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The map label for this gene is pccB [H]

Identifier: 160902029

GI number: 160902029

Start: 607367

End: 608923

Strand: Direct

Name: pccB [H]

Synonym: Pmob_0553

Alternate gene names: 160902029

Gene position: 607367-608923 (Clockwise)

Preceding gene: 160902028

Following gene: 160902030

Centisome position: 28.0

GC content: 38.41

Gene sequence:

>1557_bases
ATGCCAGATGAAGAACTAATTCAAAAAATAGAAGAGTTGAGAAAAAAGAAAGACTCCCTTCTTCTTGGTGGAGGGGAAGA
GAGAATAGAGAAACAACATAAAATGGGTAAATTAACCGCCCGTGAGAGAATAGACGCTCTTGTAGATGAAGGTACTTTCG
AAGAAATCGATATGTTAGTTAAACATAGATGTACATACTTTGATTTAGATAAAAAAGAGTTTCCATACGATGGAGTTGTC
ACAGGATTTGGAGAGATCAACGGCAAAAAAGTTGCAATTTTTTCCCAAGATTTCACCATTCAAGGTGGATCCCTTGGAGA
AATGCATGCAAAGAAAATAATGAAATTACAAGATTTGGCTATGAAATACGGTATACCTTTAATCGGAATAAATGACTCTG
GCGGAGCTAGAATACAGGAAGCTGTTGATGCCCTATATGGTTACGGTGGAATCTTTTATAGAAATACCCAGGCTTCTGGT
GTAATTCCTCAAATAACCGTTATAGCCGGCCCGTGTGCAGGAGGGGCGGTTTACTCCCCAGCGATAACTGATTTTGTAAT
TATGGTGGATCAAACTTCACAAATGTTTATCACAGGCCCTCAGGTTATAAAAACTGTGACTGGCGAGGACATTGATAAAG
AGAATTTGGGAGGGGGTAAGATTCATAACTCAAAAAGCGGTGTCGCCCACCTTTTGGCAAAAGACGATGGGCAAGCCATG
GAACTTGTCAGAAAGTTACTTTCTTACATACCTTCAAACAATGTTGATCCTGTAGAACCAATTGATTACGATAAAAATTA
TGAATTACCCGAAGAAATAAACGAAATAGTCTCACCTAACCCGAAAAAAAGTTATGATGTAAAAGATTTAATCAATTTAG
TATTTGATCCAGGGTCTTTTTTTGAAATTCATCCTCATTTTGCCAAAAATATTGTCGTAGGCTTTGCAAGATTGGAAGGA
AAATCTGTGGGGATAATAGCCAATCAACCAAAAATCTTGGCAGGTTCTCTCGATATCGATGCTTCCGATAAAGCAGCCAG
ATTTATAAGATTTTGTGACTCTTTTAATATACCTATTATCACCTTTGTTGACACACCTGGATACTTACCAGGAGTATCTC
AAGAACACGGTGGAATAATTAGACATGGAGCAAAGCTATTGTATGCTTATTCTGAATCCACCGTTCCTATGATCACAGTA
ATTTTAAGAAAAGCCTATGGTGGGGCTTATATTGCAATGGCTTCACAACATTTGGGCGCTGATTTTGTGTTTGCATACCC
AACAGCGGAAATAGCTGTTATGGGATCAGAGGGTGCCGCAAACATTATCTTCGCTAAAGAGATTGAAAGTTCTGAAAATC
CCGAAGAAAGGAGAAAAAGACGCGTTGAAGAATACAAAGAGCGGTTTGCAAATCCCTATGAAGCAGCTTCTAGGGGCTAT
ATAGAAGATGTTATAGAACCCATCGAAACAAGAAGAAGGTTAGCTACTTCTCTTTCCATAGCTTACTCAAAAGTAAAACC
GACTCCATCTAAAAAGCATGGAAATATTCCGTTATGA

Upstream 100 bases:

>100_bases
GAATATCAAAAATAGCAATTTATGGAACGAAGGGGCGCTGACACGACGTTTTAGAGTTTTCAATTATAGTATAAATATCG
CAAATGAGGAGGTCTTATAT

Downstream 100 bases:

>100_bases
TGGAGGAATAATTATGAAAAATGTATGGATTATTTCATTAATGGGAATATCTATAGTCTTTCTATTGCTAATAATTTTAA
TGGTGATCATTTGGCTTTTC

Product: carboxyl transferase

Products: NA

Alternate protein names: PCCase; Propanoyl-CoA:carbon dioxide ligase [H]

Number of amino acids: Translated: 518; Mature: 517

Protein sequence:

>518_residues
MPDEELIQKIEELRKKKDSLLLGGGEERIEKQHKMGKLTARERIDALVDEGTFEEIDMLVKHRCTYFDLDKKEFPYDGVV
TGFGEINGKKVAIFSQDFTIQGGSLGEMHAKKIMKLQDLAMKYGIPLIGINDSGGARIQEAVDALYGYGGIFYRNTQASG
VIPQITVIAGPCAGGAVYSPAITDFVIMVDQTSQMFITGPQVIKTVTGEDIDKENLGGGKIHNSKSGVAHLLAKDDGQAM
ELVRKLLSYIPSNNVDPVEPIDYDKNYELPEEINEIVSPNPKKSYDVKDLINLVFDPGSFFEIHPHFAKNIVVGFARLEG
KSVGIIANQPKILAGSLDIDASDKAARFIRFCDSFNIPIITFVDTPGYLPGVSQEHGGIIRHGAKLLYAYSESTVPMITV
ILRKAYGGAYIAMASQHLGADFVFAYPTAEIAVMGSEGAANIIFAKEIESSENPEERRKRRVEEYKERFANPYEAASRGY
IEDVIEPIETRRRLATSLSIAYSKVKPTPSKKHGNIPL

Sequences:

>Translated_518_residues
MPDEELIQKIEELRKKKDSLLLGGGEERIEKQHKMGKLTARERIDALVDEGTFEEIDMLVKHRCTYFDLDKKEFPYDGVV
TGFGEINGKKVAIFSQDFTIQGGSLGEMHAKKIMKLQDLAMKYGIPLIGINDSGGARIQEAVDALYGYGGIFYRNTQASG
VIPQITVIAGPCAGGAVYSPAITDFVIMVDQTSQMFITGPQVIKTVTGEDIDKENLGGGKIHNSKSGVAHLLAKDDGQAM
ELVRKLLSYIPSNNVDPVEPIDYDKNYELPEEINEIVSPNPKKSYDVKDLINLVFDPGSFFEIHPHFAKNIVVGFARLEG
KSVGIIANQPKILAGSLDIDASDKAARFIRFCDSFNIPIITFVDTPGYLPGVSQEHGGIIRHGAKLLYAYSESTVPMITV
ILRKAYGGAYIAMASQHLGADFVFAYPTAEIAVMGSEGAANIIFAKEIESSENPEERRKRRVEEYKERFANPYEAASRGY
IEDVIEPIETRRRLATSLSIAYSKVKPTPSKKHGNIPL
>Mature_517_residues
PDEELIQKIEELRKKKDSLLLGGGEERIEKQHKMGKLTARERIDALVDEGTFEEIDMLVKHRCTYFDLDKKEFPYDGVVT
GFGEINGKKVAIFSQDFTIQGGSLGEMHAKKIMKLQDLAMKYGIPLIGINDSGGARIQEAVDALYGYGGIFYRNTQASGV
IPQITVIAGPCAGGAVYSPAITDFVIMVDQTSQMFITGPQVIKTVTGEDIDKENLGGGKIHNSKSGVAHLLAKDDGQAME
LVRKLLSYIPSNNVDPVEPIDYDKNYELPEEINEIVSPNPKKSYDVKDLINLVFDPGSFFEIHPHFAKNIVVGFARLEGK
SVGIIANQPKILAGSLDIDASDKAARFIRFCDSFNIPIITFVDTPGYLPGVSQEHGGIIRHGAKLLYAYSESTVPMITVI
LRKAYGGAYIAMASQHLGADFVFAYPTAEIAVMGSEGAANIIFAKEIESSENPEERRKRRVEEYKERFANPYEAASRGYI
EDVIEPIETRRRLATSLSIAYSKVKPTPSKKHGNIPL

Specific function: This Protein Is A Component Of The Acetyl Coenzyme A Carboxylase Complex; First, Biotin Carboxylase Catalyzes The Carboxylation Of The Carrier Protein And Then The Transcarboxylase Transfers The Carboxyl Group To Form Malonyl-CoA. [C]

COG id: COG4799

COG function: function code I; Acetyl-CoA carboxylase, carboxyltransferase component (subunits alpha and beta)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 carboxyltransferase domain [H]

Homologues:

Organism=Homo sapiens, GI119943100, Length=512, Percent_Identity=55.46875, Blast_Score=578, Evalue=1e-165,
Organism=Homo sapiens, GI295821216, Length=532, Percent_Identity=53.3834586466165, Blast_Score=566, Evalue=1e-161,
Organism=Homo sapiens, GI11545863, Length=515, Percent_Identity=32.2330097087379, Blast_Score=247, Evalue=2e-65,
Organism=Homo sapiens, GI134142062, Length=417, Percent_Identity=24.9400479616307, Blast_Score=79, Evalue=1e-14,
Organism=Homo sapiens, GI38679971, Length=342, Percent_Identity=25.7309941520468, Blast_Score=76, Evalue=8e-14,
Organism=Homo sapiens, GI38679974, Length=342, Percent_Identity=25.7309941520468, Blast_Score=76, Evalue=9e-14,
Organism=Homo sapiens, GI38679960, Length=342, Percent_Identity=25.7309941520468, Blast_Score=76, Evalue=9e-14,
Organism=Homo sapiens, GI38679977, Length=342, Percent_Identity=25.7309941520468, Blast_Score=76, Evalue=9e-14,
Organism=Homo sapiens, GI38679967, Length=342, Percent_Identity=25.7309941520468, Blast_Score=76, Evalue=9e-14,
Organism=Escherichia coli, GI1786382, Length=180, Percent_Identity=31.1111111111111, Blast_Score=66, Evalue=5e-12,
Organism=Escherichia coli, GI1788655, Length=193, Percent_Identity=27.4611398963731, Blast_Score=66, Evalue=7e-12,
Organism=Caenorhabditis elegans, GI25147362, Length=516, Percent_Identity=53.2945736434108, Blast_Score=567, Evalue=1e-162,
Organism=Caenorhabditis elegans, GI25147359, Length=516, Percent_Identity=53.2945736434108, Blast_Score=567, Evalue=1e-162,
Organism=Caenorhabditis elegans, GI17552936, Length=523, Percent_Identity=34.0344168260038, Blast_Score=286, Evalue=1e-77,
Organism=Caenorhabditis elegans, GI71997163, Length=431, Percent_Identity=23.8979118329466, Blast_Score=78, Evalue=1e-14,
Organism=Saccharomyces cerevisiae, GI6324343, Length=344, Percent_Identity=24.1279069767442, Blast_Score=79, Evalue=2e-15,
Organism=Saccharomyces cerevisiae, GI6323863, Length=313, Percent_Identity=25.8785942492013, Blast_Score=77, Evalue=5e-15,
Organism=Drosophila melanogaster, GI24586065, Length=539, Percent_Identity=32.0964749536178, Blast_Score=266, Evalue=2e-71,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000438
- InterPro:   IPR000022
- InterPro:   IPR011763
- InterPro:   IPR011762 [H]

Pfam domain/function: PF01039 Carboxyl_trans [H]

EC number: =6.4.1.3 [H]

Molecular weight: Translated: 57104; Mature: 56973

Theoretical pI: Translated: 5.70; Mature: 5.70

Prosite motif: PS50980 COA_CT_NTER ; PS50989 COA_CT_CTER

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MPDEELIQKIEELRKKKDSLLLGGGEERIEKQHKMGKLTARERIDALVDEGTFEEIDMLV
CCHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
KHRCTYFDLDKKEFPYDGVVTGFGEINGKKVAIFSQDFTIQGGSLGEMHAKKIMKLQDLA
HCCCCEEECCCCCCCCCCEEECCCCCCCCEEEEEECCEEECCCCCCHHHHHHHHHHHHHH
MKYGIPLIGINDSGGARIQEAVDALYGYGGIFYRNTQASGVIPQITVIAGPCAGGAVYSP
HHHCCCEEEECCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEECCCCCCCCCCC
AITDFVIMVDQTSQMFITGPQVIKTVTGEDIDKENLGGGKIHNSKSGVAHLLAKDDGQAM
CCEEEEEEEECCCCEEEECHHHHHHHCCCCCCCCCCCCCCEECCCCCCEEEEECCCCHHH
ELVRKLLSYIPSNNVDPVEPIDYDKNYELPEEINEIVSPNPKKSYDVKDLINLVFDPGSF
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCC
FEIHPHFAKNIVVGFARLEGKSVGIIANQPKILAGSLDIDASDKAARFIRFCDSFNIPII
EEECHHHHHHHHEEHEEECCCEEEEEECCCEEEEECCCCCCCHHHHHHHHHHCCCCCCEE
TFVDTPGYLPGVSQEHGGIIRHGAKLLYAYSESTVPMITVILRKAYGGAYIAMASQHLGA
EEECCCCCCCCCCCCCCCHHHCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEHHHCCC
DFVFAYPTAEIAVMGSEGAANIIFAKEIESSENPEERRKRRVEEYKERFANPYEAASRGY
CEEEEECCEEEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHCCH
IEDVIEPIETRRRLATSLSIAYSKVKPTPSKKHGNIPL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC
>Mature Secondary Structure 
PDEELIQKIEELRKKKDSLLLGGGEERIEKQHKMGKLTARERIDALVDEGTFEEIDMLV
CHHHHHHHHHHHHHHHCCEEECCCHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHH
KHRCTYFDLDKKEFPYDGVVTGFGEINGKKVAIFSQDFTIQGGSLGEMHAKKIMKLQDLA
HCCCCEEECCCCCCCCCCEEECCCCCCCCEEEEEECCEEECCCCCCHHHHHHHHHHHHHH
MKYGIPLIGINDSGGARIQEAVDALYGYGGIFYRNTQASGVIPQITVIAGPCAGGAVYSP
HHHCCCEEEECCCCCHHHHHHHHHHHCCCCEEEECCCCCCCCCEEEEEECCCCCCCCCCC
AITDFVIMVDQTSQMFITGPQVIKTVTGEDIDKENLGGGKIHNSKSGVAHLLAKDDGQAM
CCEEEEEEEECCCCEEEECHHHHHHHCCCCCCCCCCCCCCEECCCCCCEEEEECCCCHHH
ELVRKLLSYIPSNNVDPVEPIDYDKNYELPEEINEIVSPNPKKSYDVKDLINLVFDPGSF
HHHHHHHHHCCCCCCCCCCCCCCCCCCCCHHHHHHHHCCCCCCCCCHHHHHHHHCCCCCC
FEIHPHFAKNIVVGFARLEGKSVGIIANQPKILAGSLDIDASDKAARFIRFCDSFNIPII
EEECHHHHHHHHEEHEEECCCEEEEEECCCEEEEECCCCCCCHHHHHHHHHHCCCCCCEE
TFVDTPGYLPGVSQEHGGIIRHGAKLLYAYSESTVPMITVILRKAYGGAYIAMASQHLGA
EEECCCCCCCCCCCCCCCHHHCCCEEEEEECCCCHHHHHHHHHHHCCCEEEEEEHHHCCC
DFVFAYPTAEIAVMGSEGAANIIFAKEIESSENPEERRKRRVEEYKERFANPYEAASRGY
CEEEEECCEEEEEECCCCCCEEEEEECCCCCCCHHHHHHHHHHHHHHHCCCHHHHHHCCH
IEDVIEPIETRRRLATSLSIAYSKVKPTPSKKHGNIPL
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8830278 [H]