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The map label for this gene is cyp18 [H]

Identifier: 161524373

GI number: 161524373

Start: 1316861

End: 1317352

Strand: Reverse

Name: cyp18 [H]

Synonym: Bmul_1200

Alternate gene names: 161524373

Gene position: 1317352-1316861 (Counterclockwise)

Preceding gene: 161524374

Following gene: 161524372

Centisome position: 38.2

GC content: 61.59

Gene sequence:

>492_bases
ATGGTTGAACTGCACACGAACCACGGCGTGATCAAGCTCGAGCTCGACGCCGCGAAGGCACCGAAGACGGTCGAGAACTT
CCTCAACTACGTGAAGAAGGGCCACTACGACGGCACCGTGTTCCACCGCGTGATCAACGGCTTCATGATCCAGGGCGGCG
GCTTCGAGCCGGGCATGAAGCAGAAGCCGACCGACGCGCCGATCGACAACGAGGCGAACAACGGCCTGAAGAACGACAAG
TACACGATCGCAATGGCGCGCACCAACGATCCGCACTCGGCCACGGCCCAGTTCTTCATCAACGTGAACGACAACGACTT
CCTGAACCACTCGTCGCCGACGCCGCAAGGCTGGGGCTACGCCGTGTTCGGCAAGGTCGTCGAAGGCCAGGACGTCGTCG
ACAAGATCAAGGGCGTGAAGACCGGCAACGCAGGCTTCCATCAGGACGTCCCGACCGACGACGTCGTGATCGAGAAGGCC
GTCGTCGTCTGA

Upstream 100 bases:

>100_bases
GTCTCGAAGTAAAACCCTGCCGGTCCGTCCGGCATCTCACGCGGCCGCGTCGCACGACCGGCCGCGTGCCATTTAAACCG
CCTCATCGAAGGAATTCATC

Downstream 100 bases:

>100_bases
CGCACGGGACCGGAGGCACTTCGATGCTGCAGGAGAGTCCGCCGCGAAGCGTCTCCGCGGGCGTGCCGGGCGAGCGCGAA
ACCGCGCACGCCGCACGCCC

Product: cyclophilin type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase cyp18; SanCyp18; Rotamase cyp18 [H]

Number of amino acids: Translated: 163; Mature: 163

Protein sequence:

>163_residues
MVELHTNHGVIKLELDAAKAPKTVENFLNYVKKGHYDGTVFHRVINGFMIQGGGFEPGMKQKPTDAPIDNEANNGLKNDK
YTIAMARTNDPHSATAQFFINVNDNDFLNHSSPTPQGWGYAVFGKVVEGQDVVDKIKGVKTGNAGFHQDVPTDDVVIEKA
VVV

Sequences:

>Translated_163_residues
MVELHTNHGVIKLELDAAKAPKTVENFLNYVKKGHYDGTVFHRVINGFMIQGGGFEPGMKQKPTDAPIDNEANNGLKNDK
YTIAMARTNDPHSATAQFFINVNDNDFLNHSSPTPQGWGYAVFGKVVEGQDVVDKIKGVKTGNAGFHQDVPTDDVVIEKA
VVV
>Mature_163_residues
MVELHTNHGVIKLELDAAKAPKTVENFLNYVKKGHYDGTVFHRVINGFMIQGGGFEPGMKQKPTDAPIDNEANNGLKNDK
YTIAMARTNDPHSATAQFFINVNDNDFLNHSSPTPQGWGYAVFGKVVEGQDVVDKIKGVKTGNAGFHQDVPTDDVVIEKA
VVV

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7706339, Length=164, Percent_Identity=34.7560975609756, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI24308049, Length=159, Percent_Identity=35.2201257861635, Blast_Score=79, Evalue=2e-15,
Organism=Homo sapiens, GI22547212, Length=163, Percent_Identity=32.5153374233129, Blast_Score=78, Evalue=3e-15,
Organism=Homo sapiens, GI7657473, Length=163, Percent_Identity=32.5153374233129, Blast_Score=78, Evalue=3e-15,
Organism=Homo sapiens, GI22547215, Length=163, Percent_Identity=32.5153374233129, Blast_Score=78, Evalue=3e-15,
Organism=Homo sapiens, GI19557636, Length=165, Percent_Identity=29.6969696969697, Blast_Score=76, Evalue=2e-14,
Organism=Homo sapiens, GI310110104, Length=152, Percent_Identity=33.5526315789474, Blast_Score=67, Evalue=8e-12,
Organism=Homo sapiens, GI310129267, Length=152, Percent_Identity=32.2368421052632, Blast_Score=64, Evalue=5e-11,
Organism=Homo sapiens, GI310120620, Length=152, Percent_Identity=32.2368421052632, Blast_Score=64, Evalue=5e-11,
Organism=Homo sapiens, GI64276486, Length=137, Percent_Identity=32.8467153284672, Blast_Score=64, Evalue=6e-11,
Organism=Escherichia coli, GI1786736, Length=162, Percent_Identity=68.5185185185185, Blast_Score=231, Evalue=2e-62,
Organism=Escherichia coli, GI1789763, Length=162, Percent_Identity=58.0246913580247, Blast_Score=176, Evalue=5e-46,
Organism=Caenorhabditis elegans, GI71980590, Length=146, Percent_Identity=34.9315068493151, Blast_Score=82, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI71980594, Length=146, Percent_Identity=34.9315068493151, Blast_Score=82, Evalue=1e-16,
Organism=Caenorhabditis elegans, GI17532641, Length=172, Percent_Identity=31.9767441860465, Blast_Score=81, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI17506311, Length=143, Percent_Identity=34.2657342657343, Blast_Score=77, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17539496, Length=162, Percent_Identity=32.7160493827161, Blast_Score=69, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI17552780, Length=158, Percent_Identity=32.2784810126582, Blast_Score=63, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17551282, Length=151, Percent_Identity=35.7615894039735, Blast_Score=63, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17551284, Length=151, Percent_Identity=35.7615894039735, Blast_Score=63, Evalue=8e-11,
Organism=Drosophila melanogaster, GI19922912, Length=162, Percent_Identity=37.6543209876543, Blast_Score=78, Evalue=3e-15,
Organism=Drosophila melanogaster, GI19922376, Length=168, Percent_Identity=29.1666666666667, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI17986117, Length=166, Percent_Identity=32.5301204819277, Blast_Score=70, Evalue=5e-13,
Organism=Drosophila melanogaster, GI24652460, Length=141, Percent_Identity=31.9148936170213, Blast_Score=67, Evalue=7e-12,

Paralogues:

None

Copy number: 780 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 60 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 17822; Mature: 17822

Theoretical pI: Translated: 6.39; Mature: 6.39

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
2.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MVELHTNHGVIKLELDAAKAPKTVENFLNYVKKGHYDGTVFHRVINGFMIQGGGFEPGMK
CEEEECCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCEEEECCCCCCCCC
QKPTDAPIDNEANNGLKNDKYTIAMARTNDPHSATAQFFINVNDNDFLNHSSPTPQGWGY
CCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCE
AVFGKVVEGQDVVDKIKGVKTGNAGFHQDVPTDDVVIEKAVVV
EEEEEEECCHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECC
>Mature Secondary Structure
MVELHTNHGVIKLELDAAKAPKTVENFLNYVKKGHYDGTVFHRVINGFMIQGGGFEPGMK
CEEEECCCCEEEEEECCCCCCHHHHHHHHHHHCCCCCHHHHHHHHCCEEEECCCCCCCCC
QKPTDAPIDNEANNGLKNDKYTIAMARTNDPHSATAQFFINVNDNDFLNHSSPTPQGWGY
CCCCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCE
AVFGKVVEGQDVVDKIKGVKTGNAGFHQDVPTDDVVIEKAVVV
EEEEEEECCHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10400660 [H]