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The map label for this gene is cyaA [H]

Identifier: 161524383

GI number: 161524383

Start: 1328979

End: 1330985

Strand: Direct

Name: cyaA [H]

Synonym: Bmul_1210

Alternate gene names: 161524383

Gene position: 1328979-1330985 (Clockwise)

Preceding gene: 161524382

Following gene: 161524384

Centisome position: 38.54

GC content: 63.28

Gene sequence:

>2007_bases
ATGTTCGGCAAACTCACACTCTCGGCGATCCCGTTCGATCAGCCCATCATCATGGGGGCCGGCGCCTTCATGGGGCTGGT
CGTGCTGGGCATTCTCGCCGCATTGACGATCACCGGCCGCTGGAAATGGCTGTGGACCGAATGGCTGACGACGGTCGACC
ACAAGAAGCTCGGCGTGATGTACATCATCGTCGCGCTGATCATGCTGCTGCGCGGCTTCGCGGACGCGATCATGATGCGC
ATGCAGCTCGCCCTCGCGTACAACGCGCCCGGCTATCTGCCGCCGCATCACTACGATCAGATCTTCACGGCGCACGGCGT
GATCATGATCTTCTTCATGGCGATGGTGTTCATGGTCGGCCTGATGAACCTGATCGTGCCGCTGCAGATCGGCGCGCGCG
ACGTCGCGTTCCCGTTCATCAACTCGCTGAGCTTCTGGATGACGGCCGTCAGCGCGATCCTGATCAACATCTCGCTCGTG
ATCGGCGAATTCGCGCAGACGGGCTGGCTCGCGTATCCGCCGCTGTCCGAGTTGCAGTTCAGTCCGGGGGTAGGGGTCGA
CTACTATCTGTGGGCGCTGCAGATTTCCGGCGTCGGCACGCTGCTGACCGGCGTGAACTTCTTCGTGACGATCATCAAGA
TGCGCGCGCCCGGCATGACGCTGATGAAGATGCCGGTGTTCACGTGGACGGCGCTCTGCACGAACGTGCTGATCATGGCG
TCGTTCCCGATCCTGACGGCCACGCTCGCGCTGCTCGGTCTCGACCGCTACCTCGGCATGCACTTCTTCACGAACGAGGC
GGGCGGCAACGCGATGCTGTACCTGAACCTGATCTGGGCGTGGGGGCATCCGGAGGTGTACATCCTGATCCTGCCGGCGT
TCGGCATCTTCTCGGAAGTCATCGCGACGTTCTCGAAGAAGCCGCTGTTCGGCTACAAGACGATGGTGTACGCGACCTGC
GCGATCATGGTGCTGTCGTTCCTCGTCTGGCTGCACCACTTCTTCACGATGGGCTCGGGCGCGAACGTCAACGCATTCTT
CGGGATCATGACGATGATCATCGCGATTCCGACCGGCGTGAAGGTGTTCAACTGGCTGTTTACGATGTACCGCGGCCGGA
TCCGTTTCACGACGCCCGTGCTGTGGACGATCGGCTTCATGGTCACGTTCACGCTCGGCGGGATGACGGGCGTCATGATG
GCGATTCCGGGCGCGGACTTCGTGCTGCATAACAGCCTGTTCCTGATCGCGCACTTCCATAACGTGATCATCGGCGGCGT
GCTGTTCGGCTATCTCGCGGGCTTCAACTACTGGTTCCCGAAGGCGTTCGGCTTCAAGCTGAACGAGAAGCTCGGCAAGG
CCGCGTTCTGGTTCTGGCAGGTCGGCTTCTACGTCGCGTTCGTGCCGCTCTACGTGCTCGGCTTCATGGGCATGACGCGC
CGGCTGAATCACTACGACAACCCGGCGTGGCATCCGTGGCTGCTCGTCGCCGCGTTCGGCGCCGTGCTGATCGCGATCGG
CATCGCGTGCCAGCTGCTGCAGCTCGTCGTCAGCATCCGCAACCGCAACCTGCCGGCGTACCGCGACACGACGGGCGATC
CGTGGGGCGGCCGCACGCTCGAATGGGCGACGACGTCGCCGCCGGCCGAGTACAACTTCGCGGTGATTCCGCAGGTGCGC
ACGCTCGACGCCTATGCGGACATGAAGGCGCGCGGCGACGCGCGCGCGAACCCGGCCGCGATCCGCGATATCCACATGCC
GTCGAACACCTGCGCGGGTCTCGTGATCGGCGTGTTCAGCCTCGTGCTCGGCTTCGCGCTCGTGTGGCACATCTGGTGGC
TCGCGATCGCCGGGCTCGTCGGCATCGTCGCGACGCTCGTGATCTATAGCTCGCGCGACAACGACGGCTACTACATCCCG
GCGTCGACCGTGCGCAAGACCGAAGACAAGCAATCGTCGAAGCGTGCGATCGCCCGCGTCGACGACGTCGAACTGGAGGC
CAACTGA

Upstream 100 bases:

>100_bases
GTCCGTCGATCCGCGGCTCTTCCACAACATCATCGCGAAATACAACGACGGCCACGTCCTCGATCTGAAGGACGCCGCCT
GCGGCACGAAGGGGTAACGC

Downstream 100 bases:

>100_bases
TGTTGCAGAAAACCTTGAGCGCCACGCTGCTCGAGCACGACGACCATCCGCCGTCGCATTCGGTGTTCGGCTTCTGGCTG
TATCTGATGACCGACTGCGT

Product: cytochrome o ubiquinol oxidase subunit I

Products: NA

Alternate protein names: Cytochrome A1 subunit 1; Oxidase BA(3) subunit 1; Ubiquinol oxidase polypeptide I [H]

Number of amino acids: Translated: 668; Mature: 668

Protein sequence:

>668_residues
MFGKLTLSAIPFDQPIIMGAGAFMGLVVLGILAALTITGRWKWLWTEWLTTVDHKKLGVMYIIVALIMLLRGFADAIMMR
MQLALAYNAPGYLPPHHYDQIFTAHGVIMIFFMAMVFMVGLMNLIVPLQIGARDVAFPFINSLSFWMTAVSAILINISLV
IGEFAQTGWLAYPPLSELQFSPGVGVDYYLWALQISGVGTLLTGVNFFVTIIKMRAPGMTLMKMPVFTWTALCTNVLIMA
SFPILTATLALLGLDRYLGMHFFTNEAGGNAMLYLNLIWAWGHPEVYILILPAFGIFSEVIATFSKKPLFGYKTMVYATC
AIMVLSFLVWLHHFFTMGSGANVNAFFGIMTMIIAIPTGVKVFNWLFTMYRGRIRFTTPVLWTIGFMVTFTLGGMTGVMM
AIPGADFVLHNSLFLIAHFHNVIIGGVLFGYLAGFNYWFPKAFGFKLNEKLGKAAFWFWQVGFYVAFVPLYVLGFMGMTR
RLNHYDNPAWHPWLLVAAFGAVLIAIGIACQLLQLVVSIRNRNLPAYRDTTGDPWGGRTLEWATTSPPAEYNFAVIPQVR
TLDAYADMKARGDARANPAAIRDIHMPSNTCAGLVIGVFSLVLGFALVWHIWWLAIAGLVGIVATLVIYSSRDNDGYYIP
ASTVRKTEDKQSSKRAIARVDDVELEAN

Sequences:

>Translated_668_residues
MFGKLTLSAIPFDQPIIMGAGAFMGLVVLGILAALTITGRWKWLWTEWLTTVDHKKLGVMYIIVALIMLLRGFADAIMMR
MQLALAYNAPGYLPPHHYDQIFTAHGVIMIFFMAMVFMVGLMNLIVPLQIGARDVAFPFINSLSFWMTAVSAILINISLV
IGEFAQTGWLAYPPLSELQFSPGVGVDYYLWALQISGVGTLLTGVNFFVTIIKMRAPGMTLMKMPVFTWTALCTNVLIMA
SFPILTATLALLGLDRYLGMHFFTNEAGGNAMLYLNLIWAWGHPEVYILILPAFGIFSEVIATFSKKPLFGYKTMVYATC
AIMVLSFLVWLHHFFTMGSGANVNAFFGIMTMIIAIPTGVKVFNWLFTMYRGRIRFTTPVLWTIGFMVTFTLGGMTGVMM
AIPGADFVLHNSLFLIAHFHNVIIGGVLFGYLAGFNYWFPKAFGFKLNEKLGKAAFWFWQVGFYVAFVPLYVLGFMGMTR
RLNHYDNPAWHPWLLVAAFGAVLIAIGIACQLLQLVVSIRNRNLPAYRDTTGDPWGGRTLEWATTSPPAEYNFAVIPQVR
TLDAYADMKARGDARANPAAIRDIHMPSNTCAGLVIGVFSLVLGFALVWHIWWLAIAGLVGIVATLVIYSSRDNDGYYIP
ASTVRKTEDKQSSKRAIARVDDVELEAN
>Mature_668_residues
MFGKLTLSAIPFDQPIIMGAGAFMGLVVLGILAALTITGRWKWLWTEWLTTVDHKKLGVMYIIVALIMLLRGFADAIMMR
MQLALAYNAPGYLPPHHYDQIFTAHGVIMIFFMAMVFMVGLMNLIVPLQIGARDVAFPFINSLSFWMTAVSAILINISLV
IGEFAQTGWLAYPPLSELQFSPGVGVDYYLWALQISGVGTLLTGVNFFVTIIKMRAPGMTLMKMPVFTWTALCTNVLIMA
SFPILTATLALLGLDRYLGMHFFTNEAGGNAMLYLNLIWAWGHPEVYILILPAFGIFSEVIATFSKKPLFGYKTMVYATC
AIMVLSFLVWLHHFFTMGSGANVNAFFGIMTMIIAIPTGVKVFNWLFTMYRGRIRFTTPVLWTIGFMVTFTLGGMTGVMM
AIPGADFVLHNSLFLIAHFHNVIIGGVLFGYLAGFNYWFPKAFGFKLNEKLGKAAFWFWQVGFYVAFVPLYVLGFMGMTR
RLNHYDNPAWHPWLLVAAFGAVLIAIGIACQLLQLVVSIRNRNLPAYRDTTGDPWGGRTLEWATTSPPAEYNFAVIPQVR
TLDAYADMKARGDARANPAAIRDIHMPSNTCAGLVIGVFSLVLGFALVWHIWWLAIAGLVGIVATLVIYSSRDNDGYYIP
ASTVRKTEDKQSSKRAIARVDDVELEAN

Specific function: Catalytic subunit of the enzyme. Electrons originating in a quinol are transferred to the bimetallic center formed by heme a and copper B [H]

COG id: COG0843

COG function: function code C; Heme/copper-type cytochrome/quinol oxidases, subunit 1

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the heme-copper respiratory oxidase family [H]

Homologues:

Organism=Homo sapiens, GI251831109, Length=509, Percent_Identity=38.7033398821218, Blast_Score=327, Evalue=2e-89,
Organism=Escherichia coli, GI1786634, Length=663, Percent_Identity=66.9683257918552, Blast_Score=929, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6226519, Length=537, Percent_Identity=38.5474860335196, Blast_Score=360, Evalue=1e-100,
Organism=Saccharomyces cerevisiae, GI6226524, Length=325, Percent_Identity=42.7692307692308, Blast_Score=253, Evalue=6e-68,
Organism=Saccharomyces cerevisiae, GI6226523, Length=245, Percent_Identity=34.2857142857143, Blast_Score=138, Evalue=3e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000883
- InterPro:   IPR014207 [H]

Pfam domain/function: PF00115 COX1 [H]

EC number: 1.10.3.-

Molecular weight: Translated: 74318; Mature: 74318

Theoretical pI: Translated: 9.39; Mature: 9.39

Prosite motif: PS50855 COX1 ; PS00077 COX1_CUB

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.2 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
5.2 %Met     (Mature Protein)
5.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MFGKLTLSAIPFDQPIIMGAGAFMGLVVLGILAALTITGRWKWLWTEWLTTVDHKKLGVM
CCCCEEEEECCCCCCCEECCHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHH
YIIVALIMLLRGFADAIMMRMQLALAYNAPGYLPPHHYDQIFTAHGVIMIFFMAMVFMVG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LMNLIVPLQIGARDVAFPFINSLSFWMTAVSAILINISLVIGEFAQTGWLAYPPLSELQF
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCHHHCCC
SPGVGVDYYLWALQISGVGTLLTGVNFFVTIIKMRAPGMTLMKMPVFTWTALCTNVLIMA
CCCCCCHHEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
SFPILTATLALLGLDRYLGMHFFTNEAGGNAMLYLNLIWAWGHPEVYILILPAFGIFSEV
HHHHHHHHHHHHHHHHHHHHHEEECCCCCCEEEEEEEEEECCCCCEEEEEECHHHHHHHH
IATFSKKPLFGYKTMVYATCAIMVLSFLVWLHHFFTMGSGANVNAFFGIMTMIIAIPTGV
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCH
KVFNWLFTMYRGRIRFTTPVLWTIGFMVTFTLGGMTGVMMAIPGADFVLHNSLFLIAHFH
HHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHCCHHHHHHCCCCCCCHHHCCHHHHHHHH
NVIIGGVLFGYLAGFNYWFPKAFGFKLNEKLGKAAFWFWQVGFYVAFVPLYVLGFMGMTR
HHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLNHYDNPAWHPWLLVAAFGAVLIAIGIACQLLQLVVSIRNRNLPAYRDTTGDPWGGRTL
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEE
EWATTSPPAEYNFAVIPQVRTLDAYADMKARGDARANPAAIRDIHMPSNTCAGLVIGVFS
EECCCCCCCCCCEEECCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHH
LVLGFALVWHIWWLAIAGLVGIVATLVIYSSRDNDGYYIPASTVRKTEDKQSSKRAIARV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEECHHHHHHHHHHHHHHHHHHHH
DDVELEAN
CCEEECCC
>Mature Secondary Structure
MFGKLTLSAIPFDQPIIMGAGAFMGLVVLGILAALTITGRWKWLWTEWLTTVDHKKLGVM
CCCCEEEEECCCCCCCEECCHHHHHHHHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHHH
YIIVALIMLLRGFADAIMMRMQLALAYNAPGYLPPHHYDQIFTAHGVIMIFFMAMVFMVG
HHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
LMNLIVPLQIGARDVAFPFINSLSFWMTAVSAILINISLVIGEFAQTGWLAYPPLSELQF
HHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEECCCHHHCCC
SPGVGVDYYLWALQISGVGTLLTGVNFFVTIIKMRAPGMTLMKMPVFTWTALCTNVLIMA
CCCCCCHHEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHH
SFPILTATLALLGLDRYLGMHFFTNEAGGNAMLYLNLIWAWGHPEVYILILPAFGIFSEV
HHHHHHHHHHHHHHHHHHHHHEEECCCCCCEEEEEEEEEECCCCCEEEEEECHHHHHHHH
IATFSKKPLFGYKTMVYATCAIMVLSFLVWLHHFFTMGSGANVNAFFGIMTMIIAIPTGV
HHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHCCCCH
KVFNWLFTMYRGRIRFTTPVLWTIGFMVTFTLGGMTGVMMAIPGADFVLHNSLFLIAHFH
HHHHHHHHHHCCCEEECCHHHHHHHHHHHHHHCCHHHHHHCCCCCCCHHHCCHHHHHHHH
NVIIGGVLFGYLAGFNYWFPKAFGFKLNEKLGKAAFWFWQVGFYVAFVPLYVLGFMGMTR
HHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
RLNHYDNPAWHPWLLVAAFGAVLIAIGIACQLLQLVVSIRNRNLPAYRDTTGDPWGGRTL
HHHCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCEE
EWATTSPPAEYNFAVIPQVRTLDAYADMKARGDARANPAAIRDIHMPSNTCAGLVIGVFS
EECCCCCCCCCCEEECCCHHHHHHHHHHHHCCCCCCCCCCEEEEECCCCHHHHHHHHHHH
LVLGFALVWHIWWLAIAGLVGIVATLVIYSSRDNDGYYIPASTVRKTEDKQSSKRAIARV
HHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCEEECHHHHHHHHHHHHHHHHHHHH
DDVELEAN
CCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: Protoheme IX (Heme B55 and B562); Copper B. [C]

Metal ions: Fe; Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: Oxidoreductases [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8392509 [H]