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The map label for this gene is ptxR [H]

Identifier: 161525054

GI number: 161525054

Start: 2057153

End: 2058088

Strand: Reverse

Name: ptxR [H]

Synonym: Bmul_1882

Alternate gene names: 161525054

Gene position: 2058088-2057153 (Counterclockwise)

Preceding gene: 161525056

Following gene: 161525053

Centisome position: 59.68

GC content: 71.9

Gene sequence:

>936_bases
ATGAATCAGCAAAATGTCCAGGCGCTCTGGCCGCACATCCACTCGCTGACGGTGCTGGCCGCCGCCGGCAGCTTCACGGC
CGCCGCGCAGCGGCTCGGGATCAGCAAGGCGGCGATGAGCCAGCGCATCGCCGATCTCGAAAAGGCGGCCGGCGTGCCGC
TCGTGCGCCGCACGACGCGCAGCGTGCGGCTCACCGACGCGGGCCAGACGCTCGTCGACAGCACGCGCGACGCGTTCGAG
TCGATCGGCCAGCATTTCGCGCGCGTGAAGGAGCTCGCGGGCGAGCCGCGCGGGCTCGTGCGCGTGACGGCGCCGGTCGC
GCTCGGCCGCCAGCAGATCGTCCCGCATCTGCCGGATTTCCTGCGCGCGCATCCGGGCGTGCATCTCGAGCTCGACCTGT
CGGACCGGCTGCATTCGCTGACGCAGGAAGGCTTCGATCTCGCGATCCGCCATACGACGACCGCGCCGCAAACGCACGTC
GCATGGAAGCTCTGCGAGACGCGCTCGCTGCTCGTCGCCAGCCGCGACTATCTCGACGCGCGCGGCGCGCCGCGCCATCC
GCGCGAACTCGTCGACCACAGCTGTCTCTGCTATCTGCGCGACAACGAGCCTGCCGCGTGGAGCTTCGAGCTACAGGGCA
GGCGGCGTGAGCGCGTCAGCGTGCCGGTGCGCGGCAGCTTCGCGGCCAACAACAGCGAGGCGATGCGCGAGGCCGCGCTC
GGCGGGCTCGGCATCGCGCTGCTGCCCGATTTCAGCGCGCGGCGCGATCTCGACGCGGGCCGGCTCGTGTCGCTGCTCGA
CGCGTGGCGGCCGTCCGGCGCGTTCGGCGACCACATCTTCGCGATCCGGCCGTACAGCGCGGTCGTGCCGAGTGCCGTGC
GCGCGCTCGTGCGCCATCTGCGCGAGCGGCTGGCGGGCGGTTTCTCGGGCCCCTAA

Upstream 100 bases:

>100_bases
AAGATTCGGGGGAAGGGAAGGCCCCAGTCTAGGCAAACGCGGCGGGCCGGAGAAGGCCGCGCAGCTTGATTCACTGTTCA
GAATTCTGAATAATCGGCGG

Downstream 100 bases:

>100_bases
CGGCCCCGTCACCGCCCCGTCACGGCCTTGCGACGGAGCCGCGATCGAGGCGCGACGGGCCAGCCTCGGATCGGCGACGG
CCGCGGGCGGCCCGCCCCGG

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 311; Mature: 311

Protein sequence:

>311_residues
MNQQNVQALWPHIHSLTVLAAAGSFTAAAQRLGISKAAMSQRIADLEKAAGVPLVRRTTRSVRLTDAGQTLVDSTRDAFE
SIGQHFARVKELAGEPRGLVRVTAPVALGRQQIVPHLPDFLRAHPGVHLELDLSDRLHSLTQEGFDLAIRHTTTAPQTHV
AWKLCETRSLLVASRDYLDARGAPRHPRELVDHSCLCYLRDNEPAAWSFELQGRRRERVSVPVRGSFAANNSEAMREAAL
GGLGIALLPDFSARRDLDAGRLVSLLDAWRPSGAFGDHIFAIRPYSAVVPSAVRALVRHLRERLAGGFSGP

Sequences:

>Translated_311_residues
MNQQNVQALWPHIHSLTVLAAAGSFTAAAQRLGISKAAMSQRIADLEKAAGVPLVRRTTRSVRLTDAGQTLVDSTRDAFE
SIGQHFARVKELAGEPRGLVRVTAPVALGRQQIVPHLPDFLRAHPGVHLELDLSDRLHSLTQEGFDLAIRHTTTAPQTHV
AWKLCETRSLLVASRDYLDARGAPRHPRELVDHSCLCYLRDNEPAAWSFELQGRRRERVSVPVRGSFAANNSEAMREAAL
GGLGIALLPDFSARRDLDAGRLVSLLDAWRPSGAFGDHIFAIRPYSAVVPSAVRALVRHLRERLAGGFSGP
>Mature_311_residues
MNQQNVQALWPHIHSLTVLAAAGSFTAAAQRLGISKAAMSQRIADLEKAAGVPLVRRTTRSVRLTDAGQTLVDSTRDAFE
SIGQHFARVKELAGEPRGLVRVTAPVALGRQQIVPHLPDFLRAHPGVHLELDLSDRLHSLTQEGFDLAIRHTTTAPQTHV
AWKLCETRSLLVASRDYLDARGAPRHPRELVDHSCLCYLRDNEPAAWSFELQGRRRERVSVPVRGSFAANNSEAMREAAL
GGLGIALLPDFSARRDLDAGRLVSLLDAWRPSGAFGDHIFAIRPYSAVVPSAVRALVRHLRERLAGGFSGP

Specific function: Transcriptional activator of the toxA (exotoxin) and regA genes [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1789440, Length=277, Percent_Identity=30.3249097472924, Blast_Score=130, Evalue=1e-31,
Organism=Escherichia coli, GI1787128, Length=248, Percent_Identity=31.0483870967742, Blast_Score=124, Evalue=7e-30,
Organism=Escherichia coli, GI87081978, Length=296, Percent_Identity=29.7297297297297, Blast_Score=123, Evalue=1e-29,
Organism=Escherichia coli, GI145693193, Length=261, Percent_Identity=29.8850574712644, Blast_Score=112, Evalue=2e-26,
Organism=Escherichia coli, GI1786401, Length=288, Percent_Identity=28.125, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1787589, Length=262, Percent_Identity=28.6259541984733, Blast_Score=107, Evalue=1e-24,
Organism=Escherichia coli, GI1790011, Length=311, Percent_Identity=26.6881028938907, Blast_Score=93, Evalue=3e-20,
Organism=Escherichia coli, GI1789639, Length=250, Percent_Identity=26.8, Blast_Score=87, Evalue=1e-18,
Organism=Escherichia coli, GI1789173, Length=257, Percent_Identity=28.7937743190661, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1786448, Length=241, Percent_Identity=27.3858921161826, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI157672245, Length=209, Percent_Identity=28.7081339712919, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1788706, Length=306, Percent_Identity=25.1633986928105, Blast_Score=71, Evalue=7e-14,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 34030; Mature: 34030

Theoretical pI: Translated: 10.55; Mature: 10.55

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.9 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.0 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNQQNVQALWPHIHSLTVLAAAGSFTAAAQRLGISKAAMSQRIADLEKAAGVPLVRRTTR
CCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHCHHHHHHHHHHHHHHHHCCCCHHHHCCC
SVRLTDAGQTLVDSTRDAFESIGQHFARVKELAGEPRGLVRVTAPVALGRQQIVPHLPDF
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHCHHHHHHCCHHH
LRAHPGVHLELDLSDRLHSLTQEGFDLAIRHTTTAPQTHVAWKLCETRSLLVASRDYLDA
HHHCCCCEEEEEHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCC
RGAPRHPRELVDHSCLCYLRDNEPAAWSFELQGRRRERVSVPVRGSFAANNSEAMREAAL
CCCCCCHHHHHCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHH
GGLGIALLPDFSARRDLDAGRLVSLLDAWRPSGAFGDHIFAIRPYSAVVPSAVRALVRHL
CCCCEEECCCCHHHCCCCHHHHHHHHHHCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHH
RERLAGGFSGP
HHHHCCCCCCC
>Mature Secondary Structure
MNQQNVQALWPHIHSLTVLAAAGSFTAAAQRLGISKAAMSQRIADLEKAAGVPLVRRTTR
CCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHCHHHHHHHHHHHHHHHHCCCCHHHHCCC
SVRLTDAGQTLVDSTRDAFESIGQHFARVKELAGEPRGLVRVTAPVALGRQQIVPHLPDF
EEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEECHHHHCHHHHHHCCHHH
LRAHPGVHLELDLSDRLHSLTQEGFDLAIRHTTTAPQTHVAWKLCETRSLLVASRDYLDA
HHHCCCCEEEEEHHHHHHHHHHCCCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHCC
RGAPRHPRELVDHSCLCYLRDNEPAAWSFELQGRRRERVSVPVRGSFAANNSEAMREAAL
CCCCCCHHHHHCCCEEEEEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHH
GGLGIALLPDFSARRDLDAGRLVSLLDAWRPSGAFGDHIFAIRPYSAVVPSAVRALVRHL
CCCCEEECCCCHHHCCCCHHHHHHHHHHCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHH
RERLAGGFSGP
HHHHCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 8843437; 10984043 [H]