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The map label for this gene is frdA [H]

Identifier: 160877180

GI number: 160877180

Start: 4807404

End: 4809410

Strand: Reverse

Name: frdA [H]

Synonym: Sbal195_4076

Alternate gene names: 160877180

Gene position: 4809410-4807404 (Counterclockwise)

Preceding gene: 160877181

Following gene: 160877179

Centisome position: 89.94

GC content: 51.77

Gene sequence:

>2007_bases
GTGAAACTGATTTATACCGATTCATTAGTGGTAGGTGCCGGACTTGCAGGCTTAAGGGTCGCCATCGCCTCGAAAGAGCG
TGGACTCGATACATTAGTCCTGTCACTCATTCCTGCGAAACGCTCCCACTCAGCTGCCGCCCAAGGCGGTATGCAGGCGA
GCTTAGGCAATGCCGTAAAAGGCATGGGCGATGATGAAGATGTACATTTTCAAGATACGGTAAAAGGTTCCGACTGGGGC
TGCGATCAAGATGTAGCGCGGATGTTTGCTCACTGTGCGCCTAAGGCAGTGCGTGAATTGGCGACGTGGGGCGTGCCTTG
GTCAAGGGTGAGTGCAGGCCCAAGGGACGTGATAGTTAACGCGCAAAAAGTGACTTTGCATGAGGCGCAGGAAGCCCATG
GACTGATTAACGCCCGTGACTTTGGCGGCACAAAAAAATGGCGCACTTGCTACACGGCCGATGGTACGGGTCATTCGCTA
TTATACGCTATGGATAACAAAGCAATTTCTATGGATATTCTCGTCCATGAACGTATCGAAGCGTTGGCACTTATTCACGA
TGGTAAGCGCTGCCATGGGGTAATCGCTCGCTGTTTGATTACGGGTGAACTCAGGGCTTATGTGGCTAAGTCCACCACCA
TCGCCACTGGCGGATATGGCCGAATTTATGAAGTGTCGACCAATGCAATTATCTGCGAAGGTATTGGCCAAGCGCTCGCG
CTAGAAACCGGCGTTGCCACCCTTGGCAATATGGAAGCGGTGCAATTCCATCCCACCGCTATCGTGCCCGTGGGCATTTT
AACCACGGAAGGCTGCCGTGGTGATGGTGGCTTATTGCGCGATAAAGACGGTTATCGCTTTATGCCAGACTATGAGCCCG
ATAAAAAAGAGTTGGCATCGCGGGATGTGGTATCGCGCCGCATGACAGAACACATACGGAAAGGGAAGGGCGTTGATAGC
CCCTATGGACCGCATTTGTGGCTGGATATTACCCTTCTGGGTCGCAAGCACATCGAAACTAACCTTAGGGAAGTGCAGGA
AATTTGTGAGAACTTCCTCGGTATCGATCCCGCTAAGGATTGGATCCCAGTACGGCCAACGCAGCATTATTCCATGGGCG
GCATTCGAACCAATGCTACGGGTGAAAGCCCGCAGCTTAAAGGCTTGTTTAGCGTCGGCGAAGCGGCGTGTTGGGACATG
CATGGTTTTAACCGTTTAGGCGGTAATTCGCTGGCCGAAACAGTGGTTGGCGGCATGATTATTGGTAAATATGTCGCCGA
TTTTTGTGAGAACAATAGCCTTGAGATCGACACTCAGCTTGCTGAACGGTTTATGCAGCAAGTGCAGAGTGAAATAGATC
TGCTGATCGAGGGTGATGGTCACGAGAGCGCCTTTGCACTCAAACGCGAAATGCAGCGCATCATGATGGATTATGTGGGG
ATTTTCCGTAATGGCCCTGAGCTTGATAAAGCCGTCGCTGAACTTAAAGTGCTGCTCGAACGTTCGCGTAAACTTGGGCT
TAAGTGTAAAAAGCGTCACGCCAATCCTGAGCTGGTCGAAGCCCTGCGGGTCAAGCGTATGCTCAAAGTCGCGCTGACTG
TGGCCTGCGGCGCAGCGGCACGAACAGAGAGCCGTGGTGCCCATGCTCGAGAAGATTATCCACAGCGCAATGATCGAGAC
TGGTTAAATCGCACCTTGGCCAGTTGGCCCGATGCCGATGCGCTCGAACCTGTGCTGAATTACGAAGCGCTTGATGTGAT
GAAGATGGAACTCCCGCCGGGCTATCGTGGCTATGGCATCAACAACGCCATAGTGCATCCCGATACCGAAAAACGTGAAC
AGCAGATTGCCAATATTTTAGCTGAGCTAGGTGAGGATGCGGACCGTTATCAACGCCAGCGGGCGCTTATGCCCTTTGAA
TTACCCGAAAGCTTACAGCCTAATAATGAACGTTTGAGTGATACCTTAAAAAGCCCGTCAGCCAATGCGTTAGGAGAAAA
ATCATAA

Upstream 100 bases:

>100_bases
AAATTAATGAATAAGTAAATCAATGAATAAGCTTATTAATGAATAGAATGTCGAACACAGCAAACTGCACAAGAGTAATA
GACCCGATTAAGGAGCAGGC

Downstream 100 bases:

>100_bases
TGAGCCAAGGTCGAACGCTCACCTTTAATATCTTTCGTTATGATCCGCTGGAGCCAAACGATAAGCCGAAAATGGTGCGT
TATCAGCTTACCGAAACGCC

Product: fumarate reductase flavoprotein subunit

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 668; Mature: 668

Protein sequence:

>668_residues
MKLIYTDSLVVGAGLAGLRVAIASKERGLDTLVLSLIPAKRSHSAAAQGGMQASLGNAVKGMGDDEDVHFQDTVKGSDWG
CDQDVARMFAHCAPKAVRELATWGVPWSRVSAGPRDVIVNAQKVTLHEAQEAHGLINARDFGGTKKWRTCYTADGTGHSL
LYAMDNKAISMDILVHERIEALALIHDGKRCHGVIARCLITGELRAYVAKSTTIATGGYGRIYEVSTNAIICEGIGQALA
LETGVATLGNMEAVQFHPTAIVPVGILTTEGCRGDGGLLRDKDGYRFMPDYEPDKKELASRDVVSRRMTEHIRKGKGVDS
PYGPHLWLDITLLGRKHIETNLREVQEICENFLGIDPAKDWIPVRPTQHYSMGGIRTNATGESPQLKGLFSVGEAACWDM
HGFNRLGGNSLAETVVGGMIIGKYVADFCENNSLEIDTQLAERFMQQVQSEIDLLIEGDGHESAFALKREMQRIMMDYVG
IFRNGPELDKAVAELKVLLERSRKLGLKCKKRHANPELVEALRVKRMLKVALTVACGAAARTESRGAHAREDYPQRNDRD
WLNRTLASWPDADALEPVLNYEALDVMKMELPPGYRGYGINNAIVHPDTEKREQQIANILAELGEDADRYQRQRALMPFE
LPESLQPNNERLSDTLKSPSANALGEKS

Sequences:

>Translated_668_residues
MKLIYTDSLVVGAGLAGLRVAIASKERGLDTLVLSLIPAKRSHSAAAQGGMQASLGNAVKGMGDDEDVHFQDTVKGSDWG
CDQDVARMFAHCAPKAVRELATWGVPWSRVSAGPRDVIVNAQKVTLHEAQEAHGLINARDFGGTKKWRTCYTADGTGHSL
LYAMDNKAISMDILVHERIEALALIHDGKRCHGVIARCLITGELRAYVAKSTTIATGGYGRIYEVSTNAIICEGIGQALA
LETGVATLGNMEAVQFHPTAIVPVGILTTEGCRGDGGLLRDKDGYRFMPDYEPDKKELASRDVVSRRMTEHIRKGKGVDS
PYGPHLWLDITLLGRKHIETNLREVQEICENFLGIDPAKDWIPVRPTQHYSMGGIRTNATGESPQLKGLFSVGEAACWDM
HGFNRLGGNSLAETVVGGMIIGKYVADFCENNSLEIDTQLAERFMQQVQSEIDLLIEGDGHESAFALKREMQRIMMDYVG
IFRNGPELDKAVAELKVLLERSRKLGLKCKKRHANPELVEALRVKRMLKVALTVACGAAARTESRGAHAREDYPQRNDRD
WLNRTLASWPDADALEPVLNYEALDVMKMELPPGYRGYGINNAIVHPDTEKREQQIANILAELGEDADRYQRQRALMPFE
LPESLQPNNERLSDTLKSPSANALGEKS
>Mature_668_residues
MKLIYTDSLVVGAGLAGLRVAIASKERGLDTLVLSLIPAKRSHSAAAQGGMQASLGNAVKGMGDDEDVHFQDTVKGSDWG
CDQDVARMFAHCAPKAVRELATWGVPWSRVSAGPRDVIVNAQKVTLHEAQEAHGLINARDFGGTKKWRTCYTADGTGHSL
LYAMDNKAISMDILVHERIEALALIHDGKRCHGVIARCLITGELRAYVAKSTTIATGGYGRIYEVSTNAIICEGIGQALA
LETGVATLGNMEAVQFHPTAIVPVGILTTEGCRGDGGLLRDKDGYRFMPDYEPDKKELASRDVVSRRMTEHIRKGKGVDS
PYGPHLWLDITLLGRKHIETNLREVQEICENFLGIDPAKDWIPVRPTQHYSMGGIRTNATGESPQLKGLFSVGEAACWDM
HGFNRLGGNSLAETVVGGMIIGKYVADFCENNSLEIDTQLAERFMQQVQSEIDLLIEGDGHESAFALKREMQRIMMDYVG
IFRNGPELDKAVAELKVLLERSRKLGLKCKKRHANPELVEALRVKRMLKVALTVACGAAARTESRGAHAREDYPQRNDRD
WLNRTLASWPDADALEPVLNYEALDVMKMELPPGYRGYGINNAIVHPDTEKREQQIANILAELGEDADRYQRQRALMPFE
LPESLQPNNERLSDTLKSPSANALGEKS

Specific function: The fumarate reductase enzyme complex is required for fumarate respiration using formate or sulfide as electron donor [H]

COG id: COG1053

COG function: function code C; Succinate dehydrogenase/fumarate reductase, flavoprotein subunit

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily [H]

Homologues:

Organism=Homo sapiens, GI156416003, Length=543, Percent_Identity=38.4898710865562, Blast_Score=322, Evalue=1e-87,
Organism=Escherichia coli, GI1786942, Length=613, Percent_Identity=37.0309951060359, Blast_Score=332, Evalue=6e-92,
Organism=Escherichia coli, GI1790597, Length=585, Percent_Identity=36.5811965811966, Blast_Score=321, Evalue=9e-89,
Organism=Escherichia coli, GI1788928, Length=562, Percent_Identity=28.6476868327402, Blast_Score=169, Evalue=4e-43,
Organism=Caenorhabditis elegans, GI17505833, Length=550, Percent_Identity=38.3636363636364, Blast_Score=325, Evalue=7e-89,
Organism=Caenorhabditis elegans, GI17550100, Length=545, Percent_Identity=38.8990825688073, Blast_Score=315, Evalue=3e-86,
Organism=Saccharomyces cerevisiae, GI6322701, Length=600, Percent_Identity=37.5, Blast_Score=329, Evalue=9e-91,
Organism=Saccharomyces cerevisiae, GI6322416, Length=593, Percent_Identity=37.2681281618887, Blast_Score=325, Evalue=1e-89,
Organism=Drosophila melanogaster, GI17137288, Length=602, Percent_Identity=37.0431893687708, Blast_Score=332, Evalue=7e-91,
Organism=Drosophila melanogaster, GI24655642, Length=602, Percent_Identity=37.0431893687708, Blast_Score=332, Evalue=7e-91,
Organism=Drosophila melanogaster, GI24655647, Length=602, Percent_Identity=37.0431893687708, Blast_Score=332, Evalue=7e-91,
Organism=Drosophila melanogaster, GI24663005, Length=571, Percent_Identity=34.5008756567426, Blast_Score=282, Evalue=6e-76,

Paralogues:

None

Copy number: 1900 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). 1360 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). 1100 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003953
- InterPro:   IPR003952
- InterPro:   IPR015939
- InterPro:   IPR004112
- InterPro:   IPR014006 [H]

Pfam domain/function: PF00890 FAD_binding_2; PF02910 Succ_DH_flav_C [H]

EC number: =1.3.99.1 [H]

Molecular weight: Translated: 73489; Mature: 73489

Theoretical pI: Translated: 6.56; Mature: 6.56

Prosite motif: PS00504 FRD_SDH_FAD_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
4.8 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
3.0 %Met     (Mature Protein)
4.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKLIYTDSLVVGAGLAGLRVAIASKERGLDTLVLSLIPAKRSHSAAAQGGMQASLGNAVK
CEEEEECCHHHHCCHHHHEEEECCCCCCHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHC
GMGDDEDVHFQDTVKGSDWGCDQDVARMFAHCAPKAVRELATWGVPWSRVSAGPRDVIVN
CCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHCHHHHHHHHHCCCCHHHHCCCCHHEEEE
AQKVTLHEAQEAHGLINARDFGGTKKWRTCYTADGTGHSLLYAMDNKAISMDILVHERIE
CHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCEEEEEECCCEEEEHHHHHHHHH
ALALIHDGKRCHGVIARCLITGELRAYVAKSTTIATGGYGRIYEVSTNAIICEGIGQALA
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEEECCEEEECCCCCHHH
LETGVATLGNMEAVQFHPTAIVPVGILTTEGCRGDGGLLRDKDGYRFMPDYEPDKKELAS
HHHHHHHHCCCCEEEECCCEEEEEEEEEECCCCCCCCCCCCCCCCEECCCCCCCHHHHHH
RDVVSRRMTEHIRKGKGVDSPYGPHLWLDITLLGRKHIETNLREVQEICENFLGIDPAKD
HHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCC
WIPVRPTQHYSMGGIRTNATGESPQLKGLFSVGEAACWDMHGFNRLGGNSLAETVVGGMI
CCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHCCHHHHCCCCCHHCCCHHHHHHHHHHHH
IGKYVADFCENNSLEIDTQLAERFMQQVQSEIDLLIEGDGHESAFALKREMQRIMMDYVG
HHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHCEEEEECCCCHHHHHHHHHHHHHHHHHHH
IFRNGPELDKAVAELKVLLERSRKLGLKCKKRHANPELVEALRVKRMLKVALTVACGAAA
HHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHH
RTESRGAHAREDYPQRNDRDWLNRTLASWPDADALEPVLNYEALDVMKMELPPGYRGYGI
CCCCCCCCCHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHCCHHHHEEEEECCCCCCCCCC
NNAIVHPDTEKREQQIANILAELGEDADRYQRQRALMPFELPESLQPNNERLSDTLKSPS
CCCEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCC
ANALGEKS
CCCCCCCC
>Mature Secondary Structure
MKLIYTDSLVVGAGLAGLRVAIASKERGLDTLVLSLIPAKRSHSAAAQGGMQASLGNAVK
CEEEEECCHHHHCCHHHHEEEECCCCCCHHHHHHHHHCCCCCCHHHHHCCCHHHHHHHHC
GMGDDEDVHFQDTVKGSDWGCDQDVARMFAHCAPKAVRELATWGVPWSRVSAGPRDVIVN
CCCCCCCCCEEECCCCCCCCCCHHHHHHHHHHCHHHHHHHHHCCCCHHHHCCCCHHEEEE
AQKVTLHEAQEAHGLINARDFGGTKKWRTCYTADGTGHSLLYAMDNKAISMDILVHERIE
CHHHHHHHHHHHCCCCCCCCCCCCCCCCEEEECCCCCCEEEEEECCCEEEEHHHHHHHHH
ALALIHDGKRCHGVIARCLITGELRAYVAKSTTIATGGYGRIYEVSTNAIICEGIGQALA
HHHHHHCCHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCEEEEEECCEEEECCCCCHHH
LETGVATLGNMEAVQFHPTAIVPVGILTTEGCRGDGGLLRDKDGYRFMPDYEPDKKELAS
HHHHHHHHCCCCEEEECCCEEEEEEEEEECCCCCCCCCCCCCCCCEECCCCCCCHHHHHH
RDVVSRRMTEHIRKGKGVDSPYGPHLWLDITLLGRKHIETNLREVQEICENFLGIDPAKD
HHHHHHHHHHHHHHCCCCCCCCCCEEEEEEEEECCHHHHHHHHHHHHHHHHHCCCCCCCC
WIPVRPTQHYSMGGIRTNATGESPQLKGLFSVGEAACWDMHGFNRLGGNSLAETVVGGMI
CCCCCCCCCCCCCCEEECCCCCCCCHHHHHHHCCHHHHCCCCCHHCCCHHHHHHHHHHHH
IGKYVADFCENNSLEIDTQLAERFMQQVQSEIDLLIEGDGHESAFALKREMQRIMMDYVG
HHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHCEEEEECCCCHHHHHHHHHHHHHHHHHHH
IFRNGPELDKAVAELKVLLERSRKLGLKCKKRHANPELVEALRVKRMLKVALTVACGAAA
HHCCCCHHHHHHHHHHHHHHHHHHCCCHHHHCCCCHHHHHHHHHHHHHHHHHHHHHCCHH
RTESRGAHAREDYPQRNDRDWLNRTLASWPDADALEPVLNYEALDVMKMELPPGYRGYGI
CCCCCCCCCHHCCCCCCCHHHHHHHHHCCCCCHHHHHHHCCHHHHEEEEECCCCCCCCCC
NNAIVHPDTEKREQQIANILAELGEDADRYQRQRALMPFELPESLQPNNERLSDTLKSPS
CCCEECCCHHHHHHHHHHHHHHHCCCHHHHHHHHCCCCCCCCCCCCCCHHHHHHHHCCCC
ANALGEKS
CCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2244791; 9492313; 14500908; 3609021; 10586875; 11248702 [H]