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The map label for this gene is glxR [H]

Identifier: 161524567

GI number: 161524567

Start: 1536733

End: 1537623

Strand: Reverse

Name: glxR [H]

Synonym: Bmul_1394

Alternate gene names: 161524567

Gene position: 1537623-1536733 (Counterclockwise)

Preceding gene: 161524568

Following gene: 161524566

Centisome position: 44.59

GC content: 65.99

Gene sequence:

>891_bases
ATGGCAACCATCGGTTTCATCGGCCTCGGCATCATGGGCGCGCACATGGCGCGTAACCTGCTCAAGGCTGATCATCGGCT
CGTCGTGAACGGCGCGTATCCGGTGCCGGACGATCTGCGCGCGAGCGCGAAAGTCGTCGCGAACTCGAGCGAAGTCGCGA
AGAACGCGGACATCATCATCTCGATGGTTCCGGACACGCCCGACGTGCGCAACGTGCTGTTCGCCGACGACGGCGTCGCG
AAGGGCCTGACGCCGGGCAAGCTCGTGATCGACATGAGCTCGATCTCGCCGCTCGACACGCAGGAATTCGCGAAGCAGAT
CAACGCGCTCGGCTGCGACTATCTCGATGCACCGGTCTCCGGCGGTGAAGTCGGCGCGCGCGACGCGTCGCTGACGATCA
TGGTCGGCGGCCCGGAGCAGGCGTTCGAGCGCGCCAAGCCGCTGTTCGAGAAGATGGGCAAGAACATCACGCTCGTCGGC
GACAACGGCGCGGGCCAGACCTGCAAGGTCGCGAACCAGATCATCGTCGCGCTGAACATCGAGGCCGTCGGCGAAGCGCT
GCTGTTCGCCGCGCGCTCGGGCGCGGACCCGGAGCGCGTGCGTCAGGCACTGATGGGCGGTTTCGCGGCATCGCGCATCC
TCGAAGTGCACGGCGCGCGGATGACCAAGCGCACGTTCGATCCGGGCTTCCGCATCGAGCTGCACCAGAAGGATCTGAAC
CTCGCGCTCGAAGGCGCACGCAAGCTCGGCCTCGCGCTGCCGCACACCGCGAGCGCGCAGCAGCTGTTCAGCGTGTGCGC
ATCGCACGGCGGCAAGGCATGGGATCACTCGGCACTCGTGCGTGCGCTCGAGATCATGTCGAACTTCGAGATCGAGAAGT
CGGCAAGCTGA

Upstream 100 bases:

>100_bases
CTCGGCTGGCTGCAAAGCGTCGCCGGCTGCACGTCGGGCGCCGCGCGCCGCGCCGCCTGAACGCCACCTTCCGTCATTCG
CCCCTATAGGAGACTTTCAC

Downstream 100 bases:

>100_bases
ACGCGGGCCGCGTCGCGCGGCTGCCATGACGCACTCTCCGTCGCGATCGCGGCGGACGGTGCGCGGCATTCACGTGCGCC
GGCCGCTGCCGGTGCATCGA

Product: 2-hydroxy-3-oxopropionate reductase

Products: NA

Alternate protein names: Tartronate semialdehyde reductase; TSAR [H]

Number of amino acids: Translated: 296; Mature: 295

Protein sequence:

>296_residues
MATIGFIGLGIMGAHMARNLLKADHRLVVNGAYPVPDDLRASAKVVANSSEVAKNADIIISMVPDTPDVRNVLFADDGVA
KGLTPGKLVIDMSSISPLDTQEFAKQINALGCDYLDAPVSGGEVGARDASLTIMVGGPEQAFERAKPLFEKMGKNITLVG
DNGAGQTCKVANQIIVALNIEAVGEALLFAARSGADPERVRQALMGGFAASRILEVHGARMTKRTFDPGFRIELHQKDLN
LALEGARKLGLALPHTASAQQLFSVCASHGGKAWDHSALVRALEIMSNFEIEKSAS

Sequences:

>Translated_296_residues
MATIGFIGLGIMGAHMARNLLKADHRLVVNGAYPVPDDLRASAKVVANSSEVAKNADIIISMVPDTPDVRNVLFADDGVA
KGLTPGKLVIDMSSISPLDTQEFAKQINALGCDYLDAPVSGGEVGARDASLTIMVGGPEQAFERAKPLFEKMGKNITLVG
DNGAGQTCKVANQIIVALNIEAVGEALLFAARSGADPERVRQALMGGFAASRILEVHGARMTKRTFDPGFRIELHQKDLN
LALEGARKLGLALPHTASAQQLFSVCASHGGKAWDHSALVRALEIMSNFEIEKSAS
>Mature_295_residues
ATIGFIGLGIMGAHMARNLLKADHRLVVNGAYPVPDDLRASAKVVANSSEVAKNADIIISMVPDTPDVRNVLFADDGVAK
GLTPGKLVIDMSSISPLDTQEFAKQINALGCDYLDAPVSGGEVGARDASLTIMVGGPEQAFERAKPLFEKMGKNITLVGD
NGAGQTCKVANQIIVALNIEAVGEALLFAARSGADPERVRQALMGGFAASRILEVHGARMTKRTFDPGFRIELHQKDLNL
ALEGARKLGLALPHTASAQQLFSVCASHGGKAWDHSALVRALEIMSNFEIEKSAS

Specific function: Glyoxylate catabolism. [C]

COG id: COG2084

COG function: function code I; 3-hydroxyisobutyrate dehydrogenase and related beta-hydroxyacid dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 3-hydroxyisobutyrate dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI23308751, Length=305, Percent_Identity=31.1475409836066, Blast_Score=145, Evalue=4e-35,
Organism=Homo sapiens, GI40556376, Length=282, Percent_Identity=28.0141843971631, Blast_Score=113, Evalue=2e-25,
Organism=Escherichia coli, GI1786719, Length=289, Percent_Identity=64.7058823529412, Blast_Score=383, Evalue=1e-107,
Organism=Escherichia coli, GI145693186, Length=292, Percent_Identity=41.7808219178082, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI1790315, Length=290, Percent_Identity=34.4827586206897, Blast_Score=141, Evalue=4e-35,
Organism=Escherichia coli, GI1789092, Length=289, Percent_Identity=29.757785467128, Blast_Score=108, Evalue=4e-25,
Organism=Caenorhabditis elegans, GI17557316, Length=288, Percent_Identity=32.9861111111111, Blast_Score=127, Evalue=5e-30,
Organism=Drosophila melanogaster, GI24655230, Length=273, Percent_Identity=38.4615384615385, Blast_Score=150, Evalue=9e-37,
Organism=Drosophila melanogaster, GI19922568, Length=273, Percent_Identity=38.4615384615385, Blast_Score=150, Evalue=9e-37,
Organism=Drosophila melanogaster, GI28574115, Length=289, Percent_Identity=29.4117647058824, Blast_Score=99, Evalue=4e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002204
- InterPro:   IPR015815
- InterPro:   IPR008927
- InterPro:   IPR006115
- InterPro:   IPR013328
- InterPro:   IPR016040
- InterPro:   IPR006183
- InterPro:   IPR006398 [H]

Pfam domain/function: PF03446 NAD_binding_2 [H]

EC number: =1.1.1.60 [H]

Molecular weight: Translated: 31282; Mature: 31151

Theoretical pI: Translated: 6.63; Mature: 6.63

Prosite motif: PS00895 3_HYDROXYISOBUT_DH

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.4 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MATIGFIGLGIMGAHMARNLLKADHRLVVNGAYPVPDDLRASAKVVANSSEVAKNADIII
CCEEHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHCCCHHEEECCHHHHCCCCEEE
SMVPDTPDVRNVLFADDGVAKGLTPGKLVIDMSSISPLDTQEFAKQINALGCDYLDAPVS
EECCCCCCCCEEEEECCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCC
GGEVGARDASLTIMVGGPEQAFERAKPLFEKMGKNITLVGDNGAGQTCKVANQIIVALNI
CCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHCCEEEEEEEH
EAVGEALLFAARSGADPERVRQALMGGFAASRILEVHGARMTKRTFDPGFRIELHQKDLN
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCEEEEECCCCH
LALEGARKLGLALPHTASAQQLFSVCASHGGKAWDHSALVRALEIMSNFEIEKSAS
HHHHHHHHHCEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCC
>Mature Secondary Structure 
ATIGFIGLGIMGAHMARNLLKADHRLVVNGAYPVPDDLRASAKVVANSSEVAKNADIII
CEEHHHHHHHHHHHHHHHHHHCCCEEEEECCCCCCHHHCCCHHEEECCHHHHCCCCEEE
SMVPDTPDVRNVLFADDGVAKGLTPGKLVIDMSSISPLDTQEFAKQINALGCDYLDAPVS
EECCCCCCCCEEEEECCCCCCCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCCCCCCCCC
GGEVGARDASLTIMVGGPEQAFERAKPLFEKMGKNITLVGDNGAGQTCKVANQIIVALNI
CCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHCCEEEEEECCCCCCHHHHCCEEEEEEEH
EAVGEALLFAARSGADPERVRQALMGGFAASRILEVHGARMTKRTFDPGFRIELHQKDLN
HHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCHHHHHCCCCCCEEEEECCCCH
LALEGARKLGLALPHTASAQQLFSVCASHGGKAWDHSALVRALEIMSNFEIEKSAS
HHHHHHHHHCEECCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10601204; 9278503 [H]