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The map label for this gene is guaB [H]

Identifier: 161524458

GI number: 161524458

Start: 1413963

End: 1415423

Strand: Direct

Name: guaB [H]

Synonym: Bmul_1285

Alternate gene names: 161524458

Gene position: 1413963-1415423 (Clockwise)

Preceding gene: 161524457

Following gene: 161524459

Centisome position: 41.0

GC content: 66.8

Gene sequence:

>1461_bases
ATGCGTCTGATCCAAAAAGCACTCACGTTCGATGACGTGCTCCTCGTCCCGGCCTTCTCCGACGTTCTGCCGCGCGACAC
CAGCCTCAAGACCAAGCTGACCCGCAACATCTCCCTGAACATGCCGCTCGTGTCCGCCGCGATGGACACGGTCACCGAAG
GTCGCCTCGCGATCGCGATGGCGCAGCAGGGTGGCGTCGGCATCATTCACAAGAACCTCACGCCGGCCGAGCAGGCGCGC
GAGGTCGCGAAGGTCAAGCGTTTCGAATCGGGTGTGGTCCGCGATCCGATCACGGTGCCGCCGCAAATGAAGGTGCGCGA
CGTGATCGCGCTGTCGCGCCAGCATGGCATCTCGGGCTTCCCGGTTGTCGAAGGTCCGCAACTCGTCGGCATCGTCACGA
ACCGCGACCTGCGCTTCGAAACGCGCCTCGACGAACCGGTCAAGTCGATCATGACGCCGCGCGAGCGTCTCGTCACCGTC
AAGGAAGGCACGCCGCTCGCCGAAGCGAAGGCGCTGATGCACAGCCACCGCCTCGAGCGCGTGCTGGTCGTCAACGACGC
GTTCGAGCTGCGCGGCCTGATGACCGTCAAGGACATCACGAAGCAGACCGAGCACCCCGATGCGTGCAAGGACGAGCACG
GCAAGCTGCGCGCAGGCGCGGCGGTCGGCGTCGGTCCGGACAACGAAGAGCGCGTCGAGCTGCTCGTGCAGGCAGGCGTC
GACGTGATCGTCGTCGATACCGCGCACGGTCACAGCAAGGGCGTGCTCGAGCGCGTGCGCTGGGTCAAGCAGAAGTTCCC
GCATGTCGAGGTGATCGGCGGCAACATCGCGACGGCCGCTGCCGCGAAGGCGCTCGTCGAGTACGGCGCGGACGCGGTCA
AGGTCGGCATCGGCCCCGGCTCGATCTGCACGACGCGCATCGTCGCGGGTGTCGGCGTGCCGCAGATCAGCGCGATCGCG
AACGTCTCGGAAGCGCTGAAGGGCACGGGCGTGCCGTGCATCGCCGACGGCGGCGTGCGTTTCTCGGGCGACGTCGCGAA
GGCGCTGGCCGCCGGCGCGAACGCCGTGATGATGGGCAGCATGTTCGCCGGCACGGAAGAAGCGCCGGGCGACGTGTTCC
TGTATCAGGGCCGCCAGTACAAGTCGTACCGCGGCATGGGCTCGGTCGGTGCGATGAAGGACGGTGCGGCCGACCGCTAC
TTCCAGGACAACTCGGCGAACATCGACAAGCTCGTGCCGGAAGGCATCGAAGGCCGCGTCGCCTACAAGGGCTCGGTCAA
CGCGATCCTGTTCCAGCTGGTCGGCGGCGTGCGCGCGAGCATGGGCTACTGCGGCTGCCGCACGATCGAGGAGCTGCACG
AGAAGGCCGAATTCGTGCAGATCACCGCGGCGGGCATGCGCGAGTCGCACGTGCACGACGTGCAGATCACCAAGGAAGCG
CCGAACTATCACGTGGACTGA

Upstream 100 bases:

>100_bases
TTCGGCCCCGGAACAGCGGAAAACGGCTAAGCCGTTGTTCGTGTTGTGAAAATTCGCCGCGCTTCGCGTATAATTCGCTT
TTGCGCCCATAGGATTTGCC

Downstream 100 bases:

>100_bases
TCGCCGATGAAACCGCTGCTGCGAGCCGTGCTGGTCGTCGATGCCGTGCTGCTGCTGGCGTTCGGGCTGCTGTTCGTGCT
GACGCCGTGGCATGCGCTGT

Product: inosine 5'-monophosphate dehydrogenase

Products: NA

Alternate protein names: IMP dehydrogenase; IMPD; IMPDH [H]

Number of amino acids: Translated: 486; Mature: 486

Protein sequence:

>486_residues
MRLIQKALTFDDVLLVPAFSDVLPRDTSLKTKLTRNISLNMPLVSAAMDTVTEGRLAIAMAQQGGVGIIHKNLTPAEQAR
EVAKVKRFESGVVRDPITVPPQMKVRDVIALSRQHGISGFPVVEGPQLVGIVTNRDLRFETRLDEPVKSIMTPRERLVTV
KEGTPLAEAKALMHSHRLERVLVVNDAFELRGLMTVKDITKQTEHPDACKDEHGKLRAGAAVGVGPDNEERVELLVQAGV
DVIVVDTAHGHSKGVLERVRWVKQKFPHVEVIGGNIATAAAAKALVEYGADAVKVGIGPGSICTTRIVAGVGVPQISAIA
NVSEALKGTGVPCIADGGVRFSGDVAKALAAGANAVMMGSMFAGTEEAPGDVFLYQGRQYKSYRGMGSVGAMKDGAADRY
FQDNSANIDKLVPEGIEGRVAYKGSVNAILFQLVGGVRASMGYCGCRTIEELHEKAEFVQITAAGMRESHVHDVQITKEA
PNYHVD

Sequences:

>Translated_486_residues
MRLIQKALTFDDVLLVPAFSDVLPRDTSLKTKLTRNISLNMPLVSAAMDTVTEGRLAIAMAQQGGVGIIHKNLTPAEQAR
EVAKVKRFESGVVRDPITVPPQMKVRDVIALSRQHGISGFPVVEGPQLVGIVTNRDLRFETRLDEPVKSIMTPRERLVTV
KEGTPLAEAKALMHSHRLERVLVVNDAFELRGLMTVKDITKQTEHPDACKDEHGKLRAGAAVGVGPDNEERVELLVQAGV
DVIVVDTAHGHSKGVLERVRWVKQKFPHVEVIGGNIATAAAAKALVEYGADAVKVGIGPGSICTTRIVAGVGVPQISAIA
NVSEALKGTGVPCIADGGVRFSGDVAKALAAGANAVMMGSMFAGTEEAPGDVFLYQGRQYKSYRGMGSVGAMKDGAADRY
FQDNSANIDKLVPEGIEGRVAYKGSVNAILFQLVGGVRASMGYCGCRTIEELHEKAEFVQITAAGMRESHVHDVQITKEA
PNYHVD
>Mature_486_residues
MRLIQKALTFDDVLLVPAFSDVLPRDTSLKTKLTRNISLNMPLVSAAMDTVTEGRLAIAMAQQGGVGIIHKNLTPAEQAR
EVAKVKRFESGVVRDPITVPPQMKVRDVIALSRQHGISGFPVVEGPQLVGIVTNRDLRFETRLDEPVKSIMTPRERLVTV
KEGTPLAEAKALMHSHRLERVLVVNDAFELRGLMTVKDITKQTEHPDACKDEHGKLRAGAAVGVGPDNEERVELLVQAGV
DVIVVDTAHGHSKGVLERVRWVKQKFPHVEVIGGNIATAAAAKALVEYGADAVKVGIGPGSICTTRIVAGVGVPQISAIA
NVSEALKGTGVPCIADGGVRFSGDVAKALAAGANAVMMGSMFAGTEEAPGDVFLYQGRQYKSYRGMGSVGAMKDGAADRY
FQDNSANIDKLVPEGIEGRVAYKGSVNAILFQLVGGVRASMGYCGCRTIEELHEKAEFVQITAAGMRESHVHDVQITKEA
PNYHVD

Specific function: GMP biosynthesis from IMP; first step. [C]

COG id: COG0516

COG function: function code F; IMP dehydrogenase/GMP reductase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 CBS domains [H]

Homologues:

Organism=Homo sapiens, GI217035146, Length=479, Percent_Identity=42.1711899791232, Blast_Score=370, Evalue=1e-102,
Organism=Homo sapiens, GI34328928, Length=479, Percent_Identity=42.1711899791232, Blast_Score=368, Evalue=1e-102,
Organism=Homo sapiens, GI34328930, Length=479, Percent_Identity=42.1711899791232, Blast_Score=368, Evalue=1e-102,
Organism=Homo sapiens, GI156616279, Length=479, Percent_Identity=42.1711899791232, Blast_Score=368, Evalue=1e-102,
Organism=Homo sapiens, GI217035152, Length=475, Percent_Identity=42.1052631578947, Blast_Score=363, Evalue=1e-100,
Organism=Homo sapiens, GI66933016, Length=482, Percent_Identity=40.6639004149378, Blast_Score=362, Evalue=1e-100,
Organism=Homo sapiens, GI217035148, Length=479, Percent_Identity=41.3361169102296, Blast_Score=358, Evalue=9e-99,
Organism=Homo sapiens, GI217035150, Length=479, Percent_Identity=39.0396659707724, Blast_Score=328, Evalue=1e-89,
Organism=Homo sapiens, GI156104880, Length=262, Percent_Identity=35.8778625954198, Blast_Score=166, Evalue=5e-41,
Organism=Homo sapiens, GI50541956, Length=245, Percent_Identity=37.1428571428571, Blast_Score=161, Evalue=1e-39,
Organism=Homo sapiens, GI50541954, Length=245, Percent_Identity=37.1428571428571, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI50541952, Length=245, Percent_Identity=37.1428571428571, Blast_Score=160, Evalue=2e-39,
Organism=Homo sapiens, GI50541948, Length=245, Percent_Identity=37.1428571428571, Blast_Score=160, Evalue=2e-39,
Organism=Escherichia coli, GI1788855, Length=487, Percent_Identity=62.8336755646817, Blast_Score=578, Evalue=1e-166,
Organism=Escherichia coli, GI1786293, Length=238, Percent_Identity=33.6134453781513, Blast_Score=139, Evalue=5e-34,
Organism=Caenorhabditis elegans, GI71994385, Length=478, Percent_Identity=37.8661087866109, Blast_Score=308, Evalue=5e-84,
Organism=Caenorhabditis elegans, GI71994389, Length=425, Percent_Identity=39.2941176470588, Blast_Score=290, Evalue=1e-78,
Organism=Caenorhabditis elegans, GI17560440, Length=239, Percent_Identity=35.9832635983264, Blast_Score=163, Evalue=2e-40,
Organism=Saccharomyces cerevisiae, GI6322012, Length=488, Percent_Identity=39.1393442622951, Blast_Score=353, Evalue=4e-98,
Organism=Saccharomyces cerevisiae, GI6323585, Length=484, Percent_Identity=39.6694214876033, Blast_Score=349, Evalue=6e-97,
Organism=Saccharomyces cerevisiae, GI6323464, Length=484, Percent_Identity=39.2561983471074, Blast_Score=341, Evalue=1e-94,
Organism=Saccharomyces cerevisiae, GI6319352, Length=342, Percent_Identity=39.1812865497076, Blast_Score=262, Evalue=8e-71,
Organism=Saccharomyces cerevisiae, GI6319353, Length=142, Percent_Identity=35.9154929577465, Blast_Score=85, Evalue=3e-17,
Organism=Drosophila melanogaster, GI24641071, Length=485, Percent_Identity=40.4123711340206, Blast_Score=349, Evalue=2e-96,
Organism=Drosophila melanogaster, GI24641073, Length=485, Percent_Identity=40.4123711340206, Blast_Score=349, Evalue=2e-96,
Organism=Drosophila melanogaster, GI28571163, Length=443, Percent_Identity=41.0835214446953, Blast_Score=316, Evalue=3e-86,

Paralogues:

None

Copy number: 600 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR000644
- InterPro:   IPR005990
- InterPro:   IPR018529
- InterPro:   IPR015875
- InterPro:   IPR001093 [H]

Pfam domain/function: PF00571 CBS; PF00478 IMPDH [H]

EC number: =1.1.1.205 [H]

Molecular weight: Translated: 52033; Mature: 52033

Theoretical pI: Translated: 7.68; Mature: 7.68

Prosite motif: PS00487 IMP_DH_GMP_RED

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRLIQKALTFDDVLLVPAFSDVLPRDTSLKTKLTRNISLNMPLVSAAMDTVTEGRLAIAM
CCHHHHHCCCCCEEEECCHHHHCCCCCCCHHEEECCEEECCCHHHHHHHHHCCCCEEEEE
AQQGGVGIIHKNLTPAEQAREVAKVKRFESGVVRDPITVPPQMKVRDVIALSRQHGISGF
ECCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCC
PVVEGPQLVGIVTNRDLRFETRLDEPVKSIMTPRERLVTVKEGTPLAEAKALMHSHRLER
CEECCCEEEEEEECCCEEEHHHHHHHHHHHHCCHHHEEEEECCCCHHHHHHHHHHHHCCE
VLVVNDAFELRGLMTVKDITKQTEHPDACKDEHGKLRAGAAVGVGPDNEERVELLVQAGV
EEEEECHHHHHCCHHHHHHHHHCCCCCCCCCCCCCEEECEEECCCCCCHHHHHHHHHCCC
DVIVVDTAHGHSKGVLERVRWVKQKFPHVEVIGGNIATAAAAKALVEYGADAVKVGIGPG
CEEEEECCCCCHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCC
SICTTRIVAGVGVPQISAIANVSEALKGTGVPCIADGGVRFSGDVAKALAAGANAVMMGS
HHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEECCCEEECCHHHHHHHCCCCEEEECH
MFAGTEEAPGDVFLYQGRQYKSYRGMGSVGAMKDGAADRYFQDNSANIDKLVPEGIEGRV
HHCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCEE
AYKGSVNAILFQLVGGVRASMGYCGCRTIEELHEKAEFVQITAAGMRESHVHDVQITKEA
EECCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHEEEEEECCCCCCCCCEEEEEECC
PNYHVD
CCCCCC
>Mature Secondary Structure
MRLIQKALTFDDVLLVPAFSDVLPRDTSLKTKLTRNISLNMPLVSAAMDTVTEGRLAIAM
CCHHHHHCCCCCEEEECCHHHHCCCCCCCHHEEECCEEECCCHHHHHHHHHCCCCEEEEE
AQQGGVGIIHKNLTPAEQAREVAKVKRFESGVVRDPITVPPQMKVRDVIALSRQHGISGF
ECCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHCCCCCC
PVVEGPQLVGIVTNRDLRFETRLDEPVKSIMTPRERLVTVKEGTPLAEAKALMHSHRLER
CEECCCEEEEEEECCCEEEHHHHHHHHHHHHCCHHHEEEEECCCCHHHHHHHHHHHHCCE
VLVVNDAFELRGLMTVKDITKQTEHPDACKDEHGKLRAGAAVGVGPDNEERVELLVQAGV
EEEEECHHHHHCCHHHHHHHHHCCCCCCCCCCCCCEEECEEECCCCCCHHHHHHHHHCCC
DVIVVDTAHGHSKGVLERVRWVKQKFPHVEVIGGNIATAAAAKALVEYGADAVKVGIGPG
CEEEEECCCCCHHHHHHHHHHHHHHCCEEEEECCCHHHHHHHHHHHHCCCCEEEEECCCC
SICTTRIVAGVGVPQISAIANVSEALKGTGVPCIADGGVRFSGDVAKALAAGANAVMMGS
HHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCCEEECCCEEECCHHHHHHHCCCCEEEECH
MFAGTEEAPGDVFLYQGRQYKSYRGMGSVGAMKDGAADRYFQDNSANIDKLVPEGIEGRV
HHCCCCCCCCCEEEECCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHCCCCCCCEE
AYKGSVNAILFQLVGGVRASMGYCGCRTIEELHEKAEFVQITAAGMRESHVHDVQITKEA
EECCCHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHEEEEEECCCCCCCCCEEEEEECC
PNYHVD
CCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA