Click here to switch to the map view.

The map label for this gene is comEC [H]

Identifier: 160903332

GI number: 160903332

Start: 2107576

End: 2108931

Strand: Direct

Name: comEC [H]

Synonym: Pmob_1903

Alternate gene names: 160903332

Gene position: 2107576-2108931 (Clockwise)

Preceding gene: 160903330

Following gene: 160903333

Centisome position: 97.14

GC content: 35.03

Gene sequence:

>1356_bases
ATGAAGAAGGTTCTACTGATATTTTGCATATTACTTCTTCCTTTTTCCCTTTCTCTATCCTTTAATTCTCCAAGCTTTAT
TTGGAGTTACGTCACGAGCTACCAAACAGATGAACTAATGTATTGGAAAGTTAACTATATCCAAAAATTAATAGACCTGA
TTGAAGATTATTTGCCATTTTTAGAAAGATCAGGCATAACTCTTCCTATCACTTCGGATATTGAAGTTCATTTTATTGAT
GTTGGCCAAGGTGATTCAGTTTATATAAAATTACCGAATAATGTTGATATTTTAATTGACGGTGGTAATAATTGGTATGG
TGACGATGTAGTTACTTACCTCAAATCCCAAGATGTTGATGATATAGAGTATTTGATAGCTACTCATCCTGATGCAGACC
ATATAGGTGGGTTAGATGATGTTTTAAAAGCCTTTGAAGTTGAAAATGTCTATGCCCCGGATGTTTCCCACACCACGAAA
ACCTATAATGATTTTGTTTTAGAAGTGAGAAACGAAGGGACCTACATTAAAACAGCTAAGGCTGGGATTACTTTAATTAA
TCCTGCTTTAGCGGCTGTGATAGGTTGCCCTTCATTCAGCAATGTGTATTTTGTTGGACCGGTGAAAAATTATGGAACAG
ATCTTAATTCTTGGAGTGCTGTTATGAAGTTAGATTTTGGAAATTCTTCTTATCTTTTCACTGGAGATGCCGATAGAATT
TCTGAAAAAGATATGATAGATAATAGTATGTTTTTAAAGGCAGATGTCCTTAAGGTTGGACATCATGGGTCCGATTCTTC
GACCTCGCAAGAGTTTTTAAAGGAAGTTAATCCAAAATATGCGGTTATATCTGTGGGTAAAAATAATAATTACGGTCATC
CAGCACAGGAAGTATTAGAAAGATTGGAAATGTGTAAGGTAGATCTTTTTCGTACAGATTTGCAGGGACATATTATAGCT
ATTAGTGATGGGAATAAAATAAATTTTAACGTTGAACCAATTAACATTGTTAATCTTATGGAAGATGCCCAAGAATCAAC
ACCACAAAAAACTTCTATATTGATTACGCATTTAGATGTTTCTGATGAAAAGGTTACTATCTGCAACAATACTGATATAG
ACGTTGATTTAACAGGATGGGTTTTGGTTAGCGAAGTTGGGAACCAAAAGTTTAATCTTCCAGATGGATATATACTTAAA
GCTGGAAAATGTGTGAATATTTTGTCAGGCCGTAACGCAATAGATGAACCTCCAACTAATTTAAAATGGACGGGCGCTTA
TATATGGAATAACGATAGCGATATTGCAGCCCTCTACGACGCAGAAGGGGTACTAATAAGCAGGGTTGAATTCTAA

Upstream 100 bases:

>100_bases
CTTATGGGTGGGCAGCGGGGCGAAGGGGCGCTAACAGATGTTTTAAAGCTCCTAAGGATAGTAAAAATATAATAATAAAC
AAAGTAATGAGGAGATACTT

Downstream 100 bases:

>100_bases
CGTTTTGTCAACTACAATAATAAAAATTAATTAGAAATTGTGATTTTATGTTAAAAAAAATGCTTGAAAAAAGAGATCAG
TTGTGTTATAATTCTTATGC

Product: beta-lactamase domain-containing protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 451; Mature: 451

Protein sequence:

>451_residues
MKKVLLIFCILLLPFSLSLSFNSPSFIWSYVTSYQTDELMYWKVNYIQKLIDLIEDYLPFLERSGITLPITSDIEVHFID
VGQGDSVYIKLPNNVDILIDGGNNWYGDDVVTYLKSQDVDDIEYLIATHPDADHIGGLDDVLKAFEVENVYAPDVSHTTK
TYNDFVLEVRNEGTYIKTAKAGITLINPALAAVIGCPSFSNVYFVGPVKNYGTDLNSWSAVMKLDFGNSSYLFTGDADRI
SEKDMIDNSMFLKADVLKVGHHGSDSSTSQEFLKEVNPKYAVISVGKNNNYGHPAQEVLERLEMCKVDLFRTDLQGHIIA
ISDGNKINFNVEPINIVNLMEDAQESTPQKTSILITHLDVSDEKVTICNNTDIDVDLTGWVLVSEVGNQKFNLPDGYILK
AGKCVNILSGRNAIDEPPTNLKWTGAYIWNNDSDIAALYDAEGVLISRVEF

Sequences:

>Translated_451_residues
MKKVLLIFCILLLPFSLSLSFNSPSFIWSYVTSYQTDELMYWKVNYIQKLIDLIEDYLPFLERSGITLPITSDIEVHFID
VGQGDSVYIKLPNNVDILIDGGNNWYGDDVVTYLKSQDVDDIEYLIATHPDADHIGGLDDVLKAFEVENVYAPDVSHTTK
TYNDFVLEVRNEGTYIKTAKAGITLINPALAAVIGCPSFSNVYFVGPVKNYGTDLNSWSAVMKLDFGNSSYLFTGDADRI
SEKDMIDNSMFLKADVLKVGHHGSDSSTSQEFLKEVNPKYAVISVGKNNNYGHPAQEVLERLEMCKVDLFRTDLQGHIIA
ISDGNKINFNVEPINIVNLMEDAQESTPQKTSILITHLDVSDEKVTICNNTDIDVDLTGWVLVSEVGNQKFNLPDGYILK
AGKCVNILSGRNAIDEPPTNLKWTGAYIWNNDSDIAALYDAEGVLISRVEF
>Mature_451_residues
MKKVLLIFCILLLPFSLSLSFNSPSFIWSYVTSYQTDELMYWKVNYIQKLIDLIEDYLPFLERSGITLPITSDIEVHFID
VGQGDSVYIKLPNNVDILIDGGNNWYGDDVVTYLKSQDVDDIEYLIATHPDADHIGGLDDVLKAFEVENVYAPDVSHTTK
TYNDFVLEVRNEGTYIKTAKAGITLINPALAAVIGCPSFSNVYFVGPVKNYGTDLNSWSAVMKLDFGNSSYLFTGDADRI
SEKDMIDNSMFLKADVLKVGHHGSDSSTSQEFLKEVNPKYAVISVGKNNNYGHPAQEVLERLEMCKVDLFRTDLQGHIIA
ISDGNKINFNVEPINIVNLMEDAQESTPQKTSILITHLDVSDEKVTICNNTDIDVDLTGWVLVSEVGNQKFNLPDGYILK
AGKCVNILSGRNAIDEPPTNLKWTGAYIWNNDSDIAALYDAEGVLISRVEF

Specific function: The comE operon is required for the binding and uptake of transforming DNA. ComEC is required for internalization but is dispensable for DNA binding [H]

COG id: COG2333

COG function: function code R; Predicted hydrolase (metallo-beta-lactamase superfamily)

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Probable) [H]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: To H.influenzae REC2, N.gonorrhoeae ComA and E.coli YcaI [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001279
- InterPro:   IPR004477
- InterPro:   IPR004797 [H]

Pfam domain/function: PF03772 Competence; PF00753 Lactamase_B [H]

EC number: NA

Molecular weight: Translated: 50321; Mature: 50321

Theoretical pI: Translated: 4.26; Mature: 4.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.7 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKVLLIFCILLLPFSLSLSFNSPSFIWSYVTSYQTDELMYWKVNYIQKLIDLIEDYLPF
CCHHHHHHHHHHHCCEEEEECCCCHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHH
LERSGITLPITSDIEVHFIDVGQGDSVYIKLPNNVDILIDGGNNWYGDDVVTYLKSQDVD
HHHCCCEEEEECCCEEEEEEECCCCEEEEECCCCEEEEEECCCCCCCHHHHHHHHCCCCC
DIEYLIATHPDADHIGGLDDVLKAFEVENVYAPDVSHTTKTYNDFVLEVRNEGTYIKTAK
CEEEEEEECCCHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEC
AGITLINPALAAVIGCPSFSNVYFVGPVKNYGTDLNSWSAVMKLDFGNSSYLFTGDADRI
CCEEEECHHHHHHCCCCCCCCEEEECCCHHCCCCCCCCEEEEEEECCCCEEEEECCHHHC
SEKDMIDNSMFLKADVLKVGHHGSDSSTSQEFLKEVNPKYAVISVGKNNNYGHPAQEVLE
CCHHHCCCCEEEEEEEEEECCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHH
RLEMCKVDLFRTDLQGHIIAISDGNKINFNVEPINIVNLMEDAQESTPQKTSILITHLDV
HHHHHHHHHEEECCCCEEEEEECCCEEEEEECCEEHHHHHHHHHHCCCCCEEEEEEEECC
SDEKVTICNNTDIDVDLTGWVLVSEVGNQKFNLPDGYILKAGKCVNILSGRNAIDEPPTN
CCCEEEEECCCCCEEEEECEEEEEECCCCCCCCCCCEEEECCCEEEEECCCCCCCCCCCC
LKWTGAYIWNNDSDIAALYDAEGVLISRVEF
EEEEEEEEECCCCCEEEEEECCCEEEEEECC
>Mature Secondary Structure
MKKVLLIFCILLLPFSLSLSFNSPSFIWSYVTSYQTDELMYWKVNYIQKLIDLIEDYLPF
CCHHHHHHHHHHHCCEEEEECCCCHHHHHHHHCCCCCCEEEEEHHHHHHHHHHHHHHHHH
LERSGITLPITSDIEVHFIDVGQGDSVYIKLPNNVDILIDGGNNWYGDDVVTYLKSQDVD
HHHCCCEEEEECCCEEEEEEECCCCEEEEECCCCEEEEEECCCCCCCHHHHHHHHCCCCC
DIEYLIATHPDADHIGGLDDVLKAFEVENVYAPDVSHTTKTYNDFVLEVRNEGTYIKTAK
CEEEEEEECCCHHHCCCHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEECCCCCEEEEEC
AGITLINPALAAVIGCPSFSNVYFVGPVKNYGTDLNSWSAVMKLDFGNSSYLFTGDADRI
CCEEEECHHHHHHCCCCCCCCEEEECCCHHCCCCCCCCEEEEEEECCCCEEEEECCHHHC
SEKDMIDNSMFLKADVLKVGHHGSDSSTSQEFLKEVNPKYAVISVGKNNNYGHPAQEVLE
CCHHHCCCCEEEEEEEEEECCCCCCCCHHHHHHHHCCCCEEEEEECCCCCCCCHHHHHHH
RLEMCKVDLFRTDLQGHIIAISDGNKINFNVEPINIVNLMEDAQESTPQKTSILITHLDV
HHHHHHHHHEEECCCCEEEEEECCCEEEEEECCEEHHHHHHHHHHCCCCCEEEEEEEECC
SDEKVTICNNTDIDVDLTGWVLVSEVGNQKFNLPDGYILKAGKCVNILSGRNAIDEPPTN
CCCEEEEECCCCCEEEEECEEEEEECCCCCCCCCCCEEEECCCEEEEECCCCCCCCCCCC
LKWTGAYIWNNDSDIAALYDAEGVLISRVEF
EEEEEEEEECCCCCEEEEEECCCEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7968523; 8969508; 9384377 [H]