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The map label for this gene is metR [H]

Identifier: 160876868

GI number: 160876868

Start: 4435405

End: 4436310

Strand: Direct

Name: metR [H]

Synonym: Sbal195_3764

Alternate gene names: 160876868

Gene position: 4435405-4436310 (Clockwise)

Preceding gene: 160876866

Following gene: 160876870

Centisome position: 82.95

GC content: 47.9

Gene sequence:

>906_bases
ATGATCGAACTAAGACATCTGCGAACCTTAATGGCCCTGAAGGAAAGTGGCAGTTTGGCGGGCGCAGCCAAAAAACGTTT
TGTCACTCAATCCGCACTCTCCCACCAAATTAAGGAGTTGGAGCAAAGGATTAACTCGCCTATTTTTGTGCGTAAGAGTA
AGCCGCTGTCATTCACCCAAGAAGGTGCACGCCTGCTTCATCTCGCGGAAGAGATTTTGCCTAAGGTGTTAGAAACCGAG
ACAGATCTTAAGAATGGCCTTGAAACCGAAACCAATCAGTTGCGTGTCGGCATTGAGTGCCACAGCTGTTTTCGCTGGTT
AATGCCTGTGATGGAGCAATTTAGACAAGACTATCCCCAAGCGGAGTTAGATCTGTCGAGCCGTCACTTGTTCGACTCGC
TCAATGCCTTGGAAATGGGTGAACTGGATATAGTGCTGACCTCAGATCCTGTACCTGGGCATTCACTCGCTTATCAGCAT
TTGTTTGATTTTGAAGTGAAGTTAGTGGTTGCTAAAGATCATCCTCTAGCAAAAGAAGCCTATGTCACCCCTAAGCAATT
AGCACACTTGCCTATTATCAGTTATCCCGTACCACTAACGCGTTTAGACATCTATCGCCACTTTTTAGAACCCGCAGGCA
TAGAAGCGGGCGAGCAAAAAACCTGTGATTTAACCATGATGTTATTGCAACGCATCGCCTGTAAAGACGGCATAGCCGCA
CTGCCGAACTGGTCGATAAATGAAGGACATGGCCTAAGCCTCACCACGGTGAAGCTAGGGCAAGAAGGCTTGAAACGCCC
TCTGTTTGGCGCCTATCGCCGCCATAGCGCCAACTCAGCCTTGATCCAAAATTGGTTACAACTGGTGGCGAGTGAAGGTT
TATCCCGCCAGCAGAAGACAAATTAA

Upstream 100 bases:

>100_bases
AATGGGCGTCTGGACGTCTAGAAGTTTATTGTGTTAGTCTCTATTCCAGCAACCGAATTGATTTCAAGCACAACATGAGC
GAATTTCACCTGGAGTGAAC

Downstream 100 bases:

>100_bases
CACAGGTGAAACCTAACAAAAAAGCCTGCTGATGCAGGCTTTCTTATTGAATTGTATGATTATTTCATAGGATCAAGCAG
CTGTTTAGCGAATCTCAAAA

Product: LysR family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 301; Mature: 301

Protein sequence:

>301_residues
MIELRHLRTLMALKESGSLAGAAKKRFVTQSALSHQIKELEQRINSPIFVRKSKPLSFTQEGARLLHLAEEILPKVLETE
TDLKNGLETETNQLRVGIECHSCFRWLMPVMEQFRQDYPQAELDLSSRHLFDSLNALEMGELDIVLTSDPVPGHSLAYQH
LFDFEVKLVVAKDHPLAKEAYVTPKQLAHLPIISYPVPLTRLDIYRHFLEPAGIEAGEQKTCDLTMMLLQRIACKDGIAA
LPNWSINEGHGLSLTTVKLGQEGLKRPLFGAYRRHSANSALIQNWLQLVASEGLSRQQKTN

Sequences:

>Translated_301_residues
MIELRHLRTLMALKESGSLAGAAKKRFVTQSALSHQIKELEQRINSPIFVRKSKPLSFTQEGARLLHLAEEILPKVLETE
TDLKNGLETETNQLRVGIECHSCFRWLMPVMEQFRQDYPQAELDLSSRHLFDSLNALEMGELDIVLTSDPVPGHSLAYQH
LFDFEVKLVVAKDHPLAKEAYVTPKQLAHLPIISYPVPLTRLDIYRHFLEPAGIEAGEQKTCDLTMMLLQRIACKDGIAA
LPNWSINEGHGLSLTTVKLGQEGLKRPLFGAYRRHSANSALIQNWLQLVASEGLSRQQKTN
>Mature_301_residues
MIELRHLRTLMALKESGSLAGAAKKRFVTQSALSHQIKELEQRINSPIFVRKSKPLSFTQEGARLLHLAEEILPKVLETE
TDLKNGLETETNQLRVGIECHSCFRWLMPVMEQFRQDYPQAELDLSSRHLFDSLNALEMGELDIVLTSDPVPGHSLAYQH
LFDFEVKLVVAKDHPLAKEAYVTPKQLAHLPIISYPVPLTRLDIYRHFLEPAGIEAGEQKTCDLTMMLLQRIACKDGIAA
LPNWSINEGHGLSLTTVKLGQEGLKRPLFGAYRRHSANSALIQNWLQLVASEGLSRQQKTN

Specific function: Control of the last step in methionine biosynthesis; metR is a positive activator of the metA, metE and metH genes. It is also a negative regulator of its own expression [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lysR-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790262, Length=288, Percent_Identity=45.4861111111111, Blast_Score=251, Evalue=3e-68,
Organism=Escherichia coli, GI1788887, Length=193, Percent_Identity=30.5699481865285, Blast_Score=83, Evalue=2e-17,
Organism=Escherichia coli, GI1787879, Length=195, Percent_Identity=28.7179487179487, Blast_Score=81, Evalue=1e-16,
Organism=Escherichia coli, GI87082024, Length=175, Percent_Identity=32.5714285714286, Blast_Score=79, Evalue=4e-16,
Organism=Escherichia coli, GI87081904, Length=199, Percent_Identity=32.1608040201005, Blast_Score=76, Evalue=2e-15,
Organism=Escherichia coli, GI1787601, Length=288, Percent_Identity=22.9166666666667, Blast_Score=76, Evalue=3e-15,
Organism=Escherichia coli, GI1790208, Length=195, Percent_Identity=25.1282051282051, Blast_Score=74, Evalue=1e-14,
Organism=Escherichia coli, GI145693105, Length=191, Percent_Identity=25.130890052356, Blast_Score=73, Evalue=3e-14,
Organism=Escherichia coli, GI1786401, Length=213, Percent_Identity=25.8215962441315, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI157672245, Length=210, Percent_Identity=26.1904761904762, Blast_Score=70, Evalue=1e-13,
Organism=Escherichia coli, GI1788296, Length=192, Percent_Identity=29.1666666666667, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI87082132, Length=176, Percent_Identity=28.9772727272727, Blast_Score=63, Evalue=3e-11,
Organism=Escherichia coli, GI1790399, Length=188, Percent_Identity=28.1914893617021, Blast_Score=61, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000847
- InterPro:   IPR005119
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00126 HTH_1; PF03466 LysR_substrate [H]

EC number: NA

Molecular weight: Translated: 33962; Mature: 33962

Theoretical pI: Translated: 7.40; Mature: 7.40

Prosite motif: PS50931 HTH_LYSR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.3 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.7 %Cys+Met (Translated Protein)
1.3 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIELRHLRTLMALKESGSLAGAAKKRFVTQSALSHQIKELEQRINSPIFVRKSKPLSFTQ
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHH
EGARLLHLAEEILPKVLETETDLKNGLETETNQLRVGIECHSCFRWLMPVMEQFRQDYPQ
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHCCC
AELDLSSRHLFDSLNALEMGELDIVLTSDPVPGHSLAYQHLFDFEVKLVVAKDHPLAKEA
CCCCCHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHCEEEEEEEECCCCCCHHH
YVTPKQLAHLPIISYPVPLTRLDIYRHFLEPAGIEAGEQKTCDLTMMLLQRIACKDGIAA
CCCHHHHHHCCEECCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCC
LPNWSINEGHGLSLTTVKLGQEGLKRPLFGAYRRHSANSALIQNWLQLVASEGLSRQQKT
CCCCCCCCCCCCEEEEEHHCHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHCC
N
C
>Mature Secondary Structure
MIELRHLRTLMALKESGSLAGAAKKRFVTQSALSHQIKELEQRINSPIFVRKSKPLSFTQ
CCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEECCCCCCHHH
EGARLLHLAEEILPKVLETETDLKNGLETETNQLRVGIECHSCFRWLMPVMEQFRQDYPQ
HHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCEEECHHHHHHHHHHHHHHHHHHHHCCC
AELDLSSRHLFDSLNALEMGELDIVLTSDPVPGHSLAYQHLFDFEVKLVVAKDHPLAKEA
CCCCCHHHHHHHHCCCCCCCCEEEEEECCCCCCHHHHHHHHHCEEEEEEEECCCCCCHHH
YVTPKQLAHLPIISYPVPLTRLDIYRHFLEPAGIEAGEQKTCDLTMMLLQRIACKDGIAA
CCCHHHHHHCCEECCCCCHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCC
LPNWSINEGHGLSLTTVKLGQEGLKRPLFGAYRRHSANSALIQNWLQLVASEGLSRQQKT
CCCCCCCCCCCCEEEEEHHCHHHHCCHHHHHHHHCCCCHHHHHHHHHHHHHHCCCHHHCC
N
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]