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The map label for this gene is gltC [H]

Identifier: 161508717

GI number: 161508717

Start: 496232

End: 497116

Strand: Reverse

Name: gltC [H]

Synonym: USA300HOU_0471

Alternate gene names: 161508717

Gene position: 497116-496232 (Counterclockwise)

Preceding gene: 161508756

Following gene: 161508716

Centisome position: 17.3

GC content: 32.99

Gene sequence:

>885_bases
ATGGAAATTAAACAATTAAGATATTTTATCGAGGTCGCTAAAAGAGAACATATCTCCGAAACAGCACTTGAACTAAACAT
TGCTCAATCAGCGATAAGCCGTCAAATTACATTATTAGAACAAGAACTTAATGTGTCTTTATTTAAAAAGCAAGGACGCA
ATATTACGCTCACATCTGAAGGGAAATTATTATTTAATGAAGCTCTGCGTATTATTGAACATTTAGATAGCACGATTGAA
CAATTTCAAAGCCATGGATTAACTAAAAATAAAAGTATCTACATTGGCTATGATGAGAGTGACGTATCCCACATGTTACT
ACCACTTATCCAAACGTTTCATTTACAAAATGATACACATGTCATACCGAGCTTATTAGAACATGACACAATTATAAATA
GCGTATTAAATGGGAATATAGACATTGGTTTCACGGAACTTACACCAGAAATACGTAAACACAAACAATTACATATGCTA
CCTTTATTCGAAGAGCACTATCATTTATATGCGCCTTCAGACGATCCAATTACGATGGCGACACACCCACCATTAATTCA
GTTTGAGCATAGTCATATTTATTGCTTGGCACCATTTGCCGAAACTGTAAAAAAACAATTGCGCAAGATTACTAAATCAG
ATGTATACACAATCAGTAGCCAACCACTTGCGCAGTATCTCCTTCGTCAAAAAGAAGGTTACATCATTTCATCACAAAAT
ATACATTTACCAGAATCTAAATCATGGATAGATATAAAATTAGATCATACTGAATTAAAAAGAACGATATGTGCTATTAC
AAAGGAGCCTTATACAAAGAGTGATATTGGCATATTATTAACACTTATTCAGCAATTAATGACTAAAACGTCTACATTCC
ATTAA

Upstream 100 bases:

>100_bases
TATATAAAATAGAAGATATTCATCTAAAAAATAGAACATTTATCAATAATATTGCTATAATAGTTACAAAACACTCATTT
TTGGAGGTGCCTATATCGCT

Downstream 100 bases:

>100_bases
GTAATTCGATGCTATCAATGATGATTTTCGTTTTACACTTAGCAGTAATATCTTTGAAAATAAAAAATTAAGGGCGTATA
ATCACCATATTAATTCATTC

Product: glutamate synthase operon transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 294; Mature: 294

Protein sequence:

>294_residues
MEIKQLRYFIEVAKREHISETALELNIAQSAISRQITLLEQELNVSLFKKQGRNITLTSEGKLLFNEALRIIEHLDSTIE
QFQSHGLTKNKSIYIGYDESDVSHMLLPLIQTFHLQNDTHVIPSLLEHDTIINSVLNGNIDIGFTELTPEIRKHKQLHML
PLFEEHYHLYAPSDDPITMATHPPLIQFEHSHIYCLAPFAETVKKQLRKITKSDVYTISSQPLAQYLLRQKEGYIISSQN
IHLPESKSWIDIKLDHTELKRTICAITKEPYTKSDIGILLTLIQQLMTKTSTFH

Sequences:

>Translated_294_residues
MEIKQLRYFIEVAKREHISETALELNIAQSAISRQITLLEQELNVSLFKKQGRNITLTSEGKLLFNEALRIIEHLDSTIE
QFQSHGLTKNKSIYIGYDESDVSHMLLPLIQTFHLQNDTHVIPSLLEHDTIINSVLNGNIDIGFTELTPEIRKHKQLHML
PLFEEHYHLYAPSDDPITMATHPPLIQFEHSHIYCLAPFAETVKKQLRKITKSDVYTISSQPLAQYLLRQKEGYIISSQN
IHLPESKSWIDIKLDHTELKRTICAITKEPYTKSDIGILLTLIQQLMTKTSTFH
>Mature_294_residues
MEIKQLRYFIEVAKREHISETALELNIAQSAISRQITLLEQELNVSLFKKQGRNITLTSEGKLLFNEALRIIEHLDSTIE
QFQSHGLTKNKSIYIGYDESDVSHMLLPLIQTFHLQNDTHVIPSLLEHDTIINSVLNGNIDIGFTELTPEIRKHKQLHML
PLFEEHYHLYAPSDDPITMATHPPLIQFEHSHIYCLAPFAETVKKQLRKITKSDVYTISSQPLAQYLLRQKEGYIISSQN
IHLPESKSWIDIKLDHTELKRTICAITKEPYTKSDIGILLTLIQQLMTKTSTFH

Specific function: Positive regulator of glutamate biosynthesis (gltAB genes). Negatively regulates its own expression [H]

COG id: COG0583

COG function: function code K; Transcriptional regulator

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1786401, Length=211, Percent_Identity=28.9099526066351, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1788481, Length=147, Percent_Identity=29.2517006802721, Blast_Score=65, Evalue=5e-12,
Organism=Escherichia coli, GI2367136, Length=202, Percent_Identity=26.2376237623762, Blast_Score=65, Evalue=7e-12,
Organism=Escherichia coli, GI1787601, Length=145, Percent_Identity=31.0344827586207, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1788887, Length=188, Percent_Identity=27.1276595744681, Blast_Score=64, Evalue=1e-11,
Organism=Escherichia coli, GI1787530, Length=184, Percent_Identity=27.1739130434783, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1787879, Length=187, Percent_Identity=25.668449197861, Blast_Score=62, Evalue=4e-11,

Paralogues:

None

Copy number: 10-20 Molecules/Cell [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33944; Mature: 33944

Theoretical pI: Translated: 6.77; Mature: 6.77

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEIKQLRYFIEVAKREHISETALELNIAQSAISRQITLLEQELNVSLFKKQGRNITLTSE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
GKLLFNEALRIIEHLDSTIEQFQSHGLTKNKSIYIGYDESDVSHMLLPLIQTFHLQNDTH
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCH
VIPSLLEHDTIINSVLNGNIDIGFTELTPEIRKHKQLHMLPLFEEHYHLYAPSDDPITMA
HHHHHHHHHHHHHHHHCCCCEEEHHHCCHHHHHCCCEEECCCHHCCEEEECCCCCCEEEE
THPPLIQFEHSHIYCLAPFAETVKKQLRKITKSDVYTISSQPLAQYLLRQKEGYIISSQN
CCCCEEEEECCEEEEECCHHHHHHHHHHHHHHHCEEEECCCHHHHHHHHHCCCEEEECCC
IHLPESKSWIDIKLDHTELKRTICAITKEPYTKSDIGILLTLIQQLMTKTSTFH
EECCCCCCEEEEEECHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MEIKQLRYFIEVAKREHISETALELNIAQSAISRQITLLEQELNVSLFKKQGRNITLTSE
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEECC
GKLLFNEALRIIEHLDSTIEQFQSHGLTKNKSIYIGYDESDVSHMLLPLIQTFHLQNDTH
CCHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHHHHHHCCCCCH
VIPSLLEHDTIINSVLNGNIDIGFTELTPEIRKHKQLHMLPLFEEHYHLYAPSDDPITMA
HHHHHHHHHHHHHHHHCCCCEEEHHHCCHHHHHCCCEEECCCHHCCEEEECCCCCCEEEE
THPPLIQFEHSHIYCLAPFAETVKKQLRKITKSDVYTISSQPLAQYLLRQKEGYIISSQN
CCCCEEEEECCEEEEECCHHHHHHHHHHHHHHHCEEEECCCHHHHHHHHHCCCEEEECCC
IHLPESKSWIDIKLDHTELKRTICAITKEPYTKSDIGILLTLIQQLMTKTSTFH
EECCCCCCEEEEEECHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 2548995; 9384377 [H]