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The map label for this gene is mrdA [H]

Identifier: 160902867

GI number: 160902867

Start: 1526784

End: 1528493

Strand: Direct

Name: mrdA [H]

Synonym: Pmob_1422

Alternate gene names: 160902867

Gene position: 1526784-1528493 (Clockwise)

Preceding gene: 160902866

Following gene: 160902868

Centisome position: 70.37

GC content: 34.09

Gene sequence:

>1710_bases
ATGAAAGAAAAAAGAGCTAAAATACTGTTTTCTTTATTTTTTTTGGGTATTGCTTTACTTTTTGCGAGATCATTTCAATT
ACAGATTTTAAACTGGGATAAATATTCAATGGAAGTTCAAGAGTTATCAACAAGAATTGTAAAAGATTCTCCTAAAAGAG
GAAATATATACGATAGAAATGGAAATTTGTTAGCATGGAACCAAAGGATATATAATTTAACGAATTTAGGAGGAACGCTC
AGTGAAGAAACAGAGGCCGAATTGTATCAAGTTCTAAAAGATGTAGTGGATAATCCGTATGCTATAATAGATAAATTAAA
TTTTCAAAAAAGAGTGAATTTAGAAATAAATTCGGTAACAGCTCAAAAGATAGCCAGTATTGACAGAAATCTACAAGTTG
AAGAAAGATATATAAGAAAATATGCCCACGAATCTTTGTACCACGTCTTAGGCTATGTCGACAATGAAGGTACTCCAAGG
TCAGGATTGGAATTAGTGTTTGATGAAGAATTACAGGGGCAGACAGGGTACAAAATGGTCAATATTGCAACAAACGAATC
AGTTTCTCCTATAATAATTAATGCCCATTCTATTAATGGAAACAATATTTATTTGACATTAGATTTAGATTTACAAATTA
AAGCGTACAATTATTTAAAAGAAAACAACTACAATGGTTCGGTGATAATCTCCGAACCAAAAACGGGAGAAATTTTAGTC
TTTGTTAGTCATCCTTCGGTAGATCCTAATTTGTTTGCCCAAGGAATGAGTAATTTAGAGTTTCAAAGAATTTTGAATGA
CAATAATTTGCCATTGTTAAATAGAGCTGCATCCGCATTGTATCCGCCTGGATCTATTATAAAACCGTTTGTTGCATATG
CTGCACTTGAGGGGGGTATATCTCCACAAGCAACCATAAATTCAACCGGAAGATACGATTTAAAGAACTCTCAAGGTAAC
GTTATCGCATCTTATTACGATTGGTATACTTTAGGACATGGTGAAACCGATTTGGTAAAATCCTTGAGAGCATCGGTTAA
CTCTTATTACTATTGGCTTGGGGAAAATTTGGGAATAGATTATTTAAAAAGTGTTGCAGATAGATTTGATATTACTTCTA
AAACAGGTATAGAAATACCAAATGAAAAAAATGGGATTTTTCCAGACCCTGAATGGAAGTATGAGAAATTTGATACTATA
TGGTATCCAGGAGAAACATTATTAACGTATATAGGTCAAGGATACATCACAATGACGCCACTTCAAATTCTAAGAATATA
TAACATCCTTGCTACAAAAGGTGAATATTATCAGTTTAGCTTATTTGAAAGAGAAGAAGATGTTTTTGGAAATATAATAA
ATAAAAATGAACCTTTACTTAGAGATTCATATGAAATGAACGAAGAATACCTGAAATATGTTTACCAAGGTATGATAGAA
GTGACTTCATTCAGTGGGCCACCTGGTGAAGAAGGTACTGCTTATCAGTCGTTTATGGATTTCCCAATAACGGTAGCCGG
AAAGACAGGTACCGCAGAAGTAGGAGGTGGAAAACCTGCTCACTCGTGGTTCGCCGGATTTTTACCAGCAAATGATCCAC
AGTACTCGATTGTGGTTGTAATAGAAAATGGAGGGATGGGGTCCACCGGTGCAGCACCTATTGCTAGAGAGATACTCGAT
GATCTACTTGAAAAATATCATATTCAATAA

Upstream 100 bases:

>100_bases
TCGCTTTATATGAGTGTCATTACTTCTTCTCTTTATCCTTTTTTATGGGATATGATTATCGTCTTTGTATTATATTTTAT
GAACATGAGGCTGGTTTTCA

Downstream 100 bases:

>100_bases
AAAAGGGTGGGGAGCGGGGGAAGGGCGCTATAGATATTAGATAGTTTTATAAAGAAAATTCTGTTTTTAAAAAAGGGTCA
CAGGGGGGGAGCTCTCCCCT

Product: peptidoglycan glycosyltransferase

Products: NA

Alternate protein names: PBP-2 [H]

Number of amino acids: Translated: 569; Mature: 569

Protein sequence:

>569_residues
MKEKRAKILFSLFFLGIALLFARSFQLQILNWDKYSMEVQELSTRIVKDSPKRGNIYDRNGNLLAWNQRIYNLTNLGGTL
SEETEAELYQVLKDVVDNPYAIIDKLNFQKRVNLEINSVTAQKIASIDRNLQVEERYIRKYAHESLYHVLGYVDNEGTPR
SGLELVFDEELQGQTGYKMVNIATNESVSPIIINAHSINGNNIYLTLDLDLQIKAYNYLKENNYNGSVIISEPKTGEILV
FVSHPSVDPNLFAQGMSNLEFQRILNDNNLPLLNRAASALYPPGSIIKPFVAYAALEGGISPQATINSTGRYDLKNSQGN
VIASYYDWYTLGHGETDLVKSLRASVNSYYYWLGENLGIDYLKSVADRFDITSKTGIEIPNEKNGIFPDPEWKYEKFDTI
WYPGETLLTYIGQGYITMTPLQILRIYNILATKGEYYQFSLFEREEDVFGNIINKNEPLLRDSYEMNEEYLKYVYQGMIE
VTSFSGPPGEEGTAYQSFMDFPITVAGKTGTAEVGGGKPAHSWFAGFLPANDPQYSIVVVIENGGMGSTGAAPIAREILD
DLLEKYHIQ

Sequences:

>Translated_569_residues
MKEKRAKILFSLFFLGIALLFARSFQLQILNWDKYSMEVQELSTRIVKDSPKRGNIYDRNGNLLAWNQRIYNLTNLGGTL
SEETEAELYQVLKDVVDNPYAIIDKLNFQKRVNLEINSVTAQKIASIDRNLQVEERYIRKYAHESLYHVLGYVDNEGTPR
SGLELVFDEELQGQTGYKMVNIATNESVSPIIINAHSINGNNIYLTLDLDLQIKAYNYLKENNYNGSVIISEPKTGEILV
FVSHPSVDPNLFAQGMSNLEFQRILNDNNLPLLNRAASALYPPGSIIKPFVAYAALEGGISPQATINSTGRYDLKNSQGN
VIASYYDWYTLGHGETDLVKSLRASVNSYYYWLGENLGIDYLKSVADRFDITSKTGIEIPNEKNGIFPDPEWKYEKFDTI
WYPGETLLTYIGQGYITMTPLQILRIYNILATKGEYYQFSLFEREEDVFGNIINKNEPLLRDSYEMNEEYLKYVYQGMIE
VTSFSGPPGEEGTAYQSFMDFPITVAGKTGTAEVGGGKPAHSWFAGFLPANDPQYSIVVVIENGGMGSTGAAPIAREILD
DLLEKYHIQ
>Mature_569_residues
MKEKRAKILFSLFFLGIALLFARSFQLQILNWDKYSMEVQELSTRIVKDSPKRGNIYDRNGNLLAWNQRIYNLTNLGGTL
SEETEAELYQVLKDVVDNPYAIIDKLNFQKRVNLEINSVTAQKIASIDRNLQVEERYIRKYAHESLYHVLGYVDNEGTPR
SGLELVFDEELQGQTGYKMVNIATNESVSPIIINAHSINGNNIYLTLDLDLQIKAYNYLKENNYNGSVIISEPKTGEILV
FVSHPSVDPNLFAQGMSNLEFQRILNDNNLPLLNRAASALYPPGSIIKPFVAYAALEGGISPQATINSTGRYDLKNSQGN
VIASYYDWYTLGHGETDLVKSLRASVNSYYYWLGENLGIDYLKSVADRFDITSKTGIEIPNEKNGIFPDPEWKYEKFDTI
WYPGETLLTYIGQGYITMTPLQILRIYNILATKGEYYQFSLFEREEDVFGNIINKNEPLLRDSYEMNEEYLKYVYQGMIE
VTSFSGPPGEEGTAYQSFMDFPITVAGKTGTAEVGGGKPAHSWFAGFLPANDPQYSIVVVIENGGMGSTGAAPIAREILD
DLLEKYHIQ

Specific function: Cell wall formation; PBP-2 is responsible for the determination of the rod shape of the cell. Its synthesize cross- linked peptidoglycan from the lipid intermediates [H]

COG id: COG0768

COG function: function code M; Cell division protein FtsI/penicillin-binding protein 2

Gene ontology:

Cell location: Cell inner membrane [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transpeptidase family [H]

Homologues:

Organism=Escherichia coli, GI1786854, Length=610, Percent_Identity=30.8196721311475, Blast_Score=259, Evalue=3e-70,
Organism=Escherichia coli, GI1786272, Length=596, Percent_Identity=24.8322147651007, Blast_Score=112, Evalue=6e-26,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR005311
- InterPro:   IPR001460
- InterPro:   IPR017790 [H]

Pfam domain/function: PF03717 PBP_dimer; PF00905 Transpeptidase [H]

EC number: NA

Molecular weight: Translated: 64319; Mature: 64319

Theoretical pI: Translated: 4.63; Mature: 4.63

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
1.6 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKEKRAKILFSLFFLGIALLFARSFQLQILNWDKYSMEVQELSTRIVKDSPKRGNIYDRN
CCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCCEEECC
GNLLAWNQRIYNLTNLGGTLSEETEAELYQVLKDVVDNPYAIIDKLNFQKRVNLEINSVT
CCEEEECCCEEEHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEEEEECHH
AQKIASIDRNLQVEERYIRKYAHESLYHVLGYVDNEGTPRSGLELVFDEELQGQTGYKMV
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCEEE
NIATNESVSPIIINAHSINGNNIYLTLDLDLQIKAYNYLKENNYNGSVIISEPKTGEILV
EEECCCCCCEEEEEEEECCCCEEEEEEEEEEEEEEEEHHHCCCCCCEEEEECCCCCEEEE
FVSHPSVDPNLFAQGMSNLEFQRILNDNNLPLLNRAASALYPPGSIIKPFVAYAALEGGI
EEECCCCCHHHHHHCCCCCCHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCC
SPQATINSTGRYDLKNSQGNVIASYYDWYTLGHGETDLVKSLRASVNSYYYWLGENLGID
CCCEEECCCCCEEEECCCCCEEEEEECEEEECCCHHHHHHHHHHHHCCEEEEECCCCCHH
YLKSVADRFDITSKTGIEIPNEKNGIFPDPEWKYEKFDTIWYPGETLLTYIGQGYITMTP
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCHHHHHHHCCCCEEECH
LQILRIYNILATKGEYYQFSLFEREEDVFGNIINKNEPLLRDSYEMNEEYLKYVYQGMIE
HHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHCCCCCCCCCCCHHCCHHHHHHHHHHHHE
VTSFSGPPGEEGTAYQSFMDFPITVAGKTGTAEVGGGKPAHSWFAGFLPANDPQYSIVVV
EEECCCCCCCCCCHHHHHCCCCEEEECCCCCCCCCCCCCCHHHHEECCCCCCCCEEEEEE
IENGGMGSTGAAPIAREILDDLLEKYHIQ
EECCCCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MKEKRAKILFSLFFLGIALLFARSFQLQILNWDKYSMEVQELSTRIVKDSPKRGNIYDRN
CCCHHHHHHHHHHHHHHHHHHHCCCEEEEEECCHHHHHHHHHHHHHHCCCCCCCCEEECC
GNLLAWNQRIYNLTNLGGTLSEETEAELYQVLKDVVDNPYAIIDKLNFQKRVNLEINSVT
CCEEEECCCEEEHHCCCCCCCCHHHHHHHHHHHHHHCCCEEEEECCCCCEEEEEEEECHH
AQKIASIDRNLQVEERYIRKYAHESLYHVLGYVDNEGTPRSGLELVFDEELQGQTGYKMV
HHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEECCCCCCCCCCEEE
NIATNESVSPIIINAHSINGNNIYLTLDLDLQIKAYNYLKENNYNGSVIISEPKTGEILV
EEECCCCCCEEEEEEEECCCCEEEEEEEEEEEEEEEEHHHCCCCCCEEEEECCCCCEEEE
FVSHPSVDPNLFAQGMSNLEFQRILNDNNLPLLNRAASALYPPGSIIKPFVAYAALEGGI
EEECCCCCHHHHHHCCCCCCHHHHHCCCCCCHHHHHHHHCCCCCHHHHHHHHHHHHHCCC
SPQATINSTGRYDLKNSQGNVIASYYDWYTLGHGETDLVKSLRASVNSYYYWLGENLGID
CCCEEECCCCCEEEECCCCCEEEEEECEEEECCCHHHHHHHHHHHHCCEEEEECCCCCHH
YLKSVADRFDITSKTGIEIPNEKNGIFPDPEWKYEKFDTIWYPGETLLTYIGQGYITMTP
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCCEEEECCHHHHHHHCCCCEEECH
LQILRIYNILATKGEYYQFSLFEREEDVFGNIINKNEPLLRDSYEMNEEYLKYVYQGMIE
HHHHHHHHHHHCCCCEEEEEEECCCHHHHHHHCCCCCCCCCCCHHCCHHHHHHHHHHHHE
VTSFSGPPGEEGTAYQSFMDFPITVAGKTGTAEVGGGKPAHSWFAGFLPANDPQYSIVVV
EEECCCCCCCCCCHHHHHCCCCEEEECCCCCCCCCCCCCCHHHHEECCCCCCCCEEEEEE
IENGGMGSTGAAPIAREILDDLLEKYHIQ
EECCCCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]