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The map label for this gene is acdA [H]

Identifier: 161508493

GI number: 161508493

Start: 272391

End: 273647

Strand: Reverse

Name: acdA [H]

Synonym: USA300HOU_0242

Alternate gene names: 161508493

Gene position: 273647-272391 (Counterclockwise)

Preceding gene: 161508494

Following gene: 161508492

Centisome position: 9.53

GC content: 38.74

Gene sequence:

>1257_bases
ATGCATTTCACATTAGTATTCATATTATTTTTAGGAGGAATTTATATGACATTTGAAAAAGAAACGGTCTTAAAAACATT
ATTTCCTGAAGATGTACTTAGTATTGCTAAAGGTTTAACAGACGGTGAAGTCGAATTTTTACAACAAGTAGATTCATTGC
TAGAAAGTAAGTACCGTGAAAATATTAATCAACATTGGATAGACGCTACTGTACCCGAGGACTATTTTAAAGATCTGGGA
GAATTAAATTATTTTAACAATCCATTACTTTACAAGGATCGTCCAAACGCCAAAATGCCTAGTCAACTATTTCAGTTTTT
CATGTCTTACCTACTCGCGCGATTTGATATTTCCTTAGCTACCCTACTCGGTGTTCACCAAGGTTTAGGGCATAACACTT
TCTATTTCGGAGGTAGCAAAGAACAAATTGCGAAATATGTACCTAAATTACAGTCACATGAACTGCGTACATGCTTTGCT
TTAACTGAACCAGAACACGGTTCGGACGTTGCGGGAGGTCTTGAAACAGTCGCTGAACGCCAAGGCGATACTTGGGTTAT
CAATGGTGAAAAGAAATGGATTGGTGGTGCACATGTATCTGATGTCATTCCAGTATTCGCAGTAAATAAAGAAACTGGCA
AACCCCATTGCTTTGTAGTCAGACCAGAACAAGATGGCGTCGATATTGAAGTCATTGATAATAAAATCGCACTTCGCATT
GTTCCTAACGCCCTAATTAAATTAACTAATGTCAAAGTAGATGAAGCGGATCGCTTACAAAACATAACAAGCTTTAAAGA
TATTGCCAAAATTCTTTATTCAACGAGAGCAGGCGTTGCTTATATGGCTACAGGTGGTATGGCTGGCGCTTTACGTGCCA
CATTAGATTATGTCACTGAGCGTAAGCAATTCGGCAAACCAATTAGTAAATATCAGTTAATACAAGAAAAGCTAGCAATG
ATGCAAGGTAATTTAGCTCAAGCAATGGCAACATGTGCTCAATTAGCTAATATGCAAGCACATGGTGAATATGACGAGGT
TGCAACTTCAACGGCGAAGATGATGAATGCCTTACGTTTGCGTGAGACAGTAGCTATGGGCCGCGGTATTACAGGTGGTA
ATGGCATACTAGCTGACGATTATGATATTGCACGTTTCTTCTCTGATGCAGAAGCGATTTACACGTACGAAGGTACACAT
GAAATTAATGCCTTAGTAATTGGACGCGCTTTGACTGGAGATTCTGCTTTCGTATAA

Upstream 100 bases:

>100_bases
AATGATGAATGACAAAGTCTCGCAAACACTTTAAAGGTGATAAAAATTTTTGACATTTAGTGTAAGCGTTTACAAATAAA
GCGTGTTGTTTTTGAATTAA

Downstream 100 bases:

>100_bases
ATAGCAAATAATTATATGAGATGCATTAATTTCACTAAAAAAGACTTATTTTAAGCATAAAGCTTTTTCCTTAAATAAGA
GGCTAAGATGACTGTCAAAG

Product: acyl-CoA dehydrogenase

Products: crotonoyl-CoA; CO2; reduced acceptor

Alternate protein names: NA

Number of amino acids: Translated: 418; Mature: 418

Protein sequence:

>418_residues
MHFTLVFILFLGGIYMTFEKETVLKTLFPEDVLSIAKGLTDGEVEFLQQVDSLLESKYRENINQHWIDATVPEDYFKDLG
ELNYFNNPLLYKDRPNAKMPSQLFQFFMSYLLARFDISLATLLGVHQGLGHNTFYFGGSKEQIAKYVPKLQSHELRTCFA
LTEPEHGSDVAGGLETVAERQGDTWVINGEKKWIGGAHVSDVIPVFAVNKETGKPHCFVVRPEQDGVDIEVIDNKIALRI
VPNALIKLTNVKVDEADRLQNITSFKDIAKILYSTRAGVAYMATGGMAGALRATLDYVTERKQFGKPISKYQLIQEKLAM
MQGNLAQAMATCAQLANMQAHGEYDEVATSTAKMMNALRLRETVAMGRGITGGNGILADDYDIARFFSDAEAIYTYEGTH
EINALVIGRALTGDSAFV

Sequences:

>Translated_418_residues
MHFTLVFILFLGGIYMTFEKETVLKTLFPEDVLSIAKGLTDGEVEFLQQVDSLLESKYRENINQHWIDATVPEDYFKDLG
ELNYFNNPLLYKDRPNAKMPSQLFQFFMSYLLARFDISLATLLGVHQGLGHNTFYFGGSKEQIAKYVPKLQSHELRTCFA
LTEPEHGSDVAGGLETVAERQGDTWVINGEKKWIGGAHVSDVIPVFAVNKETGKPHCFVVRPEQDGVDIEVIDNKIALRI
VPNALIKLTNVKVDEADRLQNITSFKDIAKILYSTRAGVAYMATGGMAGALRATLDYVTERKQFGKPISKYQLIQEKLAM
MQGNLAQAMATCAQLANMQAHGEYDEVATSTAKMMNALRLRETVAMGRGITGGNGILADDYDIARFFSDAEAIYTYEGTH
EINALVIGRALTGDSAFV
>Mature_418_residues
MHFTLVFILFLGGIYMTFEKETVLKTLFPEDVLSIAKGLTDGEVEFLQQVDSLLESKYRENINQHWIDATVPEDYFKDLG
ELNYFNNPLLYKDRPNAKMPSQLFQFFMSYLLARFDISLATLLGVHQGLGHNTFYFGGSKEQIAKYVPKLQSHELRTCFA
LTEPEHGSDVAGGLETVAERQGDTWVINGEKKWIGGAHVSDVIPVFAVNKETGKPHCFVVRPEQDGVDIEVIDNKIALRI
VPNALIKLTNVKVDEADRLQNITSFKDIAKILYSTRAGVAYMATGGMAGALRATLDYVTERKQFGKPISKYQLIQEKLAM
MQGNLAQAMATCAQLANMQAHGEYDEVATSTAKMMNALRLRETVAMGRGITGGNGILADDYDIARFFSDAEAIYTYEGTH
EINALVIGRALTGDSAFV

Specific function: Involved in the degradation of long-chain fatty acids [H]

COG id: COG1960

COG function: function code I; Acyl-CoA dehydrogenases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the acyl-CoA dehydrogenase family [H]

Homologues:

Organism=Homo sapiens, GI4503943, Length=309, Percent_Identity=33.3333333333333, Blast_Score=160, Evalue=3e-39,
Organism=Homo sapiens, GI7669494, Length=288, Percent_Identity=31.25, Blast_Score=132, Evalue=8e-31,
Organism=Homo sapiens, GI21361497, Length=418, Percent_Identity=26.7942583732057, Blast_Score=110, Evalue=2e-24,
Organism=Homo sapiens, GI76496475, Length=304, Percent_Identity=29.9342105263158, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI4557235, Length=304, Percent_Identity=29.9342105263158, Blast_Score=109, Evalue=5e-24,
Organism=Homo sapiens, GI4501859, Length=302, Percent_Identity=29.8013245033113, Blast_Score=103, Evalue=3e-22,
Organism=Homo sapiens, GI4557233, Length=311, Percent_Identity=29.903536977492, Blast_Score=102, Evalue=6e-22,
Organism=Homo sapiens, GI226958412, Length=325, Percent_Identity=27.6923076923077, Blast_Score=100, Evalue=2e-21,
Organism=Homo sapiens, GI226958414, Length=325, Percent_Identity=27.6923076923077, Blast_Score=100, Evalue=3e-21,
Organism=Homo sapiens, GI7656849, Length=281, Percent_Identity=29.1814946619217, Blast_Score=99, Evalue=7e-21,
Organism=Homo sapiens, GI4557231, Length=292, Percent_Identity=30.4794520547945, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI187960098, Length=292, Percent_Identity=30.4794520547945, Blast_Score=96, Evalue=8e-20,
Organism=Homo sapiens, GI4501857, Length=297, Percent_Identity=28.2828282828283, Blast_Score=95, Evalue=1e-19,
Organism=Escherichia coli, GI1786223, Length=286, Percent_Identity=27.972027972028, Blast_Score=84, Evalue=2e-17,
Organism=Escherichia coli, GI87081958, Length=283, Percent_Identity=27.9151943462898, Blast_Score=82, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17534353, Length=398, Percent_Identity=27.8894472361809, Blast_Score=167, Evalue=1e-41,
Organism=Caenorhabditis elegans, GI17538396, Length=311, Percent_Identity=29.903536977492, Blast_Score=113, Evalue=2e-25,
Organism=Caenorhabditis elegans, GI17506239, Length=305, Percent_Identity=27.2131147540984, Blast_Score=109, Evalue=3e-24,
Organism=Caenorhabditis elegans, GI71985184, Length=413, Percent_Identity=27.1186440677966, Blast_Score=106, Evalue=3e-23,
Organism=Caenorhabditis elegans, GI71985192, Length=323, Percent_Identity=29.1021671826625, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17569725, Length=289, Percent_Identity=30.7958477508651, Blast_Score=102, Evalue=3e-22,
Organism=Caenorhabditis elegans, GI17508101, Length=303, Percent_Identity=26.7326732673267, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI71990804, Length=236, Percent_Identity=29.2372881355932, Blast_Score=97, Evalue=2e-20,
Organism=Caenorhabditis elegans, GI32563615, Length=210, Percent_Identity=30, Blast_Score=96, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17534899, Length=286, Percent_Identity=29.7202797202797, Blast_Score=95, Evalue=7e-20,
Organism=Caenorhabditis elegans, GI17570075, Length=279, Percent_Identity=27.9569892473118, Blast_Score=80, Evalue=3e-15,
Organism=Caenorhabditis elegans, GI17533517, Length=267, Percent_Identity=25.0936329588015, Blast_Score=78, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI71982178, Length=273, Percent_Identity=24.9084249084249, Blast_Score=72, Evalue=7e-13,
Organism=Drosophila melanogaster, GI19920834, Length=308, Percent_Identity=34.7402597402597, Blast_Score=172, Evalue=3e-43,
Organism=Drosophila melanogaster, GI24666513, Length=313, Percent_Identity=29.7124600638978, Blast_Score=119, Evalue=3e-27,
Organism=Drosophila melanogaster, GI24660351, Length=293, Percent_Identity=30.3754266211604, Blast_Score=109, Evalue=3e-24,
Organism=Drosophila melanogaster, GI281363737, Length=314, Percent_Identity=30.2547770700637, Blast_Score=107, Evalue=2e-23,
Organism=Drosophila melanogaster, GI21356377, Length=354, Percent_Identity=29.3785310734463, Blast_Score=103, Evalue=3e-22,
Organism=Drosophila melanogaster, GI21355753, Length=295, Percent_Identity=28.8135593220339, Blast_Score=100, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24646207, Length=383, Percent_Identity=26.8929503916449, Blast_Score=96, Evalue=3e-20,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006089
- InterPro:   IPR006092
- InterPro:   IPR006090
- InterPro:   IPR006091
- InterPro:   IPR009075
- InterPro:   IPR013786
- InterPro:   IPR009100 [H]

Pfam domain/function: PF00441 Acyl-CoA_dh_1; PF02770 Acyl-CoA_dh_M; PF02771 Acyl-CoA_dh_N [H]

EC number: 1.3.99.7

Molecular weight: Translated: 46483; Mature: 46483

Theoretical pI: Translated: 5.30; Mature: 5.30

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHFTLVFILFLGGIYMTFEKETVLKTLFPEDVLSIAKGLTDGEVEFLQQVDSLLESKYRE
CHHHHHHHHHHCCCEEEECHHHHHHHHCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
NINQHWIDATVPEDYFKDLGELNYFNNPLLYKDRPNAKMPSQLFQFFMSYLLARFDISLA
CHHHHCCCCCCCHHHHHHHHHCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHH
TLLGVHQGLGHNTFYFGGSKEQIAKYVPKLQSHELRTCFALTEPEHGSDVAGGLETVAER
HHHHHHHCCCCCEEEECCCHHHHHHHHCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHC
QGDTWVINGEKKWIGGAHVSDVIPVFAVNKETGKPHCFVVRPEQDGVDIEVIDNKIALRI
CCCEEEECCCCCCCCCCCHHHCCEEEEECCCCCCCEEEEECCCCCCCEEEEECCEEEEEE
VPNALIKLTNVKVDEADRLQNITSFKDIAKILYSTRAGVAYMATGGMAGALRATLDYVTE
CCHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHH
RKQFGKPISKYQLIQEKLAMMQGNLAQAMATCAQLANMQAHGEYDEVATSTAKMMNALRL
HHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
RETVAMGRGITGGNGILADDYDIARFFSDAEAIYTYEGTHEINALVIGRALTGDSAFV
HHHHHHCCCCCCCCCCEECCHHHHHHHCCCCEEEEECCCCCEEEEEEEEEECCCCCCC
>Mature Secondary Structure
MHFTLVFILFLGGIYMTFEKETVLKTLFPEDVLSIAKGLTDGEVEFLQQVDSLLESKYRE
CHHHHHHHHHHCCCEEEECHHHHHHHHCHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHH
NINQHWIDATVPEDYFKDLGELNYFNNPLLYKDRPNAKMPSQLFQFFMSYLLARFDISLA
CHHHHCCCCCCCHHHHHHHHHCCCCCCCEEECCCCCCCCHHHHHHHHHHHHHHHHHHHHH
TLLGVHQGLGHNTFYFGGSKEQIAKYVPKLQSHELRTCFALTEPEHGSDVAGGLETVAER
HHHHHHHCCCCCEEEECCCHHHHHHHHCCCCCCCCCEEEEECCCCCCCHHHHHHHHHHHC
QGDTWVINGEKKWIGGAHVSDVIPVFAVNKETGKPHCFVVRPEQDGVDIEVIDNKIALRI
CCCEEEECCCCCCCCCCCHHHCCEEEEECCCCCCCEEEEECCCCCCCEEEEECCEEEEEE
VPNALIKLTNVKVDEADRLQNITSFKDIAKILYSTRAGVAYMATGGMAGALRATLDYVTE
CCHHHEEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCCCHHHHHHHHHHHHH
RKQFGKPISKYQLIQEKLAMMQGNLAQAMATCAQLANMQAHGEYDEVATSTAKMMNALRL
HHHHCCCHHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
RETVAMGRGITGGNGILADDYDIARFFSDAEAIYTYEGTHEINALVIGRALTGDSAFV
HHHHHHCCCCCCCCCCEECCHHHHHHHCCCCEEEEECCCCCEEEEEEEEEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: glutaryl-CoA; acceptor

Specific reaction: glutaryl-CoA + acceptor = crotonoyl-CoA + CO2 + reduced acceptor

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9353933; 9384377 [H]