRAMLIAMLEQLHVDVLDLGI
VRDDPAALEAALRDAVARDADAVITSGGVSVGEADFTRDVMARLGDVTFASLALRPGRPLAVGTLARGDGAPGHALFFGL
PGNPVASAVTFDAIVRAALLTLAGACVPPPAMYTAYTTQALKKRAGRTEYLRGIATRAADGRWHVAPAGSQSSASLSGLA
AANCFIVLGHDAAAVDAGAPVDILPFGSPI

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI10880983, Length=433, Percent_Identity=34.4110854503464, Blast_Score=195, Evalue=9e-50,
Organism=Homo sapiens, GI66932975, Length=433, Percent_Identity=34.4110854503464, Blast_Score=194, Evalue=1e-49,
Organism=Escherichia coli, GI1787049, Length=380, Percent_Identity=46.0526315789474, Blast_Score=330, Evalue=1e-91,
Organism=Caenorhabditis elegans, GI25147659, Length=333, Percent_Identity=29.1291291291291, Blast_Score=132, Evalue=5e-31,
Organism=Caenorhabditis elegans, GI17562606, Length=363, Percent_Identity=26.1707988980716, Blast_Score=93, Evalue=2e-19,
Organism=Drosophila melanogaster, GI17136978, Length=380, Percent_Identity=28.1578947368421, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24638841, Length=380, Percent_Identity=28.1578947368421, Blast_Score=113, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 44156; Mature: 44156

Theoretical pI: Translated: 6.05; Mature: 6.05

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MITQPSPASRAAPDSDLPLSLADAQALACRFATPVAASESVPLRDALHRVLAADVRAPFD
CCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCC
IPAYDNSAMDGYAFDGGAYASVHGDVAMRVVGAAFAGHPFDGVVPAGACVRIMTGAPMPA
CCCCCCCCCCCEEECCCEEEEECHHHHHHHHHHHHCCCCCCCCCCCCHHEEEEECCCCCC
GCDTVIPQERVHVDDDGIRFAARDIARGANCRKAGEDLARGVCALAAGRILRAADIGLLA
CCCCCCCCCCEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SFGIAHVTVRRRVRVAVFSTGDELREPGAALERGALYDSNRAMLIAMLEQLHVDVLDLGI
HHHHHHHHHHHEEEEEEEECCHHHHCCCHHHHCCCEECCCCHHHHHHHHHHHHHHHHCCE
VRDDPAALEAALRDAVARDADAVITSGGVSVGEADFTRDVMARLGDVTFASLALRPGRPL
ECCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCE
AVGTLARGDGAPGHALFFGLPGNPVASAVTFDAIVRAALLTLAGACVPPPAMYTAYTTQA
EEEEEECCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
LKKRAGRTEYLRGIATRAADGRWHVAPAGSQSSASLSGLAAANCFIVLGHDAAAVDAGAP
HHHHCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHEECCEEEEECCCHHCCCCCCC
VDILPFGSPI
EEECCCCCCC
>Mature Secondary Structure
MITQPSPASRAAPDSDLPLSLADAQALACRFATPVAASESVPLRDALHRVLAADVRAPFD
CCCCCCCCCCCCCCCCCCEEHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHCCCCC
IPAYDNSAMDGYAFDGGAYASVHGDVAMRVVGAAFAGHPFDGVVPAGACVRIMTGAPMPA
CCCCCCCCCCCEEECCCEEEEECHHHHHHHHHHHHCCCCCCCCCCCCHHEEEEECCCCCC
GCDTVIPQERVHVDDDGIRFAARDIARGANCRKAGEDLARGVCALAAGRILRAADIGLLA
CCCCCCCCCCEEECCCCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SFGIAHVTVRRRVRVAVFSTGDELREPGAALERGALYDSNRAMLIAMLEQLHVDVLDLGI
HHHHHHHHHHHEEEEEEEECCHHHHCCCHHHHCCCEECCCCHHHHHHHHHHHHHHHHCCE
VRDDPAALEAALRDAVARDADAVITSGGVSVGEADFTRDVMARLGDVTFASLALRPGRPL
ECCCHHHHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHHHHHCCCCEEEEEECCCCCE
AVGTLARGDGAPGHALFFGLPGNPVASAVTFDAIVRAALLTLAGACVPPPAMYTAYTTQA
EEEEEECCCCCCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHH
LKKRAGRTEYLRGIATRAADGRWHVAPAGSQSSASLSGLAAANCFIVLGHDAAAVDAGAP
HHHHCCHHHHHHHHHHHCCCCEEEECCCCCCCCCCHHHHEECCEEEEECCCHHCCCCCCC
VDILPFGSPI
EEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11677609 [H]