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The map label for this gene is ilvC [H]

Identifier: 160877233

GI number: 160877233

Start: 4887457

End: 4888935

Strand: Reverse

Name: ilvC [H]

Synonym: Sbal195_4129

Alternate gene names: 160877233

Gene position: 4888935-4887457 (Counterclockwise)

Preceding gene: 160877235

Following gene: 160877232

Centisome position: 91.43

GC content: 47.26

Gene sequence:

>1479_bases
ATGGCTAACTATTTTAACTCTCTGAATTTACGTCAACAATTAGCACAGCTTGGCCAATGTCGTTTCATGGATCGTTCTGA
GTTTAGCGACGGCTGTAACTACATCAAAAATTGGAATATTGTTATTTTAGGTTGTGGTGCTCAAGGTCTTAACCAAGGCT
TGAACATGCGTGATTCGGGTCTGAATATCTCTTTTGCCCTGCGTCCTGAAGCAATTGAACAGAAACGTGCCTCATGGCAG
AAAGCGACTGACAATGGTTTTCGTGTTGGTACCTTTGAAGAATTAATTCCCGCAGCGGATCTGGTGCTTAACCTGACGCC
AGACAAACAGCATTCCAACGTGGTTAACGCTGTTATGCCACTGATGAAGCAAGGTTCTACCTTGTCTTACTCACACGGCT
TCAACATCGTTGAAGAGGGCATGCAAGTTCGTCCCGATATCACTGTGGTGATGGTTGCCCCTAAGTGTCCTGGCACTGAA
GTGCGTGAAGAATACAAACGTGGTTTTGGTGTACCAACCCTTATTGCGGTTCACCCAGAAAACGATCCAGACGGTGACGG
TTTAGAGATTGCTAAAGCCTACGCTAGCGCAACGGGTGGTGACAAAGCCGGTGTTTTACTGTCGTCTTTCATCGCTGAAG
TTAAGTCGGATCTGATGGGCGAGCAGACCATTCTGTGCGGTATGTTGCAGACGGGTGCCATCTTAGGTTACGAGAAAATG
ATCGCCGATGGCGTTGAGCCAGGCTACGCGGCCAAGCTTATCCAGCAAGGTTGGGAAACGGTCACTGAAGCGCTGAAACA
CGGCGGCATCACTAACATGATGGACCGTTTGTCTAATCCAGCCAAGATTAAAGCATTTGAAATTGCAGAAGATTTAAAAG
AAATCCTCCAGCCATTATTTGAAAAGCACATGGATGACATCATCAGCGGCGAATTCTCTCGCACTATGATGGAAGACTGG
GCGAACGATGATGCGAACTTACTGCGTTGGAGAGCCGAAACTGGCGAAACAGGTTTCGAAAATGCACCCGTATCTAGCGA
GCATATCGACGAACAAACCTATTTCGACAAAGGTATTTTCCTTGTCGCTATGATCAAAGCGGGTGTGGAACTGGCATTCG
ATACCATGGTATCTGCAGGTATTGTGGAAGAGTCGGCTTATTATGAGTCACTGCATGAAACTCCACTTATCGCTAACACG
ATTGCCCGTAAGCGTTTGTACGAAATGAACGTGGTGATTTCAGACACGGCAGAATACGGTTGCTACCTGTTCAATCACGC
CGCCGTACCTATGCTGCGCGATTACGTTAATGCCATGTCATCTGAGTATTTAGGTGCTGGCCTGAAAGACAGCGCAACCG
GTGTCGACAACCTAACGCTCATCGCAGTTAACGAAGCGATTCGTGAAACGGCGGTGGAATATGTTGGCGCTGAACTTCGC
GGTTACATGACTGATATGAAAAGCATTGTTGAGGCCTAA

Upstream 100 bases:

>100_bases
ATGATAAGCATGGGTTATAGTGATTTCAATCACAATCAAGCCGTAACATTATGTTAGTTTGGTTGCGTCCAAAATTTCTG
ACTTATAGGTGGTATATCAG

Downstream 100 bases:

>100_bases
TTGATCGTTAGTTAAGCCCAACTTTGGGGGAGAGGGTTGAGATTCAAAGGACTTGGGTCTCAGCTCAGTTCCCAAGCAAC
CTCAGAGACTGAAACGCGCA

Product: ketol-acid reductoisomerase

Products: NA

Alternate protein names: Acetohydroxy-acid isomeroreductase; Alpha-keto-beta-hydroxylacil reductoisomerase [H]

Number of amino acids: Translated: 492; Mature: 491

Protein sequence:

>492_residues
MANYFNSLNLRQQLAQLGQCRFMDRSEFSDGCNYIKNWNIVILGCGAQGLNQGLNMRDSGLNISFALRPEAIEQKRASWQ
KATDNGFRVGTFEELIPAADLVLNLTPDKQHSNVVNAVMPLMKQGSTLSYSHGFNIVEEGMQVRPDITVVMVAPKCPGTE
VREEYKRGFGVPTLIAVHPENDPDGDGLEIAKAYASATGGDKAGVLLSSFIAEVKSDLMGEQTILCGMLQTGAILGYEKM
IADGVEPGYAAKLIQQGWETVTEALKHGGITNMMDRLSNPAKIKAFEIAEDLKEILQPLFEKHMDDIISGEFSRTMMEDW
ANDDANLLRWRAETGETGFENAPVSSEHIDEQTYFDKGIFLVAMIKAGVELAFDTMVSAGIVEESAYYESLHETPLIANT
IARKRLYEMNVVISDTAEYGCYLFNHAAVPMLRDYVNAMSSEYLGAGLKDSATGVDNLTLIAVNEAIRETAVEYVGAELR
GYMTDMKSIVEA

Sequences:

>Translated_492_residues
MANYFNSLNLRQQLAQLGQCRFMDRSEFSDGCNYIKNWNIVILGCGAQGLNQGLNMRDSGLNISFALRPEAIEQKRASWQ
KATDNGFRVGTFEELIPAADLVLNLTPDKQHSNVVNAVMPLMKQGSTLSYSHGFNIVEEGMQVRPDITVVMVAPKCPGTE
VREEYKRGFGVPTLIAVHPENDPDGDGLEIAKAYASATGGDKAGVLLSSFIAEVKSDLMGEQTILCGMLQTGAILGYEKM
IADGVEPGYAAKLIQQGWETVTEALKHGGITNMMDRLSNPAKIKAFEIAEDLKEILQPLFEKHMDDIISGEFSRTMMEDW
ANDDANLLRWRAETGETGFENAPVSSEHIDEQTYFDKGIFLVAMIKAGVELAFDTMVSAGIVEESAYYESLHETPLIANT
IARKRLYEMNVVISDTAEYGCYLFNHAAVPMLRDYVNAMSSEYLGAGLKDSATGVDNLTLIAVNEAIRETAVEYVGAELR
GYMTDMKSIVEA
>Mature_491_residues
ANYFNSLNLRQQLAQLGQCRFMDRSEFSDGCNYIKNWNIVILGCGAQGLNQGLNMRDSGLNISFALRPEAIEQKRASWQK
ATDNGFRVGTFEELIPAADLVLNLTPDKQHSNVVNAVMPLMKQGSTLSYSHGFNIVEEGMQVRPDITVVMVAPKCPGTEV
REEYKRGFGVPTLIAVHPENDPDGDGLEIAKAYASATGGDKAGVLLSSFIAEVKSDLMGEQTILCGMLQTGAILGYEKMI
ADGVEPGYAAKLIQQGWETVTEALKHGGITNMMDRLSNPAKIKAFEIAEDLKEILQPLFEKHMDDIISGEFSRTMMEDWA
NDDANLLRWRAETGETGFENAPVSSEHIDEQTYFDKGIFLVAMIKAGVELAFDTMVSAGIVEESAYYESLHETPLIANTI
ARKRLYEMNVVISDTAEYGCYLFNHAAVPMLRDYVNAMSSEYLGAGLKDSATGVDNLTLIAVNEAIRETAVEYVGAELRG
YMTDMKSIVEA

Specific function: Valine and isoleucine biosynthesis; second step. [C]

COG id: COG0059

COG function: function code EH; Ketol-acid reductoisomerase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ketol-acid reductoisomerase family [H]

Homologues:

Organism=Escherichia coli, GI1790210, Length=492, Percent_Identity=71.7479674796748, Blast_Score=731, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6323387, Length=294, Percent_Identity=31.6326530612245, Blast_Score=115, Evalue=1e-26,

Paralogues:

None

Copy number: 160 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 1420 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 480 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR013023
- InterPro:   IPR000506
- InterPro:   IPR013328
- InterPro:   IPR013116
- InterPro:   IPR014359
- InterPro:   IPR016040 [H]

Pfam domain/function: PF01450 IlvC; PF07991 IlvN [H]

EC number: =1.1.1.86 [H]

Molecular weight: Translated: 54135; Mature: 54004

Theoretical pI: Translated: 4.39; Mature: 4.39

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
5.7 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
4.3 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MANYFNSLNLRQQLAQLGQCRFMDRSEFSDGCNYIKNWNIVILGCGAQGLNQGLNMRDSG
CCCCHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEECCCHHHHCCCCCCCCC
LNISFALRPEAIEQKRASWQKATDNGFRVGTFEELIPAADLVLNLTPDKQHSNVVNAVMP
CEEEEEECCHHHHHHHHHHHHCCCCCCCCCCHHHHHCHHHHEEECCCCHHHHHHHHHHHH
LMKQGSTLSYSHGFNIVEEGMQVRPDITVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPE
HHHCCCEEEECCCCHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCEEEEECCC
NDPDGDGLEIAKAYASATGGDKAGVLLSSFIAEVKSDLMGEQTILCGMLQTGAILGYEKM
CCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHH
IADGVEPGYAAKLIQQGWETVTEALKHGGITNMMDRLSNPAKIKAFEIAEDLKEILQPLF
HHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
EKHMDDIISGEFSRTMMEDWANDDANLLRWRAETGETGFENAPVSSEHIDEQTYFDKGIF
HHHHHHHHCCHHHHHHHHHHCCCCCHHEEEECCCCCCCCCCCCCCHHHCCHHHHHHCHHH
LVAMIKAGVELAFDTMVSAGIVEESAYYESLHETPLIANTIARKRLYEMNVVISDTAEYG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEEEECCHHHC
CYLFNHAAVPMLRDYVNAMSSEYLGAGLKDSATGVDNLTLIAVNEAIRETAVEYVGAELR
EEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHH
GYMTDMKSIVEA
HHHHHHHHHHCC
>Mature Secondary Structure 
ANYFNSLNLRQQLAQLGQCRFMDRSEFSDGCNYIKNWNIVILGCGAQGLNQGLNMRDSG
CCCHHCCHHHHHHHHHHHCCCCCHHHHHHHHHHHCCCCEEEEECCCHHHHCCCCCCCCC
LNISFALRPEAIEQKRASWQKATDNGFRVGTFEELIPAADLVLNLTPDKQHSNVVNAVMP
CEEEEEECCHHHHHHHHHHHHCCCCCCCCCCHHHHHCHHHHEEECCCCHHHHHHHHHHHH
LMKQGSTLSYSHGFNIVEEGMQVRPDITVVMVAPKCPGTEVREEYKRGFGVPTLIAVHPE
HHHCCCEEEECCCCHHHHHCCCCCCCEEEEEECCCCCCHHHHHHHHHCCCCCEEEEECCC
NDPDGDGLEIAKAYASATGGDKAGVLLSSFIAEVKSDLMGEQTILCGMLQTGAILGYEKM
CCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHCHHHHHHHH
IADGVEPGYAAKLIQQGWETVTEALKHGGITNMMDRLSNPAKIKAFEIAEDLKEILQPLF
HHCCCCCHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHH
EKHMDDIISGEFSRTMMEDWANDDANLLRWRAETGETGFENAPVSSEHIDEQTYFDKGIF
HHHHHHHHCCHHHHHHHHHHCCCCCHHEEEECCCCCCCCCCCCCCHHHCCHHHHHHCHHH
LVAMIKAGVELAFDTMVSAGIVEESAYYESLHETPLIANTIARKRLYEMNVVISDTAEYG
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHEEEEECCHHHC
CYLFNHAAVPMLRDYVNAMSSEYLGAGLKDSATGVDNLTLIAVNEAIRETAVEYVGAELR
EEHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEHHHHHHHHHHHHHHHHH
GYMTDMKSIVEA
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 12368813 [H]