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The map label for this gene is purC [H]

Identifier: 160903385

GI number: 160903385

Start: 2165037

End: 2165753

Strand: Direct

Name: purC [H]

Synonym: Pmob_1956

Alternate gene names: 160903385

Gene position: 2165037-2165753 (Clockwise)

Preceding gene: 160903384

Following gene: 160903386

Centisome position: 99.79

GC content: 32.08

Gene sequence:

>717_bases
ATGGAAGATAAGAAAAATTTTGAGCTTTTATACGAAGGGAAAGCCAAAAAAGTATACAAGTTCGATGAGAAGAAATTGTT
GATAGAATTCAAAGATGATGTGACAGCATTCAACGGATTAAAAAAAGATCAAATCCTTAACAAAGGAAAAATCAACAAAG
AAATTTCTAAGTTCTTTTTTGAAATGCTGAATAATCAAGGTATAAATACCCATTACATCAACGATTACGATGAAAACTCT
TTCGTTGCAAAATGGACAGATTTAATTCCTCTTGAGGTTATAATTAGAAATTACACTGCCGGAGGTTTTTGTAAGAGATA
TGGAGTGAAAAAGGGATTGATGTTTGATTATCCTTTAGTTGAATTTTCTTTGAAAAATGACGAGTTAGGGGATCCGATGA
TTGCCAAAGATGCTATCCTTCTTTTGAAAATTACCACAGAAAACGTATTGGATGAAATCGCTTCTATTTCTAAAAAAGTC
AACAATATTTTAAGTGATTATTTAAAATCTAAAGGAATTATTTTGGTGGATTTTAAATTAGAGTTCGGAATCAGTAAAAA
CGATAACAAAGTTACGTTGATCGATGAGATCTCTCCTGATACGTGCCGTTTTTGGGACGCAAATACTATGGAATCTCTTG
ACAAAGATGTGTATAGGGAAAATAAAGGGGATCTTATCAACGCCTACGAAGTATTACTTGGGAGGTTAGATATATGA

Upstream 100 bases:

>100_bases
CAGATGCCTAGTGGGGTTCCTGTTGCAACCATGGGCATTGGAAGTAGTGGTATGAAAAATGCAGCATACTTTGCAAAAAG
GTTGACAGAAGGTGAAAAAG

Downstream 100 bases:

>100_bases
TGATTAAAGAGGAGCAGAAAACCTTCCGATTTGAAGTAAAAGTAAAGTTAAGGGAAGGAATTTTAGACCCACAGGGAGCT
ACTACTTTCAAGGTTTTAAG

Product: phosphoribosylaminoimidazole-succinocarboxamide synthase

Products: NA

Alternate protein names: SAICAR synthetase [H]

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MEDKKNFELLYEGKAKKVYKFDEKKLLIEFKDDVTAFNGLKKDQILNKGKINKEISKFFFEMLNNQGINTHYINDYDENS
FVAKWTDLIPLEVIIRNYTAGGFCKRYGVKKGLMFDYPLVEFSLKNDELGDPMIAKDAILLLKITTENVLDEIASISKKV
NNILSDYLKSKGIILVDFKLEFGISKNDNKVTLIDEISPDTCRFWDANTMESLDKDVYRENKGDLINAYEVLLGRLDI

Sequences:

>Translated_238_residues
MEDKKNFELLYEGKAKKVYKFDEKKLLIEFKDDVTAFNGLKKDQILNKGKINKEISKFFFEMLNNQGINTHYINDYDENS
FVAKWTDLIPLEVIIRNYTAGGFCKRYGVKKGLMFDYPLVEFSLKNDELGDPMIAKDAILLLKITTENVLDEIASISKKV
NNILSDYLKSKGIILVDFKLEFGISKNDNKVTLIDEISPDTCRFWDANTMESLDKDVYRENKGDLINAYEVLLGRLDI
>Mature_238_residues
MEDKKNFELLYEGKAKKVYKFDEKKLLIEFKDDVTAFNGLKKDQILNKGKINKEISKFFFEMLNNQGINTHYINDYDENS
FVAKWTDLIPLEVIIRNYTAGGFCKRYGVKKGLMFDYPLVEFSLKNDELGDPMIAKDAILLLKITTENVLDEIASISKKV
NNILSDYLKSKGIILVDFKLEFGISKNDNKVTLIDEISPDTCRFWDANTMESLDKDVYRENKGDLINAYEVLLGRLDI

Specific function: De novo purine biosynthesis; seventh step. [C]

COG id: COG0152

COG function: function code F; Phosphoribosylaminoimidazolesuccinocarboxamide (SAICAR) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SAICAR synthetase family [H]

Homologues:

Organism=Homo sapiens, GI119220557, Length=223, Percent_Identity=31.390134529148, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI5453539, Length=223, Percent_Identity=31.390134529148, Blast_Score=115, Evalue=3e-26,
Organism=Homo sapiens, GI119220559, Length=230, Percent_Identity=30, Blast_Score=105, Evalue=3e-23,
Organism=Escherichia coli, GI1788820, Length=230, Percent_Identity=36.9565217391304, Blast_Score=159, Evalue=2e-40,
Organism=Caenorhabditis elegans, GI17531275, Length=233, Percent_Identity=33.0472103004292, Blast_Score=104, Evalue=4e-23,
Organism=Saccharomyces cerevisiae, GI6319326, Length=261, Percent_Identity=27.5862068965517, Blast_Score=93, Evalue=3e-20,
Organism=Drosophila melanogaster, GI18860083, Length=229, Percent_Identity=31.4410480349345, Blast_Score=106, Evalue=1e-23,
Organism=Drosophila melanogaster, GI24583917, Length=221, Percent_Identity=31.6742081447964, Blast_Score=101, Evalue=6e-22,

Paralogues:

None

Copy number: 1680 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 13,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013816
- InterPro:   IPR001636
- InterPro:   IPR018236 [H]

Pfam domain/function: PF01259 SAICAR_synt [H]

EC number: =6.3.2.6 [H]

Molecular weight: Translated: 27517; Mature: 27517

Theoretical pI: Translated: 4.96; Mature: 4.96

Prosite motif: PS01058 SAICAR_SYNTHETASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEDKKNFELLYEGKAKKVYKFDEKKLLIEFKDDVTAFNGLKKDQILNKGKINKEISKFFF
CCCCCCEEEEEECCCCCEEEECCCEEEEEECCCHHHHCCCCHHHHHCCCCCHHHHHHHHH
EMLNNQGINTHYINDYDENSFVAKWTDLIPLEVIIRNYTAGGFCKRYGVKKGLMFDYPLV
HHHCCCCCCEEECCCCCCCCEEEHHHHCCHHHHHHHCCCCCCHHHHHCCCCCCEECCCEE
EFSLKNDELGDPMIAKDAILLLKITTENVLDEIASISKKVNNILSDYLKSKGIILVDFKL
EEEECCCCCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEE
EFGISKNDNKVTLIDEISPDTCRFWDANTMESLDKDVYRENKGDLINAYEVLLGRLDI
EECCCCCCCEEEEEECCCCCCEEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure
MEDKKNFELLYEGKAKKVYKFDEKKLLIEFKDDVTAFNGLKKDQILNKGKINKEISKFFF
CCCCCCEEEEEECCCCCEEEECCCEEEEEECCCHHHHCCCCHHHHHCCCCCHHHHHHHHH
EMLNNQGINTHYINDYDENSFVAKWTDLIPLEVIIRNYTAGGFCKRYGVKKGLMFDYPLV
HHHCCCCCCEEECCCCCCCCEEEHHHHCCHHHHHHHCCCCCCHHHHHCCCCCCEECCCEE
EFSLKNDELGDPMIAKDAILLLKITTENVLDEIASISKKVNNILSDYLKSKGIILVDFKL
EEEECCCCCCCCCCCCCEEEEEEECHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEEEE
EFGISKNDNKVTLIDEISPDTCRFWDANTMESLDKDVYRENKGDLINAYEVLLGRLDI
EECCCCCCCEEEEEECCCCCCEEECCCHHHHHHHHHHHHCCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11997336 [H]