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The map label for this gene is gltT [H]

Identifier: 160876777

GI number: 160876777

Start: 4331403

End: 4332737

Strand: Reverse

Name: gltT [H]

Synonym: Sbal195_3671

Alternate gene names: 160876777

Gene position: 4332737-4331403 (Counterclockwise)

Preceding gene: 160876778

Following gene: 160876775

Centisome position: 81.03

GC content: 50.64

Gene sequence:

>1335_bases
ATGACAAAACCTAAGTCGTCGGCATTAGGCCGTGTTTGGTCTCGCTGGATGTCAGTGCCGCTGTGGCTGCAAATTGTTAT
TGGTATGGTGCTAGGCATTATTGTCGGCGTCATTTTTGGTGAGCAAGCCACTTGCCTAAAGCCGCTCGGCACCTTGTTTG
TTAATGCCATAAAGATGCTGATCGTGCCACTGGTGTTTTGCTCGCTGATCGTGGGCGTTACGTCGATGCAAGACACCGGC
AAGATGGGACGAATCGGCATTAAATCCTTTGGGTTTTATCTGTTTACTACGGCTATCGCGATCAGTATCGGCCTGCTTGT
TGGTTATGTGCTGCAACCCGGCGCAGGCTTAGGATTAACGCTGGCAGAAGGCGCGACTCAAACCGCCAAAGCTGTGCCTT
CATTAGTCGATACCTTGGTTGATATAGTGCCGACAAATCCGATTGCGGCCATGGCAAGCGGCCAAATTTTGCAAGTCATC
GTATTTGCCATCGCCTTAGGTATCGCATTAGTGCTGATTGGCGAGCACGGTAAACCTGCGATTAAAGTGTTCGAAAGCCT
CGCCGAAGCCATGTACAAACTGGCTGACATGGTGATGAAACTCGCGCCCTACGGCGTCTTTGGGCTAATGGCTTGGGTGG
CGGGGGAGTATGGTATTGATATGCTTTGGCCCCTGATCAAAGTCATCATTGCTGTATACCTTGGTTGTATTATCCACGTG
CTGGGTTTCTATAGTTTTTTACTGCGCGGATTTGCGAAGTTAAGTCCGCTGCAGTTTTTTAAAGGCATTAGCAATGCCAT
GTTAGTGGCGTTTACCACGTCTAGCTCTGCGGGTACGCTCCCTGCAAGCATGAAGTGCGCGAGTGAAAACCTAGGCGTTC
ATAAGAAGATTTCTAGCTTCGTGTTACCGCTGGGCACTACCATCAATATGGATGGCACTGCGTTATACCAAGGCGTTACT
GTGCTGTTTGTCGCGCAGGCGTTTGGCATCGACCTGACTGTTGTCGATTATTTCACCATTATTTTAACCGCGACTTTGGC
TTCTATTGGCACTGCAGGTGTGCCCGGTGCTGGCTTGGTGATGCTGACGTTAGTGCTGACAACCGTAGGGCTGCCCTTAG
AAGGGGTGGCATTGATAGCGGGGATTGACCGTATTTTAGATATGGTGCGCACTGTGGTGAACGTCTCTGGCGATTTAGTG
GCGACAACTGTGATTGCCAAGTCTGAAGATGAGCTGGATATGGCGCATTACAATGCCGACACGGAGCAAAGCGCCGTGCT
AGCCGAGCAGAATATCGCCCTTGAAACGGCGGCGGAGAATAGCGCCAAAGTCTAG

Upstream 100 bases:

>100_bases
CCCCTCTGCTAGACTCGGCGATTGCCTCATGTAGACTGAGAAACTAGCGCGCTAGTTTTGGTCTTTGCCCCATCATAGTT
TCGAATTCAAGGTTATGAAT

Downstream 100 bases:

>100_bases
TTGGCTTCAGTTGCTGGCTGTGAAACTAAAAAACCGCCAATGGCGGTTTTTTTATGCGGACAAATTTTCTTTGTTGAAGC
TTACTACACTGGGTTTATTT

Product: sodium:dicarboxylate symporter

Products: L-aspartate [Cytoplasm]; Proton [Cytoplasm]; L-glutamate [Cytoplasm] [C]

Alternate protein names: Glutamate-aspartate carrier protein [H]

Number of amino acids: Translated: 444; Mature: 443

Protein sequence:

>444_residues
MTKPKSSALGRVWSRWMSVPLWLQIVIGMVLGIIVGVIFGEQATCLKPLGTLFVNAIKMLIVPLVFCSLIVGVTSMQDTG
KMGRIGIKSFGFYLFTTAIAISIGLLVGYVLQPGAGLGLTLAEGATQTAKAVPSLVDTLVDIVPTNPIAAMASGQILQVI
VFAIALGIALVLIGEHGKPAIKVFESLAEAMYKLADMVMKLAPYGVFGLMAWVAGEYGIDMLWPLIKVIIAVYLGCIIHV
LGFYSFLLRGFAKLSPLQFFKGISNAMLVAFTTSSSAGTLPASMKCASENLGVHKKISSFVLPLGTTINMDGTALYQGVT
VLFVAQAFGIDLTVVDYFTIILTATLASIGTAGVPGAGLVMLTLVLTTVGLPLEGVALIAGIDRILDMVRTVVNVSGDLV
ATTVIAKSEDELDMAHYNADTEQSAVLAEQNIALETAAENSAKV

Sequences:

>Translated_444_residues
MTKPKSSALGRVWSRWMSVPLWLQIVIGMVLGIIVGVIFGEQATCLKPLGTLFVNAIKMLIVPLVFCSLIVGVTSMQDTG
KMGRIGIKSFGFYLFTTAIAISIGLLVGYVLQPGAGLGLTLAEGATQTAKAVPSLVDTLVDIVPTNPIAAMASGQILQVI
VFAIALGIALVLIGEHGKPAIKVFESLAEAMYKLADMVMKLAPYGVFGLMAWVAGEYGIDMLWPLIKVIIAVYLGCIIHV
LGFYSFLLRGFAKLSPLQFFKGISNAMLVAFTTSSSAGTLPASMKCASENLGVHKKISSFVLPLGTTINMDGTALYQGVT
VLFVAQAFGIDLTVVDYFTIILTATLASIGTAGVPGAGLVMLTLVLTTVGLPLEGVALIAGIDRILDMVRTVVNVSGDLV
ATTVIAKSEDELDMAHYNADTEQSAVLAEQNIALETAAENSAKV
>Mature_443_residues
TKPKSSALGRVWSRWMSVPLWLQIVIGMVLGIIVGVIFGEQATCLKPLGTLFVNAIKMLIVPLVFCSLIVGVTSMQDTGK
MGRIGIKSFGFYLFTTAIAISIGLLVGYVLQPGAGLGLTLAEGATQTAKAVPSLVDTLVDIVPTNPIAAMASGQILQVIV
FAIALGIALVLIGEHGKPAIKVFESLAEAMYKLADMVMKLAPYGVFGLMAWVAGEYGIDMLWPLIKVIIAVYLGCIIHVL
GFYSFLLRGFAKLSPLQFFKGISNAMLVAFTTSSSAGTLPASMKCASENLGVHKKISSFVLPLGTTINMDGTALYQGVTV
LFVAQAFGIDLTVVDYFTIILTATLASIGTAGVPGAGLVMLTLVLTTVGLPLEGVALIAGIDRILDMVRTVVNVSGDLVA
TTVIAKSEDELDMAHYNADTEQSAVLAEQNIALETAAENSAKV

Specific function: This carrier protein is part of the Na(+)-dependent, binding-protein-independent glutamate-aspartate transport system [H]

COG id: COG1301

COG function: function code C; Na+/H+-dicarboxylate symporters

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein (Potential) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the sodium:dicarboxylate (SDF) symporter (TC 2.A.23) family [H]

Homologues:

Organism=Homo sapiens, GI21314632, Length=450, Percent_Identity=32.2222222222222, Blast_Score=201, Evalue=9e-52,
Organism=Homo sapiens, GI66773030, Length=509, Percent_Identity=30.4518664047151, Blast_Score=196, Evalue=3e-50,
Organism=Homo sapiens, GI40254478, Length=501, Percent_Identity=32.5349301397206, Blast_Score=191, Evalue=9e-49,
Organism=Homo sapiens, GI5032093, Length=389, Percent_Identity=36.2467866323907, Blast_Score=189, Evalue=5e-48,
Organism=Homo sapiens, GI169790839, Length=475, Percent_Identity=31.1578947368421, Blast_Score=186, Evalue=5e-47,
Organism=Homo sapiens, GI4827012, Length=321, Percent_Identity=36.1370716510903, Blast_Score=172, Evalue=6e-43,
Organism=Homo sapiens, GI194239697, Length=301, Percent_Identity=35.8803986710963, Blast_Score=168, Evalue=9e-42,
Organism=Homo sapiens, GI223468566, Length=292, Percent_Identity=36.3013698630137, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI223468564, Length=283, Percent_Identity=36.7491166077738, Blast_Score=167, Evalue=2e-41,
Organism=Homo sapiens, GI301601644, Length=191, Percent_Identity=37.17277486911, Blast_Score=133, Evalue=3e-31,
Organism=Homo sapiens, GI262359914, Length=383, Percent_Identity=28.1984334203655, Blast_Score=121, Evalue=1e-27,
Organism=Escherichia coli, GI1790514, Length=412, Percent_Identity=37.621359223301, Blast_Score=265, Evalue=6e-72,
Organism=Escherichia coli, GI1789947, Length=413, Percent_Identity=36.8038740920097, Blast_Score=249, Evalue=2e-67,
Organism=Escherichia coli, GI1788024, Length=432, Percent_Identity=30.787037037037, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1789473, Length=372, Percent_Identity=26.6129032258064, Blast_Score=101, Evalue=1e-22,
Organism=Caenorhabditis elegans, GI71996953, Length=484, Percent_Identity=34.504132231405, Blast_Score=239, Evalue=2e-63,
Organism=Caenorhabditis elegans, GI71983106, Length=444, Percent_Identity=34.6846846846847, Blast_Score=216, Evalue=2e-56,
Organism=Caenorhabditis elegans, GI71983099, Length=444, Percent_Identity=34.6846846846847, Blast_Score=216, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI17537407, Length=473, Percent_Identity=30.6553911205074, Blast_Score=197, Evalue=1e-50,
Organism=Caenorhabditis elegans, GI193206505, Length=410, Percent_Identity=32.6829268292683, Blast_Score=191, Evalue=7e-49,
Organism=Caenorhabditis elegans, GI193206654, Length=416, Percent_Identity=30.7692307692308, Blast_Score=182, Evalue=3e-46,
Organism=Caenorhabditis elegans, GI17541374, Length=416, Percent_Identity=31.4903846153846, Blast_Score=170, Evalue=1e-42,
Organism=Drosophila melanogaster, GI24583025, Length=471, Percent_Identity=29.0870488322718, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI17137668, Length=471, Percent_Identity=29.0870488322718, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI24583023, Length=471, Percent_Identity=29.0870488322718, Blast_Score=167, Evalue=1e-41,
Organism=Drosophila melanogaster, GI281360481, Length=471, Percent_Identity=29.2993630573248, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI281360483, Length=471, Percent_Identity=29.2993630573248, Blast_Score=141, Evalue=1e-33,
Organism=Drosophila melanogaster, GI17137666, Length=471, Percent_Identity=29.2993630573248, Blast_Score=141, Evalue=1e-33,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001991
- InterPro:   IPR018107 [H]

Pfam domain/function: PF00375 SDF [H]

EC number: NA

Molecular weight: Translated: 46667; Mature: 46536

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00714 NA_DICARBOXYL_SYMP_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
3.8 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CHHHHHHHHCCCHHEECCCCCCCC
>Mature Secondary Structure 
TKPKSSALGRVWSRWMSVPLWLQIVIGMVLGIIVGVIFGEQATCLKPLGTLFVNAIKML
CCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHH
IVPLVFCSLIVGVTSMQDTGKMGRIGIKSFGFYLFTTAIAISIGLLVGYVLQPGAGLGLT
HHHHHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEE
LAEGATQTAKAVPSLVDTLVDIVPTNPIAAMASGQILQVIVFAIALGIALVLIGEHGKPA
ECCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHCCHHHHHHHHHHHHHHHHHHHCCCCCHH
IKVFESLAEAMYKLADMVMKLAPYGVFGLMAWVAGEYGIDMLWPLIKVIIAVYLGCIIHV
HHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHH
LGFYSFLLRGFAKLSPLQFFKGISNAMLVAFTTSSSAGTLPASMKCASENLGVHKKISSF
HHHHHHHHHHHHHCCHHHHHHCCCCCEEEEEECCCCCCCCCHHHHHHHCCCCHHHHHHHH
VLPLGTTINMDGTALYQGVTVLFVAQAFGIDLTVVDYFTIILTATLASIGTAGVPGAGLV
HHCCCCEECCCCHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHCCCCCCCHHHH
MLTLVLTTVGLPLEGVALIAGIDRILDMVRTVVNVSGDLVATTVIAKSEDELDMAHYNAD
HHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHEECCCCCHHHHHCCCC
TEQSAVLAEQNIALETAAENSAKV
CHHHHHHHHCCCHHEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate [Periplasm]; Proton [Periplasm]; L-glutamate [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-aspartate [Periplasm] = Proton [Cytoplasm] + L-aspartate [Cytoplasm] Proton [Periplasm] + L-glutamate [Periplasm] = Proton [Cytoplasm] + L-glutamate [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9579061; 9384377 [H]