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The map label for this gene is cueR [H]

Identifier: 161524872

GI number: 161524872

Start: 1872304

End: 1872753

Strand: Reverse

Name: cueR [H]

Synonym: Bmul_1699

Alternate gene names: 161524872

Gene position: 1872753-1872304 (Counterclockwise)

Preceding gene: 161524875

Following gene: 161524871

Centisome position: 54.31

GC content: 63.56

Gene sequence:

>450_bases
GTGAGAATCGGAGAGTTGGCGAAGCGCACCGGTCTGACGGCCTCACGCATTCGCTTCTATGAGGCGGCGGGGCTGATCAA
CGTGGTGGAGCGCCAAGCGAATGGCTATCGGGAGTATCCCCCGGAAGCGGAAATTCTCCTGGGGATGATATCGGTCGCGC
AGCAGGCTGGCTTTACGCTCGAGCAGATTCGGCAACTGCTGCCCGTCGGCCCGGGCGCATGGGATCACGGCGCGCTGCTG
GACGCGCTCAAGCGGAAGGTGGACGAGATCGACAGCATCCGCGCGCGTCTCGACCAGAGCCGTGCTCAGCTCGTGATCGC
GATCGAGAGCATCGAGGCCAAGCCGGACGGAATCGCTTGTGCAGACAATAAGAAACGCGTGCTCGACCGCCTGCGCGAAG
CGGGAATTACGCCCGATCTAGGCAAGCTCGACGGCGGCACTGTCGGCTGA

Upstream 100 bases:

>100_bases
CGATTGCTTACCCTCGAGTCGGTCGCGCTTCGCCATGTAGTCGCCGAGCAACTTTAGGATTAAAGTCAACGTCAATGTCA
ACAGTTTTTTGGGGTGTCGC

Downstream 100 bases:

>100_bases
GTTCCTTCGGCGGCGCGAGCAAGTTATGCGAGCAGTGACATGCTCGCGACCACAGTATCGACAAAGATGTGCGCGCCCAA
TCCGTCGCTGACCGGGCCCA

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: Copper efflux regulator; Copper export regulator [H]

Number of amino acids: Translated: 149; Mature: 149

Protein sequence:

>149_residues
MRIGELAKRTGLTASRIRFYEAAGLINVVERQANGYREYPPEAEILLGMISVAQQAGFTLEQIRQLLPVGPGAWDHGALL
DALKRKVDEIDSIRARLDQSRAQLVIAIESIEAKPDGIACADNKKRVLDRLREAGITPDLGKLDGGTVG

Sequences:

>Translated_149_residues
MRIGELAKRTGLTASRIRFYEAAGLINVVERQANGYREYPPEAEILLGMISVAQQAGFTLEQIRQLLPVGPGAWDHGALL
DALKRKVDEIDSIRARLDQSRAQLVIAIESIEAKPDGIACADNKKRVLDRLREAGITPDLGKLDGGTVG
>Mature_149_residues
MRIGELAKRTGLTASRIRFYEAAGLINVVERQANGYREYPPEAEILLGMISVAQQAGFTLEQIRQLLPVGPGAWDHGALL
DALKRKVDEIDSIRARLDQSRAQLVIAIESIEAKPDGIACADNKKRVLDRLREAGITPDLGKLDGGTVG

Specific function: Regulates the transcription of the copA and cueO genes. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786695, Length=105, Percent_Identity=34.2857142857143, Blast_Score=60, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011789
- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 16232; Mature: 16232

Theoretical pI: Translated: 7.37; Mature: 7.37

Prosite motif: PS00552 HTH_MERR_1 ; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRIGELAKRTGLTASRIRFYEAAGLINVVERQANGYREYPPEAEILLGMISVAQQAGFTL
CCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCH
EQIRQLLPVGPGAWDHGALLDALKRKVDEIDSIRARLDQSRAQLVIAIESIEAKPDGIAC
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEHCCCCCCCCCCCC
ADNKKRVLDRLREAGITPDLGKLDGGTVG
CCCHHHHHHHHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MRIGELAKRTGLTASRIRFYEAAGLINVVERQANGYREYPPEAEILLGMISVAQQAGFTL
CCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCH
EQIRQLLPVGPGAWDHGALLDALKRKVDEIDSIRARLDQSRAQLVIAIESIEAKPDGIAC
HHHHHHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEHCCCCCCCCCCCC
ADNKKRVLDRLREAGITPDLGKLDGGTVG
CCCHHHHHHHHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]