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The map label for this gene is ahcY [H]

Identifier: 161523360

GI number: 161523360

Start: 203146

End: 204564

Strand: Direct

Name: ahcY [H]

Synonym: Bmul_0180

Alternate gene names: 161523360

Gene position: 203146-204564 (Clockwise)

Preceding gene: 161523359

Following gene: 161523361

Centisome position: 5.89

GC content: 64.06

Gene sequence:

>1419_bases
ATGAGCGCCGTTATCGATTCGAAAGCTTCCCAGGACTACGTCGTCGCCGACATGGCACTTGCCGGCTGGGGCCGCAAGGA
GCTGAACATCGCCGAGACCGAAATGCCGGGCCTCGTGCAGATCCGCGACGAATACAAGGCGCAGCAGCCGCTGAAGGGCG
CGCGCATCGCCGGTTCGCTGCACATGACGATCCAGACCGGCGTGCTGATCGAGACGCTGAAGGCGCTCGGCGCCGACGTG
CGTTGGGCTTCGTGCAACATCTTCTCGACGCAGGACCACGCGGCTGCCGCGATCGTCGAAGCCGGCACGCCGGTGTTCGC
GTTCAAGGGCGAATCGCTCGACGAATACTGGGAGTTCTCGCACCGCATCTTCGAATGGCCGAACGGCGAGTTCGCGAACA
TGATCCTCGACGACGGCGGCGATGCGACGCTGCTGCTGATCCTCGGCGCGAAGGCCGAGAAGGACCGCTCGGTGATCGCG
AAGCCGACCAACGAGGAAGAAGTCGCGCTGTACAAGTCGATCGCGCGTCACCTCGACATCGACGCGAACTGGTACTCGAA
GCGCCTCGCGCACATCAAGGGCGTGACCGAAGAAACGACGACCGGCGTGCACCGCCTGTACCAGATGGAAAAGGACGGCC
GCCTGCCGTTCCCGGCGTTCAACGTGAACGACTCGGTCACGAAGTCGAAGTTCGACAACCTGTACGGCTGCCGCGAGTCG
CTCGTCGACGGCATCAAGCGCGCGACCGACGTGATGATCGCGGGCAAGGTCGCGGTCGTCGCGGGCTACGGCGACGTGGG
CAAGGGCTGCGCGCAGTCGCTGCGCGGCCTCGGCGCGACCGTGTGGGTCACCGAAATCGATCCGATCTGCGCGCTGCAGG
CGGCGATGGAAGGCTACCGCGTCGTGACGATGGAATACGCGGCCGACAAGGCCGACATCTTCGTGACCGCGACCGGCAAC
TATCACGTGATCACGCACGATCACATGAAGGCGATGCGCCACAACGCGATCGTCTGCAACATCGGCCACTTCGATTCGGA
AATCGACGTCGCGTCGACGCGCCAGTACCAGTGGGAAAACATCAAGCCGCAGGTCGACCACATCATCTTCCCGGACGGCA
AGCGCATCATCCTGCTGGCCGAAGGCCGCCTCGTGAACCTCGGCTGCGCGACCGGCCACCCGTCGTTCGTGATGTCGAAC
TCGTTCGCGAACCAGACGCTCGCGCAGATCGAACTGTTCACGCGCGGCGACCAGTACGAGAACAAGGTCTACGTGCTGCC
GAAGCATCTCGACGAGAAGGTCGCGCGTCTGCACCTCGCACGCATCGGCGCGCAGCTGTCGACGCTGTCGGACGAGCAGG
CCGCGTACATCGGCGTGCAGAAGGAAGGTCCGTTCAAGCCGAACCACTACCGCTACTGA

Upstream 100 bases:

>100_bases
GGCTTCACCAGGCAGCCGTGCGGCGACATTCGCGCCGGCCCGCCTCCTGAACGGCGCTCACGTCATCAATTTCTAGAACT
TTTTTAGAAAGGAGGGCGTG

Downstream 100 bases:

>100_bases
TGCGTGCCGCCGCTGCCGCGCCGCCTGCGCCTCGCGCACACGCGGCGCGGCAGCGCGGCGTCATCCGGCCGGGCGGCCCG
CCGCATGCATGTGCGCGCGG

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 472; Mature: 471

Protein sequence:

>472_residues
MSAVIDSKASQDYVVADMALAGWGRKELNIAETEMPGLVQIRDEYKAQQPLKGARIAGSLHMTIQTGVLIETLKALGADV
RWASCNIFSTQDHAAAAIVEAGTPVFAFKGESLDEYWEFSHRIFEWPNGEFANMILDDGGDATLLLILGAKAEKDRSVIA
KPTNEEEVALYKSIARHLDIDANWYSKRLAHIKGVTEETTTGVHRLYQMEKDGRLPFPAFNVNDSVTKSKFDNLYGCRES
LVDGIKRATDVMIAGKVAVVAGYGDVGKGCAQSLRGLGATVWVTEIDPICALQAAMEGYRVVTMEYAADKADIFVTATGN
YHVITHDHMKAMRHNAIVCNIGHFDSEIDVASTRQYQWENIKPQVDHIIFPDGKRIILLAEGRLVNLGCATGHPSFVMSN
SFANQTLAQIELFTRGDQYENKVYVLPKHLDEKVARLHLARIGAQLSTLSDEQAAYIGVQKEGPFKPNHYRY

Sequences:

>Translated_472_residues
MSAVIDSKASQDYVVADMALAGWGRKELNIAETEMPGLVQIRDEYKAQQPLKGARIAGSLHMTIQTGVLIETLKALGADV
RWASCNIFSTQDHAAAAIVEAGTPVFAFKGESLDEYWEFSHRIFEWPNGEFANMILDDGGDATLLLILGAKAEKDRSVIA
KPTNEEEVALYKSIARHLDIDANWYSKRLAHIKGVTEETTTGVHRLYQMEKDGRLPFPAFNVNDSVTKSKFDNLYGCRES
LVDGIKRATDVMIAGKVAVVAGYGDVGKGCAQSLRGLGATVWVTEIDPICALQAAMEGYRVVTMEYAADKADIFVTATGN
YHVITHDHMKAMRHNAIVCNIGHFDSEIDVASTRQYQWENIKPQVDHIIFPDGKRIILLAEGRLVNLGCATGHPSFVMSN
SFANQTLAQIELFTRGDQYENKVYVLPKHLDEKVARLHLARIGAQLSTLSDEQAAYIGVQKEGPFKPNHYRY
>Mature_471_residues
SAVIDSKASQDYVVADMALAGWGRKELNIAETEMPGLVQIRDEYKAQQPLKGARIAGSLHMTIQTGVLIETLKALGADVR
WASCNIFSTQDHAAAAIVEAGTPVFAFKGESLDEYWEFSHRIFEWPNGEFANMILDDGGDATLLLILGAKAEKDRSVIAK
PTNEEEVALYKSIARHLDIDANWYSKRLAHIKGVTEETTTGVHRLYQMEKDGRLPFPAFNVNDSVTKSKFDNLYGCRESL
VDGIKRATDVMIAGKVAVVAGYGDVGKGCAQSLRGLGATVWVTEIDPICALQAAMEGYRVVTMEYAADKADIFVTATGNY
HVITHDHMKAMRHNAIVCNIGHFDSEIDVASTRQYQWENIKPQVDHIIFPDGKRIILLAEGRLVNLGCATGHPSFVMSNS
FANQTLAQIELFTRGDQYENKVYVLPKHLDEKVARLHLARIGAQLSTLSDEQAAYIGVQKEGPFKPNHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=462, Percent_Identity=59.3073593073593, Blast_Score=526, Evalue=1e-149,
Organism=Homo sapiens, GI239937451, Length=440, Percent_Identity=58.8636363636364, Blast_Score=496, Evalue=1e-140,
Organism=Homo sapiens, GI298286489, Length=470, Percent_Identity=50.4255319148936, Blast_Score=478, Evalue=1e-135,
Organism=Homo sapiens, GI24308043, Length=470, Percent_Identity=50.4255319148936, Blast_Score=477, Evalue=1e-134,
Organism=Homo sapiens, GI195539337, Length=470, Percent_Identity=50.4255319148936, Blast_Score=477, Evalue=1e-134,
Organism=Homo sapiens, GI195539349, Length=470, Percent_Identity=50.4255319148936, Blast_Score=477, Evalue=1e-134,
Organism=Homo sapiens, GI21361647, Length=470, Percent_Identity=49.7872340425532, Blast_Score=458, Evalue=1e-129,
Organism=Caenorhabditis elegans, GI17506425, Length=465, Percent_Identity=59.3548387096774, Blast_Score=528, Evalue=1e-150,
Organism=Saccharomyces cerevisiae, GI6320882, Length=483, Percent_Identity=57.3498964803313, Blast_Score=515, Evalue=1e-147,
Organism=Drosophila melanogaster, GI24642172, Length=462, Percent_Identity=59.95670995671, Blast_Score=533, Evalue=1e-152,
Organism=Drosophila melanogaster, GI24656245, Length=471, Percent_Identity=50.5307855626327, Blast_Score=471, Evalue=1e-133,
Organism=Drosophila melanogaster, GI45553387, Length=469, Percent_Identity=49.680170575693, Blast_Score=449, Evalue=1e-126,
Organism=Drosophila melanogaster, GI45553385, Length=468, Percent_Identity=49.5726495726496, Blast_Score=446, Evalue=1e-125,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 52210; Mature: 52079

Theoretical pI: Translated: 6.20; Mature: 6.20

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSAVIDSKASQDYVVADMALAGWGRKELNIAETEMPGLVQIRDEYKAQQPLKGARIAGSL
CCCCCCCCCCCCEEEEEHHHHCCCCCCCEEECCCCCCEEEEHHHHCCCCCCCCCEEECEE
HMTIQTGVLIETLKALGADVRWASCNIFSTQDHAAAAIVEAGTPVFAFKGESLDEYWEFS
EEEEECCHHHHHHHHHCCCCEEEEEEEECCCCCHHEEEEECCCEEEEEECCCHHHHHHHH
HRIFEWPNGEFANMILDDGGDATLLLILGAKAEKDRSVIAKPTNEEEVALYKSIARHLDI
HHEEECCCCCEEEEEEECCCCEEEEEEEECCCCCCCCEEECCCCCHHHHHHHHHHHHCCC
DANWYSKRLAHIKGVTEETTTGVHRLYQMEKDGRLPFPAFNVNDSVTKSKFDNLYGCRES
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCEECCCCCHHHHHHHHHHHHHHH
LVDGIKRATDVMIAGKVAVVAGYGDVGKGCAQSLRGLGATVWVTEIDPICALQAAMEGYR
HHHHHHHHHHEEEECCEEEEECCCCCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHCCEE
VVTMEYAADKADIFVTATGNYHVITHDHMKAMRHNAIVCNIGHFDSEIDVASTRQYQWEN
EEEEEECCCCCCEEEEECCCEEEEEHHHHHHHHCCEEEEEECCCCCCCCCCCCCCEECCC
IKPQVDHIIFPDGKRIILLAEGRLVNLGCATGHPSFVMSNSFANQTLAQIELFTRGDQYE
CCCCCCEEECCCCCEEEEEECCEEEEEEECCCCCCEEEECCHHHHHEEEEEEEECCCCCC
NKVYVLPKHLDEKVARLHLARIGAQLSTLSDEQAAYIGVQKEGPFKPNHYRY
CEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCC
>Mature Secondary Structure 
SAVIDSKASQDYVVADMALAGWGRKELNIAETEMPGLVQIRDEYKAQQPLKGARIAGSL
CCCCCCCCCCCEEEEEHHHHCCCCCCCEEECCCCCCEEEEHHHHCCCCCCCCCEEECEE
HMTIQTGVLIETLKALGADVRWASCNIFSTQDHAAAAIVEAGTPVFAFKGESLDEYWEFS
EEEEECCHHHHHHHHHCCCCEEEEEEEECCCCCHHEEEEECCCEEEEEECCCHHHHHHHH
HRIFEWPNGEFANMILDDGGDATLLLILGAKAEKDRSVIAKPTNEEEVALYKSIARHLDI
HHEEECCCCCEEEEEEECCCCEEEEEEEECCCCCCCCEEECCCCCHHHHHHHHHHHHCCC
DANWYSKRLAHIKGVTEETTTGVHRLYQMEKDGRLPFPAFNVNDSVTKSKFDNLYGCRES
CCCHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCCCCCCEECCCCCHHHHHHHHHHHHHHH
LVDGIKRATDVMIAGKVAVVAGYGDVGKGCAQSLRGLGATVWVTEIDPICALQAAMEGYR
HHHHHHHHHHEEEECCEEEEECCCCCCHHHHHHHHHCCCEEEEEECCHHHHHHHHHCCEE
VVTMEYAADKADIFVTATGNYHVITHDHMKAMRHNAIVCNIGHFDSEIDVASTRQYQWEN
EEEEEECCCCCCEEEEECCCEEEEEHHHHHHHHCCEEEEEECCCCCCCCCCCCCCEECCC
IKPQVDHIIFPDGKRIILLAEGRLVNLGCATGHPSFVMSNSFANQTLAQIELFTRGDQYE
CCCCCCEEECCCCCEEEEEECCEEEEEEECCCCCCEEEECCHHHHHEEEEEEEECCCCCC
NKVYVLPKHLDEKVARLHLARIGAQLSTLSDEQAAYIGVQKEGPFKPNHYRY
CEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA