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The map label for this gene is degP [H]

Identifier: 161523862

GI number: 161523862

Start: 746853

End: 748337

Strand: Direct

Name: degP [H]

Synonym: Bmul_0682

Alternate gene names: 161523862

Gene position: 746853-748337 (Clockwise)

Preceding gene: 161523861

Following gene: 161523863

Centisome position: 21.66

GC content: 68.35

Gene sequence:

>1485_bases
ATGAACACCCGATTCCTTGCGCGTAGCGCCGTCGTGGTCGCAGTGGCCGCCGCGCTGTCCGCCGGCTACGTCGCCGGCAC
GCGCCGCGCCGATCCGCAGATCATCGCGCCCGCGCACGCGGCGGCGATGATGCCGGCCGAAGCGGCCGCGAAGACCGGCA
TCCCCGATTTCTCCGGGCTGGTCGAGACTTACGGTCCGGCCGTCGTCAACATCAGCGCAAAGCACGTCGTGAAGCAGGTC
GCGCGGCGCGTGCCGCAGCCGCAGTTGCCGATCGACCCGAGCGATCCGTTCTATCAGTTCTTCAAGCGCTTCTATGGACA
GGTGCCGGGCATGGGCGGCGACGCGCAGCCGGACGACCAGCCGAGCGCGAGCCTCGGGTCGGGTTTCATCATCAGCCCGG
ACGGATACATCCTCACGAATGCGCACGTGATCGACGGTGCGAACGTCGTCACGGTAAAGCTGACCGACAAGCGCGAGTAC
AAGGCGAAGGTCGTCGGCTCCGACAAGCAGTCCGACGTCGCGGTGCTGAAGATCGACGCCACCGGCCTGCCGACCGTGAA
GATCGGCGATCCGGCGCAGAGCAAGGTCGGCCAGTGGGTCGTCGCGATCGGCTCGCCGTACGGCTTCGACAACACGGTCA
CGTCGGGCATCATCAGCGCGAAGTCGCGCGCGCTGCCCGACGAGAACTACACGCCGTTCATCCAGACCGACGTGCCGGTC
AACCCCGGCAACTCGGGCGGCCCGCTGTTCAACCTGCAGGGCGAGGTGATCGGGATCAACTCGATGATCTATTCGCAGAC
GGGCGGCTTCCAGGGCCTGTCGTTCGCGATTCCGATCAACGAAGCGATCAAGGTGAAGGACGAGCTCGTGAAGACCGGGC
ACGTGAGCCGCGGCCGGCTCGGCGTCGCGGTGCAGGGGCTGAACCAGACGCTCGCGAGCTCGTTCGGGCTCGCGAAGCCG
GACGGTGCGCTCGTCAGCTCGGTCGATCCGAACGGCCCGGCCGCGAAGGCCGGCCTGCAGCCGGGCGACGTGATCCTGTC
GGTCAACGGCACGCCGGTCGTCGATTCGACGACGCTGCCGTCGCAGATCGCGAACCTGAAGCCGGGCTCGAAGGCCGACC
TGCAGATCTGGCGCGACAAGGCGAAGCAGTCCGTCACCGTCACGCTCGGCGCGATGACCGACGCGAAGCTCGCGTCGAAC
GACGGCGGTCCGGTCGAGCAGGGGCGCCTCGGCGTCGCGGTGCGGCCGCTGACGCCGCAGGAACGCAGCGCCGACAACCT
GTCGCACGGGCTGATCGTCCAGCAGGCCGGCGGCCCGGCCGCGAGCGCCGGCATTCAGCCGGGCGACGTGATCCTGGCCG
TGAACGGCCGCCCCGTCACGAGCCCCGAGCAGCTGCGCGAAGCGGTCAAGAGCGCGGGCAACAGTCTTGCTCTGCTGATC
CAGCGCGATAATGCACAGATCTTCGTGCCGGTCGACCTGAGCTGA

Upstream 100 bases:

>100_bases
AAGGCGCGCGGCAGGCGGCTTAAGTTGCGCTTAAGGCTGATTAAGCCTCCTTTAAGTCAGCATCGTTACGCTGCGACGTA
ACAAAAGAGGAGGTCCTACG

Downstream 100 bases:

>100_bases
CCGTGCGCCCGCCGTGGGCCGGGTTGGCCGGCCGCGGCGGGCGCCGCCGACGTCCGCGCATCGCCGCGGCCCCCGTATGT
GTTCCGACCCAAAGGAGAGA

Product: protease Do

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 494; Mature: 494

Protein sequence:

>494_residues
MNTRFLARSAVVVAVAAALSAGYVAGTRRADPQIIAPAHAAAMMPAEAAAKTGIPDFSGLVETYGPAVVNISAKHVVKQV
ARRVPQPQLPIDPSDPFYQFFKRFYGQVPGMGGDAQPDDQPSASLGSGFIISPDGYILTNAHVIDGANVVTVKLTDKREY
KAKVVGSDKQSDVAVLKIDATGLPTVKIGDPAQSKVGQWVVAIGSPYGFDNTVTSGIISAKSRALPDENYTPFIQTDVPV
NPGNSGGPLFNLQGEVIGINSMIYSQTGGFQGLSFAIPINEAIKVKDELVKTGHVSRGRLGVAVQGLNQTLASSFGLAKP
DGALVSSVDPNGPAAKAGLQPGDVILSVNGTPVVDSTTLPSQIANLKPGSKADLQIWRDKAKQSVTVTLGAMTDAKLASN
DGGPVEQGRLGVAVRPLTPQERSADNLSHGLIVQQAGGPAASAGIQPGDVILAVNGRPVTSPEQLREAVKSAGNSLALLI
QRDNAQIFVPVDLS

Sequences:

>Translated_494_residues
MNTRFLARSAVVVAVAAALSAGYVAGTRRADPQIIAPAHAAAMMPAEAAAKTGIPDFSGLVETYGPAVVNISAKHVVKQV
ARRVPQPQLPIDPSDPFYQFFKRFYGQVPGMGGDAQPDDQPSASLGSGFIISPDGYILTNAHVIDGANVVTVKLTDKREY
KAKVVGSDKQSDVAVLKIDATGLPTVKIGDPAQSKVGQWVVAIGSPYGFDNTVTSGIISAKSRALPDENYTPFIQTDVPV
NPGNSGGPLFNLQGEVIGINSMIYSQTGGFQGLSFAIPINEAIKVKDELVKTGHVSRGRLGVAVQGLNQTLASSFGLAKP
DGALVSSVDPNGPAAKAGLQPGDVILSVNGTPVVDSTTLPSQIANLKPGSKADLQIWRDKAKQSVTVTLGAMTDAKLASN
DGGPVEQGRLGVAVRPLTPQERSADNLSHGLIVQQAGGPAASAGIQPGDVILAVNGRPVTSPEQLREAVKSAGNSLALLI
QRDNAQIFVPVDLS
>Mature_494_residues
MNTRFLARSAVVVAVAAALSAGYVAGTRRADPQIIAPAHAAAMMPAEAAAKTGIPDFSGLVETYGPAVVNISAKHVVKQV
ARRVPQPQLPIDPSDPFYQFFKRFYGQVPGMGGDAQPDDQPSASLGSGFIISPDGYILTNAHVIDGANVVTVKLTDKREY
KAKVVGSDKQSDVAVLKIDATGLPTVKIGDPAQSKVGQWVVAIGSPYGFDNTVTSGIISAKSRALPDENYTPFIQTDVPV
NPGNSGGPLFNLQGEVIGINSMIYSQTGGFQGLSFAIPINEAIKVKDELVKTGHVSRGRLGVAVQGLNQTLASSFGLAKP
DGALVSSVDPNGPAAKAGLQPGDVILSVNGTPVVDSTTLPSQIANLKPGSKADLQIWRDKAKQSVTVTLGAMTDAKLASN
DGGPVEQGRLGVAVRPLTPQERSADNLSHGLIVQQAGGPAASAGIQPGDVILAVNGRPVTSPEQLREAVKSAGNSLALLI
QRDNAQIFVPVDLS

Specific function: Serine Protease That Is Required At High Temperature. Involved In The Degradation Of Damaged Proteins. It Can Degrade Icia, Ada, Casein And Globin. Shared Specificity With Degq. [C]

COG id: COG0265

COG function: function code O; Trypsin-like serine proteases, typically periplasmic, contain C-terminal PDZ domain

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 PDZ (DHR) domains [H]

Homologues:

Organism=Homo sapiens, GI22129776, Length=265, Percent_Identity=37.7358490566038, Blast_Score=157, Evalue=2e-38,
Organism=Homo sapiens, GI4506141, Length=283, Percent_Identity=37.1024734982332, Blast_Score=156, Evalue=3e-38,
Organism=Homo sapiens, GI7019477, Length=289, Percent_Identity=36.3321799307958, Blast_Score=142, Evalue=6e-34,
Organism=Homo sapiens, GI24308541, Length=251, Percent_Identity=35.8565737051793, Blast_Score=141, Evalue=1e-33,
Organism=Escherichia coli, GI1786356, Length=482, Percent_Identity=35.6846473029046, Blast_Score=251, Evalue=8e-68,
Organism=Escherichia coli, GI1789629, Length=488, Percent_Identity=35.2459016393443, Blast_Score=249, Evalue=3e-67,
Organism=Escherichia coli, GI1789630, Length=271, Percent_Identity=40.590405904059, Blast_Score=193, Evalue=2e-50,
Organism=Drosophila melanogaster, GI24646839, Length=300, Percent_Identity=36.3333333333333, Blast_Score=152, Evalue=6e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001478
- InterPro:   IPR009003
- InterPro:   IPR011782
- InterPro:   IPR001254
- InterPro:   IPR001940 [H]

Pfam domain/function: PF00595 PDZ; PF00089 Trypsin [H]

EC number: 3.4.21.- [C]

Molecular weight: Translated: 51120; Mature: 51120

Theoretical pI: Translated: 8.67; Mature: 8.67

Prosite motif: PS50106 PDZ

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.2 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.2 %Met     (Mature Protein)
1.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTRFLARSAVVVAVAAALSAGYVAGTRRADPQIIAPAHAAAMMPAEAAAKTGIPDFSGL
CCCCHHHHHHHHHHHHHHHHCCCEECCCCCCCCEECCCHHHHHCCHHHHHHCCCCCHHHH
VETYGPAVVNISAKHVVKQVARRVPQPQLPIDPSDPFYQFFKRFYGQVPGMGGDAQPDDQ
HHHCCCEEEEECHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCC
PSASLGSGFIISPDGYILTNAHVIDGANVVTVKLTDKREYKAKVVGSDKQSDVAVLKIDA
CCCCCCCCEEECCCCEEEEEEEEECCCCEEEEEEECCCCEEEEEECCCCCCCEEEEEEEC
TGLPTVKIGDPAQSKVGQWVVAIGSPYGFDNTVTSGIISAKSRALPDENYTPFIQTDVPV
CCCCEEEECCCHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCCC
NPGNSGGPLFNLQGEVIGINSMIYSQTGGFQGLSFAIPINEAIKVKDELVKTGHVSRGRL
CCCCCCCCEEEECCCEEEECEEEEECCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCEE
GVAVQGLNQTLASSFGLAKPDGALVSSVDPNGPAAKAGLQPGDVILSVNGTPVVDSTTLP
EEEEECHHHHHHHHCCCCCCCCCEEECCCCCCCCHHCCCCCCCEEEEECCCCEECCCCCH
SQIANLKPGSKADLQIWRDKAKQSVTVTLGAMTDAKLASNDGGPVEQGRLGVAVRPLTPQ
HHHHCCCCCCCCHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCC
ERSADNLSHGLIVQQAGGPAASAGIQPGDVILAVNGRPVTSPEQLREAVKSAGNSLALLI
CCCCCCCCCCEEEEECCCCHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCEEEEEE
QRDNAQIFVPVDLS
EECCCEEEEEEECC
>Mature Secondary Structure
MNTRFLARSAVVVAVAAALSAGYVAGTRRADPQIIAPAHAAAMMPAEAAAKTGIPDFSGL
CCCCHHHHHHHHHHHHHHHHCCCEECCCCCCCCEECCCHHHHHCCHHHHHHCCCCCHHHH
VETYGPAVVNISAKHVVKQVARRVPQPQLPIDPSDPFYQFFKRFYGQVPGMGGDAQPDDQ
HHHCCCEEEEECHHHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCC
PSASLGSGFIISPDGYILTNAHVIDGANVVTVKLTDKREYKAKVVGSDKQSDVAVLKIDA
CCCCCCCCEEECCCCEEEEEEEEECCCCEEEEEEECCCCEEEEEECCCCCCCEEEEEEEC
TGLPTVKIGDPAQSKVGQWVVAIGSPYGFDNTVTSGIISAKSRALPDENYTPFIQTDVPV
CCCCEEEECCCHHHCCCCEEEEECCCCCCCHHHHHHHHHHHHHCCCCCCCCCEEEECCCC
NPGNSGGPLFNLQGEVIGINSMIYSQTGGFQGLSFAIPINEAIKVKDELVKTGHVSRGRL
CCCCCCCCEEEECCCEEEECEEEEECCCCCCCEEEEECCCHHHHHHHHHHHCCCCCCCEE
GVAVQGLNQTLASSFGLAKPDGALVSSVDPNGPAAKAGLQPGDVILSVNGTPVVDSTTLP
EEEEECHHHHHHHHCCCCCCCCCEEECCCCCCCCHHCCCCCCCEEEEECCCCEECCCCCH
SQIANLKPGSKADLQIWRDKAKQSVTVTLGAMTDAKLASNDGGPVEQGRLGVAVRPLTPQ
HHHHCCCCCCCCHHHHHHHHCCCEEEEEEECCCCCCCCCCCCCCCCCCCCCEEEECCCCC
ERSADNLSHGLIVQQAGGPAASAGIQPGDVILAVNGRPVTSPEQLREAVKSAGNSLALLI
CCCCCCCCCCEEEEECCCCHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHCCCEEEEEE
QRDNAQIFVPVDLS
EECCCEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: Serine endopeptidases [C]

General reaction: Hydrolase; Acting on peptide bonds (Peptidases) [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7861951 [H]