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The map label for this gene is macA [H]

Identifier: 161523387

GI number: 161523387

Start: 230229

End: 231431

Strand: Reverse

Name: macA [H]

Synonym: Bmul_0207

Alternate gene names: 161523387

Gene position: 231431-230229 (Counterclockwise)

Preceding gene: 161523389

Following gene: 161523386

Centisome position: 6.71

GC content: 71.4

Gene sequence:

>1203_bases
TTGCCCGATCACAATCTGGACAAGCTGAAGATCGACCGAGGCCCGATCGCAGCGCCGCGCCGGCGACGCTGGGTTCGCTA
TGCGGCCGTCGCGGCGCTCGCCGTCGTCGCGCTCCTCGCAGGCCTTACCGTCACACGCCGGCCGACCGTCGACACGACGG
CCGTCACGTCCGCGTATCCCTATCAGAACGACACGCAGCTGAACGCGACCGGCTACGTGGTCCCGCAGCGCAAGGCGGCC
GTCGCATCGAAGGGCCAGGGGCGCGTCGAATGGCTCGGCGTGCTCGAGGGCACGCGCGTGAAGAAGGACGAAATCATCGC
GCGGCTCGAAAGCCGCGACGTCGAAGCATCGCTCGCGCAGGCGCTTGCCCAGGTGAAGGTGGCGCGCGCGAACCTCGGCG
TGCAGCAGGCCGAGCTGAAGGATGCCGAGATCGCGCTGCGCCGCACCGCGGCGCTCGCGCCGCGCGGCGCCGTGCCGGCC
GCGCAGCTCGACACCGACACCGCACGCGTCAACAAGGCGCGCGCGTCGGTGAACAGCGGCGAGGCCGCCGTCGCGTCGGC
CGAAGCGAATGCCCGCGCCGCGCAGGTCGCAGTCGACCAGACGGTGATCCGCGCGCCGTTCGACGGGATCGTGCTGGCGA
AGCACGCGAACGTCGGCGACAACATCACGCCGTTCTCGTCCGCATCGGACAGCAAGGGCGCGGTCGTGACGATCGCCGAC
ATGGATACGCTCGAAGTCGAGGCCGACGTCGCCGAATCGAACATCGCGAAGATCCGCGCCGGGCAGCCGTGCGAAATCCA
GCTCGACGCGCTGCCCGACATGCGCTTCGCGGGCCGCGTGTCGCGGATCGTGCCGACCGTCGACCGCTCGAAGGCGACCG
TGCTCGTGAAGGTGCGCTTCGTCGATCGCGACGACCGCGTGCTGCCCGACATGAGCGCGAAGATCGCGTTCCTGTCGAAG
CCCGTGTCGGCGCAGGACCGCCAGCCGGTGACGGCCGTGCAGGCGAGCGCCGTCGTCGAGCGCGACGGCCGGCCGGTCGT
GTTCGCGCTGCAGGACGACACCGTGCACGCGGTGCCCGTCGCGCGCGGCGCGCGCATCGGCGAGCTGGTCGCGGTGCGCG
GCGTGAAGCCCGGCGACACGGTCGTGCTCGCGCCCGGCGCGGCGCTGAAGGACGGCGCGAAAGTGACCGTCGCGAAGAAG
TAG

Upstream 100 bases:

>100_bases
CGTTCGCGGCGACGCTATACTGAGCGACCTTCCGTCCCTTTCCCGGACACGCTCCCGGCACCGGACCGCGGCCCCGAGAC
CGCCGCCAAGAGGCACCCAA

Downstream 100 bases:

>100_bases
CGTGAGCGCCGCACCGCCGCCCCTCGTCGAGATCAGCCACGTCGCGAAGTCGTACCGGCGCGGCAGCCAGGTCGTGCCCG
TGCTGACCGACATCACGCTC

Product: RND family efflux transporter MFP subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 400; Mature: 399

Protein sequence:

>400_residues
MPDHNLDKLKIDRGPIAAPRRRRWVRYAAVAALAVVALLAGLTVTRRPTVDTTAVTSAYPYQNDTQLNATGYVVPQRKAA
VASKGQGRVEWLGVLEGTRVKKDEIIARLESRDVEASLAQALAQVKVARANLGVQQAELKDAEIALRRTAALAPRGAVPA
AQLDTDTARVNKARASVNSGEAAVASAEANARAAQVAVDQTVIRAPFDGIVLAKHANVGDNITPFSSASDSKGAVVTIAD
MDTLEVEADVAESNIAKIRAGQPCEIQLDALPDMRFAGRVSRIVPTVDRSKATVLVKVRFVDRDDRVLPDMSAKIAFLSK
PVSAQDRQPVTAVQASAVVERDGRPVVFALQDDTVHAVPVARGARIGELVAVRGVKPGDTVVLAPGAALKDGAKVTVAKK

Sequences:

>Translated_400_residues
MPDHNLDKLKIDRGPIAAPRRRRWVRYAAVAALAVVALLAGLTVTRRPTVDTTAVTSAYPYQNDTQLNATGYVVPQRKAA
VASKGQGRVEWLGVLEGTRVKKDEIIARLESRDVEASLAQALAQVKVARANLGVQQAELKDAEIALRRTAALAPRGAVPA
AQLDTDTARVNKARASVNSGEAAVASAEANARAAQVAVDQTVIRAPFDGIVLAKHANVGDNITPFSSASDSKGAVVTIAD
MDTLEVEADVAESNIAKIRAGQPCEIQLDALPDMRFAGRVSRIVPTVDRSKATVLVKVRFVDRDDRVLPDMSAKIAFLSK
PVSAQDRQPVTAVQASAVVERDGRPVVFALQDDTVHAVPVARGARIGELVAVRGVKPGDTVVLAPGAALKDGAKVTVAKK
>Mature_399_residues
PDHNLDKLKIDRGPIAAPRRRRWVRYAAVAALAVVALLAGLTVTRRPTVDTTAVTSAYPYQNDTQLNATGYVVPQRKAAV
ASKGQGRVEWLGVLEGTRVKKDEIIARLESRDVEASLAQALAQVKVARANLGVQQAELKDAEIALRRTAALAPRGAVPAA
QLDTDTARVNKARASVNSGEAAVASAEANARAAQVAVDQTVIRAPFDGIVLAKHANVGDNITPFSSASDSKGAVVTIADM
DTLEVEADVAESNIAKIRAGQPCEIQLDALPDMRFAGRVSRIVPTVDRSKATVLVKVRFVDRDDRVLPDMSAKIAFLSKP
VSAQDRQPVTAVQASAVVERDGRPVVFALQDDTVHAVPVARGARIGELVAVRGVKPGDTVVLAPGAALKDGAKVTVAKK

Specific function: Efflux transporter for macrolide antibiotics [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family [H]

Homologues:

Organism=Escherichia coli, GI87081796, Length=383, Percent_Identity=26.8929503916449, Blast_Score=89, Evalue=5e-19,
Organism=Escherichia coli, GI87082036, Length=358, Percent_Identity=27.3743016759777, Blast_Score=80, Evalue=2e-16,
Organism=Escherichia coli, GI1789900, Length=256, Percent_Identity=25, Blast_Score=62, Evalue=7e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006143 [H]

Pfam domain/function: PF00529 HlyD [H]

EC number: NA

Molecular weight: Translated: 42258; Mature: 42127

Theoretical pI: Translated: 10.41; Mature: 10.41

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.0 %Met     (Translated Protein)
1.2 %Cys+Met (Translated Protein)
0.3 %Cys     (Mature Protein)
0.8 %Met     (Mature Protein)
1.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDHNLDKLKIDRGPIAAPRRRRWVRYAAVAALAVVALLAGLTVTRRPTVDTTAVTSAYP
CCCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCEEEEECC
YQNDTQLNATGYVVPQRKAAVASKGQGRVEWLGVLEGTRVKKDEIIARLESRDVEASLAQ
CCCCCEECEEEEEECCHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHCCCHHHHHHH
ALAQVKVARANLGVQQAELKDAEIALRRTAALAPRGAVPAAQLDTDTARVNKARASVNSG
HHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHCCCCCCCCCHHCCCCHHHHHHHHHCCCCC
EAAVASAEANARAAQVAVDQTVIRAPFDGIVLAKHANVGDNITPFSSASDSKGAVVTIAD
CEEEEECCCCCHHHEEEHHHHHEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEEC
MDTLEVEADVAESNIAKIRAGQPCEIQLDALPDMRFAGRVSRIVPTVDRSKATVLVKVRF
CCEEEEECCCCCCCHHEEECCCCCEEEECCCCCCHHHHHHHHHCCCCCCCCEEEEEEEEE
VDRDDRVLPDMSAKIAFLSKPVSAQDRQPVTAVQASAVVERDGRPVVFALQDDTVHAVPV
ECCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCEEEEEC
ARGARIGELVAVRGVKPGDTVVLAPGAALKDGAKVTVAKK
CCCCCCCCEEEEECCCCCCEEEECCCCCCCCCCEEEEECC
>Mature Secondary Structure 
PDHNLDKLKIDRGPIAAPRRRRWVRYAAVAALAVVALLAGLTVTRRPTVDTTAVTSAYP
CCCCCCEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHCCEEECCCCCCCCEEEEECC
YQNDTQLNATGYVVPQRKAAVASKGQGRVEWLGVLEGTRVKKDEIIARLESRDVEASLAQ
CCCCCEECEEEEEECCHHHHHHCCCCCCEEEEEEECCCCCCHHHHHHHHHCCCHHHHHHH
ALAQVKVARANLGVQQAELKDAEIALRRTAALAPRGAVPAAQLDTDTARVNKARASVNSG
HHHHHHHHHHHCCCCHHHCCHHHHHHHHHHHCCCCCCCCCHHCCCCHHHHHHHHHCCCCC
EAAVASAEANARAAQVAVDQTVIRAPFDGIVLAKHANVGDNITPFSSASDSKGAVVTIAD
CEEEEECCCCCHHHEEEHHHHHEECCCCCEEEEEECCCCCCCCCCCCCCCCCCCEEEEEC
MDTLEVEADVAESNIAKIRAGQPCEIQLDALPDMRFAGRVSRIVPTVDRSKATVLVKVRF
CCEEEEECCCCCCCHHEEECCCCCEEEECCCCCCHHHHHHHHHCCCCCCCCEEEEEEEEE
VDRDDRVLPDMSAKIAFLSKPVSAQDRQPVTAVQASAVVERDGRPVVFALQDDTVHAVPV
ECCCCCCCCCCCCEEEEEECCCCCCCCCCHHHHHHHHHHCCCCCEEEEEEECCCEEEEEC
ARGARIGELVAVRGVKPGDTVVLAPGAALKDGAKVTVAKK
CCCCCCCCEEEEECCCCCCEEEECCCCCCCCCCEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]