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The map label for this gene is rotA [H]

Identifier: 161524374

GI number: 161524374

Start: 1317441

End: 1318016

Strand: Reverse

Name: rotA [H]

Synonym: Bmul_1201

Alternate gene names: 161524374

Gene position: 1318016-1317441 (Counterclockwise)

Preceding gene: 161524375

Following gene: 161524373

Centisome position: 38.22

GC content: 63.19

Gene sequence:

>576_bases
ATGAAACGTCTGTTGCTGGCGCTTGGCGGCGCCGCCCTTCTCGCGACCGCGCCCGCGTTCGCGCAAACGGCCACCGCGCA
CCCCGTCGTGCAGCTGAAGACCTCGCAGGGCGACATCCGCGTCGAACTGTATCCGGAGAAGGCGCCGAAGACCGTCGCGA
ACTTCCTCGATTACGTGAAGGCAGGCCAGTACAACGGCACGATCTTTCATCGCGTGATCAAGGGCTTCATGATCCAGGGC
GGCGGCTACAAGGCGAATTTCGACGAGAAGCCGACGCGCGCGCCGATCCCGCTCGAAAGCCGCAACGGTCTGAAGAACCT
GACCGGCACGATTGCAATGGCGCGCACGAGCGATCCGAATTCCGCGACCGCACAGTTCTTCATCAACACGGTCGACAACA
GCGGCCTCGACTACCCGAATCCGGACGGCAACGGCTATGCGGTGTTCGGCAAGGTCGTGTCGGGTCTCGACGTCGTGAAG
AAGATCGAAGCTGTACCGACGACGTCGCGCGGCCCGATGCAGGACGTGCCCGCGCAGCCGGTCGTGATCGAATCGGCGAG
CATCGTCTCGAAGTAA

Upstream 100 bases:

>100_bases
TCCAGTTCAGCGGCCCGTCCGGTGCACTCGCGGCACCGTACGTCGCGCCGTCGCAGTAAGCGGCGCGGCCCCTTCCTTTC
ATTCCAACCTGAGGATCGCA

Downstream 100 bases:

>100_bases
AACCCTGCCGGTCCGTCCGGCATCTCACGCGGCCGCGTCGCACGACCGGCCGCGTGCCATTTAAACCGCCTCATCGAAGG
AATTCATCATGGTTGAACTG

Product: cyclophilin type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase A; Cyclophilin A; Rotamase A [H]

Number of amino acids: Translated: 191; Mature: 191

Protein sequence:

>191_residues
MKRLLLALGGAALLATAPAFAQTATAHPVVQLKTSQGDIRVELYPEKAPKTVANFLDYVKAGQYNGTIFHRVIKGFMIQG
GGYKANFDEKPTRAPIPLESRNGLKNLTGTIAMARTSDPNSATAQFFINTVDNSGLDYPNPDGNGYAVFGKVVSGLDVVK
KIEAVPTTSRGPMQDVPAQPVVIESASIVSK

Sequences:

>Translated_191_residues
MKRLLLALGGAALLATAPAFAQTATAHPVVQLKTSQGDIRVELYPEKAPKTVANFLDYVKAGQYNGTIFHRVIKGFMIQG
GGYKANFDEKPTRAPIPLESRNGLKNLTGTIAMARTSDPNSATAQFFINTVDNSGLDYPNPDGNGYAVFGKVVSGLDVVK
KIEAVPTTSRGPMQDVPAQPVVIESASIVSK
>Mature_191_residues
MKRLLLALGGAALLATAPAFAQTATAHPVVQLKTSQGDIRVELYPEKAPKTVANFLDYVKAGQYNGTIFHRVIKGFMIQG
GGYKANFDEKPTRAPIPLESRNGLKNLTGTIAMARTSDPNSATAQFFINTVDNSGLDYPNPDGNGYAVFGKVVSGLDVVK
KIEAVPTTSRGPMQDVPAQPVVIESASIVSK

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI19557636, Length=170, Percent_Identity=34.1176470588235, Blast_Score=92, Evalue=3e-19,
Organism=Homo sapiens, GI22547212, Length=162, Percent_Identity=33.9506172839506, Blast_Score=85, Evalue=5e-17,
Organism=Homo sapiens, GI7657473, Length=162, Percent_Identity=33.9506172839506, Blast_Score=85, Evalue=5e-17,
Organism=Homo sapiens, GI22547215, Length=162, Percent_Identity=33.9506172839506, Blast_Score=84, Evalue=6e-17,
Organism=Homo sapiens, GI24308049, Length=168, Percent_Identity=35.1190476190476, Blast_Score=83, Evalue=1e-16,
Organism=Homo sapiens, GI7706339, Length=171, Percent_Identity=35.672514619883, Blast_Score=83, Evalue=1e-16,
Organism=Homo sapiens, GI5454154, Length=185, Percent_Identity=35.6756756756757, Blast_Score=80, Evalue=8e-16,
Organism=Homo sapiens, GI4758950, Length=201, Percent_Identity=33.3333333333333, Blast_Score=71, Evalue=7e-13,
Organism=Homo sapiens, GI64276486, Length=127, Percent_Identity=34.6456692913386, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI10863927, Length=140, Percent_Identity=35, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1789763, Length=190, Percent_Identity=54.2105263157895, Blast_Score=185, Evalue=1e-48,
Organism=Escherichia coli, GI1786736, Length=162, Percent_Identity=54.320987654321, Blast_Score=181, Evalue=3e-47,
Organism=Caenorhabditis elegans, GI71980594, Length=160, Percent_Identity=35.625, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI71980590, Length=144, Percent_Identity=36.8055555555556, Blast_Score=92, Evalue=2e-19,
Organism=Caenorhabditis elegans, GI17552780, Length=200, Percent_Identity=32, Blast_Score=77, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17539496, Length=154, Percent_Identity=33.1168831168831, Blast_Score=77, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17506311, Length=160, Percent_Identity=34.375, Blast_Score=75, Evalue=3e-14,
Organism=Caenorhabditis elegans, GI17532641, Length=167, Percent_Identity=32.9341317365269, Blast_Score=74, Evalue=6e-14,
Organism=Caenorhabditis elegans, GI17559074, Length=155, Percent_Identity=34.1935483870968, Blast_Score=73, Evalue=8e-14,
Organism=Caenorhabditis elegans, GI17565860, Length=167, Percent_Identity=32.9341317365269, Blast_Score=70, Evalue=8e-13,
Organism=Caenorhabditis elegans, GI17566266, Length=153, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17552782, Length=160, Percent_Identity=33.125, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17506307, Length=165, Percent_Identity=33.3333333333333, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI17532643, Length=175, Percent_Identity=34.8571428571429, Blast_Score=68, Evalue=3e-12,
Organism=Saccharomyces cerevisiae, GI6323562, Length=166, Percent_Identity=35.5421686746988, Blast_Score=69, Evalue=4e-13,
Organism=Saccharomyces cerevisiae, GI6320359, Length=139, Percent_Identity=35.2517985611511, Blast_Score=67, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320510, Length=211, Percent_Identity=32.2274881516588, Blast_Score=66, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17986117, Length=170, Percent_Identity=32.9411764705882, Blast_Score=86, Evalue=1e-17,
Organism=Drosophila melanogaster, GI19922376, Length=170, Percent_Identity=32.3529411764706, Blast_Score=84, Evalue=5e-17,
Organism=Drosophila melanogaster, GI19922912, Length=166, Percent_Identity=36.144578313253, Blast_Score=81, Evalue=4e-16,
Organism=Drosophila melanogaster, GI45549139, Length=168, Percent_Identity=36.3095238095238, Blast_Score=75, Evalue=2e-14,
Organism=Drosophila melanogaster, GI17136360, Length=205, Percent_Identity=29.7560975609756, Blast_Score=74, Evalue=4e-14,
Organism=Drosophila melanogaster, GI24652460, Length=152, Percent_Identity=29.6052631578947, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI20130249, Length=160, Percent_Identity=35.625, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24650807, Length=168, Percent_Identity=32.7380952380952, Blast_Score=64, Evalue=8e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 20290; Mature: 20290

Theoretical pI: Translated: 9.94; Mature: 9.94

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKRLLLALGGAALLATAPAFAQTATAHPVVQLKTSQGDIRVELYPEKAPKTVANFLDYVK
CCCEEEECCCHHHHHCCCHHHHHCCCCCEEEEEECCCCEEEEEECCCCHHHHHHHHHHHH
AGQYNGTIFHRVIKGFMIQGGGYKANFDEKPTRAPIPLESRNGLKNLTGTIAMARTSDPN
CCCCCCHHHHHHHHHHEECCCCEECCCCCCCCCCCCCCCCCCCCCHHHEEEEEEECCCCC
SATAQFFINTVDNSGLDYPNPDGNGYAVFGKVVSGLDVVKKIEAVPTTSRGPMQDVPAQP
CCEEEEEEEECCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
VVIESASIVSK
EEEECCHHHCC
>Mature Secondary Structure
MKRLLLALGGAALLATAPAFAQTATAHPVVQLKTSQGDIRVELYPEKAPKTVANFLDYVK
CCCEEEECCCHHHHHCCCHHHHHCCCCCEEEEEECCCCEEEEEECCCCHHHHHHHHHHHH
AGQYNGTIFHRVIKGFMIQGGGYKANFDEKPTRAPIPLESRNGLKNLTGTIAMARTSDPN
CCCCCCHHHHHHHHHHEECCCCEECCCCCCCCCCCCCCCCCCCCCHHHEEEEEEECCCCC
SATAQFFINTVDNSGLDYPNPDGNGYAVFGKVVSGLDVVKKIEAVPTTSRGPMQDVPAQP
CCEEEEEEEECCCCCCCCCCCCCCCEEEHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCC
VVIESASIVSK
EEEECCHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9418240 [H]