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The map label for this gene is moaA [H]

Identifier: 161525364

GI number: 161525364

Start: 2410824

End: 2411936

Strand: Direct

Name: moaA [H]

Synonym: Bmul_2194

Alternate gene names: 161525364

Gene position: 2410824-2411936 (Clockwise)

Preceding gene: 161525363

Following gene: 161525365

Centisome position: 69.91

GC content: 70.26

Gene sequence:

>1113_bases
ATGTCCCGACGCATCATTCCTCTCGCCGACGTCAGCGGCGTGCCGGACGTTTCCGGCGTGCCGCACGCGCCGGACGGCAC
GCTCGCCGACACGTTCGGCCGGCCGCTGCGCGACCTGCGCATCTCGGTGACGGATCGCTGCAACTTCCGCTGCGTGTACT
GCATGCCGCGCGAGGTCTTCGGCAAGGACTATCCGTTCCTGCCGCACAGCGCGCTGCTCACGCACGAGGAGATCGAGCGC
GTCGCACGCATCTTCGTCGCGCACGGCGTCGAGAAGATTCGCATCACCGGCGGCGAGCCGCTGCTGCGCAAGAACCTCGA
GTTCCTGATCGAGCGGCTCGCACGCCTGACCACGCGCGAGGGCCGCCCGCTCGACCTCACGCTGACGACCAACGGTTCGC
TGCTCGCGCGCAAGGCGCGCGCGCTGAAGGACGCCGGCCTCACGCGCGTGACGGTCAGCCTCGACGCGCTCGACGACGCG
CTGTTCAAACGGATGAACGACGCGGACTTCGCGAGCGCCGACGTGCTCGACGGCATCTTCGCCGCGCAGGCCGCGGGGCT
CGCGCCCGTGAAGGTCAACATGGTCGTGAAGCGCGGCACGAACGACACCGAGATCCTGCCGATGGCCGAGCGCTTTCGCG
GCACCGGCGTGATCCTGCGCTTCATCGAATACATGGACGTCGGCACGTCGAACGGCTGGAACATGACCGAGGTGCTGCCG
TCGGCCGACGTCGTCGCGCGGATCGCCGAGCGCTTCCCGCTTGTCCCGCTCGAGCCGCATACGGCGGCCGAGACTGCGCA
GCGCTGGGGCTACGCGGACGGCAGCGGCGAGATCGGCGTGATCTCGAGCGTCACGCAGGCGTTCTGCGGCGACTGCACGC
GCGCGCGGCTGTCGACCGAAGGCAAGCTCTATCTCTGCCTGTTCGCGTCGAGCGGTCACGATCTGCGCGCACTCGTGCGC
GGCGGCGCGACCGACGCCGAGATCGCGACCGCGATCGCGCGCATCTGGCATGCACGCACCGACCGCTACTCGCAGCTGCG
CGGCAGCGCCGCCGCGGCGGACGCGGCCGACGGCGCGCGCAAGCGCGTCGAGATGTCGTACATCGGCGGCTGA

Upstream 100 bases:

>100_bases
GCCGGCGGGCTTTTTCACATCCGCGCTACGGGTTTCCGCTCACGCGGCCCGGCGCGCGGCTTACGGCTAAAATACAGGCT
TGGTTCGCCTATCTTTCAAC

Downstream 100 bases:

>100_bases
ACGGTCCGTCGCTGCGCACGATGTCCGCTTCCTCCGCCCGCCCCCCGATCGCCGGCCTGCTGCTCGCCGGCGGCCGCGCG
ACGCGCATGGACGGCGTCGA

Product: molybdenum cofactor biosynthesis protein A

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 370; Mature: 369

Protein sequence:

>370_residues
MSRRIIPLADVSGVPDVSGVPHAPDGTLADTFGRPLRDLRISVTDRCNFRCVYCMPREVFGKDYPFLPHSALLTHEEIER
VARIFVAHGVEKIRITGGEPLLRKNLEFLIERLARLTTREGRPLDLTLTTNGSLLARKARALKDAGLTRVTVSLDALDDA
LFKRMNDADFASADVLDGIFAAQAAGLAPVKVNMVVKRGTNDTEILPMAERFRGTGVILRFIEYMDVGTSNGWNMTEVLP
SADVVARIAERFPLVPLEPHTAAETAQRWGYADGSGEIGVISSVTQAFCGDCTRARLSTEGKLYLCLFASSGHDLRALVR
GGATDAEIATAIARIWHARTDRYSQLRGSAAAADAADGARKRVEMSYIGG

Sequences:

>Translated_370_residues
MSRRIIPLADVSGVPDVSGVPHAPDGTLADTFGRPLRDLRISVTDRCNFRCVYCMPREVFGKDYPFLPHSALLTHEEIER
VARIFVAHGVEKIRITGGEPLLRKNLEFLIERLARLTTREGRPLDLTLTTNGSLLARKARALKDAGLTRVTVSLDALDDA
LFKRMNDADFASADVLDGIFAAQAAGLAPVKVNMVVKRGTNDTEILPMAERFRGTGVILRFIEYMDVGTSNGWNMTEVLP
SADVVARIAERFPLVPLEPHTAAETAQRWGYADGSGEIGVISSVTQAFCGDCTRARLSTEGKLYLCLFASSGHDLRALVR
GGATDAEIATAIARIWHARTDRYSQLRGSAAAADAADGARKRVEMSYIGG
>Mature_369_residues
SRRIIPLADVSGVPDVSGVPHAPDGTLADTFGRPLRDLRISVTDRCNFRCVYCMPREVFGKDYPFLPHSALLTHEEIERV
ARIFVAHGVEKIRITGGEPLLRKNLEFLIERLARLTTREGRPLDLTLTTNGSLLARKARALKDAGLTRVTVSLDALDDAL
FKRMNDADFASADVLDGIFAAQAAGLAPVKVNMVVKRGTNDTEILPMAERFRGTGVILRFIEYMDVGTSNGWNMTEVLPS
ADVVARIAERFPLVPLEPHTAAETAQRWGYADGSGEIGVISSVTQAFCGDCTRARLSTEGKLYLCLFASSGHDLRALVRG
GATDAEIATAIARIWHARTDRYSQLRGSAAAADAADGARKRVEMSYIGG

Specific function: Together with moaC, is involved in the conversion of a guanosine derivative (5'-GTP) into molybdopterin precursor Z [H]

COG id: COG2896

COG function: function code H; Molybdenum cofactor biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the radical SAM superfamily. MoaA family [H]

Homologues:

Organism=Homo sapiens, GI116734668, Length=327, Percent_Identity=38.2262996941896, Blast_Score=205, Evalue=4e-53,
Organism=Homo sapiens, GI22027536, Length=306, Percent_Identity=38.8888888888889, Blast_Score=205, Evalue=5e-53,
Organism=Escherichia coli, GI1786999, Length=310, Percent_Identity=35.4838709677419, Blast_Score=163, Evalue=2e-41,
Organism=Caenorhabditis elegans, GI17561210, Length=307, Percent_Identity=33.5504885993485, Blast_Score=174, Evalue=6e-44,
Organism=Caenorhabditis elegans, GI32566331, Length=324, Percent_Identity=31.1728395061728, Blast_Score=173, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI32566329, Length=345, Percent_Identity=31.304347826087, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI28574490, Length=303, Percent_Identity=37.2937293729373, Blast_Score=184, Evalue=9e-47,
Organism=Drosophila melanogaster, GI28574488, Length=303, Percent_Identity=37.2937293729373, Blast_Score=184, Evalue=1e-46,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR006638
- InterPro:   IPR013483
- InterPro:   IPR000385
- InterPro:   IPR010505
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06463 Mob_synth_C; PF04055 Radical_SAM [H]

EC number: NA

Molecular weight: Translated: 40257; Mature: 40125

Theoretical pI: Translated: 7.85; Mature: 7.85

Prosite motif: PS01305 MOAA_NIFB_PQQE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRRIIPLADVSGVPDVSGVPHAPDGTLADTFGRPLRDLRISVTDRCNFRCVYCMPREVF
CCCCEEEECCCCCCCCCCCCCCCCCCCCHHHHCCCHHHEEEEEECCCCEEEEEECCHHHC
GKDYPFLPHSALLTHEEIERVARIFVAHGVEKIRITGGEPLLRKNLEFLIERLARLTTRE
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCC
GRPLDLTLTTNGSLLARKARALKDAGLTRVTVSLDALDDALFKRMNDADFASADVLDGIF
CCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHCCCCCCCHHHHHHHHH
AAQAAGLAPVKVNMVVKRGTNDTEILPMAERFRGTGVILRFIEYMDVGTSNGWNMTEVLP
HHHHCCCCEEEEEEEEECCCCCCEECCHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHCC
SADVVARIAERFPLVPLEPHTAAETAQRWGYADGSGEIGVISSVTQAFCGDCTRARLSTE
CHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCHHHHHCCCC
GKLYLCLFASSGHDLRALVRGGATDAEIATAIARIWHARTDRYSQLRGSAAAADAADGAR
CCEEEEEEECCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHCHHH
KRVEMSYIGG
HEEEEEECCC
>Mature Secondary Structure 
SRRIIPLADVSGVPDVSGVPHAPDGTLADTFGRPLRDLRISVTDRCNFRCVYCMPREVF
CCCEEEECCCCCCCCCCCCCCCCCCCCHHHHCCCHHHEEEEEECCCCEEEEEECCHHHC
GKDYPFLPHSALLTHEEIERVARIFVAHGVEKIRITGGEPLLRKNLEFLIERLARLTTRE
CCCCCCCCCHHHHHHHHHHHHHHHHHHCCCEEEEEECCCHHHHHHHHHHHHHHHHHHCCC
GRPLDLTLTTNGSLLARKARALKDAGLTRVTVSLDALDDALFKRMNDADFASADVLDGIF
CCCEEEEEECCCHHHHHHHHHHHHCCCEEEEEEHHHHHHHHHHHCCCCCCCHHHHHHHHH
AAQAAGLAPVKVNMVVKRGTNDTEILPMAERFRGTGVILRFIEYMDVGTSNGWNMTEVLP
HHHHCCCCEEEEEEEEECCCCCCEECCHHHHHCCCHHHHHHHHHHHCCCCCCCCHHHHCC
SADVVARIAERFPLVPLEPHTAAETAQRWGYADGSGEIGVISSVTQAFCGDCTRARLSTE
CHHHHHHHHHHCCCCCCCCCCHHHHHHHCCCCCCCCCCHHHHHHHHHHHCCHHHHHCCCC
GKLYLCLFASSGHDLRALVRGGATDAEIATAIARIWHARTDRYSQLRGSAAAADAADGAR
CCEEEEEEECCCCHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHCCHHCHHH
KRVEMSYIGG
HEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Fe [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]