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The map label for this gene is cobQ [H]

Identifier: 161524027

GI number: 161524027

Start: 923511

End: 925016

Strand: Direct

Name: cobQ [H]

Synonym: Bmul_0848

Alternate gene names: 161524027

Gene position: 923511-925016 (Clockwise)

Preceding gene: 161524022

Following gene: 161524028

Centisome position: 26.78

GC content: 71.45

Gene sequence:

>1506_bases
ATGAATGCACCCGACCTGCTGCCGCGCGGCACGCTGATGATCCAGGGCACGACGTCCGATGCGGGCAAGAGCACGCTCGT
CGCGGGCCTGTGCCGCCTTGCGCGCCGTGCCGGCGTGCGCGTTGCGCCGTTCAAGCCGCAGAACATGGCGCTCAACAGCG
CGGTCACGGCCGACGGCGGCGAGATCGGCCGCGCGCAGGCGCTGCAGGCGCTGGCCGCGGGCGTCGCGCCGCATACGGAT
TTCAATCCGGTGCTGCTGAAGCCGACCAGCGATCGCGGCGCGCAGGTGATCATCCACGGCAAGGCGCGCGCGAACCTGAA
CGCGCGCGCGTATCACGACTACAAGCCGGTCGCGTTCGATGCGGTGCTCGAATCGTACGCGCGGCTGCGCGCCGGTTACG
ACGCGGTGATCGTCGAAGGTGCCGGCAGCCCGGCCGAGATCAACCTGCGCGAAGGCGACATCGCGAACATGGGCTTTGCC
GAGCGCGTAGACTGTCCGGTCGTGCTGGTCGCCGACATCGACCGCGGCGGCGTGTTCGCGCATCTCGTCGGCACGCTCGC
ATGCCTGTCGGACAGCGAGCGCGCGCGCGTGCGCGGCTTCGTGATCAACCGCTTCCGCGGCGATATCGCGCTGCTGGAGC
CGGGCCTCGACTGGCTGCGCGCGCAGACGGGCAAGCCGGTGTTCGGCGTGCTGCCGTACCTGCACGGGCTGCTGCTCGAT
GCCGAGGACATGCTGCCCGCGCAGGCGCGCAGCGCGGCCGCGCGCGGCGACGCGGGCGTGCTGCGCGTCGTCGTGCCGGC
GCTGCCGCGCATCAGCAATCACACCGACTTCGATGCACTGCGCGCGCATCCGCAGGTCGAATTCACGTACTGGAAGAGCG
GCCCCGTGCCGAACGCGGACCTGCTGATCCTGCCCGGCTCGAAGAGCGTGCAGCGCGATCTCGCGTGGCTGCGCGACGCG
GGCTGGGAAACGGTCATTCAGCGCCATCTGCGCTACGGCGGCAAGGTGATCGGCATCTGCGGCGGGATGCAGATGCTCGG
CCGCACGCTCGACGATCCGCTCGGCCTCGAAGGCGCGCCCGGCAGCGTGCCGGGGCTCGGGCTGCTCGACTTCGCGACGA
CGCTGCAGCCCGACAAGACGCTGAAGAACGTGACCGGGCGCCTCGCGCTGCCGGGCGCCGCCGCGGTACACGGCTACGAA
ATCCACATGGGCGAAACGCGCGGGCCCGCGCTCGCGTCGCCGGCCCTCGAGCTGGCGGAAGACGGCGCAGCGACGGGTGG
CATGCGTGCGGACGGCGCGCTGTCGGCGGACGGGCAGATTCTCGCGACCTACGTGCACGGGCTGTTCGACGCGCCGGACG
CATGCACGGCGCTGCTCGCGTGGGCCGGGCTCGACCGCGCCGAACGGATCGATTATCCGGCGCTGCGCGAAGCATCGCTG
GAGCGGCTCGCGGACACGTTCGCCGCGCATCTGGACCTCGGCGCGCTGTACGCGGCGTTTCGCTGA

Upstream 100 bases:

>100_bases
AAGGTGAGGTCGTGCGGAATCATCGCGTGATTGTAACGGCGCCGCGCGTCGCGACGCGGGCGATAATGCCGCCTTTGCGT
CGCTCCGGATTTTTCTCACG

Downstream 100 bases:

>100_bases
GTCGCGCGGCGGCGGGCGGGAGGGGGCTCGGAGCGGCTTGTCCCGGCTCGGCTTCGCTGGGCTCGGCTCGGCTCGGCTCA
GCTCGGCTCAGCTCGGCTCA

Product: cobyric acid synthase

Products: ADP; Dethiobiotin; H+; Phosphate [C]

Alternate protein names: NA

Number of amino acids: Translated: 501; Mature: 501

Protein sequence:

>501_residues
MNAPDLLPRGTLMIQGTTSDAGKSTLVAGLCRLARRAGVRVAPFKPQNMALNSAVTADGGEIGRAQALQALAAGVAPHTD
FNPVLLKPTSDRGAQVIIHGKARANLNARAYHDYKPVAFDAVLESYARLRAGYDAVIVEGAGSPAEINLREGDIANMGFA
ERVDCPVVLVADIDRGGVFAHLVGTLACLSDSERARVRGFVINRFRGDIALLEPGLDWLRAQTGKPVFGVLPYLHGLLLD
AEDMLPAQARSAAARGDAGVLRVVVPALPRISNHTDFDALRAHPQVEFTYWKSGPVPNADLLILPGSKSVQRDLAWLRDA
GWETVIQRHLRYGGKVIGICGGMQMLGRTLDDPLGLEGAPGSVPGLGLLDFATTLQPDKTLKNVTGRLALPGAAAVHGYE
IHMGETRGPALASPALELAEDGAATGGMRADGALSADGQILATYVHGLFDAPDACTALLAWAGLDRAERIDYPALREASL
ERLADTFAAHLDLGALYAAFR

Sequences:

>Translated_501_residues
MNAPDLLPRGTLMIQGTTSDAGKSTLVAGLCRLARRAGVRVAPFKPQNMALNSAVTADGGEIGRAQALQALAAGVAPHTD
FNPVLLKPTSDRGAQVIIHGKARANLNARAYHDYKPVAFDAVLESYARLRAGYDAVIVEGAGSPAEINLREGDIANMGFA
ERVDCPVVLVADIDRGGVFAHLVGTLACLSDSERARVRGFVINRFRGDIALLEPGLDWLRAQTGKPVFGVLPYLHGLLLD
AEDMLPAQARSAAARGDAGVLRVVVPALPRISNHTDFDALRAHPQVEFTYWKSGPVPNADLLILPGSKSVQRDLAWLRDA
GWETVIQRHLRYGGKVIGICGGMQMLGRTLDDPLGLEGAPGSVPGLGLLDFATTLQPDKTLKNVTGRLALPGAAAVHGYE
IHMGETRGPALASPALELAEDGAATGGMRADGALSADGQILATYVHGLFDAPDACTALLAWAGLDRAERIDYPALREASL
ERLADTFAAHLDLGALYAAFR
>Mature_501_residues
MNAPDLLPRGTLMIQGTTSDAGKSTLVAGLCRLARRAGVRVAPFKPQNMALNSAVTADGGEIGRAQALQALAAGVAPHTD
FNPVLLKPTSDRGAQVIIHGKARANLNARAYHDYKPVAFDAVLESYARLRAGYDAVIVEGAGSPAEINLREGDIANMGFA
ERVDCPVVLVADIDRGGVFAHLVGTLACLSDSERARVRGFVINRFRGDIALLEPGLDWLRAQTGKPVFGVLPYLHGLLLD
AEDMLPAQARSAAARGDAGVLRVVVPALPRISNHTDFDALRAHPQVEFTYWKSGPVPNADLLILPGSKSVQRDLAWLRDA
GWETVIQRHLRYGGKVIGICGGMQMLGRTLDDPLGLEGAPGSVPGLGLLDFATTLQPDKTLKNVTGRLALPGAAAVHGYE
IHMGETRGPALASPALELAEDGAATGGMRADGALSADGQILATYVHGLFDAPDACTALLAWAGLDRAERIDYPALREASL
ERLADTFAAHLDLGALYAAFR

Specific function: Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation [H]

COG id: COG1492

COG function: function code H; Cobyric acid synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GATase cobBQ-type domain [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002586
- InterPro:   IPR017929
- InterPro:   IPR004459
- InterPro:   IPR011698 [H]

Pfam domain/function: PF01656 CbiA; PF07685 GATase_3 [H]

EC number: 6.3.3.3 [C]

Molecular weight: Translated: 52919; Mature: 52919

Theoretical pI: Translated: 6.51; Mature: 6.51

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNAPDLLPRGTLMIQGTTSDAGKSTLVAGLCRLARRAGVRVAPFKPQNMALNSAVTADGG
CCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCEECCCCCCCCEECCEEECCCC
EIGRAQALQALAAGVAPHTDFNPVLLKPTSDRGAQVIIHGKARANLNARAYHDYKPVAFD
CCCHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCEEEEEECCCCCCCCEEECCCCCHHHH
AVLESYARLRAGYDAVIVEGAGSPAEINLREGDIANMGFAERVDCPVVLVADIDRGGVFA
HHHHHHHHHHCCCCEEEEECCCCCCEEEECCCCCCCCCCHHHCCCCEEEEEECCCCCHHH
HLVGTLACLSDSERARVRGFVINRFRGDIALLEPGLDWLRAQTGKPVFGVLPYLHGLLLD
HHHHHHHHHCCCCHHHHHHHEEEHHCCCEEEECCCHHHHHHCCCCCHHHHHHHHHHHHCC
AEDMLPAQARSAAARGDAGVLRVVVPALPRISNHTDFDALRAHPQVEFTYWKSGPVPNAD
HHHCCCHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCHHHHHCCCCEEEEEECCCCCCCCC
LLILPGSKSVQRDLAWLRDAGWETVIQRHLRYGGKVIGICGGMQMLGRTLDDPLGLEGAP
EEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHCCEEEEEECCHHHHHHHCCCCCCCCCCC
GSVPGLGLLDFATTLQPDKTLKNVTGRLALPGAAAVHGYEIHMGETRGPALASPALELAE
CCCCCCCHHHHHHHCCCHHHHHHCCCCEECCCCHHEEEEEEEECCCCCCCCCCHHHHHHH
DGAATGGMRADGALSADGQILATYVHGLFDAPDACTALLAWAGLDRAERIDYPALREASL
CCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHCCCCHHHHHHH
ERLADTFAAHLDLGALYAAFR
HHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNAPDLLPRGTLMIQGTTSDAGKSTLVAGLCRLARRAGVRVAPFKPQNMALNSAVTADGG
CCCCCCCCCCEEEEEECCCCCCHHHHHHHHHHHHHHCCCEECCCCCCCCEECCEEECCCC
EIGRAQALQALAAGVAPHTDFNPVLLKPTSDRGAQVIIHGKARANLNARAYHDYKPVAFD
CCCHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCEEEEEECCCCCCCCEEECCCCCHHHH
AVLESYARLRAGYDAVIVEGAGSPAEINLREGDIANMGFAERVDCPVVLVADIDRGGVFA
HHHHHHHHHHCCCCEEEEECCCCCCEEEECCCCCCCCCCHHHCCCCEEEEEECCCCCHHH
HLVGTLACLSDSERARVRGFVINRFRGDIALLEPGLDWLRAQTGKPVFGVLPYLHGLLLD
HHHHHHHHHCCCCHHHHHHHEEEHHCCCEEEECCCHHHHHHCCCCCHHHHHHHHHHHHCC
AEDMLPAQARSAAARGDAGVLRVVVPALPRISNHTDFDALRAHPQVEFTYWKSGPVPNAD
HHHCCCHHHHHHHCCCCCCHHHHHHHHCCCCCCCCCHHHHHCCCCEEEEEECCCCCCCCC
LLILPGSKSVQRDLAWLRDAGWETVIQRHLRYGGKVIGICGGMQMLGRTLDDPLGLEGAP
EEEECCCHHHHHHHHHHHHCCHHHHHHHHHHHCCEEEEEECCHHHHHHHCCCCCCCCCCC
GSVPGLGLLDFATTLQPDKTLKNVTGRLALPGAAAVHGYEIHMGETRGPALASPALELAE
CCCCCCCHHHHHHHCCCHHHHHHCCCCEECCCCHHEEEEEEEECCCCCCCCCCHHHHHHH
DGAATGGMRADGALSADGQILATYVHGLFDAPDACTALLAWAGLDRAERIDYPALREASL
CCCCCCCCCCCCCCCCCCCHHHHHHHHHCCCCHHHHHHHHHHCCCHHHHCCCCHHHHHHH
ERLADTFAAHLDLGALYAAFR
HHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: Mg; Cl- [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; CO2; 7,8-Diaminononanoate [C]

Specific reaction: ATP + CO2 + 7,8-Diaminononanoate <==> ADP + Dethiobiotin + (3) H+ + Phosphate [C]

General reaction: Carboxylation; Heteroatomic ring closure [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA