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The map label for this gene is srrB [H]

Identifier: 161509720

GI number: 161509720

Start: 1609121

End: 1610815

Strand: Reverse

Name: srrB [H]

Synonym: USA300HOU_1493

Alternate gene names: 161509720

Gene position: 1610815-1609121 (Counterclockwise)

Preceding gene: 161509721

Following gene: 161509719

Centisome position: 56.07

GC content: 33.22

Gene sequence:

>1695_bases
GTGACGACAGTTTTAATTTTATTAAGTATTGCTTTAATTACCTTTATGCAATACTATTTCACACAAGAAACCGAAAATGC
CATAAGAGAAGATGCTAGACGTATAAGTTCACTGGTCGAACAATCACATAATAAAGAAGAAGCAATAAAATATAGTCAAA
CATTAATTGAAAATCCTGGTGGGTTGATGATTATAAATAATAAACATCGTCAATCAACGGCTTCACTTTCTAATATTAAA
AAGCAAATGTTGAATGAAGTAGTCAACAACGACCATTTTGACGATGTGTTTGATAAAGGTAAATCTGTTACTCGAAATGT
AACGATTAAAGAAAAGGGCTCATCTCAAACATATATTTTGTTAGGCTATCCAACAAAAGCACAGAAGAATAGTCATAGCA
AATATAGTGGAGTCTTTATATATAAAGACTTGAAATCAATCGAAGATACAAATAATGCTATTACGATTATCACCATAATT
ACGGCTGTTATTTTCTTAACAATTACAACAGTCTTTGCGTTTTTCTTATCGTCAAGAATTACAAAACCTTTAAGACGTTT
AAGAGACCAAGCTACACGTGTATCTGAAGGGGATTACTCTTATAAACCTTCTGTCACAACGAAAGATGAAATTGGTCAAT
TATCGCAGGCATTTAATCAGATGAGTACAGAAATCGAAGAGCATGTCGACGCATTATCCACATCTAAAAATATTAGAGAC
AGCTTAATTAACTCTATGGTAGAAGGTGTCCTAGGTATTAATGAGAGTCGACAAATTATCTTATCTAATAAGATGGCGAA
TGATATTATGGACAATATTGATGAAGATGCTAAAGCTTTCTTATTAAGACAAATAGAAGATACTTTTAAATCAAAACAAA
CTGAAATGCGCGATTTAGAAATGAATGCACGATTCTTTGTTGTGACCACAAGCTATATCGACAAGATTGAACAGGGAGGT
AAAAGTGGTGTTGTTGTGACAGTTCGTGATATGACTAATGAGCACAATCTAGATCAAATGAAGAAAGATTTCATTGCTAA
TGTATCACATGAATTACGTACACCGATATCATTACTTCAAGGTTATACTGAATCAATTGTAGATGGTATTGTTACAGAAC
CGGATGAAATAAAAGAATCGCTTGCCATTGTCCTTGATGAATCGAAACGTTTAAATCGTTTAGTTAATGAATTGTTAAAT
GTCGCACGCATGGATGCTGAAGGGTTATCCGTAAATAAAGAAGTTCAGCCTATTGCAGCGTTACTAGATAAGATGAAAAT
TAAGTATCGCCAACAAGCTGATGATTTAGGTCTAAATATGACTTTTAATTATTGTAAGAAGCGTGTTTGGAGTTATGATA
TGGATCGCATGGACCAAGTACTAACGAACTTAATTGATAATGCATCACGTTATACGAAACCTGGAGATGAAATTGCAATT
ACTTGTGATGAAAATGAAAGCGAAGATATTTTATACATTAAAGATACAGGTACAGGCATTGCACCAGAACATTTACAACA
AGTATTTGATCGTTTTTATAAAGTTGATGCAGCGAGAACGCGAGGTAAACAAGGTACCGGTTTAGGTTTGTTCATTTGTA
AAATGATTATCGAAGAGCATGGTGGTTCCATAGATGTTAAAAGCGAATTAGGGAAAGGCACAACATTTATTATTAAACTA
CCAAAACCAGAATAA

Upstream 100 bases:

>100_bases
CAAACAGTCTGGGGCGTTGGGTATAAATTTGAGGTTAAATCTAATGATGAGCCGGCTAAATAGTGTCGTAATTAAACTGT
GGTTAACTATTATTTTAATA

Downstream 100 bases:

>100_bases
AATTGAATATAGTTATTTCAGAACGCATGTTATTGATTAGAGACTCTAATTTATAGCATGCGTTTTTTGATTGATGTGGG
GAATTTTGTATGTGGATTAG

Product: sensor histidine kinase SrrB

Products: NA

Alternate protein names: Staphylococcal respiratory response protein B [H]

Number of amino acids: Translated: 564; Mature: 563

Protein sequence:

>564_residues
MTTVLILLSIALITFMQYYFTQETENAIREDARRISSLVEQSHNKEEAIKYSQTLIENPGGLMIINNKHRQSTASLSNIK
KQMLNEVVNNDHFDDVFDKGKSVTRNVTIKEKGSSQTYILLGYPTKAQKNSHSKYSGVFIYKDLKSIEDTNNAITIITII
TAVIFLTITTVFAFFLSSRITKPLRRLRDQATRVSEGDYSYKPSVTTKDEIGQLSQAFNQMSTEIEEHVDALSTSKNIRD
SLINSMVEGVLGINESRQIILSNKMANDIMDNIDEDAKAFLLRQIEDTFKSKQTEMRDLEMNARFFVVTTSYIDKIEQGG
KSGVVVTVRDMTNEHNLDQMKKDFIANVSHELRTPISLLQGYTESIVDGIVTEPDEIKESLAIVLDESKRLNRLVNELLN
VARMDAEGLSVNKEVQPIAALLDKMKIKYRQQADDLGLNMTFNYCKKRVWSYDMDRMDQVLTNLIDNASRYTKPGDEIAI
TCDENESEDILYIKDTGTGIAPEHLQQVFDRFYKVDAARTRGKQGTGLGLFICKMIIEEHGGSIDVKSELGKGTTFIIKL
PKPE

Sequences:

>Translated_564_residues
MTTVLILLSIALITFMQYYFTQETENAIREDARRISSLVEQSHNKEEAIKYSQTLIENPGGLMIINNKHRQSTASLSNIK
KQMLNEVVNNDHFDDVFDKGKSVTRNVTIKEKGSSQTYILLGYPTKAQKNSHSKYSGVFIYKDLKSIEDTNNAITIITII
TAVIFLTITTVFAFFLSSRITKPLRRLRDQATRVSEGDYSYKPSVTTKDEIGQLSQAFNQMSTEIEEHVDALSTSKNIRD
SLINSMVEGVLGINESRQIILSNKMANDIMDNIDEDAKAFLLRQIEDTFKSKQTEMRDLEMNARFFVVTTSYIDKIEQGG
KSGVVVTVRDMTNEHNLDQMKKDFIANVSHELRTPISLLQGYTESIVDGIVTEPDEIKESLAIVLDESKRLNRLVNELLN
VARMDAEGLSVNKEVQPIAALLDKMKIKYRQQADDLGLNMTFNYCKKRVWSYDMDRMDQVLTNLIDNASRYTKPGDEIAI
TCDENESEDILYIKDTGTGIAPEHLQQVFDRFYKVDAARTRGKQGTGLGLFICKMIIEEHGGSIDVKSELGKGTTFIIKL
PKPE
>Mature_563_residues
TTVLILLSIALITFMQYYFTQETENAIREDARRISSLVEQSHNKEEAIKYSQTLIENPGGLMIINNKHRQSTASLSNIKK
QMLNEVVNNDHFDDVFDKGKSVTRNVTIKEKGSSQTYILLGYPTKAQKNSHSKYSGVFIYKDLKSIEDTNNAITIITIIT
AVIFLTITTVFAFFLSSRITKPLRRLRDQATRVSEGDYSYKPSVTTKDEIGQLSQAFNQMSTEIEEHVDALSTSKNIRDS
LINSMVEGVLGINESRQIILSNKMANDIMDNIDEDAKAFLLRQIEDTFKSKQTEMRDLEMNARFFVVTTSYIDKIEQGGK
SGVVVTVRDMTNEHNLDQMKKDFIANVSHELRTPISLLQGYTESIVDGIVTEPDEIKESLAIVLDESKRLNRLVNELLNV
ARMDAEGLSVNKEVQPIAALLDKMKIKYRQQADDLGLNMTFNYCKKRVWSYDMDRMDQVLTNLIDNASRYTKPGDEIAIT
CDENESEDILYIKDTGTGIAPEHLQQVFDRFYKVDAARTRGKQGTGLGLFICKMIIEEHGGSIDVKSELGKGTTFIIKLP
KPE

Specific function: Member of the two-component regulatory system srrA/srrB, which is involved in the global regulation of staphylococcal virulence factors in response to environmental oxygen levels. Probably phosphorylates srrA [H]

COG id: COG0642

COG function: function code T; Signal transduction histidine kinase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 histidine kinase domain [H]

Homologues:

Organism=Escherichia coli, GI1786600, Length=336, Percent_Identity=28.2738095238095, Blast_Score=133, Evalue=3e-32,
Organism=Escherichia coli, GI1788393, Length=223, Percent_Identity=32.2869955156951, Blast_Score=132, Evalue=4e-32,
Organism=Escherichia coli, GI1786783, Length=221, Percent_Identity=34.3891402714932, Blast_Score=125, Evalue=5e-30,
Organism=Escherichia coli, GI1788713, Length=228, Percent_Identity=29.3859649122807, Blast_Score=102, Evalue=7e-23,
Organism=Escherichia coli, GI48994928, Length=465, Percent_Identity=24.0860215053763, Blast_Score=100, Evalue=3e-22,
Organism=Escherichia coli, GI1790436, Length=239, Percent_Identity=29.7071129707113, Blast_Score=99, Evalue=5e-22,
Organism=Escherichia coli, GI1789149, Length=226, Percent_Identity=30.5309734513274, Blast_Score=99, Evalue=8e-22,
Organism=Escherichia coli, GI145693157, Length=232, Percent_Identity=30.6034482758621, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI1790346, Length=268, Percent_Identity=26.4925373134328, Blast_Score=94, Evalue=3e-20,
Organism=Escherichia coli, GI1786912, Length=229, Percent_Identity=28.82096069869, Blast_Score=92, Evalue=6e-20,
Organism=Escherichia coli, GI1788549, Length=423, Percent_Identity=23.8770685579196, Blast_Score=90, Evalue=5e-19,
Organism=Escherichia coli, GI1787894, Length=222, Percent_Identity=31.0810810810811, Blast_Score=84, Evalue=3e-17,
Organism=Escherichia coli, GI87081816, Length=237, Percent_Identity=27.4261603375527, Blast_Score=83, Evalue=5e-17,
Organism=Escherichia coli, GI1788279, Length=229, Percent_Identity=32.7510917030568, Blast_Score=75, Evalue=1e-14,
Organism=Escherichia coli, GI87082128, Length=232, Percent_Identity=25.8620689655172, Blast_Score=74, Evalue=3e-14,
Organism=Escherichia coli, GI1787374, Length=200, Percent_Identity=23.5, Blast_Score=72, Evalue=9e-14,
Organism=Escherichia coli, GI1789403, Length=220, Percent_Identity=27.7272727272727, Blast_Score=70, Evalue=2e-13,
Organism=Escherichia coli, GI1790861, Length=207, Percent_Identity=24.1545893719807, Blast_Score=70, Evalue=3e-13,
Organism=Escherichia coli, GI1790300, Length=240, Percent_Identity=25.4166666666667, Blast_Score=67, Evalue=2e-12,
Organism=Escherichia coli, GI1790567, Length=353, Percent_Identity=25.2124645892351, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1789808, Length=245, Percent_Identity=24.8979591836735, Blast_Score=64, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003594
- InterPro:   IPR003660
- InterPro:   IPR004358
- InterPro:   IPR003661
- InterPro:   IPR005467
- InterPro:   IPR009082 [H]

Pfam domain/function: PF00672 HAMP; PF02518 HATPase_c; PF00512 HisKA [H]

EC number: =2.7.13.3 [H]

Molecular weight: Translated: 63883; Mature: 63751

Theoretical pI: Translated: 5.47; Mature: 5.47

Prosite motif: PS50885 HAMP ; PS50109 HIS_KIN

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTVLILLSIALITFMQYYFTQETENAIREDARRISSLVEQSHNKEEAIKYSQTLIENPG
CHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCC
GLMIINNKHRQSTASLSNIKKQMLNEVVNNDHFDDVFDKGKSVTRNVTIKEKGSSQTYIL
CEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCEEEEEEEECCCCCEEEE
LGYPTKAQKNSHSKYSGVFIYKDLKSIEDTNNAITIITIITAVIFLTITTVFAFFLSSRI
EECCCCCCCCCCCCCCCEEEEHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
TKPLRRLRDQATRVSEGDYSYKPSVTTKDEIGQLSQAFNQMSTEIEEHVDALSTSKNIRD
HHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLINSMVEGVLGINESRQIILSNKMANDIMDNIDEDAKAFLLRQIEDTFKSKQTEMRDLE
HHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
MNARFFVVTTSYIDKIEQGGKSGVVVTVRDMTNEHNLDQMKKDFIANVSHELRTPISLLQ
CCCEEEEEEHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
GYTESIVDGIVTEPDEIKESLAIVLDESKRLNRLVNELLNVARMDAEGLSVNKEVQPIAA
HHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
LLDKMKIKYRQQADDLGLNMTFNYCKKRVWSYDMDRMDQVLTNLIDNASRYTKPGDEIAI
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCEEE
TCDENESEDILYIKDTGTGIAPEHLQQVFDRFYKVDAARTRGKQGTGLGLFICKMIIEEH
EECCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHC
GGSIDVKSELGKGTTFIIKLPKPE
CCCEEEHHHCCCCCEEEEECCCCC
>Mature Secondary Structure 
TTVLILLSIALITFMQYYFTQETENAIREDARRISSLVEQSHNKEEAIKYSQTLIENPG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCC
GLMIINNKHRQSTASLSNIKKQMLNEVVNNDHFDDVFDKGKSVTRNVTIKEKGSSQTYIL
CEEEEECCCHHHHHHHHHHHHHHHHHHHCCCCCHHHHHCCCCCEEEEEEEECCCCCEEEE
LGYPTKAQKNSHSKYSGVFIYKDLKSIEDTNNAITIITIITAVIFLTITTVFAFFLSSRI
EECCCCCCCCCCCCCCCEEEEHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
TKPLRRLRDQATRVSEGDYSYKPSVTTKDEIGQLSQAFNQMSTEIEEHVDALSTSKNIRD
HHHHHHHHHHHHCCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SLINSMVEGVLGINESRQIILSNKMANDIMDNIDEDAKAFLLRQIEDTFKSKQTEMRDLE
HHHHHHHHHHHCCCCCCEEEEHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHC
MNARFFVVTTSYIDKIEQGGKSGVVVTVRDMTNEHNLDQMKKDFIANVSHELRTPISLLQ
CCCEEEEEEHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHHHHHH
GYTESIVDGIVTEPDEIKESLAIVLDESKRLNRLVNELLNVARMDAEGLSVNKEVQPIAA
HHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHH
LLDKMKIKYRQQADDLGLNMTFNYCKKRVWSYDMDRMDQVLTNLIDNASRYTKPGDEIAI
HHHHHHHHHHHHHHHCCCCCCHHHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCEEE
TCDENESEDILYIKDTGTGIAPEHLQQVFDRFYKVDAARTRGKQGTGLGLFICKMIIEEH
EECCCCCCCEEEEECCCCCCCHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHC
GGSIDVKSELGKGTTFIIKLPKPE
CCCEEEHHHCCCCCEEEEECCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA