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The map label for this gene is purH [H]

Identifier: 160903096

GI number: 160903096

Start: 1817048

End: 1818517

Strand: Direct

Name: purH [H]

Synonym: Pmob_1660

Alternate gene names: 160903096

Gene position: 1817048-1818517 (Clockwise)

Preceding gene: 160903095

Following gene: 160903097

Centisome position: 83.75

GC content: 30.88

Gene sequence:

>1470_bases
ATGAATATTAAAAGGGCAATTATTTCAGTTTATGACAAAACTAATTTAGAGGATTTAGCTAGTTTCTTATATCGCAATGG
TGTCGAAATTATATGTACAGAAGGAACAAATAAATATTTACAAGAAAAGGGAATCCCTACTGTAAAAATGGCTGATTATA
TTGGATTTCCTGAAATTTTAGGAGGTCGTGTTAAAAGCATAGATCCAAAATTAGCCGGTGGCATTTTAGCCAAGTCTAAC
GATAAAAAGCATGAAGAAGATATGATTAATTACAATATAAAAAGGATAGATATGGTTGTGGGTAATTTTCCTACTTTTGA
GGAAATTGCCAAAAAAACAAAGAATGAGGAAACACTTTTAGAAAATATCGATATTGGAGGCTATTCTCTTCTTAGAGCAG
CAGCAAAAAACTATAAGGATGTTGTAGCATTGGCAGATCCAAAAGATTATCAAACAGTTATTGATAATTTAGAGGATTGT
GGCGATGTCCCCTTACAGTTAAGAAGAAAGTTGGCATTGAAAGTTTTCTTTTCTACTTCTAAGTACGATGCAAGTATTCA
TAAAATTTTTTCAGAACTATTTGCAGCTGAAAAGTTTGACCATGAATTTTTTGAAATATTGGGGAACTTAAGATATGGTT
CTAATCCAATGCAAGAAGCGATTCTAATGAAATTTTTAGAAAAAGATACTTTTATCAACTATTTAGAAAATTTGACCTTT
CACAAAAAACCTACTTTAAGGATGTTAAAAGACATAAAATTACTTTTTCATTTGGCGAGTTTGACAAACAATGAATTTTT
GGGTTTTGCGAAAAAAGGAATTTTCGTATTTGGTTATTGTGCTCCTACTCAAGAAGAGAAAAAACAATTCATTAGAATTA
TTAAAGAACTTAAAGGTGGGATAGTTTATAGTGACGATCCAAATATAATTTTTGAACTGAAAGATTCAAAACATGACGGA
ATGATGACTTCTTATAATCTTGAACAAAAAGAAGAGATAATTTCTTTTAAACCCATGGTTTTTAAGGTTAATAAGAAAGT
TCTGAAACAAGAAGAAGAATATATTGTGGATAGTGATCTGGTCGTAAAGCAAAATTTCCAAGAGATTTCCTTGGATTTGT
CTCCTTCAGAACAATTAGGATTTGAGGTCGCTAAAATTCATAAATCTGATACCGCTGTGTATGTTAAAAATAATCTCATT
TGTTCTGGTAATCAATCTTGTTTGAACAGAGAAATCGCACTAAATGCACTCGAAAACACTTTGGAAAAGTTTGAAGTTCT
TCCGAAGGAAGGGACAATTATATTTGATTCTCCTATAAATTCAGAGAAGATAACCGATATAATATTAAATTGGCAGGTTG
AAAAGGTAATTGTTCCTCCAACCTTACCGGGATACGAAAAATATTTAAACGATTTAGAAGAAAAAGGAGTTACTTTGTTG
GTAACACAGGGAAGGTATCATAGATATTAA

Upstream 100 bases:

>100_bases
AAAAACCTAGAAAATGTAACTCAAAGCAAGAGACGTAAATGTTGAACGTCTCTGCTTTTCCTTTCATAAAAATTAACTTA
TTTTTCACTGGAGGTATCTC

Downstream 100 bases:

>100_bases
TGTTCATTAAGGGGCAAGCCCCTTAAGAACCCCAAAATCGCGTAACATCATTTGCAAAGCAAATGAGATTAGGAAAGTTA
TTCAAAAACATTACAAAAGA

Product: phosphoribosylaminoimidazolecarboxamide formyltransferase

Products: NA

Alternate protein names: Phosphoribosylaminoimidazolecarboxamide formyltransferase; AICAR transformylase; IMP cyclohydrolase; ATIC; IMP synthase; Inosinicase [H]

Number of amino acids: Translated: 489; Mature: 489

Protein sequence:

>489_residues
MNIKRAIISVYDKTNLEDLASFLYRNGVEIICTEGTNKYLQEKGIPTVKMADYIGFPEILGGRVKSIDPKLAGGILAKSN
DKKHEEDMINYNIKRIDMVVGNFPTFEEIAKKTKNEETLLENIDIGGYSLLRAAAKNYKDVVALADPKDYQTVIDNLEDC
GDVPLQLRRKLALKVFFSTSKYDASIHKIFSELFAAEKFDHEFFEILGNLRYGSNPMQEAILMKFLEKDTFINYLENLTF
HKKPTLRMLKDIKLLFHLASLTNNEFLGFAKKGIFVFGYCAPTQEEKKQFIRIIKELKGGIVYSDDPNIIFELKDSKHDG
MMTSYNLEQKEEIISFKPMVFKVNKKVLKQEEEYIVDSDLVVKQNFQEISLDLSPSEQLGFEVAKIHKSDTAVYVKNNLI
CSGNQSCLNREIALNALENTLEKFEVLPKEGTIIFDSPINSEKITDIILNWQVEKVIVPPTLPGYEKYLNDLEEKGVTLL
VTQGRYHRY

Sequences:

>Translated_489_residues
MNIKRAIISVYDKTNLEDLASFLYRNGVEIICTEGTNKYLQEKGIPTVKMADYIGFPEILGGRVKSIDPKLAGGILAKSN
DKKHEEDMINYNIKRIDMVVGNFPTFEEIAKKTKNEETLLENIDIGGYSLLRAAAKNYKDVVALADPKDYQTVIDNLEDC
GDVPLQLRRKLALKVFFSTSKYDASIHKIFSELFAAEKFDHEFFEILGNLRYGSNPMQEAILMKFLEKDTFINYLENLTF
HKKPTLRMLKDIKLLFHLASLTNNEFLGFAKKGIFVFGYCAPTQEEKKQFIRIIKELKGGIVYSDDPNIIFELKDSKHDG
MMTSYNLEQKEEIISFKPMVFKVNKKVLKQEEEYIVDSDLVVKQNFQEISLDLSPSEQLGFEVAKIHKSDTAVYVKNNLI
CSGNQSCLNREIALNALENTLEKFEVLPKEGTIIFDSPINSEKITDIILNWQVEKVIVPPTLPGYEKYLNDLEEKGVTLL
VTQGRYHRY
>Mature_489_residues
MNIKRAIISVYDKTNLEDLASFLYRNGVEIICTEGTNKYLQEKGIPTVKMADYIGFPEILGGRVKSIDPKLAGGILAKSN
DKKHEEDMINYNIKRIDMVVGNFPTFEEIAKKTKNEETLLENIDIGGYSLLRAAAKNYKDVVALADPKDYQTVIDNLEDC
GDVPLQLRRKLALKVFFSTSKYDASIHKIFSELFAAEKFDHEFFEILGNLRYGSNPMQEAILMKFLEKDTFINYLENLTF
HKKPTLRMLKDIKLLFHLASLTNNEFLGFAKKGIFVFGYCAPTQEEKKQFIRIIKELKGGIVYSDDPNIIFELKDSKHDG
MMTSYNLEQKEEIISFKPMVFKVNKKVLKQEEEYIVDSDLVVKQNFQEISLDLSPSEQLGFEVAKIHKSDTAVYVKNNLI
CSGNQSCLNREIALNALENTLEKFEVLPKEGTIIFDSPINSEKITDIILNWQVEKVIVPPTLPGYEKYLNDLEEKGVTLL
VTQGRYHRY

Specific function: De novo purine biosynthesis; ninth step. De novo purine biosynthesis; tenth step. [C]

COG id: COG0138

COG function: function code F; AICAR transformylase/IMP cyclohydrolase PurH (only IMP cyclohydrolase domain in Aful)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the purH family [H]

Homologues:

Organism=Homo sapiens, GI20127454, Length=233, Percent_Identity=35.1931330472103, Blast_Score=131, Evalue=1e-30,
Organism=Escherichia coli, GI1790439, Length=236, Percent_Identity=37.2881355932203, Blast_Score=152, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI71985564, Length=215, Percent_Identity=41.3953488372093, Blast_Score=146, Evalue=3e-35,
Organism=Saccharomyces cerevisiae, GI6323768, Length=229, Percent_Identity=39.3013100436681, Blast_Score=154, Evalue=3e-38,
Organism=Saccharomyces cerevisiae, GI6323056, Length=217, Percent_Identity=41.0138248847926, Blast_Score=152, Evalue=1e-37,
Organism=Drosophila melanogaster, GI24649832, Length=217, Percent_Identity=35.9447004608295, Blast_Score=129, Evalue=5e-30,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 640 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002695
- InterPro:   IPR013982
- InterPro:   IPR016193
- InterPro:   IPR011607 [H]

Pfam domain/function: PF01808 AICARFT_IMPCHas; PF02142 MGS [H]

EC number: =2.1.2.3; =3.5.4.10 [H]

Molecular weight: Translated: 56021; Mature: 56021

Theoretical pI: Translated: 5.78; Mature: 5.78

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
2.0 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIKRAIISVYDKTNLEDLASFLYRNGVEIICTEGTNKYLQEKGIPTVKMADYIGFPEIL
CCHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEECCCHHHHHHCCCCCEEHHHHCCCHHHH
GGRVKSIDPKLAGGILAKSNDKKHEEDMINYNIKRIDMVVGNFPTFEEIAKKTKNEETLL
CCCHHCCCCHHHCCEEECCCCCCCHHHHHHCCCEEEEEEECCCCCHHHHHHHCCCHHHHH
ENIDIGGYSLLRAAAKNYKDVVALADPKDYQTVIDNLEDCGDVPLQLRRKLALKVFFSTS
HHCCCCHHHHHHHHHCCCCCEEEECCCCHHHHHHHCHHHCCCCCHHHHHHHHHHEEEECC
KYDASIHKIFSELFAAEKFDHEFFEILGNLRYGSNPMQEAILMKFLEKDTFINYLENLTF
CCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
HKKPTLRMLKDIKLLFHLASLTNNEFLGFAKKGIFVFGYCAPTQEEKKQFIRIIKELKGG
CCCCHHHHHHHHHHHHHHHHHCCCCCCCEECCCEEEEEECCCCHHHHHHHHHHHHHHHCC
IVYSDDPNIIFELKDSKHDGMMTSYNLEQKEEIISFKPMVFKVNKKVLKQEEEYIVDSDL
EEEECCCCEEEEECCCCCCCCEEECCCHHHHHHHHCCCHHEEHHHHHHHCHHHHCCCCCH
VVKQNFQEISLDLSPSEQLGFEVAKIHKSDTAVYVKNNLICSGNQSCLNREIALNALENT
HHHCCHHHEEECCCCCHHHCCHHEEEECCCCEEEEECCEEECCCHHHHHHHHHHHHHHHH
LEKFEVLPKEGTIIFDSPINSEKITDIILNWQVEKVIVPPTLPGYEKYLNDLEEKGVTLL
HHHHHCCCCCCCEEECCCCCCHHHHHEEEEEEEEEEEECCCCCCHHHHHHHHHHCCEEEE
VTQGRYHRY
EECCCCCCC
>Mature Secondary Structure
MNIKRAIISVYDKTNLEDLASFLYRNGVEIICTEGTNKYLQEKGIPTVKMADYIGFPEIL
CCHHHHHHHHHCCCCHHHHHHHHHHCCCEEEEECCCHHHHHHCCCCCEEHHHHCCCHHHH
GGRVKSIDPKLAGGILAKSNDKKHEEDMINYNIKRIDMVVGNFPTFEEIAKKTKNEETLL
CCCHHCCCCHHHCCEEECCCCCCCHHHHHHCCCEEEEEEECCCCCHHHHHHHCCCHHHHH
ENIDIGGYSLLRAAAKNYKDVVALADPKDYQTVIDNLEDCGDVPLQLRRKLALKVFFSTS
HHCCCCHHHHHHHHHCCCCCEEEECCCCHHHHHHHCHHHCCCCCHHHHHHHHHHEEEECC
KYDASIHKIFSELFAAEKFDHEFFEILGNLRYGSNPMQEAILMKFLEKDTFINYLENLTF
CCCHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCC
HKKPTLRMLKDIKLLFHLASLTNNEFLGFAKKGIFVFGYCAPTQEEKKQFIRIIKELKGG
CCCCHHHHHHHHHHHHHHHHHCCCCCCCEECCCEEEEEECCCCHHHHHHHHHHHHHHHCC
IVYSDDPNIIFELKDSKHDGMMTSYNLEQKEEIISFKPMVFKVNKKVLKQEEEYIVDSDL
EEEECCCCEEEEECCCCCCCCEEECCCHHHHHHHHCCCHHEEHHHHHHHCHHHHCCCCCH
VVKQNFQEISLDLSPSEQLGFEVAKIHKSDTAVYVKNNLICSGNQSCLNREIALNALENT
HHHCCHHHEEECCCCCHHHCCHHEEEECCCCEEEEECCEEECCCHHHHHHHHHHHHHHHH
LEKFEVLPKEGTIIFDSPINSEKITDIILNWQVEKVIVPPTLPGYEKYLNDLEEKGVTLL
HHHHHCCCCCCCEEECCCCCCHHHHHEEEEEEEEEEEECCCCCCHHHHHHHHHHCCEEEE
VTQGRYHRY
EECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA