Click here to switch to the map view.

The map label for this gene is parC [H]

Identifier: 161524096

GI number: 161524096

Start: 1006146

End: 1008467

Strand: Direct

Name: parC [H]

Synonym: Bmul_0920

Alternate gene names: 161524096

Gene position: 1006146-1008467 (Clockwise)

Preceding gene: 161524095

Following gene: 161524097

Centisome position: 29.18

GC content: 66.49

Gene sequence:

>2322_bases
ATGGACGACAACACCTCCGATCTCTTTGCCGGGTCCGACGCGCCCGAGGCCGATGCGCTGACGCTCGGCAATTACGCGGA
GCAGGCGTATCTCAGCTATGCGGTCAGCGTCGTGAAGAGCCGCGCGCTGCCCGACGTCTGCGACGGCCAGAAGCCGGTGC
AGCGCCGCATTCTCTATGCGATGAACGAAATGGGCCTCGGCCCGGACGCGAAGCCGGTGAAATCGGCGCGCGTGGTCGGC
GACGTGCTCGGCAAGTATCACCCGCACGGCGATCAGTCGGCGTACGACGCGCTCGTCCGTCTCGCACAGGACTTCTCGCT
GCGCTACCCGCTGATCGACGGTCAGGGCAACTTCGGCTCGCGCGACGGCGACGGCGCGGCGGCGATGCGCTATACCGAAG
CGCGGCTCACGCCGATCTCGAAGCTGCTGCTCGACGAGATCGACCAGGGCACGGTCGACTTCATGCCGAACTACGACGGC
TCGTTCGAGGAACCGAAGACGCTGCCGAGCCGCATGCCGTTCGTGCTGCTGAACGGCGCATCGGGCATCGCGGTCGGTCT
CGCGACCGAAATTCCGTCGCACAACCTGCGCGAGGTCGCGGCAGCCGCAGTCGCGCTGATCCGCAACCCGAAGCTCACGC
ACGAAGAGCTGATGACGCTGATCCCGGGGCCCGATTTCCCGGGCGGCGGGCAGATCATTTCGAGCGACGCCGAAATCGCG
TCGGCCTACGAGACGGGCCGCGGCAGCCTGAAGGTGCGCGCGCGCTGGAAGATCGAGGATCTCGCGCGCGGGCAGTGGCA
GCTCGTCGTCACCGAGCTGCCGCCAAACACGTCGTGCCAGAAGGTGCTCGAGGAAATCGAGGAACTGACGAACCCGAAGC
TCAAGCTCGGCAAGAAGACGCTGACGCCCGAGCAGCTGAACACGAAGAAGGCGATGCTCGATCTGCTCGACGCGGTGCGC
GACGAATCGGGCAAGGAAGCGGCGGTGCGGCTCGTGTTCGAGCCGAAGTCGCGCACGATCGACCAGACGGAATTCGTGAA
CTCGCTGCTCGCGCATACGAGCCTCGAATCGAACGCGACGCTGAACCTCGTGATGATCGGCGCCGACGGCCGGCCGGGTC
AGAAGGGGCTGCTGACGATCCTCGACGAATGGGTGAAGTTCCGCCAGATGACGATGACGCGTCGCTGCCGCCATCGTCTC
GGCAAGGTCGACGATCGCATCCACATCCTCGAAGGGCGGATGATCGTCTTCCTGAATCTCGACGAGGTGATCCGCATCAT
CCGCGAGTCGGACGAGCCGAAGGCCGCGCTGATGAGTGCATTCGGACTCACGGACCGTCAGGCCGAGGACATCCTCGAAA
TCCGGCTGCGTCAGCTCGCGCGGCTCGAGAAGATCAAGATCGAGAAGGAGCTCGAATCGCTGCGCGACGAGAAGGCGAAG
CTGGAAGAACTGCTCGCGAACGAGAGCGCGATGAAGCGGCTGATGATCAAGGAGATCGAGGCCGACGCGAAGCAGTACGG
CGACGATCGTCGCACGCTGATCCAGCAGGAGAAGCGCGCGACGTTCGAGGCGAAGGTCGTCGACGAACCGGTGACGGTCG
TCGTGTCGCAGAAGGGCTGGGTGCGCGCACTGAAGGGCCACGGGCTCGATCCGGCGGGCTTCTCGTTCAAGGCCGGCGAC
AGCCTGTACGCGGCGTTCCAGTGCCGCACGCCGGATCGGCTGATTGCGTGGGGCAGCAGCGGCCGCGTGTACTCGGTCGA
CGTGTCGGTACTGCCGGGCGGCCGCGGCGACGGCGTGCCCGTCACGTCGCTGATCGAGCTCGAATCGGGCTCGCATCTGA
TGCATTACTACGCGGCGTCGGCCGACCAGCCGCTGCTGCTCGCTTCGAGCAACGGCTTCGGCTTCATCGCGAAGGTCGGC
GACATGGTGAGCCGCGTGAAGGCCGGCAAGTCGTTCATGACGATCGATCCGGGCGCGGTGCCGCTCGCGCCGATGCCGGT
GCTGCCGAACGCGACGCAGGTCGCGTGTCTGTCGAGCGGCGGTCGGTTGCTGGTGTTCGGCATCGACGAGATGAAGACGC
TGTCGGGCGGCGGCCGCGGCGTGACGCTGATGGCGCTCGACGACAAGGAAACGCTCGTGCAGGCGCTCGCGATCGATCCG
GCCGGCGTCGTGCTGATCGGCGCGGGTCGCGGCGGCAAGGTGCAGGACGAGACGCTGTCGTATGCGGGTCTCGCGCCGCA
TATCGGCAAGCGCGCGCGCAAGGGGCGCGCACCCGACACGAAGCTGAAGGTCGTGACCGAGCTGCGCCCGCTGCTCGGCT
GA

Upstream 100 bases:

>100_bases
GAAAAGGGCAACGACGTCGAAGCGGATATCTAAGCGCCCCGAGCGCGGCTGCGCATGACGCGCGGCGCGCCCTCACGCCA
CTTACGAATACGGAATTCAG

Downstream 100 bases:

>100_bases
CAGGCCGCGCGCCCGGCATCGAAAAGCCGCACGTTCCGCTTCGGCGGGCGTGCGGCTTTTTTGCTGTGCACGGGTGCCGC
GCCGCGCATCGTCGCGCGTA

Product: DNA topoisomerase IV subunit A

Products: NA

Alternate protein names: Topoisomerase IV subunit A [H]

Number of amino acids: Translated: 773; Mature: 773

Protein sequence:

>773_residues
MDDNTSDLFAGSDAPEADALTLGNYAEQAYLSYAVSVVKSRALPDVCDGQKPVQRRILYAMNEMGLGPDAKPVKSARVVG
DVLGKYHPHGDQSAYDALVRLAQDFSLRYPLIDGQGNFGSRDGDGAAAMRYTEARLTPISKLLLDEIDQGTVDFMPNYDG
SFEEPKTLPSRMPFVLLNGASGIAVGLATEIPSHNLREVAAAAVALIRNPKLTHEELMTLIPGPDFPGGGQIISSDAEIA
SAYETGRGSLKVRARWKIEDLARGQWQLVVTELPPNTSCQKVLEEIEELTNPKLKLGKKTLTPEQLNTKKAMLDLLDAVR
DESGKEAAVRLVFEPKSRTIDQTEFVNSLLAHTSLESNATLNLVMIGADGRPGQKGLLTILDEWVKFRQMTMTRRCRHRL
GKVDDRIHILEGRMIVFLNLDEVIRIIRESDEPKAALMSAFGLTDRQAEDILEIRLRQLARLEKIKIEKELESLRDEKAK
LEELLANESAMKRLMIKEIEADAKQYGDDRRTLIQQEKRATFEAKVVDEPVTVVVSQKGWVRALKGHGLDPAGFSFKAGD
SLYAAFQCRTPDRLIAWGSSGRVYSVDVSVLPGGRGDGVPVTSLIELESGSHLMHYYAASADQPLLLASSNGFGFIAKVG
DMVSRVKAGKSFMTIDPGAVPLAPMPVLPNATQVACLSSGGRLLVFGIDEMKTLSGGGRGVTLMALDDKETLVQALAIDP
AGVVLIGAGRGGKVQDETLSYAGLAPHIGKRARKGRAPDTKLKVVTELRPLLG

Sequences:

>Translated_773_residues
MDDNTSDLFAGSDAPEADALTLGNYAEQAYLSYAVSVVKSRALPDVCDGQKPVQRRILYAMNEMGLGPDAKPVKSARVVG
DVLGKYHPHGDQSAYDALVRLAQDFSLRYPLIDGQGNFGSRDGDGAAAMRYTEARLTPISKLLLDEIDQGTVDFMPNYDG
SFEEPKTLPSRMPFVLLNGASGIAVGLATEIPSHNLREVAAAAVALIRNPKLTHEELMTLIPGPDFPGGGQIISSDAEIA
SAYETGRGSLKVRARWKIEDLARGQWQLVVTELPPNTSCQKVLEEIEELTNPKLKLGKKTLTPEQLNTKKAMLDLLDAVR
DESGKEAAVRLVFEPKSRTIDQTEFVNSLLAHTSLESNATLNLVMIGADGRPGQKGLLTILDEWVKFRQMTMTRRCRHRL
GKVDDRIHILEGRMIVFLNLDEVIRIIRESDEPKAALMSAFGLTDRQAEDILEIRLRQLARLEKIKIEKELESLRDEKAK
LEELLANESAMKRLMIKEIEADAKQYGDDRRTLIQQEKRATFEAKVVDEPVTVVVSQKGWVRALKGHGLDPAGFSFKAGD
SLYAAFQCRTPDRLIAWGSSGRVYSVDVSVLPGGRGDGVPVTSLIELESGSHLMHYYAASADQPLLLASSNGFGFIAKVG
DMVSRVKAGKSFMTIDPGAVPLAPMPVLPNATQVACLSSGGRLLVFGIDEMKTLSGGGRGVTLMALDDKETLVQALAIDP
AGVVLIGAGRGGKVQDETLSYAGLAPHIGKRARKGRAPDTKLKVVTELRPLLG
>Mature_773_residues
MDDNTSDLFAGSDAPEADALTLGNYAEQAYLSYAVSVVKSRALPDVCDGQKPVQRRILYAMNEMGLGPDAKPVKSARVVG
DVLGKYHPHGDQSAYDALVRLAQDFSLRYPLIDGQGNFGSRDGDGAAAMRYTEARLTPISKLLLDEIDQGTVDFMPNYDG
SFEEPKTLPSRMPFVLLNGASGIAVGLATEIPSHNLREVAAAAVALIRNPKLTHEELMTLIPGPDFPGGGQIISSDAEIA
SAYETGRGSLKVRARWKIEDLARGQWQLVVTELPPNTSCQKVLEEIEELTNPKLKLGKKTLTPEQLNTKKAMLDLLDAVR
DESGKEAAVRLVFEPKSRTIDQTEFVNSLLAHTSLESNATLNLVMIGADGRPGQKGLLTILDEWVKFRQMTMTRRCRHRL
GKVDDRIHILEGRMIVFLNLDEVIRIIRESDEPKAALMSAFGLTDRQAEDILEIRLRQLARLEKIKIEKELESLRDEKAK
LEELLANESAMKRLMIKEIEADAKQYGDDRRTLIQQEKRATFEAKVVDEPVTVVVSQKGWVRALKGHGLDPAGFSFKAGD
SLYAAFQCRTPDRLIAWGSSGRVYSVDVSVLPGGRGDGVPVTSLIELESGSHLMHYYAASADQPLLLASSNGFGFIAKVG
DMVSRVKAGKSFMTIDPGAVPLAPMPVLPNATQVACLSSGGRLLVFGIDEMKTLSGGGRGVTLMALDDKETLVQALAIDP
AGVVLIGAGRGGKVQDETLSYAGLAPHIGKRARKGRAPDTKLKVVTELRPLLG

Specific function: Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule [H]

COG id: COG0188

COG function: function code L; Type IIA topoisomerase (DNA gyrase/topo II, topoisomerase IV), A subunit

Gene ontology:

Cell location: Cell membrane; Peripheral membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the topoisomerase gyrA/parC subunit family [H]

Homologues:

Organism=Homo sapiens, GI19913408, Length=275, Percent_Identity=28.3636363636364, Blast_Score=91, Evalue=3e-18,
Organism=Homo sapiens, GI19913406, Length=276, Percent_Identity=27.536231884058, Blast_Score=87, Evalue=6e-17,
Organism=Escherichia coli, GI1789396, Length=750, Percent_Identity=46.1333333333333, Blast_Score=640, Evalue=0.0,
Organism=Escherichia coli, GI1788562, Length=766, Percent_Identity=36.1618798955614, Blast_Score=384, Evalue=1e-108,
Organism=Caenorhabditis elegans, GI17535065, Length=173, Percent_Identity=35.2601156069364, Blast_Score=91, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI212645845, Length=393, Percent_Identity=26.4631043256997, Blast_Score=91, Evalue=3e-18,
Organism=Caenorhabditis elegans, GI212645657, Length=172, Percent_Identity=33.1395348837209, Blast_Score=82, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI115534553, Length=169, Percent_Identity=31.9526627218935, Blast_Score=79, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6324241, Length=248, Percent_Identity=31.0483870967742, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI17136538, Length=234, Percent_Identity=28.6324786324786, Blast_Score=89, Evalue=9e-18,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020899
- InterPro:   IPR002205
- InterPro:   IPR013758
- InterPro:   IPR013757
- InterPro:   IPR013760
- InterPro:   IPR005742 [H]

Pfam domain/function: PF00521 DNA_topoisoIV [H]

EC number: 5.99.1.-

Molecular weight: Translated: 84097; Mature: 84097

Theoretical pI: Translated: 6.33; Mature: 6.33

Prosite motif: PS00178 AA_TRNA_LIGASE_I

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDDNTSDLFAGSDAPEADALTLGNYAEQAYLSYAVSVVKSRALPDVCDGQKPVQRRILYA
CCCCCCCCCCCCCCCCCCCEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
MNEMGLGPDAKPVKSARVVGDVLGKYHPHGDQSAYDALVRLAQDFSLRYPLIDGQGNFGS
HHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCEECCEECCCCCCCC
RDGDGAAAMRYTEARLTPISKLLLDEIDQGTVDFMPNYDGSFEEPKTLPSRMPFVLLNGA
CCCCCCHHEEEHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCEEEEECC
SGIAVGLATEIPSHNLREVAAAAVALIRNPKLTHEELMTLIPGPDFPGGGQIISSDAEIA
CCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCEEECCHHHH
SAYETGRGSLKVRARWKIEDLARGQWQLVVTELPPNTSCQKVLEEIEELTNPKLKLGKKT
HHHHCCCCCEEEEEEECHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCEECCCCC
LTPEQLNTKKAMLDLLDAVRDESGKEAAVRLVFEPKSRTIDQTEFVNSLLAHTSLESNAT
CCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCE
LNLVMIGADGRPGQKGLLTILDEWVKFRQMTMTRRCRHRLGKVDDRIHILEGRMIVFLNL
EEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCEEEEECH
DEVIRIIRESDEPKAALMSAFGLTDRQAEDILEIRLRQLARLEKIKIEKELESLRDEKAK
HHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEELLANESAMKRLMIKEIEADAKQYGDDRRTLIQQEKRATFEAKVVDEPVTVVVSQKGW
HHHHHHCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEEECCCCEEEEEECCCH
VRALKGHGLDPAGFSFKAGDSLYAAFQCRTPDRLIAWGSSGRVYSVDVSVLPGGRGDGVP
HHHHHCCCCCCCCCEECCCCCEEEEEEECCCCEEEEECCCCEEEEEEEEEECCCCCCCCC
VTSLIELESGSHLMHYYAASADQPLLLASSNGFGFIAKVGDMVSRVKAGKSFMTIDPGAV
EEEEEEECCCCEEEEEEECCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCEEEECCCCC
PLAPMPVLPNATQVACLSSGGRLLVFGIDEMKTLSGGGRGVTLMALDDKETLVQALAIDP
CCCCCCCCCCCCEEEEECCCCEEEEEECCHHHHCCCCCCEEEEEEECCHHHHHHHHHCCC
AGVVLIGAGRGGKVQDETLSYAGLAPHIGKRARKGRAPDTKLKVVTELRPLLG
CCEEEEECCCCCCCCHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCC
>Mature Secondary Structure
MDDNTSDLFAGSDAPEADALTLGNYAEQAYLSYAVSVVKSRALPDVCDGQKPVQRRILYA
CCCCCCCCCCCCCCCCCCCEECCHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHH
MNEMGLGPDAKPVKSARVVGDVLGKYHPHGDQSAYDALVRLAQDFSLRYPLIDGQGNFGS
HHHCCCCCCCCHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHCCEECCEECCCCCCCC
RDGDGAAAMRYTEARLTPISKLLLDEIDQGTVDFMPNYDGSFEEPKTLPSRMPFVLLNGA
CCCCCCHHEEEHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCEEEEECC
SGIAVGLATEIPSHNLREVAAAAVALIRNPKLTHEELMTLIPGPDFPGGGQIISSDAEIA
CCEEEEEECCCCCCHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCCCCCCCEEECCHHHH
SAYETGRGSLKVRARWKIEDLARGQWQLVVTELPPNTSCQKVLEEIEELTNPKLKLGKKT
HHHHCCCCCEEEEEEECHHHHCCCCEEEEEEECCCCCHHHHHHHHHHHHCCCCEECCCCC
LTPEQLNTKKAMLDLLDAVRDESGKEAAVRLVFEPKSRTIDQTEFVNSLLAHTSLESNAT
CCHHHHHHHHHHHHHHHHHHCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHCCCCCCCE
LNLVMIGADGRPGQKGLLTILDEWVKFRQMTMTRRCRHRLGKVDDRIHILEGRMIVFLNL
EEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEECCEEEEECH
DEVIRIIRESDEPKAALMSAFGLTDRQAEDILEIRLRQLARLEKIKIEKELESLRDEKAK
HHHHHHHHCCCCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LEELLANESAMKRLMIKEIEADAKQYGDDRRTLIQQEKRATFEAKVVDEPVTVVVSQKGW
HHHHHHCHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHCCEEEEECCCCEEEEEECCCH
VRALKGHGLDPAGFSFKAGDSLYAAFQCRTPDRLIAWGSSGRVYSVDVSVLPGGRGDGVP
HHHHHCCCCCCCCCEECCCCCEEEEEEECCCCEEEEECCCCEEEEEEEEEECCCCCCCCC
VTSLIELESGSHLMHYYAASADQPLLLASSNGFGFIAKVGDMVSRVKAGKSFMTIDPGAV
EEEEEEECCCCEEEEEEECCCCCCEEEECCCCCCHHHHHHHHHHHHHCCCCEEEECCCCC
PLAPMPVLPNATQVACLSSGGRLLVFGIDEMKTLSGGGRGVTLMALDDKETLVQALAIDP
CCCCCCCCCCCCEEEEECCCCEEEEEECCHHHHCCCCCCEEEEEEECCHHHHHHHHHCCC
AGVVLIGAGRGGKVQDETLSYAGLAPHIGKRARKGRAPDTKLKVVTELRPLLG
CCEEEEECCCCCCCCHHHHHHCCCCHHHHHHHHCCCCCCHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7830580 [H]