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The map label for this gene is argH [H]

Identifier: 161524044

GI number: 161524044

Start: 945540

End: 947009

Strand: Reverse

Name: argH [H]

Synonym: Bmul_0865

Alternate gene names: 161524044

Gene position: 947009-945540 (Counterclockwise)

Preceding gene: 161524045

Following gene: 161524043

Centisome position: 27.46

GC content: 67.14

Gene sequence:

>1470_bases
ATGTTAGAATCGCGGGATTCCTCGGCGGCGCACGCCGCCCAACTCCCTCGAAGAATCGCCATGACGTCCCAACTGCACAA
AAAGGGCGAGGCCTGGTCGGCCCGCTTCTCGGAACCGATGTCGGAGCTGGTCAAGCGCTACACGTCGTCGGTGTTTTTCG
ACAAGCGCCTGGCGCTCGTCGACATCGCCGGCTCGCTCGCGCACGCGAACATGCTCGCGGCGCAGAAGATCATCAGCGCC
GACGATCTGGCCGCGATCGAGCGCGGGATGGCGCAGATCAAGGGCGAAATCGAGCGTGGCGAATTCGAATGGCAGCTCGA
TCTCGAGGACGTCCACCTGAACATCGAAGCGCGCCTGACCGCGCTGATCGGCGACGCAGGCAAGCGCCTGCATACGGGCC
GCTCGCGCAACGACCAGGTCGCGACCGACATCCGTCTGTGGCTGCGCGGCGAAATCGACCGCATCGGCGGGTTGCTGAAC
GATCTGCGCGGCGCGCTGATCGACCTCGCGGAGCAAAACGCGGACACGATCATGCCGGGCTTCACGCACCTGCAGGTCGC
GCAGCCCGTCACGTTCGGCCATCACCTGCTCGCGTACGTCGAGATGTTCTCGCGCGACGCGGAGCGCATGCGCGACTGCC
GCACGCGCGTGAACCGTCTGCCGCTCGGCGCGGCCGCGCTCGCGGGCACGAGCTATCCGATCGACCGTCATGCAGTCGCG
AAGTCGCTCGGCTTCGACGGCATCTGCGCGAACTCGCTCGACGCGGTGTCCGACCGCGATTTCGCGATCGAATTCACGGC
TGCGGCCGCGCTCGTGATGACGCACGTATCGCGCTTCTCCGAGGAACTCGTGCTGTGGATGAGCCCGCGCGTCGGCTTCA
TCGACATCGCCGACCGCTTCTGCACGGGCAGCTCGATCATGCCGCAGAAGAAGAACCCGGACGTGCCCGAGCTCGCGCGC
GGCAAGACGGGCCGCGTGAACGGCCATCTGATGGCGCTGCTCACGCTGATGAAGGGCCAGCCGCTCGCGTACAACAAGGA
CAACCAGGAAGACAAGGAGCCGCTGTTCGACACGGTCGATACCGTCGCCGACACGCTGCGCATCTTCGCGGAGATGGTCG
CCGGCATCACGGTGAAGCCGGACGCGATGCGCGCGGCCGCGCTGCAGGGCTTCTCGACCGCGACCGACCTCGCCGACTAT
CTGGTCAAGCGCGGGCTGCCGTTCCGCGACGCGCACGAAGCGGTCGCGCATGCGGTGAAGATCTGCGACGATCGCGGCAT
CGACCTCGCGGATCTGACGCTCGACGAAATGAAGCGCGAGCTGCCGAACGTCGCGCAGCTGATCGGCGACGACGTGTTCG
ACTATCTGACGCTCGAAGGCTCGGTCGCGAGCCGCAACCACCCGGGCGGCACCGCGCCCGACCAGGTGCGTGCGGCCGCG
CAGGCCGCGCGCGCCGCGCTCGGCAAGTAA

Upstream 100 bases:

>100_bases
TCACGCTGAAGCCCGCGCATCGCGAGGATCTGAAACTCGTTGTGCTGGTGCGCGACTGACGCGACCGGCCGACGCGCGGC
CGCGGCGGCCCTGCGCGCGA

Downstream 100 bases:

>100_bases
GCGCTGCACCGTCACCGCGGACGCCTGCACGGCGTCCGTTTTTTTTCGCATGCGCCGCCGCGCACCGCCCTTTTCCGGAT
AACCCCGATGACCTTCTCCG

Product: argininosuccinate lyase

Products: NA

Alternate protein names: ASAL; Arginosuccinase [H]

Number of amino acids: Translated: 489; Mature: 489

Protein sequence:

>489_residues
MLESRDSSAAHAAQLPRRIAMTSQLHKKGEAWSARFSEPMSELVKRYTSSVFFDKRLALVDIAGSLAHANMLAAQKIISA
DDLAAIERGMAQIKGEIERGEFEWQLDLEDVHLNIEARLTALIGDAGKRLHTGRSRNDQVATDIRLWLRGEIDRIGGLLN
DLRGALIDLAEQNADTIMPGFTHLQVAQPVTFGHHLLAYVEMFSRDAERMRDCRTRVNRLPLGAAALAGTSYPIDRHAVA
KSLGFDGICANSLDAVSDRDFAIEFTAAAALVMTHVSRFSEELVLWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELAR
GKTGRVNGHLMALLTLMKGQPLAYNKDNQEDKEPLFDTVDTVADTLRIFAEMVAGITVKPDAMRAAALQGFSTATDLADY
LVKRGLPFRDAHEAVAHAVKICDDRGIDLADLTLDEMKRELPNVAQLIGDDVFDYLTLEGSVASRNHPGGTAPDQVRAAA
QAARAALGK

Sequences:

>Translated_489_residues
MLESRDSSAAHAAQLPRRIAMTSQLHKKGEAWSARFSEPMSELVKRYTSSVFFDKRLALVDIAGSLAHANMLAAQKIISA
DDLAAIERGMAQIKGEIERGEFEWQLDLEDVHLNIEARLTALIGDAGKRLHTGRSRNDQVATDIRLWLRGEIDRIGGLLN
DLRGALIDLAEQNADTIMPGFTHLQVAQPVTFGHHLLAYVEMFSRDAERMRDCRTRVNRLPLGAAALAGTSYPIDRHAVA
KSLGFDGICANSLDAVSDRDFAIEFTAAAALVMTHVSRFSEELVLWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELAR
GKTGRVNGHLMALLTLMKGQPLAYNKDNQEDKEPLFDTVDTVADTLRIFAEMVAGITVKPDAMRAAALQGFSTATDLADY
LVKRGLPFRDAHEAVAHAVKICDDRGIDLADLTLDEMKRELPNVAQLIGDDVFDYLTLEGSVASRNHPGGTAPDQVRAAA
QAARAALGK
>Mature_489_residues
MLESRDSSAAHAAQLPRRIAMTSQLHKKGEAWSARFSEPMSELVKRYTSSVFFDKRLALVDIAGSLAHANMLAAQKIISA
DDLAAIERGMAQIKGEIERGEFEWQLDLEDVHLNIEARLTALIGDAGKRLHTGRSRNDQVATDIRLWLRGEIDRIGGLLN
DLRGALIDLAEQNADTIMPGFTHLQVAQPVTFGHHLLAYVEMFSRDAERMRDCRTRVNRLPLGAAALAGTSYPIDRHAVA
KSLGFDGICANSLDAVSDRDFAIEFTAAAALVMTHVSRFSEELVLWMSPRVGFIDIADRFCTGSSIMPQKKNPDVPELAR
GKTGRVNGHLMALLTLMKGQPLAYNKDNQEDKEPLFDTVDTVADTLRIFAEMVAGITVKPDAMRAAALQGFSTATDLADY
LVKRGLPFRDAHEAVAHAVKICDDRGIDLADLTLDEMKRELPNVAQLIGDDVFDYLTLEGSVASRNHPGGTAPDQVRAAA
QAARAALGK

Specific function: Arginine biosynthesis; eighth (last) step. [C]

COG id: COG0165

COG function: function code E; Argininosuccinate lyase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the lyase 1 family. Argininosuccinate lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI31541964, Length=466, Percent_Identity=39.6995708154506, Blast_Score=348, Evalue=1e-95,
Organism=Homo sapiens, GI68303542, Length=466, Percent_Identity=39.6995708154506, Blast_Score=348, Evalue=1e-95,
Organism=Homo sapiens, GI68303547, Length=466, Percent_Identity=37.5536480686695, Blast_Score=318, Evalue=1e-86,
Organism=Homo sapiens, GI68303549, Length=466, Percent_Identity=37.3390557939914, Blast_Score=308, Evalue=5e-84,
Organism=Escherichia coli, GI1790398, Length=458, Percent_Identity=45.1965065502183, Blast_Score=400, Evalue=1e-113,
Organism=Saccharomyces cerevisiae, GI6321806, Length=448, Percent_Identity=41.2946428571429, Blast_Score=337, Evalue=3e-93,
Organism=Drosophila melanogaster, GI221473854, Length=457, Percent_Identity=38.074398249453, Blast_Score=309, Evalue=3e-84,
Organism=Drosophila melanogaster, GI78706858, Length=457, Percent_Identity=38.074398249453, Blast_Score=309, Evalue=3e-84,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009049
- InterPro:   IPR003031
- InterPro:   IPR000362
- InterPro:   IPR020557
- InterPro:   IPR008948
- InterPro:   IPR022761 [H]

Pfam domain/function: PF00206 Lyase_1 [H]

EC number: =4.3.2.1 [H]

Molecular weight: Translated: 53491; Mature: 53491

Theoretical pI: Translated: 6.04; Mature: 6.04

Prosite motif: PS00163 FUMARATE_LYASES

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
3.3 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLESRDSSAAHAAQLPRRIAMTSQLHKKGEAWSARFSEPMSELVKRYTSSVFFDKRLALV
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DIAGSLAHANMLAAQKIISADDLAAIERGMAQIKGEIERGEFEWQLDLEDVHLNIEARLT
HHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHEEEEHHHHHH
ALIGDAGKRLHTGRSRNDQVATDIRLWLRGEIDRIGGLLNDLRGALIDLAEQNADTIMPG
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
FTHLQVAQPVTFGHHLLAYVEMFSRDAERMRDCRTRVNRLPLGAAALAGTSYPIDRHAVA
CHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCHHHHHH
KSLGFDGICANSLDAVSDRDFAIEFTAAAALVMTHVSRFSEELVLWMSPRVGFIDIADRF
HHCCCCCCCCCCHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHEEEEECCCCCCEEHHHHH
CTGSSIMPQKKNPDVPELARGKTGRVNGHLMALLTLMKGQPLAYNKDNQEDKEPLFDTVD
CCCCCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHH
TVADTLRIFAEMVAGITVKPDAMRAAALQGFSTATDLADYLVKRGLPFRDAHEAVAHAVK
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHH
ICDDRGIDLADLTLDEMKRELPNVAQLIGDDVFDYLTLEGSVASRNHPGGTAPDQVRAAA
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCHHHHHHHH
QAARAALGK
HHHHHHCCC
>Mature Secondary Structure
MLESRDSSAAHAAQLPRRIAMTSQLHKKGEAWSARFSEPMSELVKRYTSSVFFDKRLALV
CCCCCCCCHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
DIAGSLAHANMLAAQKIISADDLAAIERGMAQIKGEIERGEFEWQLDLEDVHLNIEARLT
HHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHCCCCCCCEEEEEEHHHEEEEHHHHHH
ALIGDAGKRLHTGRSRNDQVATDIRLWLRGEIDRIGGLLNDLRGALIDLAEQNADTIMPG
HHHHHHHHHHHCCCCCCCCHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCC
FTHLQVAQPVTFGHHLLAYVEMFSRDAERMRDCRTRVNRLPLGAAALAGTSYPIDRHAVA
CHHEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHCCCCCCCHHHHHH
KSLGFDGICANSLDAVSDRDFAIEFTAAAALVMTHVSRFSEELVLWMSPRVGFIDIADRF
HHCCCCCCCCCCHHCCCCCCEEEEHHHHHHHHHHHHHHHHHHEEEEECCCCCCEEHHHHH
CTGSSIMPQKKNPDVPELARGKTGRVNGHLMALLTLMKGQPLAYNKDNQEDKEPLFDTVD
CCCCCCCCCCCCCCCCHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHH
TVADTLRIFAEMVAGITVKPDAMRAAALQGFSTATDLADYLVKRGLPFRDAHEAVAHAVK
HHHHHHHHHHHHHCCCCCCCHHHHHHHHHCCCHHHHHHHHHHHCCCCCCHHHHHHHHHHH
ICDDRGIDLADLTLDEMKRELPNVAQLIGDDVFDYLTLEGSVASRNHPGGTAPDQVRAAA
HHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHEECCCCCCCCCCCCCCHHHHHHHH
QAARAALGK
HHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA