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The map label for this gene is hmrR [H]

Identifier: 161524236

GI number: 161524236

Start: 1160932

End: 1161336

Strand: Direct

Name: hmrR [H]

Synonym: Bmul_1060

Alternate gene names: 161524236

Gene position: 1160932-1161336 (Clockwise)

Preceding gene: 161524231

Following gene: 161524237

Centisome position: 33.67

GC content: 61.23

Gene sequence:

>405_bases
ATGAATATCGGCGACGCATCGCGCGCATCCGGCGTCAGCGCAAAAATGATCCGGTACTACGAGCATGTCGGTCTGCTGAC
GCCAAGCAAGCGCAGCGACGCCGGCTATCGGATCTACGGTCCGGACGAAATCCATACGCTGCGGTTTATCCGCCAGGCAC
GTCGACTCGGCTTTCTCGTCGAGGACATTCGAAAGCTGTTGACGCTATGGCAAGACCGGTCGCGAGCGAGTGCCGAAGTG
AAGTCGATCGCGCTCGGCCACGTCGCGGAGCTCGACAAACGAATCGCCGAGCTCACCGATATGCGCGACACGCTGATGGA
TCTCGCCGCGCACTGTCACGGTGACGCGCGACCCGAATGCCCGATTTTGGCGCGTCTTGCCGAGCCCGTCGGTGAACCAC
ATTAG

Upstream 100 bases:

>100_bases
TTTCCATGTCGAACGGCAGCCGCAAGCCGAACCGCACGATTTGATACGATCGAGATCTGTCGGACAGTCATCCGAACGAG
ATCGCGAAAGAGGGCATGGA

Downstream 100 bases:

>100_bases
TGCGCGCGCTCGACACGCCGAACCGAGGCTTTACGCCAACCCCTTAAGAATCAAGCGGTTACGAATAGAGGGCAGCGCTT
CATTCCAAAACGGAATGGCT

Product: MerR family transcriptional regulator

Products: NA

Alternate protein names: Copper efflux regulator; Copper export regulator [H]

Number of amino acids: Translated: 134; Mature: 134

Protein sequence:

>134_residues
MNIGDASRASGVSAKMIRYYEHVGLLTPSKRSDAGYRIYGPDEIHTLRFIRQARRLGFLVEDIRKLLTLWQDRSRASAEV
KSIALGHVAELDKRIAELTDMRDTLMDLAAHCHGDARPECPILARLAEPVGEPH

Sequences:

>Translated_134_residues
MNIGDASRASGVSAKMIRYYEHVGLLTPSKRSDAGYRIYGPDEIHTLRFIRQARRLGFLVEDIRKLLTLWQDRSRASAEV
KSIALGHVAELDKRIAELTDMRDTLMDLAAHCHGDARPECPILARLAEPVGEPH
>Mature_134_residues
MNIGDASRASGVSAKMIRYYEHVGLLTPSKRSDAGYRIYGPDEIHTLRFIRQARRLGFLVEDIRKLLTLWQDRSRASAEV
KSIALGHVAELDKRIAELTDMRDTLMDLAAHCHGDARPECPILARLAEPVGEPH

Specific function: Regulates the transcription of actP. It detects cytoplasmic copper stress and activates transcription in response to increasing copper concentrations. In the absence of copper, it negatively regulates the transcription of actP [H]

COG id: COG0789

COG function: function code K; Predicted transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH merR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786695, Length=127, Percent_Identity=44.0944881889764, Blast_Score=117, Evalue=3e-28,
Organism=Escherichia coli, GI1789687, Length=129, Percent_Identity=35.6589147286822, Blast_Score=79, Evalue=8e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011789
- InterPro:   IPR009061
- InterPro:   IPR000551
- InterPro:   IPR015358 [H]

Pfam domain/function: PF00376 MerR; PF09278 MerR-DNA-bind [H]

EC number: NA

Molecular weight: Translated: 15047; Mature: 15047

Theoretical pI: Translated: 8.25; Mature: 8.25

Prosite motif: PS00552 HTH_MERR_1 ; PS50937 HTH_MERR_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIGDASRASGVSAKMIRYYEHVGLLTPSKRSDAGYRIYGPDEIHTLRFIRQARRLGFLV
CCCCCCCHHCCHHHHHHHHHHHHCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHH
EDIRKLLTLWQDRSRASAEVKSIALGHVAELDKRIAELTDMRDTLMDLAAHCHGDARPEC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PILARLAEPVGEPH
HHHHHHHHHCCCCC
>Mature Secondary Structure
MNIGDASRASGVSAKMIRYYEHVGLLTPSKRSDAGYRIYGPDEIHTLRFIRQARRLGFLV
CCCCCCCHHCCHHHHHHHHHHHHCCCCCCCCCCCCEEEECCHHHHHHHHHHHHHHHHHHH
EDIRKLLTLWQDRSRASAEVKSIALGHVAELDKRIAELTDMRDTLMDLAAHCHGDARPEC
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCC
PILARLAEPVGEPH
HHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11936079 [H]