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The map label for this gene is glmS [H]

Identifier: 160903277

GI number: 160903277

Start: 2030412

End: 2032250

Strand: Direct

Name: glmS [H]

Synonym: Pmob_1846

Alternate gene names: 160903277

Gene position: 2030412-2032250 (Clockwise)

Preceding gene: 160903276

Following gene: 160903278

Centisome position: 93.59

GC content: 37.03

Gene sequence:

>1839_bases
TTGTGTGGGATAGTAGGGTTTGTTTCCGATAGAAAAGTGAAAGTTGAAGATCTTATTTCTGGATTGAAAAAACTTGAGTA
TCGAGGATACGATTCCGCAGGTTTAGCTTACAATGTGAATCATTCTATAAAATACCTAAAAATGCCGGGAAGAATAAGCG
AGATTGAAAAATTACTACTAAATGAAGGTTTAATGAAAGAAAGTTTTTATTCTGGAATAGCCCACACAAGATGGGCAACG
CACGGCGTTGTTTCAGAACAAAATTCCCATCCACATTTGGATTGTAAAGAAGAGTTAGCCGTTGTACATAACGGCATCAT
AGAGAACTTTCAAGAGTTGAAAACGGAGCTTGAAGTTAAGGGCCATATCTTCAAATCAGAAACGGATTCAGAAGTTATCG
CACATTTGATAGAAGATAAGTACAATGGAGATCTTTTTGATTCTGTTTTAAAAGCTTTAGAAGAACTCGAAGGTGCGTAT
GCTATTGCTGTTGTTCATAAAGACAAACCCGATCAAATAGTTGCTGCAAGAAAAGGCAGTCCTTTAGTGATTGCAAGTAA
TAATAGTATTAGTATGTTAGCTTCAGATGTTACTCCTTTACTGAAGTATTCAAAAGAGATGAATTTTTTGAATGATGGAG
AGGTAGCTATTTTAACTCCTAAAGGTTACTCTTTATTTAACTTAGATGGTGTCCCTCTTGAGAGAAAACCAATACTTATA
ACCTGGGATGAGTCGCTGGCAGAAAAATCAGGATATCCGCATTTCATGTTGAAAGAAATCTTTGAGCAACCGATAGCTTT
AGAATCCGTTCTGGTTGGTCGATTAAAAGATGGGAAACCACAGATAAAAGAAGTACGATCTTTAGAAGGTTTTGTTAAGA
ACCAAATGAAAAAAGTATATGTGGTTGCATGCGGTACGAGTTATCATGCTGGTTTAGCTGCAAAATACTTCATGAATAGA
TATTCAGATATTGATTTTGACATTGAGGTTGCATCAGAGTTCAGATACATGAATCCGGCGATAGATGGTAATACTTTGGT
GTTGGCTATCTCTCAATCTGGGGAGACTATAGATACGTTAGAAGGTGTCAGATTAGCAAAGAAAAAAGGTGCATATGTAT
TAGCTATAAGTAACGTAGTTGGGTCAACTATTCCGAGAGAATCTGACGCAGTCCTTTATCTCAACACTGGTCCAGAGATA
GGGGTTGCTGCAACGAAAACTTATACGGCACAGATAGCTTTGCTTTACACCTTAGCTTCCCAACTCATCCGTTGGAAAGG
TTACGAAAACGAAGAGTTGGATGAAATTATGAGAACCATCGAAAAAATCCCAGAATTATTTAAAATGATCTTGAATGAAA
CAAACGGTCACATGATGGAATTGGTAAAGAAGTATAAAAACTTCAAAGACATGATGTACATTGGTAGAGTTTTTGGTTTT
CCCGCAGCTTTGGAAGGGGCTTTGAAATTAAAAGAGATCAGTTATATCAATGCGATCGCCTATCAAGCAGGAGAATTAAA
ACATGGGCCAATAGCACTATTAGATGATAATTTTCCAGTCTTTGCGATAGTTCCTTCAGGGAAGTTAAGAGAAAAAATGA
TTTCAAACATTATGGAAGTAAAAGCGCGTGGCGCAAGGGTTATAGCTTTAACCCCAAAAGATGATCTACAAACGAAAAAA
ATATGTGATGATTACATCGATGTGCCTACTGTTCTGGAACCTTTAATACCGTTGGTAGTAGCTCCTATTACTCAATTGTT
CGCTTACTACATAGCGGTGCAAAAAGGTTTGGACCCAGATAAACCGAGAAATTTGGCAAAAAGTGTCACAGTAGAATAA

Upstream 100 bases:

>100_bases
TTCAGACGCTGAAGCAATAGCTAATGCATTGTACGTGGCTTACCGTGCCGCCAAATTTGACTTGATCGAAAAGATTGAGA
TTTAAAAGGGGGTTTAACAA

Downstream 100 bases:

>100_bases
TTTTAGTGGAGGTGATAAATTTTTGTTAAAAACTGATGTTTTGAATTCCGTTAAGGAAATAGTGGAATTGTTAGAAGAAA
AAGATGGAGAAAATATTGTT

Product: glucosamine--fructose-6-phosphate aminotransferase

Products: NA

Alternate protein names: D-fructose-6-phosphate amidotransferase; GFAT; Glucosamine-6-phosphate synthase; Hexosephosphate aminotransferase; L-glutamine-D-fructose-6-phosphate amidotransferase [H]

Number of amino acids: Translated: 612; Mature: 612

Protein sequence:

>612_residues
MCGIVGFVSDRKVKVEDLISGLKKLEYRGYDSAGLAYNVNHSIKYLKMPGRISEIEKLLLNEGLMKESFYSGIAHTRWAT
HGVVSEQNSHPHLDCKEELAVVHNGIIENFQELKTELEVKGHIFKSETDSEVIAHLIEDKYNGDLFDSVLKALEELEGAY
AIAVVHKDKPDQIVAARKGSPLVIASNNSISMLASDVTPLLKYSKEMNFLNDGEVAILTPKGYSLFNLDGVPLERKPILI
TWDESLAEKSGYPHFMLKEIFEQPIALESVLVGRLKDGKPQIKEVRSLEGFVKNQMKKVYVVACGTSYHAGLAAKYFMNR
YSDIDFDIEVASEFRYMNPAIDGNTLVLAISQSGETIDTLEGVRLAKKKGAYVLAISNVVGSTIPRESDAVLYLNTGPEI
GVAATKTYTAQIALLYTLASQLIRWKGYENEELDEIMRTIEKIPELFKMILNETNGHMMELVKKYKNFKDMMYIGRVFGF
PAALEGALKLKEISYINAIAYQAGELKHGPIALLDDNFPVFAIVPSGKLREKMISNIMEVKARGARVIALTPKDDLQTKK
ICDDYIDVPTVLEPLIPLVVAPITQLFAYYIAVQKGLDPDKPRNLAKSVTVE

Sequences:

>Translated_612_residues
MCGIVGFVSDRKVKVEDLISGLKKLEYRGYDSAGLAYNVNHSIKYLKMPGRISEIEKLLLNEGLMKESFYSGIAHTRWAT
HGVVSEQNSHPHLDCKEELAVVHNGIIENFQELKTELEVKGHIFKSETDSEVIAHLIEDKYNGDLFDSVLKALEELEGAY
AIAVVHKDKPDQIVAARKGSPLVIASNNSISMLASDVTPLLKYSKEMNFLNDGEVAILTPKGYSLFNLDGVPLERKPILI
TWDESLAEKSGYPHFMLKEIFEQPIALESVLVGRLKDGKPQIKEVRSLEGFVKNQMKKVYVVACGTSYHAGLAAKYFMNR
YSDIDFDIEVASEFRYMNPAIDGNTLVLAISQSGETIDTLEGVRLAKKKGAYVLAISNVVGSTIPRESDAVLYLNTGPEI
GVAATKTYTAQIALLYTLASQLIRWKGYENEELDEIMRTIEKIPELFKMILNETNGHMMELVKKYKNFKDMMYIGRVFGF
PAALEGALKLKEISYINAIAYQAGELKHGPIALLDDNFPVFAIVPSGKLREKMISNIMEVKARGARVIALTPKDDLQTKK
ICDDYIDVPTVLEPLIPLVVAPITQLFAYYIAVQKGLDPDKPRNLAKSVTVE
>Mature_612_residues
MCGIVGFVSDRKVKVEDLISGLKKLEYRGYDSAGLAYNVNHSIKYLKMPGRISEIEKLLLNEGLMKESFYSGIAHTRWAT
HGVVSEQNSHPHLDCKEELAVVHNGIIENFQELKTELEVKGHIFKSETDSEVIAHLIEDKYNGDLFDSVLKALEELEGAY
AIAVVHKDKPDQIVAARKGSPLVIASNNSISMLASDVTPLLKYSKEMNFLNDGEVAILTPKGYSLFNLDGVPLERKPILI
TWDESLAEKSGYPHFMLKEIFEQPIALESVLVGRLKDGKPQIKEVRSLEGFVKNQMKKVYVVACGTSYHAGLAAKYFMNR
YSDIDFDIEVASEFRYMNPAIDGNTLVLAISQSGETIDTLEGVRLAKKKGAYVLAISNVVGSTIPRESDAVLYLNTGPEI
GVAATKTYTAQIALLYTLASQLIRWKGYENEELDEIMRTIEKIPELFKMILNETNGHMMELVKKYKNFKDMMYIGRVFGF
PAALEGALKLKEISYINAIAYQAGELKHGPIALLDDNFPVFAIVPSGKLREKMISNIMEVKARGARVIALTPKDDLQTKK
ICDDYIDVPTVLEPLIPLVVAPITQLFAYYIAVQKGLDPDKPRNLAKSVTVE

Specific function: Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source [H]

COG id: COG0449

COG function: function code M; Glucosamine 6-phosphate synthetase, contains amidotransferase and phosphosugar isomerase domains

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 SIS domains [H]

Homologues:

Organism=Homo sapiens, GI4826742, Length=695, Percent_Identity=34.3884892086331, Blast_Score=360, Evalue=2e-99,
Organism=Homo sapiens, GI205277386, Length=690, Percent_Identity=33.9130434782609, Blast_Score=358, Evalue=7e-99,
Organism=Escherichia coli, GI1790167, Length=619, Percent_Identity=42.0032310177706, Blast_Score=473, Evalue=1e-134,
Organism=Escherichia coli, GI87082251, Length=326, Percent_Identity=22.3926380368098, Blast_Score=86, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17532899, Length=430, Percent_Identity=33.2558139534884, Blast_Score=234, Evalue=8e-62,
Organism=Caenorhabditis elegans, GI17532897, Length=430, Percent_Identity=33.2558139534884, Blast_Score=234, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI17539970, Length=440, Percent_Identity=33.4090909090909, Blast_Score=232, Evalue=5e-61,
Organism=Saccharomyces cerevisiae, GI6322745, Length=430, Percent_Identity=33.953488372093, Blast_Score=229, Evalue=1e-60,
Organism=Saccharomyces cerevisiae, GI6323731, Length=437, Percent_Identity=29.0617848970252, Blast_Score=164, Evalue=3e-41,
Organism=Saccharomyces cerevisiae, GI6323730, Length=212, Percent_Identity=42.4528301886792, Blast_Score=138, Evalue=3e-33,
Organism=Drosophila melanogaster, GI21357745, Length=697, Percent_Identity=33.8593974175036, Blast_Score=370, Evalue=1e-102,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000583
- InterPro:   IPR017932
- InterPro:   IPR005855
- InterPro:   IPR001347 [H]

Pfam domain/function: PF00310 GATase_2; PF01380 SIS [H]

EC number: =2.6.1.16 [H]

Molecular weight: Translated: 68224; Mature: 68224

Theoretical pI: Translated: 6.10; Mature: 6.10

Prosite motif: PS00443 GATASE_TYPE_II

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MCGIVGFVSDRKVKVEDLISGLKKLEYRGYDSAGLAYNVNHSIKYLKMPGRISEIEKLLL
CCCEEEECCCCCEEHHHHHHHHHHHHCCCCCCCCCEEECCCCEEEEECCCCHHHHHHHHH
NEGLMKESFYSGIAHTRWATHGVVSEQNSHPHLDCKEELAVVHNGIIENFQELKTELEVK
HCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GHIFKSETDSEVIAHLIEDKYNGDLFDSVLKALEELEGAYAIAVVHKDKPDQIVAARKGS
CEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCEEEECCCC
PLVIASNNSISMLASDVTPLLKYSKEMNFLNDGEVAILTPKGYSLFNLDGVPLERKPILI
EEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCEEEECCCCCCCCCCEEE
TWDESLAEKSGYPHFMLKEIFEQPIALESVLVGRLKDGKPQIKEVRSLEGFVKNQMKKVY
EECHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEE
VVACGTSYHAGLAAKYFMNRYSDIDFDIEVASEFRYMNPAIDGNTLVLAISQSGETIDTL
EEEECCCCCHHHHHHHHHHHCCCCCEEEEEHHHHHCCCCCCCCCEEEEEECCCCCCHHHH
EGVRLAKKKGAYVLAISNVVGSTIPRESDAVLYLNTGPEIGVAATKTYTAQIALLYTLAS
HHHHHHHHCCCEEEEEHHHHCCCCCCCCCEEEEEECCCCCCEEECHHHHHHHHHHHHHHH
QLIRWKGYENEELDEIMRTIEKIPELFKMILNETNGHMMELVKKYKNFKDMMYIGRVFGF
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
PAALEGALKLKEISYINAIAYQAGELKHGPIALLDDNFPVFAIVPSGKLREKMISNIMEV
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEECCCHHHHHHHHHHHHH
KARGARVIALTPKDDLQTKKICDDYIDVPTVLEPLIPLVVAPITQLFAYYIAVQKGLDPD
HCCCCEEEEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
KPRNLAKSVTVE
CCHHHHHHCCCC
>Mature Secondary Structure
MCGIVGFVSDRKVKVEDLISGLKKLEYRGYDSAGLAYNVNHSIKYLKMPGRISEIEKLLL
CCCEEEECCCCCEEHHHHHHHHHHHHCCCCCCCCCEEECCCCEEEEECCCCHHHHHHHHH
NEGLMKESFYSGIAHTRWATHGVVSEQNSHPHLDCKEELAVVHNGIIENFQELKTELEVK
HCCHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
GHIFKSETDSEVIAHLIEDKYNGDLFDSVLKALEELEGAYAIAVVHKDKPDQIVAARKGS
CEEECCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEEECCCCCCEEEECCCC
PLVIASNNSISMLASDVTPLLKYSKEMNFLNDGEVAILTPKGYSLFNLDGVPLERKPILI
EEEEECCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEEECCCCCEEEECCCCCCCCCCEEE
TWDESLAEKSGYPHFMLKEIFEQPIALESVLVGRLKDGKPQIKEVRSLEGFVKNQMKKVY
EECHHHHHHCCCCHHHHHHHHHCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHCCCEEE
VVACGTSYHAGLAAKYFMNRYSDIDFDIEVASEFRYMNPAIDGNTLVLAISQSGETIDTL
EEEECCCCCHHHHHHHHHHHCCCCCEEEEEHHHHHCCCCCCCCCEEEEEECCCCCCHHHH
EGVRLAKKKGAYVLAISNVVGSTIPRESDAVLYLNTGPEIGVAATKTYTAQIALLYTLAS
HHHHHHHHCCCEEEEEHHHHCCCCCCCCCEEEEEECCCCCCEEECHHHHHHHHHHHHHHH
QLIRWKGYENEELDEIMRTIEKIPELFKMILNETNGHMMELVKKYKNFKDMMYIGRVFGF
HHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHCC
PAALEGALKLKEISYINAIAYQAGELKHGPIALLDDNFPVFAIVPSGKLREKMISNIMEV
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEEEECCCHHHHHHHHHHHHH
KARGARVIALTPKDDLQTKKICDDYIDVPTVLEPLIPLVVAPITQLFAYYIAVQKGLDPD
HCCCCEEEEECCCCCCCHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCC
KPRNLAKSVTVE
CCHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 10360571 [H]