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The map label for this gene is cyp18 [H]

Identifier: 160876825

GI number: 160876825

Start: 4388672

End: 4389256

Strand: Direct

Name: cyp18 [H]

Synonym: Sbal195_3721

Alternate gene names: 160876825

Gene position: 4388672-4389256 (Clockwise)

Preceding gene: 160876824

Following gene: 160876826

Centisome position: 82.07

GC content: 47.86

Gene sequence:

>585_bases
ATGCTCCGTTGGATATCAGCCCTCTTATTTCTCTTTATGAGTCACAATAGCTTCGCACTCGACATTCAGGCCGATACCTT
GTATCCCAGAGTCGAGTTTGACACTAGCTTAGGCAAAATAGTGGTCGAGCTAGATAGGACACGCGCACCGATCACTGTCG
ATAACTTTTTAACTTATGTCGTCAAAGGCGAATACGACAACACGATATTTCACCGTGTGATCAGTGACTTTGTGGTGCAA
GGCGGTGGACTCACCCCTAAGTATGAAGAGTTGCCAGACGGCAAGCCGATAATCAACGAATCTGGAAATGGTCTCACCAA
CAGCATAGGCACTATCGCCATGGCGCGGGAAAACGAGCCGCACTCAGCCACACGCCAGTTCTACTTCAACGTGGCCGACA
ATACTAAGCTCGACCCATCCAAACGCCGTTGGGGTTATGCCGTATTTGGTGAAGTGATTGAAGGTAAAACAGTCCTCGAA
GCTATGGCTGTCGTTGAGACAGGCACGAACACTAAGCTCAATTGGCCTGATGTCCCTGTGACACCTATCATATTGAAAAC
CGCTAAGTTATTACCTAAACAGTAA

Upstream 100 bases:

>100_bases
ATAAATTACTCGGCCAACTCACAGGTGAAATTCTCAATGATCCTGAGCTTAATCAGTTTCTACAACAATAACAGCGTCAG
TTTATTATAAGGAAATCAAT

Downstream 100 bases:

>100_bases
TCCAAAAATAATTTCGAGCAAAAGCGCTAATTTTGCATCTATACTGTTATAGCAAACAGAAAGGAGGCAAACGATGACGG
CAACTGAGTTCATCGATAAT

Product: cyclophilin type peptidyl-prolyl cis-trans isomerase

Products: NA

Alternate protein names: PPIase cyp18; SanCyp18; Rotamase cyp18 [H]

Number of amino acids: Translated: 194; Mature: 194

Protein sequence:

>194_residues
MLRWISALLFLFMSHNSFALDIQADTLYPRVEFDTSLGKIVVELDRTRAPITVDNFLTYVVKGEYDNTIFHRVISDFVVQ
GGGLTPKYEELPDGKPIINESGNGLTNSIGTIAMARENEPHSATRQFYFNVADNTKLDPSKRRWGYAVFGEVIEGKTVLE
AMAVVETGTNTKLNWPDVPVTPIILKTAKLLPKQ

Sequences:

>Translated_194_residues
MLRWISALLFLFMSHNSFALDIQADTLYPRVEFDTSLGKIVVELDRTRAPITVDNFLTYVVKGEYDNTIFHRVISDFVVQ
GGGLTPKYEELPDGKPIINESGNGLTNSIGTIAMARENEPHSATRQFYFNVADNTKLDPSKRRWGYAVFGEVIEGKTVLE
AMAVVETGTNTKLNWPDVPVTPIILKTAKLLPKQ
>Mature_194_residues
MLRWISALLFLFMSHNSFALDIQADTLYPRVEFDTSLGKIVVELDRTRAPITVDNFLTYVVKGEYDNTIFHRVISDFVVQ
GGGLTPKYEELPDGKPIINESGNGLTNSIGTIAMARENEPHSATRQFYFNVADNTKLDPSKRRWGYAVFGEVIEGKTVLE
AMAVVETGTNTKLNWPDVPVTPIILKTAKLLPKQ

Specific function: PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides [H]

COG id: COG0652

COG function: function code O; Peptidyl-prolyl cis-trans isomerase (rotamase) - cyclophilin family

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 PPIase cyclophilin-type domain [H]

Homologues:

Organism=Homo sapiens, GI7706339, Length=147, Percent_Identity=32.6530612244898, Blast_Score=67, Evalue=1e-11,
Organism=Escherichia coli, GI1789763, Length=186, Percent_Identity=43.5483870967742, Blast_Score=152, Evalue=1e-38,
Organism=Escherichia coli, GI1786736, Length=160, Percent_Identity=45.625, Blast_Score=137, Evalue=7e-34,
Organism=Caenorhabditis elegans, GI17539496, Length=148, Percent_Identity=31.7567567567568, Blast_Score=68, Evalue=3e-12,
Organism=Drosophila melanogaster, GI17986117, Length=162, Percent_Identity=31.4814814814815, Blast_Score=72, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR015891
- InterPro:   IPR020892
- InterPro:   IPR002130 [H]

Pfam domain/function: PF00160 Pro_isomerase [H]

EC number: =5.2.1.8 [H]

Molecular weight: Translated: 21721; Mature: 21721

Theoretical pI: Translated: 5.73; Mature: 5.73

Prosite motif: PS00170 CSA_PPIASE_1 ; PS50072 CSA_PPIASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.1 %Met     (Translated Protein)
2.1 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
2.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MLRWISALLFLFMSHNSFALDIQADTLYPRVEFDTSLGKIVVELDRTRAPITVDNFLTYV
CHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEECCCCCEEEEEECCCCCCEEHHHEEEEE
VKGEYDNTIFHRVISDFVVQGGGLTPKYEELPDGKPIINESGNGLTNSIGTIAMARENEP
EECCCCHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCEECCCCCCCCCCCCEEEEECCCCC
HSATRQFYFNVADNTKLDPSKRRWGYAVFGEVIEGKTVLEAMAVVETGTNTKLNWPDVPV
CCCEEEEEEEECCCCCCCCCHHHCCHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCC
TPIILKTAKLLPKQ
CHHHHHHHHHCCCC
>Mature Secondary Structure
MLRWISALLFLFMSHNSFALDIQADTLYPRVEFDTSLGKIVVELDRTRAPITVDNFLTYV
CHHHHHHHHHHHHCCCCEEEEEECCCCCCEEEECCCCCEEEEEECCCCCCEEHHHEEEEE
VKGEYDNTIFHRVISDFVVQGGGLTPKYEELPDGKPIINESGNGLTNSIGTIAMARENEP
EECCCCHHHHHHHHHHHHHCCCCCCCCHHHCCCCCCEECCCCCCCCCCCCEEEEECCCCC
HSATRQFYFNVADNTKLDPSKRRWGYAVFGEVIEGKTVLEAMAVVETGTNTKLNWPDVPV
CCCEEEEEEEECCCCCCCCCHHHCCHHHHHHHHCCHHHHHHHHHHCCCCCCCCCCCCCCC
TPIILKTAKLLPKQ
CHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 10400660 [H]