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The map label for this gene is hemN [H]

Identifier: 160877594

GI number: 160877594

Start: 5306520

End: 5307860

Strand: Direct

Name: hemN [H]

Synonym: Sbal195_4493

Alternate gene names: 160877594

Gene position: 5306520-5307860 (Clockwise)

Preceding gene: 160877593

Following gene: 160877596

Centisome position: 99.24

GC content: 44.74

Gene sequence:

>1341_bases
ATGATCGAAAAGTATAACTACAGCGGTCCCCGTTATACCTCTTACCCAACGGCATTGGAGTTCGATGACACATTCACCGA
ACAAAACCTGCTAACGGCCATTGAAAATAGCAAAAGCGATAAACTGTCGCTGTATATTCATATCCCGTTCTGCGCCAAGC
TTTGTTATTACTGCGGCTGTAATAAAGTCATCACCCGCCACCAACACAAAGCCGATCAGTACATTGAATATTTAAGCCAA
GAAATTATCAAACGTGCGCCCCTGTTTAAACATTACAGTGTGACCCAAATGCATTGGGGCGGCGGTACACCTACGTTCTT
AAATCCTGAGCAGATTCTTAAACTTACGTCATTGATTAAAGCTAACTTTAACTTTGCGGAAGAAGGCGAGTACTCGATTG
AAGTCGATCCTCGCGAGATAGAGCTGTCAATGCTCGACACGTTGAAAGAAGCGGGCTTCAACCGGATCTCCATCGGCGTA
CAAGATTTCAATAAAGAAGTACAAATTGCCGTTAATCGCGAACAAGACGAGCAATTTATCTTCGACTTGATGGCCAAAGC
GAAAGCCATGGGTTTTGTGTCAACCAACATAGATTTAATCTATGGTTTGCCACACCAAACGCCAGAAACCTTTGCCGTCA
CTATGCAGCGCGTTTTAGATTTATCGCCTGACCGTCTATCGGTATTTAACTATGCTCACTTACCTGCGCGCTTTGCCGCT
CAACGTAAGATCAAAGATGAGCATTTACCTTCGCCAAAACAAAAACTCGAAATGCTGCACCAAACTATCGAGACCTTAAC
TGGCGCTGGCTACCAATATATCGGTATGGACCACTTTGCTAAACCCGATGACGAGTTAGCCAAGTTACAGCGCGAAGGCA
GACTGCACCGCAACTTCCAAGGTTATACCACCCAAGAAGAATGCGATTTGTTAGGTCTTGGCGTGTCATCCATCAGCCAG
ATTGGCGACTGCTATGCGCAAAACCAGAAAGATATCCGCCCTTACTATGAAGCCATAGATAAGGAAGGCCATGCTTTGTG
GAAAGGTTGTAGCCTGAACCGTGACGATGAAATCCGCCGCGTAGTGATTAAACAGCTGATTTGCCACTTCGAACTAGATA
TGGCGAAAATTGATGAGAAACTGGGGATTAACTTCGAAACCTATTTCGCGGAAGATCTTAAGTTAATGCAGACATTTATC
GATGACAAGTTAGTTGAAATCGTCGACAGACAGATCACTATCAGCCCAACTGGCCGTTTATTGATCCGCAATATCTGTAT
GTGTTTCGACCTTTACTATCGTCAAAAAGCGCGTCAGCAACAGTTCTCGCGCGTGATCTAA

Upstream 100 bases:

>100_bases
AGGTTATTTACTTAAGAACCTTGCATACTTCGCTTGTTGCTAATTTACCCACGGAGGACACGCCTTGAAGCAGCCCACTC
AGATTAGCTGGGATCAGTCG

Downstream 100 bases:

>100_bases
AGCGCCTATCGCTGTACTCGTGAACGCTCATAAAAAAATCCGACTCTAGAGTCGGATTTTTTATTTATAGCTATTTTTAT
TAATGACTCAGAGCTTATAC

Product: coproporphyrinogen III oxidase

Products: NA

Alternate protein names: Coprogen oxidase; Coproporphyrinogenase [H]

Number of amino acids: Translated: 446; Mature: 446

Protein sequence:

>446_residues
MIEKYNYSGPRYTSYPTALEFDDTFTEQNLLTAIENSKSDKLSLYIHIPFCAKLCYYCGCNKVITRHQHKADQYIEYLSQ
EIIKRAPLFKHYSVTQMHWGGGTPTFLNPEQILKLTSLIKANFNFAEEGEYSIEVDPREIELSMLDTLKEAGFNRISIGV
QDFNKEVQIAVNREQDEQFIFDLMAKAKAMGFVSTNIDLIYGLPHQTPETFAVTMQRVLDLSPDRLSVFNYAHLPARFAA
QRKIKDEHLPSPKQKLEMLHQTIETLTGAGYQYIGMDHFAKPDDELAKLQREGRLHRNFQGYTTQEECDLLGLGVSSISQ
IGDCYAQNQKDIRPYYEAIDKEGHALWKGCSLNRDDEIRRVVIKQLICHFELDMAKIDEKLGINFETYFAEDLKLMQTFI
DDKLVEIVDRQITISPTGRLLIRNICMCFDLYYRQKARQQQFSRVI

Sequences:

>Translated_446_residues
MIEKYNYSGPRYTSYPTALEFDDTFTEQNLLTAIENSKSDKLSLYIHIPFCAKLCYYCGCNKVITRHQHKADQYIEYLSQ
EIIKRAPLFKHYSVTQMHWGGGTPTFLNPEQILKLTSLIKANFNFAEEGEYSIEVDPREIELSMLDTLKEAGFNRISIGV
QDFNKEVQIAVNREQDEQFIFDLMAKAKAMGFVSTNIDLIYGLPHQTPETFAVTMQRVLDLSPDRLSVFNYAHLPARFAA
QRKIKDEHLPSPKQKLEMLHQTIETLTGAGYQYIGMDHFAKPDDELAKLQREGRLHRNFQGYTTQEECDLLGLGVSSISQ
IGDCYAQNQKDIRPYYEAIDKEGHALWKGCSLNRDDEIRRVVIKQLICHFELDMAKIDEKLGINFETYFAEDLKLMQTFI
DDKLVEIVDRQITISPTGRLLIRNICMCFDLYYRQKARQQQFSRVI
>Mature_446_residues
MIEKYNYSGPRYTSYPTALEFDDTFTEQNLLTAIENSKSDKLSLYIHIPFCAKLCYYCGCNKVITRHQHKADQYIEYLSQ
EIIKRAPLFKHYSVTQMHWGGGTPTFLNPEQILKLTSLIKANFNFAEEGEYSIEVDPREIELSMLDTLKEAGFNRISIGV
QDFNKEVQIAVNREQDEQFIFDLMAKAKAMGFVSTNIDLIYGLPHQTPETFAVTMQRVLDLSPDRLSVFNYAHLPARFAA
QRKIKDEHLPSPKQKLEMLHQTIETLTGAGYQYIGMDHFAKPDDELAKLQREGRLHRNFQGYTTQEECDLLGLGVSSISQ
IGDCYAQNQKDIRPYYEAIDKEGHALWKGCSLNRDDEIRRVVIKQLICHFELDMAKIDEKLGINFETYFAEDLKLMQTFI
DDKLVEIVDRQITISPTGRLLIRNICMCFDLYYRQKARQQQFSRVI

Specific function: Anaerobic transformation of coproporphyrinogen-III into protoporphyrinogen-IX [H]

COG id: COG0635

COG function: function code H; Coproporphyrinogen III oxidase and related Fe-S oxidoreductases

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the anaerobic coproporphyrinogen-III oxidase family [H]

Homologues:

Organism=Homo sapiens, GI8922911, Length=245, Percent_Identity=25.3061224489796, Blast_Score=87, Evalue=2e-17,
Organism=Escherichia coli, GI87082341, Length=446, Percent_Identity=65.695067264574, Blast_Score=630, Evalue=0.0,
Organism=Escherichia coli, GI1789325, Length=245, Percent_Identity=30.2040816326531, Blast_Score=120, Evalue=2e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006638
- InterPro:   IPR004558
- InterPro:   IPR010723
- InterPro:   IPR007197 [H]

Pfam domain/function: PF06969 HemN_C; PF04055 Radical_SAM [H]

EC number: =1.3.99.22 [H]

Molecular weight: Translated: 51738; Mature: 51738

Theoretical pI: Translated: 6.07; Mature: 6.07

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.2 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
2.2 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIEKYNYSGPRYTSYPTALEFDDTFTEQNLLTAIENSKSDKLSLYIHIPFCAKLCYYCGC
CCCCCCCCCCCCCCCCCEECCCCCHHHHHHHHHHHCCCCCEEEEEEECHHHHHHHHHHCC
NKVITRHQHKADQYIEYLSQEIIKRAPLFKHYSVTQMHWGGGTPTFLNPEQILKLTSLIK
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCEEEEECCCCCCCCCCHHHHHHHHHHHH
ANFNFAEEGEYSIEVDPREIELSMLDTLKEAGFNRISIGVQDFNKEVQIAVNREQDEQFI
HCCCCCCCCCEEEEECHHHHHHHHHHHHHHCCCCEEEEEHHHCCCEEEEEECCCCHHHHH
FDLMAKAKAMGFVSTNIDLIYGLPHQTPETFAVTMQRVLDLSPDRLSVFNYAHLPARFAA
HHHHHHHHHHHEEECCCEEEECCCCCCCHHHHHHHHHHHCCCCCCEEHHHHHHCHHHHHH
QRKIKDEHLPSPKQKLEMLHQTIETLTGAGYQYIGMDHFAKPDDELAKLQREGRLHRNFQ
HHHCCHHCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHCCHHCCCC
GYTTQEECDLLGLGVSSISQIGDCYAQNQKDIRPYYEAIDKEGHALWKGCSLNRDDEIRR
CCCCHHHCCEEECCHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCEECCCCCCCCHHHHH
VVIKQLICHFELDMAKIDEKLGINFETYFAEDLKLMQTFIDDKLVEIVDRQITISPTGRL
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHH
LIRNICMCFDLYYRQKARQQQFSRVI
HHHHHHHHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MIEKYNYSGPRYTSYPTALEFDDTFTEQNLLTAIENSKSDKLSLYIHIPFCAKLCYYCGC
CCCCCCCCCCCCCCCCCEECCCCCHHHHHHHHHHHCCCCCEEEEEEECHHHHHHHHHHCC
NKVITRHQHKADQYIEYLSQEIIKRAPLFKHYSVTQMHWGGGTPTFLNPEQILKLTSLIK
HHHHHHHHHHHHHHHHHHHHHHHHHCCCHHCCCEEEEECCCCCCCCCCHHHHHHHHHHHH
ANFNFAEEGEYSIEVDPREIELSMLDTLKEAGFNRISIGVQDFNKEVQIAVNREQDEQFI
HCCCCCCCCCEEEEECHHHHHHHHHHHHHHCCCCEEEEEHHHCCCEEEEEECCCCHHHHH
FDLMAKAKAMGFVSTNIDLIYGLPHQTPETFAVTMQRVLDLSPDRLSVFNYAHLPARFAA
HHHHHHHHHHHEEECCCEEEECCCCCCCHHHHHHHHHHHCCCCCCEEHHHHHHCHHHHHH
QRKIKDEHLPSPKQKLEMLHQTIETLTGAGYQYIGMDHFAKPDDELAKLQREGRLHRNFQ
HHHCCHHCCCCHHHHHHHHHHHHHHHHCCCEEEECCCCCCCCCHHHHHHHHHCCHHCCCC
GYTTQEECDLLGLGVSSISQIGDCYAQNQKDIRPYYEAIDKEGHALWKGCSLNRDDEIRR
CCCCHHHCCEEECCHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCEECCCCCCCCHHHHH
VVIKQLICHFELDMAKIDEKLGINFETYFAEDLKLMQTFIDDKLVEIVDRQITISPTGRL
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEEEECCCHHH
LIRNICMCFDLYYRQKARQQQFSRVI
HHHHHHHHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 7768836; 8346018; 9278503 [H]