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The map label for this gene is maeB [H]

Identifier: 161523400

GI number: 161523400

Start: 244331

End: 246601

Strand: Direct

Name: maeB [H]

Synonym: Bmul_0220

Alternate gene names: 161523400

Gene position: 244331-246601 (Clockwise)

Preceding gene: 161523393

Following gene: 161523402

Centisome position: 7.09

GC content: 66.36

Gene sequence:

>2271_bases
ATGGACGAACAACTGAAGCAGGCCGCTCTCGCCTATCACCAGAACCCGAAACCCGGCAAGATTTCGGTCACGCCGACCAA
GCCGCTGTCGAATCAGCTCGACCTGTCGCTCGCGTATTCGCCCGGCGTCGCGGCCGCGTGCGAGGCGATCCACGCCGATC
CGCTCGACGCGCAGAAATACACGTCGCGCGGCAACCTCGTCGGCGTCGTGACGAACGGCACGGCCGTGCTCGGGCTCGGC
AACATCGGCCCGCTGGCCGCGAAGCCGGTGATGGAAGGCAAGGGCTGCCTGTTCAAGAAGTTCGCCGGCATCGACGTGTT
CGACATCGAACTCTCGGAATCCGACCCCGACAAGCTCGTCGAAGCGATCGCGATGCTCGAGCCGACGCTCGGCGGCATCA
ACCTCGAGGACATCAAGGCGCCGGAATGCTTCTACATCGAGCAGAAGCTGCGCGAGCGCATGAAGATTCCCGTCTTCCAC
GACGACCAGCACGGCACCGCGATCATCGCATCGGCCGCGATCCTGAACGGCCTGAAGGTCGTCGGCAAGAACCTCGCGGA
CGTGAAGCTCGTGTGTTCGGGCGCCGGCGCCGCGGCGATCGCATGTCTGGACCTGCTCGTGAACCTCGGGCTCACGAAGT
CGAACATCCTCGTGACCGACTCGAAGGGCGTGATCTACGAAGGGCGCGGCAATCTCGATCCGTCGAAGCAGCGCTACGCG
GCGACCACCGACGCGCGCACGCTCGCCGATGCGATCGTCGGCGCGGACGTGTTCCTCGGCTGCTCGAGCGCAGGCGTGCT
GAAGCAGGACATGGTCAAGGCGATGGCCGACAAGCCGCTGATCCTCGCGCTCGCGAACCCGGAGCCGGAAATCCGCCCGG
AAGACGCGAAGGCCGTGCGCCCGGACGCGATCGTCGCGACCGGCCGTTCGGACTACCCGAACCAGGTCAACAACGTGCTC
TGCTTCCCGTTCATCTTCCGCGGCGCGCTCGACGTCGGCGCGACGACGATCACGGAAGAGATGAAGCTCGCCTGCGTGCG
CGCGATCGCGGAGCTGGCGCAGGAAACCGACCAGAGCGAGGAAGTCGCGAAGGCGTATGAAGGCCATTCGCTCGAATTCG
GGCCGGAATACCTGATTCCGAAGCCGTTCGATCCGCGCCTGATCATCAAGATCGCGCCGGCCGTCGCGCAGGCCGCGATG
GATTCGGGCGTCGCGACGCGTCCGATCCAGGACATGGACGCATACCGCGAACAACTCGGCGCAACGGTGTACCGCACGGG
CATGGTGATGCGCCCGGTGTTCGCGACCGCGAAGAAGGCCGCGGCACGCATCGTGTTTGCCGAGGGCGAGGACGAGCGCG
TGCTGCGCGCCGCGCAGTTCGTGCTGCTCGAGAAGATCGCGAAGCCGATCATCATCGGCCGTCCGTCGGTCGTCGAGATG
CGGCTCGCGAAGATCGGCTCGAAGCTGAAGGCGGGTGTCGACTTCGAGATCGTCAATCCGGAAGACGACACGCGCTACCA
CCGCTACTGGCAGGCGTACCACGGGATCGGCGCGCGCGACGGCGTGACGCCCGAAGTCGCGAAGGCCGCGCTGCGCAAGT
TCAACACGCTGATCGGCGCGATGCTCGTGCACCTGGGCGATGCGGACGGGATGATCTGCGGGATGATCGACACGTACCAC
AGCCACCTGAAGTTCATCGAGCAGGTGCTGGGCCGCGCGAAGGGCGCCGAGCACTTCGCGGCGATGAACCTGCTGATGCT
GCCGGGCCGCAACCTGTTCGTCTGCGACACGTACGTGAACGAACTGCCGAGCGCCGAGCAGCTCGCCGACATGACGATCC
AGGCCGCGGCCGAGATCGAGCGCTTCGGGATCGTGCCGAAGGCCGCGCTGCTGTCGAACTCGAACTTCGGCAGCGCGCCG
TCGGCGTCGTCGCGCCGGATGGCCGAGGCCCGCAAGCTGATCGTCGAACGTGCGCCGAACCTCGAGGTCGACGGTGAAAT
GCACGGCGACGCCGCGCTGTCCGAAGCGGTCCGCAAGGCCGCGTTCCCGGGCACGACGCTGTCGGGCGAAGCGAACCTGC
TGATCATGCCGAACGTCGAAGCGGCGAACATCGCGTACAACCTGCTGAAGATGGTCGGCGGCGAAGGCGTGACGGTCGGC
CCGTTCCTGCTCGGCGCGGCGAAGCCGGTCCACATCCTGACGCCGGCCGCGACCGTGCGCCGGATCATCAACATGACGGC
CGTTGCCGCCGCGAACGTGAACACGAAGTAA

Upstream 100 bases:

>100_bases
GGCCGTCTCGCAGTCGACCATCCCCTCGATTCACGCAGACGCGGCTCAAGGTGCTGTGTACCGGACCGTCAACATTTCGC
ATGTCTCTCGCAGGTCAATC

Downstream 100 bases:

>100_bases
GCGTGCGCGCGTGCCGCGCCCGCCGCGCGGCGCAAAGAAAAAGCCACGGAACCTTGCGTTCCGTGGCTTTTTTTATCGCG
ATCGGCCGGTACGGCAAGCG

Product: malic enzyme

Products: NA

Alternate protein names: NADP-ME [H]

Number of amino acids: Translated: 756; Mature: 756

Protein sequence:

>756_residues
MDEQLKQAALAYHQNPKPGKISVTPTKPLSNQLDLSLAYSPGVAAACEAIHADPLDAQKYTSRGNLVGVVTNGTAVLGLG
NIGPLAAKPVMEGKGCLFKKFAGIDVFDIELSESDPDKLVEAIAMLEPTLGGINLEDIKAPECFYIEQKLRERMKIPVFH
DDQHGTAIIASAAILNGLKVVGKNLADVKLVCSGAGAAAIACLDLLVNLGLTKSNILVTDSKGVIYEGRGNLDPSKQRYA
ATTDARTLADAIVGADVFLGCSSAGVLKQDMVKAMADKPLILALANPEPEIRPEDAKAVRPDAIVATGRSDYPNQVNNVL
CFPFIFRGALDVGATTITEEMKLACVRAIAELAQETDQSEEVAKAYEGHSLEFGPEYLIPKPFDPRLIIKIAPAVAQAAM
DSGVATRPIQDMDAYREQLGATVYRTGMVMRPVFATAKKAAARIVFAEGEDERVLRAAQFVLLEKIAKPIIIGRPSVVEM
RLAKIGSKLKAGVDFEIVNPEDDTRYHRYWQAYHGIGARDGVTPEVAKAALRKFNTLIGAMLVHLGDADGMICGMIDTYH
SHLKFIEQVLGRAKGAEHFAAMNLLMLPGRNLFVCDTYVNELPSAEQLADMTIQAAAEIERFGIVPKAALLSNSNFGSAP
SASSRRMAEARKLIVERAPNLEVDGEMHGDAALSEAVRKAAFPGTTLSGEANLLIMPNVEAANIAYNLLKMVGGEGVTVG
PFLLGAAKPVHILTPAATVRRIINMTAVAAANVNTK

Sequences:

>Translated_756_residues
MDEQLKQAALAYHQNPKPGKISVTPTKPLSNQLDLSLAYSPGVAAACEAIHADPLDAQKYTSRGNLVGVVTNGTAVLGLG
NIGPLAAKPVMEGKGCLFKKFAGIDVFDIELSESDPDKLVEAIAMLEPTLGGINLEDIKAPECFYIEQKLRERMKIPVFH
DDQHGTAIIASAAILNGLKVVGKNLADVKLVCSGAGAAAIACLDLLVNLGLTKSNILVTDSKGVIYEGRGNLDPSKQRYA
ATTDARTLADAIVGADVFLGCSSAGVLKQDMVKAMADKPLILALANPEPEIRPEDAKAVRPDAIVATGRSDYPNQVNNVL
CFPFIFRGALDVGATTITEEMKLACVRAIAELAQETDQSEEVAKAYEGHSLEFGPEYLIPKPFDPRLIIKIAPAVAQAAM
DSGVATRPIQDMDAYREQLGATVYRTGMVMRPVFATAKKAAARIVFAEGEDERVLRAAQFVLLEKIAKPIIIGRPSVVEM
RLAKIGSKLKAGVDFEIVNPEDDTRYHRYWQAYHGIGARDGVTPEVAKAALRKFNTLIGAMLVHLGDADGMICGMIDTYH
SHLKFIEQVLGRAKGAEHFAAMNLLMLPGRNLFVCDTYVNELPSAEQLADMTIQAAAEIERFGIVPKAALLSNSNFGSAP
SASSRRMAEARKLIVERAPNLEVDGEMHGDAALSEAVRKAAFPGTTLSGEANLLIMPNVEAANIAYNLLKMVGGEGVTVG
PFLLGAAKPVHILTPAATVRRIINMTAVAAANVNTK
>Mature_756_residues
MDEQLKQAALAYHQNPKPGKISVTPTKPLSNQLDLSLAYSPGVAAACEAIHADPLDAQKYTSRGNLVGVVTNGTAVLGLG
NIGPLAAKPVMEGKGCLFKKFAGIDVFDIELSESDPDKLVEAIAMLEPTLGGINLEDIKAPECFYIEQKLRERMKIPVFH
DDQHGTAIIASAAILNGLKVVGKNLADVKLVCSGAGAAAIACLDLLVNLGLTKSNILVTDSKGVIYEGRGNLDPSKQRYA
ATTDARTLADAIVGADVFLGCSSAGVLKQDMVKAMADKPLILALANPEPEIRPEDAKAVRPDAIVATGRSDYPNQVNNVL
CFPFIFRGALDVGATTITEEMKLACVRAIAELAQETDQSEEVAKAYEGHSLEFGPEYLIPKPFDPRLIIKIAPAVAQAAM
DSGVATRPIQDMDAYREQLGATVYRTGMVMRPVFATAKKAAARIVFAEGEDERVLRAAQFVLLEKIAKPIIIGRPSVVEM
RLAKIGSKLKAGVDFEIVNPEDDTRYHRYWQAYHGIGARDGVTPEVAKAALRKFNTLIGAMLVHLGDADGMICGMIDTYH
SHLKFIEQVLGRAKGAEHFAAMNLLMLPGRNLFVCDTYVNELPSAEQLADMTIQAAAEIERFGIVPKAALLSNSNFGSAP
SASSRRMAEARKLIVERAPNLEVDGEMHGDAALSEAVRKAAFPGTTLSGEANLLIMPNVEAANIAYNLLKMVGGEGVTVG
PFLLGAAKPVHILTPAATVRRIINMTAVAAANVNTK

Specific function: Unknown

COG id: COG0281

COG function: function code C; Malic enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family [H]

Homologues:

Organism=Homo sapiens, GI4505143, Length=356, Percent_Identity=28.0898876404494, Blast_Score=93, Evalue=1e-18,
Organism=Homo sapiens, GI62420882, Length=353, Percent_Identity=26.628895184136, Blast_Score=83, Evalue=9e-16,
Organism=Homo sapiens, GI62420880, Length=353, Percent_Identity=26.628895184136, Blast_Score=83, Evalue=9e-16,
Organism=Homo sapiens, GI239049447, Length=353, Percent_Identity=26.628895184136, Blast_Score=83, Evalue=9e-16,
Organism=Homo sapiens, GI4505145, Length=359, Percent_Identity=27.0194986072423, Blast_Score=70, Evalue=5e-12,
Organism=Homo sapiens, GI270265879, Length=317, Percent_Identity=27.7602523659306, Blast_Score=67, Evalue=6e-11,
Organism=Escherichia coli, GI1788806, Length=758, Percent_Identity=64.5118733509235, Blast_Score=995, Evalue=0.0,
Organism=Escherichia coli, GI1788635, Length=341, Percent_Identity=29.9120234604106, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI1788800, Length=340, Percent_Identity=31.7647058823529, Blast_Score=136, Evalue=4e-33,
Organism=Escherichia coli, GI87081919, Length=411, Percent_Identity=23.3576642335766, Blast_Score=81, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6322823, Length=268, Percent_Identity=30.5970149253731, Blast_Score=98, Evalue=4e-21,
Organism=Drosophila melanogaster, GI21356279, Length=404, Percent_Identity=26.980198019802, Blast_Score=95, Evalue=1e-19,
Organism=Drosophila melanogaster, GI281362674, Length=404, Percent_Identity=26.980198019802, Blast_Score=95, Evalue=2e-19,
Organism=Drosophila melanogaster, GI281362672, Length=404, Percent_Identity=26.980198019802, Blast_Score=95, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24646388, Length=350, Percent_Identity=30.8571428571429, Blast_Score=90, Evalue=5e-18,
Organism=Drosophila melanogaster, GI24646386, Length=350, Percent_Identity=30.5714285714286, Blast_Score=90, Evalue=7e-18,
Organism=Drosophila melanogaster, GI78707242, Length=410, Percent_Identity=23.1707317073171, Blast_Score=69, Evalue=1e-11,
Organism=Drosophila melanogaster, GI78707238, Length=410, Percent_Identity=23.1707317073171, Blast_Score=69, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015884
- InterPro:   IPR012301
- InterPro:   IPR012302
- InterPro:   IPR012188
- InterPro:   IPR016040
- InterPro:   IPR002505 [H]

Pfam domain/function: PF00390 malic; PF03949 Malic_M; PF01515 PTA_PTB [H]

EC number: =1.1.1.40 [H]

Molecular weight: Translated: 80718; Mature: 80718

Theoretical pI: Translated: 6.22; Mature: 6.22

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.4 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MDEQLKQAALAYHQNPKPGKISVTPTKPLSNQLDLSLAYSPGVAAACEAIHADPLDAQKY
CCHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCEEEEECCCHHHHHHHHCCCCCCHHHH
TSRGNLVGVVTNGTAVLGLGNIGPLAAKPVMEGKGCLFKKFAGIDVFDIELSESDPDKLV
CCCCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCCHHHHHCCCEEEEEEECCCCHHHHH
EAIAMLEPTLGGINLEDIKAPECFYIEQKLRERMKIPVFHDDQHGTAIIASAAILNGLKV
HHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCCEECCCCCCCHHHHHHHHHHHHH
VGKNLADVKLVCSGAGAAAIACLDLLVNLGLTKSNILVTDSKGVIYEGRGNLDPSKQRYA
HCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEECCCCEEECCCCCCCCCHHHHC
ATTDARTLADAIVGADVFLGCSSAGVLKQDMVKAMADKPLILALANPEPEIRPEDAKAVR
CCCHHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCC
PDAIVATGRSDYPNQVNNVLCFPFIFRGALDVGATTITEEMKLACVRAIAELAQETDQSE
CCEEEECCCCCCCHHHCCEEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHH
EVAKAYEGHSLEFGPEYLIPKPFDPRLIIKIAPAVAQAAMDSGVATRPIQDMDAYREQLG
HHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHCCCCCCCHHHHHHHHHHHC
ATVYRTGMVMRPVFATAKKAAARIVFAEGEDERVLRAAQFVLLEKIAKPIIIGRPSVVEM
CHHHHCCCHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHCCEEECCCHHHHH
RLAKIGSKLKAGVDFEIVNPEDDTRYHRYWQAYHGIGARDGVTPEVAKAALRKFNTLIGA
HHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
MLVHLGDADGMICGMIDTYHSHLKFIEQVLGRAKGAEHFAAMNLLMLPGRNLFVCDTYVN
HHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHEEEECCCCEEEEEHHHH
ELPSAEQLADMTIQAAAEIERFGIVPKAALLSNSNFGSAPSASSRRMAEARKLIVERAPN
HCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
LEVDGEMHGDAALSEAVRKAAFPGTTLSGEANLLIMPNVEAANIAYNLLKMVGGEGVTVG
CCCCCCCCCHHHHHHHHHHHCCCCCEECCCCCEEEECCCCHHHHHHHHHHHHCCCCCEEH
PFLLGAAKPVHILTPAATVRRIINMTAVAAANVNTK
HHHHCCCCCEEEECCHHHHHHHHHHHHHEECCCCCC
>Mature Secondary Structure
MDEQLKQAALAYHQNPKPGKISVTPTKPLSNQLDLSLAYSPGVAAACEAIHADPLDAQKY
CCHHHHHHHHHHCCCCCCCEEEECCCCCCCCCCCEEEEECCCHHHHHHHHCCCCCCHHHH
TSRGNLVGVVTNGTAVLGLGNIGPLAAKPVMEGKGCLFKKFAGIDVFDIELSESDPDKLV
CCCCCEEEEEECCEEEEEECCCCCCCCCCCCCCCCCHHHHHCCCEEEEEEECCCCHHHHH
EAIAMLEPTLGGINLEDIKAPECFYIEQKLRERMKIPVFHDDQHGTAIIASAAILNGLKV
HHHHHHCCCCCCCCHHHCCCCCHHHHHHHHHHHCCCCCEECCCCCCCHHHHHHHHHHHHH
VGKNLADVKLVCSGAGAAAIACLDLLVNLGLTKSNILVTDSKGVIYEGRGNLDPSKQRYA
HCCCCCCEEEEECCCCHHHHHHHHHHHHCCCCCCCEEEECCCCEEECCCCCCCCCHHHHC
ATTDARTLADAIVGADVFLGCSSAGVLKQDMVKAMADKPLILALANPEPEIRPEDAKAVR
CCCHHHHHHHHHHCCHHHCCCCCCCHHHHHHHHHHCCCCEEEEECCCCCCCCCCCCCCCC
PDAIVATGRSDYPNQVNNVLCFPFIFRGALDVGATTITEEMKLACVRAIAELAQETDQSE
CCEEEECCCCCCCHHHCCEEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHCCCHH
EVAKAYEGHSLEFGPEYLIPKPFDPRLIIKIAPAVAQAAMDSGVATRPIQDMDAYREQLG
HHHHHHCCCCCCCCCCCCCCCCCCCEEEEEECHHHHHHHHHCCCCCCCHHHHHHHHHHHC
ATVYRTGMVMRPVFATAKKAAARIVFAEGEDERVLRAAQFVLLEKIAKPIIIGRPSVVEM
CHHHHCCCHHHHHHHHHHHHHEEEEEECCCCHHHHHHHHHHHHHHHHCCEEECCCHHHHH
RLAKIGSKLKAGVDFEIVNPEDDTRYHRYWQAYHGIGARDGVTPEVAKAALRKFNTLIGA
HHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHH
MLVHLGDADGMICGMIDTYHSHLKFIEQVLGRAKGAEHFAAMNLLMLPGRNLFVCDTYVN
HHHHCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHEEEECCCCEEEEEHHHH
ELPSAEQLADMTIQAAAEIERFGIVPKAALLSNSNFGSAPSASSRRMAEARKLIVERAPN
HCCCHHHHHHHHHHHHHHHHHHCCCCCHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCC
LEVDGEMHGDAALSEAVRKAAFPGTTLSGEANLLIMPNVEAANIAYNLLKMVGGEGVTVG
CCCCCCCCCHHHHHHHHHHHCCCCCEECCCCCEEEECCCCHHHHHHHHHHHHCCCCCEEH
PFLLGAAKPVHILTPAATVRRIINMTAVAAANVNTK
HHHHCCCCCEEEECCHHHHHHHHHHHHHEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9205837; 9278503; 36376 [H]