Click here to switch to the map view.

The map label for this gene is pepA [H]

Identifier: 161524007

GI number: 161524007

Start: 905115

End: 906626

Strand: Direct

Name: pepA [H]

Synonym: Bmul_0828

Alternate gene names: 161524007

Gene position: 905115-906626 (Clockwise)

Preceding gene: 161524003

Following gene: 161524008

Centisome position: 26.25

GC content: 67.06

Gene sequence:

>1512_bases
ATGGACTTTAGCATAAAAGGCTGTGATTGGAGCAAAGGCGAGGCGAAGGGGTTCCTGACCGGGAAGTCCGACTGCATCGT
GCTCGGCATCTTCGAAGCGCAGACGCTGTCGGGCGCAGCGCTGGACATCGACACGGCCACCAAGGGACTGATTTCGCGCG
TCGTGAAGGCCGGCGACATGGACGGCAAGCGCGGCAAGACGCTGTTCCTGCCCGAAGTGTCGGGCATCGGCGCGTCGCGC
GTGCTGCTGGTCGGCCTCGGCAAGCAGGATGCTTTCAACCAGAAAGCCTACAACGACGCCGTCACGGCCGCATGGCGCGC
GCTGCTCGCGACGAAGGTCGTCCAGGTCACGTTCACGCTCGCGCAGCTGCCGGTCGACGAGCGCGGCTCGGACTGGGGCG
TGCGCGCGGCGATTCTCGCGCTGCGCAACGAAACCTACCGCTTCACGCAGATGAAGAGCAAGCCGGAACCGGTCTCGCAT
ACGTTGAAGCGCGTCGTGTTCAGCGTCGAGCCGGCCGACGAGAAGGCCGCGAAGGTCGCGGTCAAGCAGGCCGTCGCGCT
CGCGAACGGGATGGATCTGACCCGCGACCTCGGCAACCTGCCGGGCAACGTCTGCACGCCGACCTATCTCGCAAACACCG
CGAAGCAGCTCGCGAAGGACTGGGGGATGAAGGCCGAGGTGCTCGGCCTGAAGCAGATCCAGGCGCTGAAGATGGGCTCG
TTCCTGTCGGTCGCGCGCGCGTCGGTCGAGCCGCCGCAGTTCATCGTGCTGCACTATCAGGGCGCCGCCGCGAAGGCCGC
GCCGATCGTGCTGGTCGGCAAGGGCATCACCTTCGACACGGGCGGCATCTCGCTGAAGCCGGGCGAGGGCATGGATGAAA
TGAAGTACGACATGTGCGGCGCCGGCTCGGTGCTCGGCACGATCCGCGCGGTCGCCGAGATGGGGCTGAAGCTGAACGTC
GTCGGCATCATCCCGACCTGCGAGAACATGCCGGGCGGCAACGCGACGAAGCCGGGCGACGTCGTGACAAGCATGAAGGG
GCTGACGATCGAGGTGCTGAACACCGACGCCGAAGGCCGCCTGATCCTGTGCGATGCGCTCACGTACGCCGAGCGTTTCA
AGCCGGCCGCGGTGATCGACATCGCGACGCTGACGGGCGCGTGCATCATCGCGCTCGGCCACCACAACAGCGGGCTGTTC
TCGAAGGACGACGCGCTCGCGGGCGAGCTGCTCGACGCGTCGCGCGAGGCGAACGATCCGGCATGGCGTCTGCCGCTCGA
CGACGAGTATCAGGATCAGCTGAAGTCGAACTTCGCGGATCTCGCCAACATCGGCGGGCGTCCGGCCGGCAGCGTGACGG
CTGCCTGCTTCCTGTCGCGCTTCACCGAGAACTACCCGTGGGCGCACCTCGACATCGCGGGCACCGCGTGGAAGAGCGGG
GCGGCGAAGGGCGCGACCGGCCGTCCGGTGCCGTTGCTCGCGCAGTTCCTGATCGACCGCGCCGGCCAGTAA

Upstream 100 bases:

>100_bases
GGCAGCGCCCGCGTGGTGCGGCGCTCGCGCCGCCACGGGAAAAATAGCGGATAATTGCGGCTTTCATCCTTAGCCCAGAT
TTTATCCGAGGACAAGCGCG

Downstream 100 bases:

>100_bases
TGGCGCGAGCGACGACGATGCGGGTACGCGGGTCATGACGCGAATCGATTTCCATTCGAACGTCGGCGATTCGCTCGCGT
ATGCGTGCCGGCTGCTGCGC

Product: leucyl aminopeptidase

Products: NA

Alternate protein names: Leucine aminopeptidase; LAP; Leucyl aminopeptidase [H]

Number of amino acids: Translated: 503; Mature: 503

Protein sequence:

>503_residues
MDFSIKGCDWSKGEAKGFLTGKSDCIVLGIFEAQTLSGAALDIDTATKGLISRVVKAGDMDGKRGKTLFLPEVSGIGASR
VLLVGLGKQDAFNQKAYNDAVTAAWRALLATKVVQVTFTLAQLPVDERGSDWGVRAAILALRNETYRFTQMKSKPEPVSH
TLKRVVFSVEPADEKAAKVAVKQAVALANGMDLTRDLGNLPGNVCTPTYLANTAKQLAKDWGMKAEVLGLKQIQALKMGS
FLSVARASVEPPQFIVLHYQGAAAKAAPIVLVGKGITFDTGGISLKPGEGMDEMKYDMCGAGSVLGTIRAVAEMGLKLNV
VGIIPTCENMPGGNATKPGDVVTSMKGLTIEVLNTDAEGRLILCDALTYAERFKPAAVIDIATLTGACIIALGHHNSGLF
SKDDALAGELLDASREANDPAWRLPLDDEYQDQLKSNFADLANIGGRPAGSVTAACFLSRFTENYPWAHLDIAGTAWKSG
AAKGATGRPVPLLAQFLIDRAGQ

Sequences:

>Translated_503_residues
MDFSIKGCDWSKGEAKGFLTGKSDCIVLGIFEAQTLSGAALDIDTATKGLISRVVKAGDMDGKRGKTLFLPEVSGIGASR
VLLVGLGKQDAFNQKAYNDAVTAAWRALLATKVVQVTFTLAQLPVDERGSDWGVRAAILALRNETYRFTQMKSKPEPVSH
TLKRVVFSVEPADEKAAKVAVKQAVALANGMDLTRDLGNLPGNVCTPTYLANTAKQLAKDWGMKAEVLGLKQIQALKMGS
FLSVARASVEPPQFIVLHYQGAAAKAAPIVLVGKGITFDTGGISLKPGEGMDEMKYDMCGAGSVLGTIRAVAEMGLKLNV
VGIIPTCENMPGGNATKPGDVVTSMKGLTIEVLNTDAEGRLILCDALTYAERFKPAAVIDIATLTGACIIALGHHNSGLF
SKDDALAGELLDASREANDPAWRLPLDDEYQDQLKSNFADLANIGGRPAGSVTAACFLSRFTENYPWAHLDIAGTAWKSG
AAKGATGRPVPLLAQFLIDRAGQ
>Mature_503_residues
MDFSIKGCDWSKGEAKGFLTGKSDCIVLGIFEAQTLSGAALDIDTATKGLISRVVKAGDMDGKRGKTLFLPEVSGIGASR
VLLVGLGKQDAFNQKAYNDAVTAAWRALLATKVVQVTFTLAQLPVDERGSDWGVRAAILALRNETYRFTQMKSKPEPVSH
TLKRVVFSVEPADEKAAKVAVKQAVALANGMDLTRDLGNLPGNVCTPTYLANTAKQLAKDWGMKAEVLGLKQIQALKMGS
FLSVARASVEPPQFIVLHYQGAAAKAAPIVLVGKGITFDTGGISLKPGEGMDEMKYDMCGAGSVLGTIRAVAEMGLKLNV
VGIIPTCENMPGGNATKPGDVVTSMKGLTIEVLNTDAEGRLILCDALTYAERFKPAAVIDIATLTGACIIALGHHNSGLF
SKDDALAGELLDASREANDPAWRLPLDDEYQDQLKSNFADLANIGGRPAGSVTAACFLSRFTENYPWAHLDIAGTAWKSG
AAKGATGRPVPLLAQFLIDRAGQ

Specific function: Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides [H]

COG id: COG0260

COG function: function code E; Leucyl aminopeptidase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M17 family [H]

Homologues:

Organism=Homo sapiens, GI41393561, Length=434, Percent_Identity=40.7834101382488, Blast_Score=271, Evalue=1e-72,
Organism=Homo sapiens, GI47155554, Length=369, Percent_Identity=32.520325203252, Blast_Score=134, Evalue=2e-31,
Organism=Escherichia coli, GI1790710, Length=506, Percent_Identity=50.197628458498, Blast_Score=509, Evalue=1e-145,
Organism=Escherichia coli, GI87082123, Length=319, Percent_Identity=42.0062695924765, Blast_Score=212, Evalue=5e-56,
Organism=Caenorhabditis elegans, GI17556903, Length=314, Percent_Identity=33.1210191082803, Blast_Score=140, Evalue=1e-33,
Organism=Caenorhabditis elegans, GI17565172, Length=249, Percent_Identity=30.5220883534137, Blast_Score=81, Evalue=1e-15,
Organism=Drosophila melanogaster, GI21355725, Length=335, Percent_Identity=37.6119402985075, Blast_Score=214, Evalue=1e-55,
Organism=Drosophila melanogaster, GI24661038, Length=335, Percent_Identity=37.3134328358209, Blast_Score=213, Evalue=2e-55,
Organism=Drosophila melanogaster, GI20129969, Length=523, Percent_Identity=31.1663479923518, Blast_Score=205, Evalue=5e-53,
Organism=Drosophila melanogaster, GI24662227, Length=499, Percent_Identity=31.6633266533066, Blast_Score=204, Evalue=9e-53,
Organism=Drosophila melanogaster, GI161077148, Length=499, Percent_Identity=30.4609218436874, Blast_Score=201, Evalue=1e-51,
Organism=Drosophila melanogaster, GI20130057, Length=499, Percent_Identity=30.4609218436874, Blast_Score=201, Evalue=1e-51,
Organism=Drosophila melanogaster, GI21355645, Length=490, Percent_Identity=30.6122448979592, Blast_Score=197, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24662223, Length=490, Percent_Identity=30.6122448979592, Blast_Score=197, Evalue=2e-50,
Organism=Drosophila melanogaster, GI20129963, Length=500, Percent_Identity=28.6, Blast_Score=176, Evalue=5e-44,
Organism=Drosophila melanogaster, GI19922386, Length=323, Percent_Identity=34.0557275541796, Blast_Score=171, Evalue=8e-43,
Organism=Drosophila melanogaster, GI21357381, Length=312, Percent_Identity=32.3717948717949, Blast_Score=142, Evalue=6e-34,
Organism=Drosophila melanogaster, GI221379063, Length=310, Percent_Identity=32.5806451612903, Blast_Score=141, Evalue=8e-34,
Organism=Drosophila melanogaster, GI221379062, Length=310, Percent_Identity=32.5806451612903, Blast_Score=141, Evalue=8e-34,
Organism=Drosophila melanogaster, GI24646701, Length=236, Percent_Identity=30.5084745762712, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24646703, Length=236, Percent_Identity=30.5084745762712, Blast_Score=87, Evalue=2e-17,
Organism=Drosophila melanogaster, GI21358201, Length=236, Percent_Identity=30.5084745762712, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011356
- InterPro:   IPR000819
- InterPro:   IPR023042
- InterPro:   IPR008283 [H]

Pfam domain/function: PF00883 Peptidase_M17; PF02789 Peptidase_M17_N [H]

EC number: =3.4.11.1; =3.4.11.10 [H]

Molecular weight: Translated: 53184; Mature: 53184

Theoretical pI: Translated: 7.71; Mature: 7.71

Prosite motif: PS00631 CYTOSOL_AP

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDFSIKGCDWSKGEAKGFLTGKSDCIVLGIFEAQTLSGAALDIDTATKGLISRVVKAGDM
CCCCCCCCCCCCCCCCEEEECCCCEEEEEEEECCCCCCCEEECHHHHHHHHHHHHHHCCC
DGKRGKTLFLPEVSGIGASRVLLVGLGKQDAFNQKAYNDAVTAAWRALLATKVVQVTFTL
CCCCCCEEEECCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQLPVDERGSDWGVRAAILALRNETYRFTQMKSKPEPVSHTLKRVVFSVEPADEKAAKVA
HHCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHEECCCCHHHHHHHH
VKQAVALANGMDLTRDLGNLPGNVCTPTYLANTAKQLAKDWGMKAEVLGLKQIQALKMGS
HHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHCH
FLSVARASVEPPQFIVLHYQGAAAKAAPIVLVGKGITFDTGGISLKPGEGMDEMKYDMCG
HHHHHHHCCCCCEEEEEEECCCCCCCCCEEEEECCEEECCCCEEECCCCCHHHHHHHHCC
AGSVLGTIRAVAEMGLKLNVVGIIPTCENMPGGNATKPGDVVTSMKGLTIEVLNTDAEGR
CCHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCC
LILCDALTYAERFKPAAVIDIATLTGACIIALGHHNSGLFSKDDALAGELLDASREANDP
EEEEEHHHHHHHCCCCEEEEHHHHCCEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCC
AWRLPLDDEYQDQLKSNFADLANIGGRPAGSVTAACFLSRFTENYPWAHLDIAGTAWKSG
EEECCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCC
AAKGATGRPVPLLAQFLIDRAGQ
CCCCCCCCCHHHHHHHHHHHCCC
>Mature Secondary Structure
MDFSIKGCDWSKGEAKGFLTGKSDCIVLGIFEAQTLSGAALDIDTATKGLISRVVKAGDM
CCCCCCCCCCCCCCCCEEEECCCCEEEEEEEECCCCCCCEEECHHHHHHHHHHHHHHCCC
DGKRGKTLFLPEVSGIGASRVLLVGLGKQDAFNQKAYNDAVTAAWRALLATKVVQVTFTL
CCCCCCEEEECCCCCCCCCEEEEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHH
AQLPVDERGSDWGVRAAILALRNETYRFTQMKSKPEPVSHTLKRVVFSVEPADEKAAKVA
HHCCCCCCCCCCCHHHHHHHHHCCCEEEEECCCCCCHHHHHHHHHHEECCCCHHHHHHHH
VKQAVALANGMDLTRDLGNLPGNVCTPTYLANTAKQLAKDWGMKAEVLGLKQIQALKMGS
HHHHHHHHCCCHHHHHHHCCCCCCCCHHHHHHHHHHHHHHCCCCEEEHHHHHHHHHHHCH
FLSVARASVEPPQFIVLHYQGAAAKAAPIVLVGKGITFDTGGISLKPGEGMDEMKYDMCG
HHHHHHHCCCCCEEEEEEECCCCCCCCCEEEEECCEEECCCCEEECCCCCHHHHHHHHCC
AGSVLGTIRAVAEMGLKLNVVGIIPTCENMPGGNATKPGDVVTSMKGLTIEVLNTDAEGR
CCHHHHHHHHHHHCCCEEEEEEEEECCCCCCCCCCCCCCHHHHHCCCCEEEEEECCCCCC
LILCDALTYAERFKPAAVIDIATLTGACIIALGHHNSGLFSKDDALAGELLDASREANDP
EEEEEHHHHHHHCCCCEEEEHHHHCCEEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCC
AWRLPLDDEYQDQLKSNFADLANIGGRPAGSVTAACFLSRFTENYPWAHLDIAGTAWKSG
EEECCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCC
AAKGATGRPVPLLAQFLIDRAGQ
CCCCCCCCCHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA