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The map label for this gene is relA [H]

Identifier: 160903362

GI number: 160903362

Start: 2138474

End: 2140612

Strand: Direct

Name: relA [H]

Synonym: Pmob_1933

Alternate gene names: 160903362

Gene position: 2138474-2140612 (Clockwise)

Preceding gene: 160903350

Following gene: 160903363

Centisome position: 98.57

GC content: 32.21

Gene sequence:

>2139_bases
ATGTTGATTGAATCGAAAAGTTATGAGAAAGAAGTAGAAAAGCTATTAAATGTGAAGCTTACTAAAAAAGAAAAAGAAAG
AATAAAAATTGCCTATGAATTGGCTGAAACATCTCATAGTGGTCAATTTAGGGATTCTGGTGAGGAATTTTTTGAGCATC
CAAAAAGTGTTGGATTGATACTCGCAGGTTTAAAAATGGATGTGGATACTATTATAGCTGGTCTTTTGCACGATGTAGTT
GAAGATTGTGGTGTTTCAATAGATAAAATAAAAGATCTTTTTGGGATCGATGTTGCTAATATAGTTTCAGGTGTCACTAA
GATTAGCAATTTAAAGCTCAATGAGCGGCTAAACGAAAATGACATGAAATCTTTAGAAAAAGTAGAAACTATCAGAAAGA
TGCTTTTTGCTATGTCTGAGGATATAAGAGTCATAATCGTTAAATTGGCAGATAGATTACATAACATGAGAACTTTAGAA
TTCGTCGATAGAAAAAAGCAGATAGCCAAGGCCGACGAAACTTTAAAAATATACGCACCTATTGCCCATAGATTGGGTAT
CTATAAGATGAAGGAAGAGTTGGAAGATTTGTCTTTTCGGTATTTGTATCCTGAGACATATTTTGATCTAAAGACGAAAA
TCGAGGAAAAAATTAGACTTGGGCAAAATCGATTGAACGAATACGCGCAGATTATTAAACAAGAGCTTGATAATCAGAAA
ATTAAAGCGACGGTTGAAGGTCGCTCTAAGCATTTATATAGTATATGGGATAAGATGATTCGAAAAGGAAAAACTTTAGA
TGAAATATATGACTACATAGCTCTTAGGATAATTACTGAAGATCAGAATAAATGCTATGCTGTGTTGGGAATAATTCATT
CTATTTGGTCCCCTGTTCCAGGTAGAATAAAAGATTACATTGCAACCCCTAAATTCAATGGTTATAAATCCCTGCATACC
ACCGTTATAACCCATAAAGGAGATCCTTTGGAAATTCAAATTCGAGATTGGGAAATGCATGAAGAAGCTGAATACGGCTT
AGCTGCCCATTGGGTCTATAAAGAGGGTGTTAGTCAGGAAAAATTGAAATTTTTAACTGATCTTATGGAATTACATAGGT
ATATTGCTCAAAATGCTTTTGAATTGAAAGATATCGAAACGAATCTTCTTTCAAAAGAAACTTTTGTATTTACACCAAAG
GGAGAAATAATCCATTTACCAAGAGGAGCAACACCTATTGATTTTGCTTTTGCTATTCATACTGAGGTTGGCAATCATTT
TTCTGGAGCGAAAGTCAACGGTAAATTAGTCCCTATTTCATACAAATTACAGACTGGGGACATAGTAGAGATATTGATCA
ATAGGAATTTTCAAGGACCTAGTATTGATTGGTTAAAATATGCTCATTCTCCCAAGACTATATCAAAGATAAAAAAATAT
TACAGGCAAAAAAACGAAGTGGAGTTAATAGAAAGAGGCAAAGACAAGTTTAGAGAGCTGTCTAAAAAACTTAATTTTTC
TATGGATGAAATTCTCGAGAAATTGAAAGAAATAGGATTTTATATTAAATACAATATAAAAAGTGACGACGAATTTTTCA
TTAAGTTATCTTTAGAAGATATCAGTATTAATACTATTAGAAATATTTTTACCCTCAATGAAAAAGAAGAGGAAACAATC
ACTACGGTCGAAAAAACTAATTCAAGTAGGAAAGGGATCTCCGTTCTTGTTGATGGTGAAGAAGGAGTCGAAAGTTATTT
TGCTAAATGTTGTATGCCTGTTCCAGGTGATGAAATTATTGGTGTGATAACCCGTAGAGGCATCGGCATACATAGAAAAG
ATTGTAATAATATTCAGGATATTGATGATAGTAAGAAGGTAAATGTTGAGTGGAACGAACTCAATCAAAACAAATTTTCT
ACGGTATTAATGATTGATGTGGAAAGTAAAAATGTCTTAAATAACGTTAGAAATGTTATAAATAATGAAGGGGGACATAT
TGAAAAATTCGAAATGACAAATAATTCTAATTATCTTAATATTAGGATATATTTAGCTGTTCAGAATTTAAAGCATCTGA
GTCTTTTGAGTAATAAATTGAAAAATTCTAAAGGTGTTTATTCTGTTAGGAGGGTATAA

Upstream 100 bases:

>100_bases
ATTCTGTTTCAAATTTCTAGAATTTGTGCTATAATTTTATTGTACTGTTTTTAAATGAAATAAGTAATTATTTTTAAGAA
TCGTTAAGAGGTGTTTGATT

Downstream 100 bases:

>100_bases
TTTGAGGGCAGTGGTTCAAAGAGTATCACAAGCTTCCGTAACCATTTCTGATAACATTGTTGCTCAAATAGAAAAAGGTC
TCCTGGTTTTCTTGGGCATT

Product: (p)ppGpp synthetase I SpoT/RelA

Products: NA

Alternate protein names: (p)ppGpp synthase; ATP:GTP 3'-pyrophosphotransferase; ppGpp synthase I [H]

Number of amino acids: Translated: 712; Mature: 712

Protein sequence:

>712_residues
MLIESKSYEKEVEKLLNVKLTKKEKERIKIAYELAETSHSGQFRDSGEEFFEHPKSVGLILAGLKMDVDTIIAGLLHDVV
EDCGVSIDKIKDLFGIDVANIVSGVTKISNLKLNERLNENDMKSLEKVETIRKMLFAMSEDIRVIIVKLADRLHNMRTLE
FVDRKKQIAKADETLKIYAPIAHRLGIYKMKEELEDLSFRYLYPETYFDLKTKIEEKIRLGQNRLNEYAQIIKQELDNQK
IKATVEGRSKHLYSIWDKMIRKGKTLDEIYDYIALRIITEDQNKCYAVLGIIHSIWSPVPGRIKDYIATPKFNGYKSLHT
TVITHKGDPLEIQIRDWEMHEEAEYGLAAHWVYKEGVSQEKLKFLTDLMELHRYIAQNAFELKDIETNLLSKETFVFTPK
GEIIHLPRGATPIDFAFAIHTEVGNHFSGAKVNGKLVPISYKLQTGDIVEILINRNFQGPSIDWLKYAHSPKTISKIKKY
YRQKNEVELIERGKDKFRELSKKLNFSMDEILEKLKEIGFYIKYNIKSDDEFFIKLSLEDISINTIRNIFTLNEKEEETI
TTVEKTNSSRKGISVLVDGEEGVESYFAKCCMPVPGDEIIGVITRRGIGIHRKDCNNIQDIDDSKKVNVEWNELNQNKFS
TVLMIDVESKNVLNNVRNVINNEGGHIEKFEMTNNSNYLNIRIYLAVQNLKHLSLLSNKLKNSKGVYSVRRV

Sequences:

>Translated_712_residues
MLIESKSYEKEVEKLLNVKLTKKEKERIKIAYELAETSHSGQFRDSGEEFFEHPKSVGLILAGLKMDVDTIIAGLLHDVV
EDCGVSIDKIKDLFGIDVANIVSGVTKISNLKLNERLNENDMKSLEKVETIRKMLFAMSEDIRVIIVKLADRLHNMRTLE
FVDRKKQIAKADETLKIYAPIAHRLGIYKMKEELEDLSFRYLYPETYFDLKTKIEEKIRLGQNRLNEYAQIIKQELDNQK
IKATVEGRSKHLYSIWDKMIRKGKTLDEIYDYIALRIITEDQNKCYAVLGIIHSIWSPVPGRIKDYIATPKFNGYKSLHT
TVITHKGDPLEIQIRDWEMHEEAEYGLAAHWVYKEGVSQEKLKFLTDLMELHRYIAQNAFELKDIETNLLSKETFVFTPK
GEIIHLPRGATPIDFAFAIHTEVGNHFSGAKVNGKLVPISYKLQTGDIVEILINRNFQGPSIDWLKYAHSPKTISKIKKY
YRQKNEVELIERGKDKFRELSKKLNFSMDEILEKLKEIGFYIKYNIKSDDEFFIKLSLEDISINTIRNIFTLNEKEEETI
TTVEKTNSSRKGISVLVDGEEGVESYFAKCCMPVPGDEIIGVITRRGIGIHRKDCNNIQDIDDSKKVNVEWNELNQNKFS
TVLMIDVESKNVLNNVRNVINNEGGHIEKFEMTNNSNYLNIRIYLAVQNLKHLSLLSNKLKNSKGVYSVRRV
>Mature_712_residues
MLIESKSYEKEVEKLLNVKLTKKEKERIKIAYELAETSHSGQFRDSGEEFFEHPKSVGLILAGLKMDVDTIIAGLLHDVV
EDCGVSIDKIKDLFGIDVANIVSGVTKISNLKLNERLNENDMKSLEKVETIRKMLFAMSEDIRVIIVKLADRLHNMRTLE
FVDRKKQIAKADETLKIYAPIAHRLGIYKMKEELEDLSFRYLYPETYFDLKTKIEEKIRLGQNRLNEYAQIIKQELDNQK
IKATVEGRSKHLYSIWDKMIRKGKTLDEIYDYIALRIITEDQNKCYAVLGIIHSIWSPVPGRIKDYIATPKFNGYKSLHT
TVITHKGDPLEIQIRDWEMHEEAEYGLAAHWVYKEGVSQEKLKFLTDLMELHRYIAQNAFELKDIETNLLSKETFVFTPK
GEIIHLPRGATPIDFAFAIHTEVGNHFSGAKVNGKLVPISYKLQTGDIVEILINRNFQGPSIDWLKYAHSPKTISKIKKY
YRQKNEVELIERGKDKFRELSKKLNFSMDEILEKLKEIGFYIKYNIKSDDEFFIKLSLEDISINTIRNIFTLNEKEEETI
TTVEKTNSSRKGISVLVDGEEGVESYFAKCCMPVPGDEIIGVITRRGIGIHRKDCNNIQDIDDSKKVNVEWNELNQNKFS
TVLMIDVESKNVLNNVRNVINNEGGHIEKFEMTNNSNYLNIRIYLAVQNLKHLSLLSNKLKNSKGVYSVRRV

Specific function: In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which i

COG id: COG0317

COG function: function code TK; Guanosine polyphosphate pyrophosphohydrolases/synthetases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HD domain [H]

Homologues:

Organism=Escherichia coli, GI1790082, Length=724, Percent_Identity=35.3591160220994, Blast_Score=426, Evalue=1e-120,
Organism=Escherichia coli, GI1789147, Length=684, Percent_Identity=32.6023391812866, Blast_Score=393, Evalue=1e-110,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002912
- InterPro:   IPR012675
- InterPro:   IPR003607
- InterPro:   IPR007685
- InterPro:   IPR004811
- InterPro:   IPR004095
- InterPro:   IPR012676 [H]

Pfam domain/function: PF01842 ACT; PF04607 RelA_SpoT; PF02824 TGS [H]

EC number: =2.7.6.5 [H]

Molecular weight: Translated: 82331; Mature: 82331

Theoretical pI: Translated: 7.97; Mature: 7.97

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLIESKSYEKEVEKLLNVKLTKKEKERIKIAYELAETSHSGQFRDSGEEFFEHPKSVGLI
CCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHEEEHHCCCCCCCCCCCHHHHHCCHHHEEE
LAGLKMDVDTIIAGLLHDVVEDCGVSIDKIKDLFGIDVANIVSGVTKISNLKLNERLNEN
EEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHCCCHHHCCCHH
DMKSLEKVETIRKMLFAMSEDIRVIIVKLADRLHNMRTLEFVDRKKQIAKADETLKIYAP
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEEC
IAHRLGIYKMKEELEDLSFRYLYPETYFDLKTKIEEKIRLGQNRLNEYAQIIKQELDNQK
HHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
IKATVEGRSKHLYSIWDKMIRKGKTLDEIYDYIALRIITEDQNKCYAVLGIIHSIWSPVP
EEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHEEEEEECCCCCHHHHHHHHHHHCCCCC
GRIKDYIATPKFNGYKSLHTTVITHKGDPLEIQIRDWEMHEEAEYGLAAHWVYKEGVSQE
CHHHHHHCCCCCCCCCCEEEEEEEECCCCEEEEEECCCCCCHHCCCCEEEEHHHCCCCHH
KLKFLTDLMELHRYIAQNAFELKDIETNLLSKETFVFTPKGEIIHLPRGATPIDFAFAIH
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEECCCCCEEECCCCCCCCEEEEEEE
TEVGNHFSGAKVNGKLVPISYKLQTGDIVEILINRNFQGPSIDWLKYAHSPKTISKIKKY
ECCCCCCCCCEECCEEEEEEEEECCCCEEEEEECCCCCCCCCHHHHHCCCCHHHHHHHHH
YRQKNEVELIERGKDKFRELSKKLNFSMDEILEKLKEIGFYIKYNIKSDDEFFIKLSLED
HHCCCHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHCCEEEEEEECCCCEEEEEEEECC
ISINTIRNIFTLNEKEEETITTVEKTNSSRKGISVLVDGEEGVESYFAKCCMPVPGDEII
CCHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHCCCCCCCHHHH
GVITRRGIGIHRKDCNNIQDIDDSKKVNVEWNELNQNKFSTVLMIDVESKNVLNNVRNVI
HHHHHCCCCCCCCCCCCCCCCCCCCEEEEEHHHCCCCCCEEEEEEEECCHHHHHHHHHHH
NNEGGHIEKFEMTNNSNYLNIRIYLAVQNLKHLSLLSNKLKNSKGVYSVRRV
CCCCCCEEEEEECCCCCEEEEEEEEEECCHHHHHHHHHHHCCCCCCEEECCC
>Mature Secondary Structure
MLIESKSYEKEVEKLLNVKLTKKEKERIKIAYELAETSHSGQFRDSGEEFFEHPKSVGLI
CCCCCCHHHHHHHHHHCCCCCCCHHHHHHHHEEEHHCCCCCCCCCCCHHHHHCCHHHEEE
LAGLKMDVDTIIAGLLHDVVEDCGVSIDKIKDLFGIDVANIVSGVTKISNLKLNERLNEN
EEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHCCCHHHCCCHH
DMKSLEKVETIRKMLFAMSEDIRVIIVKLADRLHNMRTLEFVDRKKQIAKADETLKIYAP
HHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCEEEEEC
IAHRLGIYKMKEELEDLSFRYLYPETYFDLKTKIEEKIRLGQNRLNEYAQIIKQELDNQK
HHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCE
IKATVEGRSKHLYSIWDKMIRKGKTLDEIYDYIALRIITEDQNKCYAVLGIIHSIWSPVP
EEEEECCCHHHHHHHHHHHHHCCCCHHHHHHHHEEEEEECCCCCHHHHHHHHHHHCCCCC
GRIKDYIATPKFNGYKSLHTTVITHKGDPLEIQIRDWEMHEEAEYGLAAHWVYKEGVSQE
CHHHHHHCCCCCCCCCCEEEEEEEECCCCEEEEEECCCCCCHHCCCCEEEEHHHCCCCHH
KLKFLTDLMELHRYIAQNAFELKDIETNLLSKETFVFTPKGEIIHLPRGATPIDFAFAIH
HHHHHHHHHHHHHHHHCCCCCHHHHHHHHCCCCEEEECCCCCEEECCCCCCCCEEEEEEE
TEVGNHFSGAKVNGKLVPISYKLQTGDIVEILINRNFQGPSIDWLKYAHSPKTISKIKKY
ECCCCCCCCCEECCEEEEEEEEECCCCEEEEEECCCCCCCCCHHHHHCCCCHHHHHHHHH
YRQKNEVELIERGKDKFRELSKKLNFSMDEILEKLKEIGFYIKYNIKSDDEFFIKLSLED
HHCCCHHHHHHCCHHHHHHHHHHHCCCHHHHHHHHHHCCEEEEEEECCCCEEEEEEEECC
ISINTIRNIFTLNEKEEETITTVEKTNSSRKGISVLVDGEEGVESYFAKCCMPVPGDEII
CCHHHHHHHHCCCCCCHHHHHHHHHCCCCCCCEEEEECCHHHHHHHHHHCCCCCCCHHHH
GVITRRGIGIHRKDCNNIQDIDDSKKVNVEWNELNQNKFSTVLMIDVESKNVLNNVRNVI
HHHHHCCCCCCCCCCCCCCCCCCCCEEEEEHHHCCCCCCEEEEEEEECCHHHHHHHHHHH
NNEGGHIEKFEMTNNSNYLNIRIYLAVQNLKHLSLLSNKLKNSKGVYSVRRV
CCCCCCEEEEEECCCCCEEEEEEEEEECCHHHHHHHHHHHCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9383190; 9384377 [H]