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The map label for this gene is lrp [H]

Identifier: 161523404

GI number: 161523404

Start: 252153

End: 252809

Strand: Direct

Name: lrp [H]

Synonym: Bmul_0224

Alternate gene names: 161523404

Gene position: 252153-252809 (Clockwise)

Preceding gene: 161523402

Following gene: 161523413

Centisome position: 7.31

GC content: 64.84

Gene sequence:

>657_bases
ATGGCGCGCGAAACGATCGAGTACGTGCGACAAAGTGTAGCGGGCCGCGTGGAGCGTAAACTTGCGAACTTGGTCGCGCG
CTCCTACGATGGCGCAATTTCCAGTCTCGAAACGACTTTCGGAGGGCAGAAGATGGCGCAGGTCGAATTGGACGCGATCG
ACCGGCGGATCCTCGCGATTCTTCAGGAGAACGGGCGCCTGTCGAACCAGGAGATCGCCGAACGCGTGAACCTGTCGCCG
AGCCCGTGTCTGCGGCGAATCCGTCGCCTCGAGGAGATCGGCGTGATCACCGGCTACGTCGCGCTGCTCGACCCGCAGAA
ACTCGGGCTCGATCTGCTCGCATACGTGAGCGTGCGGCTCGAGAAGCGCGGCGGCGTCGTGCCGGTGCGCGCGGACGAAA
CGGCGGCGCGCGCGGGCGCGACGCACGCGGAGCTGTTCCGCGCGGCCGTGCAGGCCTGGCCTGAAGTCGTCGCGTGCCAC
GCGATGACGGGCGATATGGATTACCTGCTGCGCGTGCAGGTGGAGGACATGGCGCATTTCTCCCGCTTCGTGCAGGAGCA
GTTGCTGCACCATCCGTCGGTGATCGACGTGAAAACGAGCTTTTCGCTCGAATGCTTCAAGGAGACGACGGCGCTGCCGA
TCCGGTCGATGCGCTAG

Upstream 100 bases:

>100_bases
CCGACGGGGTTGTCCCAGGTGGGGATCTGCATGCGTGTCTCCTGAGTCGGCCGCGGCGATGCGGAGCGCCGTCGGTCCTG
TGTCGAGGGGGGGCGCGCCG

Downstream 100 bases:

>100_bases
CGGCGGCGGGAAGGCGGGAGGGCGAAGCGAGAACCGCCGGGCGCGAGCGACGCGCCGCGGCGGAGCACTGGTGTTACGCG
CTGAGCGCGGCGGGCATCAG

Product: AsnC family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 218; Mature: 217

Protein sequence:

>218_residues
MARETIEYVRQSVAGRVERKLANLVARSYDGAISSLETTFGGQKMAQVELDAIDRRILAILQENGRLSNQEIAERVNLSP
SPCLRRIRRLEEIGVITGYVALLDPQKLGLDLLAYVSVRLEKRGGVVPVRADETAARAGATHAELFRAAVQAWPEVVACH
AMTGDMDYLLRVQVEDMAHFSRFVQEQLLHHPSVIDVKTSFSLECFKETTALPIRSMR

Sequences:

>Translated_218_residues
MARETIEYVRQSVAGRVERKLANLVARSYDGAISSLETTFGGQKMAQVELDAIDRRILAILQENGRLSNQEIAERVNLSP
SPCLRRIRRLEEIGVITGYVALLDPQKLGLDLLAYVSVRLEKRGGVVPVRADETAARAGATHAELFRAAVQAWPEVVACH
AMTGDMDYLLRVQVEDMAHFSRFVQEQLLHHPSVIDVKTSFSLECFKETTALPIRSMR
>Mature_217_residues
ARETIEYVRQSVAGRVERKLANLVARSYDGAISSLETTFGGQKMAQVELDAIDRRILAILQENGRLSNQEIAERVNLSPS
PCLRRIRRLEEIGVITGYVALLDPQKLGLDLLAYVSVRLEKRGGVVPVRADETAARAGATHAELFRAAVQAWPEVVACHA
MTGDMDYLLRVQVEDMAHFSRFVQEQLLHHPSVIDVKTSFSLECFKETTALPIRSMR

Specific function: Mediates a global response to leucine. Exogenous leucine affects the expression of a number of different operons; lrp mediates this effect for at least some of these operons. For example it is regulator of the branched-chain amino acid transport genes [H]

COG id: COG1522

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH asnC-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1787116, Length=168, Percent_Identity=41.0714285714286, Blast_Score=130, Evalue=5e-32,
Organism=Escherichia coli, GI87081742, Length=165, Percent_Identity=41.2121212121212, Blast_Score=127, Evalue=8e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011008
- InterPro:   IPR000485
- InterPro:   IPR019885
- InterPro:   IPR019888
- InterPro:   IPR019887
- InterPro:   IPR011991 [H]

Pfam domain/function: PF01037 AsnC_trans_reg [H]

EC number: NA

Molecular weight: Translated: 24359; Mature: 24228

Theoretical pI: Translated: 7.56; Mature: 7.56

Prosite motif: PS00519 HTH_ASNC_1 ; PS50956 HTH_ASNC_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARETIEYVRQSVAGRVERKLANLVARSYDGAISSLETTFGGQKMAQVELDAIDRRILAI
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
LQENGRLSNQEIAERVNLSPSPCLRRIRRLEEIGVITGYVALLDPQKLGLDLLAYVSVRL
HHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
EKRGGVVPVRADETAARAGATHAELFRAAVQAWPEVVACHAMTGDMDYLLRVQVEDMAHF
HCCCCEEEEECCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
SRFVQEQLLHHPSVIDVKTSFSLECFKETTALPIRSMR
HHHHHHHHHHCCCEEEEECCCHHHHHHHHHCCCCCCCC
>Mature Secondary Structure 
ARETIEYVRQSVAGRVERKLANLVARSYDGAISSLETTFGGQKMAQVELDAIDRRILAI
CHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHCCCCHHHHHHHHHHHHHHHHH
LQENGRLSNQEIAERVNLSPSPCLRRIRRLEEIGVITGYVALLDPQKLGLDLLAYVSVRL
HHHCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHH
EKRGGVVPVRADETAARAGATHAELFRAAVQAWPEVVACHAMTGDMDYLLRVQVEDMAHF
HCCCCEEEEECCHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHH
SRFVQEQLLHHPSVIDVKTSFSLECFKETTALPIRSMR
HHHHHHHHHHCCCEEEEECCCHHHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]