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The map label for this gene is uvrD [H]

Identifier: 161525045

GI number: 161525045

Start: 2044242

End: 2046602

Strand: Reverse

Name: uvrD [H]

Synonym: Bmul_1873

Alternate gene names: 161525045

Gene position: 2046602-2044242 (Counterclockwise)

Preceding gene: 161525048

Following gene: 161525044

Centisome position: 59.35

GC content: 67.09

Gene sequence:

>2361_bases
ATGCCTGATCTGCTCGCCAATCTGAACCCCGAACAATACGCCGCCGTCACGCTGCCGAACGAACCGGCGCTGATCCTCGC
GGGGGCGGGCAGCGGCAAGACCCGCGTGCTGATCACGCGCATCGCGTGGCTGATCCAGCAGGGCTACGCGTCGCCGGCCA
CCGTGCTCGCCGTCACGTTCACGAACAAGGCCGCGCGCGAGATGATGGCGCGGCTCTCCGCGATGATGCCGATCGACACG
CGCGGGATGTGGATCGGCACGTTCCACGGCCTCTGCAACCGGATGCTGCGCGCGCACTACCGCGACGCGGGCCTGCCGCA
GACCTTCCAGATCCTCGACACGGCCGATCAGCTGTCCGCGATCAAGCGGCTGATGAAGACGCTGAACGTCGACGACGAGA
AATATCCGCCGAAGAACGTGCAGTACTTCATCAACAACGCGAAGGAGCAGGGGCTGCGCCCCGACAAGGTCGACGCGTCC
GACAACTTCAACCGCAAGTTCGTCGAGCTCTATCAGGCCTACGACCAGCAGTGCCAGCGCGAGGGCGTCGTCGACTTTCC
GGAACTGCTGCTGCGCTGCTACGAGCTGCTCGCGTACAACGCGCCGCTGCGCGCGCACTACCAGGCGCGCTTCCGGCACA
TCCTCGTCGACGAGTTCCAGGACACCAACAAGCTGCAGTACGCGTGGCTGAAGATGCTCGCGGGCGGGCAGAACGCGATC
TTCGCGGTCGGCGACGACGATCAGTCGATCTACGCGTTCCGCGGCGCGAACGTCGGCAACATGCGCGACTTCGAGGACGA
ATTCCGCGTACGCAACCTGATCAAGCTCGAGCAGAACTATCGCTCGCACGGCAACATCCTCGATGCGGCGAACCAGCTGA
TCTCGAACAACGCACACCGTCTCGGCAAGAACCTGCGCACCGACGCGGGCCATGGCGAGCCGGTGCGCGTGTACGAGGCG
AGCACCGATGCGCAGGAAGCCGGCTGGATCGTCGAGGAGATCCGTTCGATGATCAACACGGGGCTGTCGCGCAGCGAAAT
CGCGGTGCTCTATCGCAGCAACGCGCAGTCGCGCGCGATCGAGCACACGCTGATGACGTCGGGCATCCCGTATCGCGTGT
ACGGTGGCCTGCGCTTTTTCGAGCGTCAGGAAGTCAAGCATGCGCTCGCGTATCTGCGCCTGATCGACAATCCGAACGAC
GACACCGCGTTTGCACGCGTCGTGAACTTCCCGACGCGCGGGATCGGCGCGCGCTCGATCGAGCAGCTGGCCGACGCCGC
GCGTCTGTACGGCTGCTCGATGGCTGCCGCGATTCCCTACGTGACGGGCAAGGCCGGCACGAGCCTCGGCGCGTTCGCGA
ACCTGATCGCGAAGATGCGTGCGGAAACGCAGCAGATGAGCCTGCCCGAGACCGTCGAATACGTCGTGCGCGCGAGCGGC
CTCGCCGATTTCTATCAGGGCGAGCGCGAAGGGCAGGATCGCCTCGAGAACTTGCAGGAACTCGTGAACGCGGCCACCGC
GTTCGTCAGCGAGGAAGGCTACGGGCTCGACACGCCCGCGCGCTCGATTCCGCTGCGCCCGGGCGCGATCGCGGCGCCCG
AGATCGGCGCGGCCCGCGACGATGCGTCGGTCGACGTGCTCGCGCCGGCCTCGCTCGACGATCCCGCGCAGAACCCCGAC
ACGATGACGCCGCTCGCGGGCTTTCTGTCGCACGCGTCGCTCGAGGCCGGCGACAACCAGGCGCAGGCCGGCCAGGACGC
CGTGCAGCTGATGACCGTGCACGCGGCGAAGGGGCTCGAATTCTCGGCGGTGTTCATCACCGGGCTCGAGGAAGGGCTGT
TCCCGCACGAGAACAGCGTGCTCGAATCGGACGGTCTCGAGGAAGAGCGCCGGCTGATGTACGTCGCGATCACGCGCGCG
AAGGAGCGGCTCTATCTGTCGTTCGCGCAGAGCCGGATGCTGCACGGCCAGACGCGCTACAACGTGCGCTCGCGCTTTTT
CGACGAACTGCCGCAGCACGTGCTGAAGTGGCTGACGCCGAAGGTCGAAGCCGGTGCGCGCTGGGGCGGCCGCTCCGACA
ACGCGGGCTGGGGGCGCGACTGGTTCGCGCGGCCCGGCGCCGGGCGCGAGCAGTACGTCGACGCGGCGGTGTCCGCGCCG
CTGCCCGCGTTCGCCGACCAGCAGCGGGCGGCCGACGTCGGTTTTCGCGTCGGCCAGCAGGTGTTCCATACGAAATTCGG
CGAAGGGACGGTGACCGCGCTCGAAGGCAGCGGCGCCGATGCGAAGGCGCAGGTGAAGTTCAAGCGGCACGGCGAGAAAT
GGCTCGCGCTCGCGGTCGCGAAGCTGCAGGCGGTGGAATGA

Upstream 100 bases:

>100_bases
GACGCGCATCGCGCGCGACGTGCGCCGGCCGAAAACGGCAGCGCGCGGCCGACTTATAATGGCGGGTCCGCATTTTTTCA
CGCCCGTCCGCTGCCGCTCC

Downstream 100 bases:

>100_bases
CGAGCCTCGACATCGCAACCGGCGCCGCGCCGCGCCCGCTCGGCATTCTCGCCGCCCTGCCGGAGGAACTCGGCGACCTG
ATCGCCGCGATGCGCGCGGA

Product: UvrD/REP helicase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 786; Mature: 785

Protein sequence:

>786_residues
MPDLLANLNPEQYAAVTLPNEPALILAGAGSGKTRVLITRIAWLIQQGYASPATVLAVTFTNKAAREMMARLSAMMPIDT
RGMWIGTFHGLCNRMLRAHYRDAGLPQTFQILDTADQLSAIKRLMKTLNVDDEKYPPKNVQYFINNAKEQGLRPDKVDAS
DNFNRKFVELYQAYDQQCQREGVVDFPELLLRCYELLAYNAPLRAHYQARFRHILVDEFQDTNKLQYAWLKMLAGGQNAI
FAVGDDDQSIYAFRGANVGNMRDFEDEFRVRNLIKLEQNYRSHGNILDAANQLISNNAHRLGKNLRTDAGHGEPVRVYEA
STDAQEAGWIVEEIRSMINTGLSRSEIAVLYRSNAQSRAIEHTLMTSGIPYRVYGGLRFFERQEVKHALAYLRLIDNPND
DTAFARVVNFPTRGIGARSIEQLADAARLYGCSMAAAIPYVTGKAGTSLGAFANLIAKMRAETQQMSLPETVEYVVRASG
LADFYQGEREGQDRLENLQELVNAATAFVSEEGYGLDTPARSIPLRPGAIAAPEIGAARDDASVDVLAPASLDDPAQNPD
TMTPLAGFLSHASLEAGDNQAQAGQDAVQLMTVHAAKGLEFSAVFITGLEEGLFPHENSVLESDGLEEERRLMYVAITRA
KERLYLSFAQSRMLHGQTRYNVRSRFFDELPQHVLKWLTPKVEAGARWGGRSDNAGWGRDWFARPGAGREQYVDAAVSAP
LPAFADQQRAADVGFRVGQQVFHTKFGEGTVTALEGSGADAKAQVKFKRHGEKWLALAVAKLQAVE

Sequences:

>Translated_786_residues
MPDLLANLNPEQYAAVTLPNEPALILAGAGSGKTRVLITRIAWLIQQGYASPATVLAVTFTNKAAREMMARLSAMMPIDT
RGMWIGTFHGLCNRMLRAHYRDAGLPQTFQILDTADQLSAIKRLMKTLNVDDEKYPPKNVQYFINNAKEQGLRPDKVDAS
DNFNRKFVELYQAYDQQCQREGVVDFPELLLRCYELLAYNAPLRAHYQARFRHILVDEFQDTNKLQYAWLKMLAGGQNAI
FAVGDDDQSIYAFRGANVGNMRDFEDEFRVRNLIKLEQNYRSHGNILDAANQLISNNAHRLGKNLRTDAGHGEPVRVYEA
STDAQEAGWIVEEIRSMINTGLSRSEIAVLYRSNAQSRAIEHTLMTSGIPYRVYGGLRFFERQEVKHALAYLRLIDNPND
DTAFARVVNFPTRGIGARSIEQLADAARLYGCSMAAAIPYVTGKAGTSLGAFANLIAKMRAETQQMSLPETVEYVVRASG
LADFYQGEREGQDRLENLQELVNAATAFVSEEGYGLDTPARSIPLRPGAIAAPEIGAARDDASVDVLAPASLDDPAQNPD
TMTPLAGFLSHASLEAGDNQAQAGQDAVQLMTVHAAKGLEFSAVFITGLEEGLFPHENSVLESDGLEEERRLMYVAITRA
KERLYLSFAQSRMLHGQTRYNVRSRFFDELPQHVLKWLTPKVEAGARWGGRSDNAGWGRDWFARPGAGREQYVDAAVSAP
LPAFADQQRAADVGFRVGQQVFHTKFGEGTVTALEGSGADAKAQVKFKRHGEKWLALAVAKLQAVE
>Mature_785_residues
PDLLANLNPEQYAAVTLPNEPALILAGAGSGKTRVLITRIAWLIQQGYASPATVLAVTFTNKAAREMMARLSAMMPIDTR
GMWIGTFHGLCNRMLRAHYRDAGLPQTFQILDTADQLSAIKRLMKTLNVDDEKYPPKNVQYFINNAKEQGLRPDKVDASD
NFNRKFVELYQAYDQQCQREGVVDFPELLLRCYELLAYNAPLRAHYQARFRHILVDEFQDTNKLQYAWLKMLAGGQNAIF
AVGDDDQSIYAFRGANVGNMRDFEDEFRVRNLIKLEQNYRSHGNILDAANQLISNNAHRLGKNLRTDAGHGEPVRVYEAS
TDAQEAGWIVEEIRSMINTGLSRSEIAVLYRSNAQSRAIEHTLMTSGIPYRVYGGLRFFERQEVKHALAYLRLIDNPNDD
TAFARVVNFPTRGIGARSIEQLADAARLYGCSMAAAIPYVTGKAGTSLGAFANLIAKMRAETQQMSLPETVEYVVRASGL
ADFYQGEREGQDRLENLQELVNAATAFVSEEGYGLDTPARSIPLRPGAIAAPEIGAARDDASVDVLAPASLDDPAQNPDT
MTPLAGFLSHASLEAGDNQAQAGQDAVQLMTVHAAKGLEFSAVFITGLEEGLFPHENSVLESDGLEEERRLMYVAITRAK
ERLYLSFAQSRMLHGQTRYNVRSRFFDELPQHVLKWLTPKVEAGARWGGRSDNAGWGRDWFARPGAGREQYVDAAVSAPL
PAFADQQRAADVGFRVGQQVFHTKFGEGTVTALEGSGADAKAQVKFKRHGEKWLALAVAKLQAVE

Specific function: Has both ATPase and helicase activities. Unwinds DNA duplexes with 3' to 5' polarity with respect to the bound strand and initiates unwinding most effectively when a single-stranded region is present. Involved in the post-incision events of nucleotide exc

COG id: COG0210

COG function: function code L; Superfamily I DNA and RNA helicases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 uvrD-like helicase C-terminal domain [H]

Homologues:

Organism=Escherichia coli, GI2367296, Length=797, Percent_Identity=44.4165621079046, Blast_Score=649, Evalue=0.0,
Organism=Escherichia coli, GI48994965, Length=684, Percent_Identity=35.5263157894737, Blast_Score=367, Evalue=1e-102,
Organism=Escherichia coli, GI1787196, Length=340, Percent_Identity=28.8235294117647, Blast_Score=107, Evalue=3e-24,
Organism=Saccharomyces cerevisiae, GI6322369, Length=761, Percent_Identity=27.5952693823916, Blast_Score=213, Evalue=9e-56,
Organism=Saccharomyces cerevisiae, GI6324477, Length=718, Percent_Identity=23.6768802228412, Blast_Score=116, Evalue=2e-26,

Paralogues:

None

Copy number: 3000 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005753
- InterPro:   IPR013986
- InterPro:   IPR014017
- InterPro:   IPR000212
- InterPro:   IPR014016 [H]

Pfam domain/function: PF00580 UvrD-helicase [H]

EC number: =3.6.4.12 [H]

Molecular weight: Translated: 87076; Mature: 86945

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDLLANLNPEQYAAVTLPNEPALILAGAGSGKTRVLITRIAWLIQQGYASPATVLAVTF
CCCCCCCCCCCCEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEE
TNKAAREMMARLSAMMPIDTRGMWIGTFHGLCNRMLRAHYRDAGLPQTFQILDTADQLSA
CCHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
IKRLMKTLNVDDEKYPPKNVQYFINNAKEQGLRPDKVDASDNFNRKFVELYQAYDQQCQR
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
EGVVDFPELLLRCYELLAYNAPLRAHYQARFRHILVDEFQDTNKLQYAWLKMLAGGQNAI
CCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEE
FAVGDDDQSIYAFRGANVGNMRDFEDEFRVRNLIKLEQNYRSHGNILDAANQLISNNAHR
EEECCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHH
LGKNLRTDAGHGEPVRVYEASTDAQEAGWIVEEIRSMINTGLSRSEIAVLYRSNAQSRAI
HHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHEEEEEECCCHHHHH
EHTLMTSGIPYRVYGGLRFFERQEVKHALAYLRLIDNPNDDTAFARVVNFPTRGIGARSI
HHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCHHHH
EQLADAARLYGCSMAAAIPYVTGKAGTSLGAFANLIAKMRAETQQMSLPETVEYVVRASG
HHHHHHHHHHCCHHHHHCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCC
LADFYQGEREGQDRLENLQELVNAATAFVSEEGYGLDTPARSIPLRPGAIAAPEIGAARD
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
DASVDVLAPASLDDPAQNPDTMTPLAGFLSHASLEAGDNQAQAGQDAVQLMTVHAAKGLE
CCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHCHHHHHHHHHHHHHCCCE
FSAVFITGLEEGLFPHENSVLESDGLEEERRLMYVAITRAKERLYLSFAQSRMLHGQTRY
EEEEEEECHHHCCCCCCCCCCCCCCCCHHHHEEEEEEHHHHHHHHHHHHHHHHHCCCHHH
NVRSRFFDELPQHVLKWLTPKVEAGARWGGRSDNAGWGRDWFARPGAGREQYVDAAVSAP
HHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCC
LPAFADQQRAADVGFRVGQQVFHTKFGEGTVTALEGSGADAKAQVKFKRHGEKWLALAVA
CCCHHCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEHHHHCCHHHHHHHHH
KLQAVE
HHHHCC
>Mature Secondary Structure 
PDLLANLNPEQYAAVTLPNEPALILAGAGSGKTRVLITRIAWLIQQGYASPATVLAVTF
CCCCCCCCCCCEEEEECCCCCEEEEEECCCCCHHHHHHHHHHHHHHCCCCCCEEEEEEE
TNKAAREMMARLSAMMPIDTRGMWIGTFHGLCNRMLRAHYRDAGLPQTFQILDTADQLSA
CCHHHHHHHHHHHHCCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHH
IKRLMKTLNVDDEKYPPKNVQYFINNAKEQGLRPDKVDASDNFNRKFVELYQAYDQQCQR
HHHHHHHCCCCCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHH
EGVVDFPELLLRCYELLAYNAPLRAHYQARFRHILVDEFQDTNKLQYAWLKMLAGGQNAI
CCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCCEE
FAVGDDDQSIYAFRGANVGNMRDFEDEFRVRNLIKLEQNYRSHGNILDAANQLISNNAHR
EEECCCCCCEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCCHHH
LGKNLRTDAGHGEPVRVYEASTDAQEAGWIVEEIRSMINTGLSRSEIAVLYRSNAQSRAI
HHCCCCCCCCCCCEEEEEECCCCHHHHHHHHHHHHHHHHCCCCHHHEEEEEECCCHHHHH
EHTLMTSGIPYRVYGGLRFFERQEVKHALAYLRLIDNPNDDTAFARVVNFPTRGIGARSI
HHHHHHCCCCEEEECCHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCHHHH
EQLADAARLYGCSMAAAIPYVTGKAGTSLGAFANLIAKMRAETQQMSLPETVEYVVRASG
HHHHHHHHHHCCHHHHHCCEEECCCCCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCC
LADFYQGEREGQDRLENLQELVNAATAFVSEEGYGLDTPARSIPLRPGAIAAPEIGAARD
HHHHHCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCC
DASVDVLAPASLDDPAQNPDTMTPLAGFLSHASLEAGDNQAQAGQDAVQLMTVHAAKGLE
CCCEEEEECCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCHHHCHHHHHHHHHHHHHCCCE
FSAVFITGLEEGLFPHENSVLESDGLEEERRLMYVAITRAKERLYLSFAQSRMLHGQTRY
EEEEEEECHHHCCCCCCCCCCCCCCCCHHHHEEEEEEHHHHHHHHHHHHHHHHHCCCHHH
NVRSRFFDELPQHVLKWLTPKVEAGARWGGRSDNAGWGRDWFARPGAGREQYVDAAVSAP
HHHHHHHHHHHHHHHHHHCCCHHCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHCCC
LPAFADQQRAADVGFRVGQQVFHTKFGEGTVTALEGSGADAKAQVKFKRHGEKWLALAVA
CCCHHCHHHHHHHHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEEHHHHCCHHHHHHHHH
KLQAVE
HHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 6379604; 2943729; 1379743; 9278503; 6324092; 2254268; 8419285 [H]