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The map label for this gene is phhA [H]

Identifier: 161523258

GI number: 161523258

Start: 82972

End: 83946

Strand: Reverse

Name: phhA [H]

Synonym: Bmul_0078

Alternate gene names: 161523258

Gene position: 83946-82972 (Counterclockwise)

Preceding gene: 161523260

Following gene: 161523257

Centisome position: 2.43

GC content: 67.9

Gene sequence:

>975_bases
ATGCGCCAATTTTGCGCCCAAGCCGCGCGTAACCCGCTCTACACTTGCATGCATCCAAAACCACAGCATGCCGAGCGTCT
CATGTCCACCGTCGTCACCGCGAAACTGCAGGAGCAGTTCGATGCGGGCCTCGAAACCCGCGCCGATTTCACCATCGACC
AGCCGCTGCAGCGTTACGGCCGCGTCGACCACGCGGTGTGGCAGCAGCTCTATGCGCGCCAGTCGGCGCTGCTGCGCGGG
CGCGCATGCGACGCGTTCGTCGCCGGGCTCGGCAACATCGACCTGCCGGCCGATCGCGTGCCCTCGTTCGCGGACGTGAA
CCGTCAACTGATGCCGGCAACGGGCTGGCAGATCGTCGCGGTGCCGGGCCTCGTGCCCGATCGCGTGTTCTTCGAACACC
TCGCGAACCGGCGCTTTCCGGTCACCTGGTGGATGCGTCGCCCCGATCAGCTCGACTACCTGCAGGAGCCCGACTGCTTC
CACGACCTGTTCGGCCACGTGCCGCTGCTGATCGAGCCCGTTTTTGCCGACTACATGCAGGCATACGGCCGCATCGCGCT
CGCGGTCGCCGACGACGAAGCGGCGCTCGCGCGCCTCGCGCGGCTCTACTGGTATACGGTCGAATTCGGGCTGATCCGCG
ACGGGCGCGGCCCCGGCGGGCTATCGATCTACGGCGCCGGCATCGTGTCGAGCAAGGGCGAGAGCCTGTACAGCGTCGAA
AGCGCGGCGCCGAACCGGCTCGGCTTCGATCTCGAGCGCGTGATGCGCACGCGTTACCGGATCGATACGTTCCAGAAGAC
CTACTTCGTGATCGACGATTTCGCGCAGCTGTTCGCGCTGGCGGAGCTCGATGGCCGCGCGCTCGCCGCGCGCCTCGCGG
GGCTGCCGGAGTTCGACGCCGGCGCGGTGCTCGACACCGATCGCGTGCTGCATCGCGGCACCGGCGAAGGCTGGCCCGAC
GACGCCGACGCGTAA

Upstream 100 bases:

>100_bases
CACGTCCAGCAGCGCGAGATCGAAGTGATCGAGTTCCAGCATGTCCATCCTCCGCATGATTCGATGATTTAATGCGCGAT
TATCGCATTACATCCTGAAT

Downstream 100 bases:

>100_bases
TGTGACGCACGCCGCACGTGCCGACGCGCGGCGCGCAACTATGAAAGAATGACCGGTGCCGGCCCCGCCGCGCGGCGCAT
GCCGCGCGCGAGCGCCGTTA

Product: phenylalanine 4-monooxygenase

Products: NA

Alternate protein names: PAH; Phe-4-monooxygenase [H]

Number of amino acids: Translated: 324; Mature: 324

Protein sequence:

>324_residues
MRQFCAQAARNPLYTCMHPKPQHAERLMSTVVTAKLQEQFDAGLETRADFTIDQPLQRYGRVDHAVWQQLYARQSALLRG
RACDAFVAGLGNIDLPADRVPSFADVNRQLMPATGWQIVAVPGLVPDRVFFEHLANRRFPVTWWMRRPDQLDYLQEPDCF
HDLFGHVPLLIEPVFADYMQAYGRIALAVADDEAALARLARLYWYTVEFGLIRDGRGPGGLSIYGAGIVSSKGESLYSVE
SAAPNRLGFDLERVMRTRYRIDTFQKTYFVIDDFAQLFALAELDGRALAARLAGLPEFDAGAVLDTDRVLHRGTGEGWPD
DADA

Sequences:

>Translated_324_residues
MRQFCAQAARNPLYTCMHPKPQHAERLMSTVVTAKLQEQFDAGLETRADFTIDQPLQRYGRVDHAVWQQLYARQSALLRG
RACDAFVAGLGNIDLPADRVPSFADVNRQLMPATGWQIVAVPGLVPDRVFFEHLANRRFPVTWWMRRPDQLDYLQEPDCF
HDLFGHVPLLIEPVFADYMQAYGRIALAVADDEAALARLARLYWYTVEFGLIRDGRGPGGLSIYGAGIVSSKGESLYSVE
SAAPNRLGFDLERVMRTRYRIDTFQKTYFVIDDFAQLFALAELDGRALAARLAGLPEFDAGAVLDTDRVLHRGTGEGWPD
DADA
>Mature_324_residues
MRQFCAQAARNPLYTCMHPKPQHAERLMSTVVTAKLQEQFDAGLETRADFTIDQPLQRYGRVDHAVWQQLYARQSALLRG
RACDAFVAGLGNIDLPADRVPSFADVNRQLMPATGWQIVAVPGLVPDRVFFEHLANRRFPVTWWMRRPDQLDYLQEPDCF
HDLFGHVPLLIEPVFADYMQAYGRIALAVADDEAALARLARLYWYTVEFGLIRDGRGPGGLSIYGAGIVSSKGESLYSVE
SAAPNRLGFDLERVMRTRYRIDTFQKTYFVIDDFAQLFALAELDGRALAARLAGLPEFDAGAVLDTDRVLHRGTGEGWPD
DADA

Specific function: Unknown

COG id: COG3186

COG function: function code E; Phenylalanine-4-hydroxylase

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the biopterin-dependent aromatic amino acid hydroxylase family [H]

Homologues:

Organism=Homo sapiens, GI88900503, Length=278, Percent_Identity=32.7338129496403, Blast_Score=131, Evalue=9e-31,
Organism=Homo sapiens, GI88900505, Length=225, Percent_Identity=34.6666666666667, Blast_Score=131, Evalue=1e-30,
Organism=Homo sapiens, GI88900501, Length=225, Percent_Identity=34.6666666666667, Blast_Score=130, Evalue=1e-30,
Organism=Homo sapiens, GI4557819, Length=227, Percent_Identity=32.5991189427313, Blast_Score=120, Evalue=2e-27,
Organism=Homo sapiens, GI4759248, Length=224, Percent_Identity=32.5892857142857, Blast_Score=112, Evalue=4e-25,
Organism=Homo sapiens, GI31795563, Length=229, Percent_Identity=32.3144104803493, Blast_Score=111, Evalue=9e-25,
Organism=Caenorhabditis elegans, GI71980736, Length=229, Percent_Identity=33.1877729257642, Blast_Score=127, Evalue=8e-30,
Organism=Caenorhabditis elegans, GI17531391, Length=225, Percent_Identity=34.6666666666667, Blast_Score=123, Evalue=2e-28,
Organism=Caenorhabditis elegans, GI115532103, Length=239, Percent_Identity=30.9623430962343, Blast_Score=114, Evalue=8e-26,
Organism=Caenorhabditis elegans, GI115533973, Length=239, Percent_Identity=30.9623430962343, Blast_Score=114, Evalue=1e-25,
Organism=Caenorhabditis elegans, GI71980731, Length=150, Percent_Identity=31.3333333333333, Blast_Score=91, Evalue=1e-18,
Organism=Drosophila melanogaster, GI62472054, Length=224, Percent_Identity=33.9285714285714, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI24660393, Length=224, Percent_Identity=33.9285714285714, Blast_Score=124, Evalue=1e-28,
Organism=Drosophila melanogaster, GI17136776, Length=224, Percent_Identity=29.9107142857143, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI17136774, Length=224, Percent_Identity=29.9107142857143, Blast_Score=112, Evalue=4e-25,
Organism=Drosophila melanogaster, GI24654994, Length=199, Percent_Identity=35.678391959799, Blast_Score=111, Evalue=6e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001273
- InterPro:   IPR018301
- InterPro:   IPR019774
- InterPro:   IPR005960 [H]

Pfam domain/function: PF00351 Biopterin_H [H]

EC number: =1.14.16.1 [H]

Molecular weight: Translated: 36414; Mature: 36414

Theoretical pI: Translated: 5.40; Mature: 5.40

Prosite motif: PS00367 BIOPTERIN_HYDROXYL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRQFCAQAARNPLYTCMHPKPQHAERLMSTVVTAKLQEQFDAGLETRADFTIDQPLQRYG
CHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHC
RVDHAVWQQLYARQSALLRGRACDAFVAGLGNIDLPADRVPSFADVNRQLMPATGWQIVA
CHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCHHHCCCHHHCCCCCCCCCCCEEEE
VPGLVPDRVFFEHLANRRFPVTWWMRRPDQLDYLQEPDCFHDLFGHVPLLIEPVFADYMQ
ECCCCCHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHH
AYGRIALAVADDEAALARLARLYWYTVEFGLIRDGRGPGGLSIYGAGIVSSKGESLYSVE
HCCCEEEEEECCHHHHHHHHHHHHHHHEEEEEECCCCCCCEEEEECCEECCCCCCEEEHH
SAAPNRLGFDLERVMRTRYRIDTFQKTYFVIDDFAQLFALAELDGRALAARLAGLPEFDA
HCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCC
GAVLDTDRVLHRGTGEGWPDDADA
CCEECHHHHHHCCCCCCCCCCCCC
>Mature Secondary Structure
MRQFCAQAARNPLYTCMHPKPQHAERLMSTVVTAKLQEQFDAGLETRADFTIDQPLQRYG
CHHHHHHHHCCCCEEECCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHHHHHHC
RVDHAVWQQLYARQSALLRGRACDAFVAGLGNIDLPADRVPSFADVNRQLMPATGWQIVA
CHHHHHHHHHHHHHHHHHHCCCHHHHHHCCCCCCCCHHHCCCHHHCCCCCCCCCCCEEEE
VPGLVPDRVFFEHLANRRFPVTWWMRRPDQLDYLQEPDCFHDLFGHVPLLIEPVFADYMQ
ECCCCCHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCHHHHHHCCCHHHHHHHHHHHHH
AYGRIALAVADDEAALARLARLYWYTVEFGLIRDGRGPGGLSIYGAGIVSSKGESLYSVE
HCCCEEEEEECCHHHHHHHHHHHHHHHEEEEEECCCCCCCEEEEECCEECCCCCCEEEHH
SAAPNRLGFDLERVMRTRYRIDTFQKTYFVIDDFAQLFALAELDGRALAARLAGLPEFDA
HCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCCCCC
GAVLDTDRVLHRGTGEGWPDDADA
CCEECHHHHHHCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11823852 [H]