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The map label for this gene is patB [H]

Identifier: 160903190

GI number: 160903190

Start: 1923845

End: 1925017

Strand: Direct

Name: patB [H]

Synonym: Pmob_1758

Alternate gene names: 160903190

Gene position: 1923845-1925017 (Clockwise)

Preceding gene: 160903189

Following gene: 160903191

Centisome position: 88.67

GC content: 32.65

Gene sequence:

>1173_bases
TTGAAGAATAATTTCAACGAAATTGTGGACAGAAAATCTACAGAGTCAGTAAAATGGAACGGTGTCAAAAGTCTTTATGG
TAGAGATGATGTTATCCCCATGTGGGTAGCTGATATGGATTTTAAATCTCCACCTGAAGTAATTGAAGCATTAAAACAAC
GAGCAGAACATGGAATTTTTGGATATCCAATGTTAGACGAAGATTACTTTGTTCCTTTTATAAATTGGATCAAGGCAAGA
CATGGCATCGAGATAAAAAAAGAGTGGATAGTGACTACTGACGGTGTGGTTGACGCCTTAAAAATAGCCATACTTGCCTA
CTCCAAACCAGGAGACAACGTTGTAATTCAAACACCTGTTTACTATCCTTTTTATAACATCATCAAATCCAATGGCCGAA
TGATAATAAAAAATTCTCTAAAATTTGAAAACAGAAATTATAGCATGGATTTTGATGATTTAGAAAAGAAATTATCACTC
AAAAGAACGAAATTATTCATCTTATGTAATCCGCACAACCCAGTGGGAAGAGTTTGGAAACGGGAAGAATTAGAAAAGTT
AGTTCAATTATGTATTAAACATAACGTTCTTTTGTTATCCGACGAAATACATTCAGATCTAGTATTTTCTCCCAACAAAC
ATATTCCAATATTTTCGATCTCACAAGATATAAAAGAGGGTTCTTTAACTTTTTATGCCCCAAGTAAAACATTCAATTTA
GCTGGCTTAAAAGCCTCGTTTGCTGTTATCCCAAATGAACAATTAAGAACTGAATACAAAAATGTTATTGAGAGTCTTTC
AAGTGATAATTTAAATATCTTTGGAATGGTTGCAGCTAAAGTTGCTTATGAAAGAGGTGAAGATTGGCTTGATGATTTAC
TAAATTACTTGAGAGCCAATATCGATTACGTGTACGATTTCTTCAATGAAAAACTACCTAAAGTAAAATTGCAAAAACCA
GAAGGAACATATTTAATGTGGTTAGATTTTAGGGCATATGGAGATGAGCAAAAAGTCAAAGATATACTCGTAAACAAAGC
AAAAGTTGGTTTAGAAGAAGGTAGCATCTTTGGAGAAGAAGGTAAAGGCTTTTTTAGAATGAATATTGGATGTCCCATAT
CTATGTTAAAAGATGCATGCAACAATATTTACGATGCTTTTAAAAATTTATAA

Upstream 100 bases:

>100_bases
AGTTAACACCTGTACCCGGTGGTGTTGGAAGCGTCACAACAGCTATTCTAATGAGAAATGTTTTTAGAGCGGCTAACAAT
AAAAAGGGAGATATGCAACT

Downstream 100 bases:

>100_bases
AAATAGAAAAAGTAAAAGGGAGAATTTAATGTATAACTCTGCAAAGCAACTATTAGAACTTTGTGAAAAGCAAAAAAAGC
CAATCTATCAAGTAGTTATA

Product: class I and II aminotransferase

Products: NA

Alternate protein names: CBL; Beta-cystathionase; Cysteine lyase [H]

Number of amino acids: Translated: 390; Mature: 390

Protein sequence:

>390_residues
MKNNFNEIVDRKSTESVKWNGVKSLYGRDDVIPMWVADMDFKSPPEVIEALKQRAEHGIFGYPMLDEDYFVPFINWIKAR
HGIEIKKEWIVTTDGVVDALKIAILAYSKPGDNVVIQTPVYYPFYNIIKSNGRMIIKNSLKFENRNYSMDFDDLEKKLSL
KRTKLFILCNPHNPVGRVWKREELEKLVQLCIKHNVLLLSDEIHSDLVFSPNKHIPIFSISQDIKEGSLTFYAPSKTFNL
AGLKASFAVIPNEQLRTEYKNVIESLSSDNLNIFGMVAAKVAYERGEDWLDDLLNYLRANIDYVYDFFNEKLPKVKLQKP
EGTYLMWLDFRAYGDEQKVKDILVNKAKVGLEEGSIFGEEGKGFFRMNIGCPISMLKDACNNIYDAFKNL

Sequences:

>Translated_390_residues
MKNNFNEIVDRKSTESVKWNGVKSLYGRDDVIPMWVADMDFKSPPEVIEALKQRAEHGIFGYPMLDEDYFVPFINWIKAR
HGIEIKKEWIVTTDGVVDALKIAILAYSKPGDNVVIQTPVYYPFYNIIKSNGRMIIKNSLKFENRNYSMDFDDLEKKLSL
KRTKLFILCNPHNPVGRVWKREELEKLVQLCIKHNVLLLSDEIHSDLVFSPNKHIPIFSISQDIKEGSLTFYAPSKTFNL
AGLKASFAVIPNEQLRTEYKNVIESLSSDNLNIFGMVAAKVAYERGEDWLDDLLNYLRANIDYVYDFFNEKLPKVKLQKP
EGTYLMWLDFRAYGDEQKVKDILVNKAKVGLEEGSIFGEEGKGFFRMNIGCPISMLKDACNNIYDAFKNL
>Mature_390_residues
MKNNFNEIVDRKSTESVKWNGVKSLYGRDDVIPMWVADMDFKSPPEVIEALKQRAEHGIFGYPMLDEDYFVPFINWIKAR
HGIEIKKEWIVTTDGVVDALKIAILAYSKPGDNVVIQTPVYYPFYNIIKSNGRMIIKNSLKFENRNYSMDFDDLEKKLSL
KRTKLFILCNPHNPVGRVWKREELEKLVQLCIKHNVLLLSDEIHSDLVFSPNKHIPIFSISQDIKEGSLTFYAPSKTFNL
AGLKASFAVIPNEQLRTEYKNVIESLSSDNLNIFGMVAAKVAYERGEDWLDDLLNYLRANIDYVYDFFNEKLPKVKLQKP
EGTYLMWLDFRAYGDEQKVKDILVNKAKVGLEEGSIFGEEGKGFFRMNIGCPISMLKDACNNIYDAFKNL

Specific function: Catalyzes the transformation of cystathionine to homocysteine. Also exhibits cysteine desulfhydrase activity in vitro, producing sulfide from cysteine [H]

COG id: COG1168

COG function: function code E; Bifunctional PLP-dependent enzyme with beta-cystathionase and maltose regulon repressor activities

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. MalY/PatB cystathionine beta-lyase subfamily [H]

Homologues:

Organism=Homo sapiens, GI56713256, Length=190, Percent_Identity=31.0526315789474, Blast_Score=96, Evalue=7e-20,
Organism=Homo sapiens, GI56713254, Length=190, Percent_Identity=31.0526315789474, Blast_Score=95, Evalue=9e-20,
Organism=Homo sapiens, GI4507369, Length=361, Percent_Identity=22.7146814404432, Blast_Score=93, Evalue=5e-19,
Organism=Homo sapiens, GI95147551, Length=352, Percent_Identity=25.8522727272727, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI169881279, Length=352, Percent_Identity=25.8522727272727, Blast_Score=91, Evalue=2e-18,
Organism=Homo sapiens, GI169881281, Length=215, Percent_Identity=26.9767441860465, Blast_Score=80, Evalue=4e-15,
Organism=Escherichia coli, GI1787909, Length=392, Percent_Identity=34.1836734693878, Blast_Score=262, Evalue=3e-71,
Organism=Escherichia coli, GI1786816, Length=243, Percent_Identity=26.3374485596708, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1788627, Length=304, Percent_Identity=25, Blast_Score=85, Evalue=9e-18,
Organism=Escherichia coli, GI1788722, Length=375, Percent_Identity=24.5333333333333, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1787710, Length=296, Percent_Identity=23.6486486486486, Blast_Score=76, Evalue=4e-15,
Organism=Escherichia coli, GI1790797, Length=397, Percent_Identity=21.6624685138539, Blast_Score=70, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI71994472, Length=250, Percent_Identity=26.8, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI71994476, Length=250, Percent_Identity=26.8, Blast_Score=90, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17567663, Length=355, Percent_Identity=23.0985915492958, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI17567369, Length=237, Percent_Identity=28.2700421940928, Blast_Score=87, Evalue=2e-17,
Organism=Saccharomyces cerevisiae, GI6322401, Length=266, Percent_Identity=25.9398496240602, Blast_Score=90, Evalue=5e-19,
Organism=Drosophila melanogaster, GI28573069, Length=254, Percent_Identity=30.3149606299213, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI24646114, Length=254, Percent_Identity=30.3149606299213, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI28573067, Length=254, Percent_Identity=30.3149606299213, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI28573065, Length=254, Percent_Identity=30.3149606299213, Blast_Score=98, Evalue=1e-20,
Organism=Drosophila melanogaster, GI18859735, Length=319, Percent_Identity=23.5109717868339, Blast_Score=87, Evalue=2e-17,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004839
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =4.4.1.8 [H]

Molecular weight: Translated: 45020; Mature: 45020

Theoretical pI: Translated: 6.80; Mature: 6.80

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.6 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNNFNEIVDRKSTESVKWNGVKSLYGRDDVIPMWVADMDFKSPPEVIEALKQRAEHGIF
CCCCHHHHHCCCCCCCEEECCHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCC
GYPMLDEDYFVPFINWIKARHGIEIKKEWIVTTDGVVDALKIAILAYSKPGDNVVIQTPV
CCCCCCCCCHHHHHHHHHHHCCCEEEEEEEEEECCHHHHHHEEEEEECCCCCCEEEECCC
YYPFYNIIKSNGRMIIKNSLKFENRNYSMDFDDLEKKLSLKRTKLFILCNPHNPVGRVWK
CHHHHHHHHCCCCEEEEECCEECCCCCCCCHHHHHHHHCCEEEEEEEEECCCCHHHHHHH
REELEKLVQLCIKHNVLLLSDEIHSDLVFSPNKHIPIFSISQDIKEGSLTFYAPSKTFNL
HHHHHHHHHHHHHCCEEEEECCCCCCEEECCCCCCEEEECCCCCCCCCEEEEECCCEEEE
AGLKASFAVIPNEQLRTEYKNVIESLSSDNLNIFGMVAAKVAYERGEDWLDDLLNYLRAN
ECCEEEEEECCCHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCHHHHHHHHHHHHHH
IDYVYDFFNEKLPKVKLQKPEGTYLMWLDFRAYGDEQKVKDILVNKAKVGLEEGSIFGEE
HHHHHHHHHCCCCCEEEECCCCCEEEEEEEEECCCHHHHHHHHHHHHHCCCCCCCEECCC
GKGFFRMNIGCPISMLKDACNNIYDAFKNL
CCEEEEEECCCCHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MKNNFNEIVDRKSTESVKWNGVKSLYGRDDVIPMWVADMDFKSPPEVIEALKQRAEHGIF
CCCCHHHHHCCCCCCCEEECCHHHHCCCCCCCEEEEECCCCCCCHHHHHHHHHHHHCCCC
GYPMLDEDYFVPFINWIKARHGIEIKKEWIVTTDGVVDALKIAILAYSKPGDNVVIQTPV
CCCCCCCCCHHHHHHHHHHHCCCEEEEEEEEEECCHHHHHHEEEEEECCCCCCEEEECCC
YYPFYNIIKSNGRMIIKNSLKFENRNYSMDFDDLEKKLSLKRTKLFILCNPHNPVGRVWK
CHHHHHHHHCCCCEEEEECCEECCCCCCCCHHHHHHHHCCEEEEEEEEECCCCHHHHHHH
REELEKLVQLCIKHNVLLLSDEIHSDLVFSPNKHIPIFSISQDIKEGSLTFYAPSKTFNL
HHHHHHHHHHHHHCCEEEEECCCCCCEEECCCCCCEEEECCCCCCCCCEEEEECCCEEEE
AGLKASFAVIPNEQLRTEYKNVIESLSSDNLNIFGMVAAKVAYERGEDWLDDLLNYLRAN
ECCEEEEEECCCHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCHHHHHHHHHHHHHH
IDYVYDFFNEKLPKVKLQKPEGTYLMWLDFRAYGDEQKVKDILVNKAKVGLEEGSIFGEE
HHHHHHHHHCCCCCEEEECCCCCEEEEEEEEECCCHHHHHHHHHHHHHCCCCCCCEECCC
GKGFFRMNIGCPISMLKDACNNIYDAFKNL
CCEEEEEECCCCHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8497199; 9274030; 9384377 [H]