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The map label for this gene is pepD [H]

Identifier: 160876653

GI number: 160876653

Start: 4169749

End: 4171209

Strand: Direct

Name: pepD [H]

Synonym: Sbal195_3547

Alternate gene names: 160876653

Gene position: 4169749-4171209 (Clockwise)

Preceding gene: 160876646

Following gene: 160876654

Centisome position: 77.98

GC content: 48.12

Gene sequence:

>1461_bases
GTGACAGCTTTAAGTCAGTTATACCCACAGCCATTATGGCAATGGTTTGAACAAATCTGCGCTATTCCCCACCCATCTAA
GCATGAGCAAGCCTTAAGCCAGCACATTCAAGCGTGGGCAAAAAGCAAACAACTTGCCGTCGTTGAAGATGCCGTTGGCA
ACTTGATCATCCGCAAACCGGCTACGCCTGGAATGGAAGATCGTAAAATCGTGGTCATTCAAGCCCATATCGATATGGTG
CCGCAGAAGAATGCCGACAAAGTACACGACTTCACCCAAGATCCTATCGAAGCTTATGTCGATGGTGATTGGGTTAAAGC
CAAAGGCACGACCTTAGGTTCAGATAACGGTATCGGCATGGCATCGGCGCTGGCCATTTTGGGCTCTGATGACATCAAGC
ACGGTCCATTAGAAGTACTGCTGACCATCGATGAAGAGGCGGGCATGACCGGCGCCTTCGGTTTACAGGCGGGCATGTTA
GACGCAGAGATCCTGATCAACACAGATTCTGAGCAAGAAGGTGAAATTTACATGGGCTGCGCCGGTGGCGTCGATGCTCA
AATCACCCTGCCTATGGTGTGGCAAGCGTCTGAGCAAAGTTACTCTGCCTTTAGCCTGCATTTATCTGGCTTAAAAGGCG
GTCACTCTGGAGTGAACATTCACTTAGGTCGCGGCAATGCCAATAAGTTATTGGCGCGTTTCCTATTTGAAAATGCAGAT
GATTTAGCGTTAGAGCTGACACAATTTAGCGGCGGTTCATTGCGTAATGCGATCCCACGTGAAGCCAACATAAGCTTTAT
GTTGCCTGAAGAAAACATCAGTGCCTTAAACGAAAAAGTCGCTGAGTTTGAAGCGCTTATCCGTACAGAACTTACCATTG
CCGATCCTGATATGCGCTTAGTGCTAAACAATATCCCCACGCCAAAACGTGTGATGAGCGAAAACAGCCAAAATACCCTG
ATCGATTTGCTGCATGTGTGCCCGAACGGCGTGATCCGCATGAGCGATGAAGTCGAAGGTGTGACTGAAACCTCACTCAA
CGTTGGCGTCATCAGCACTGACGATGAACAAGTCACTATACTGTGTCTTATTCGCTCACTGATTGATTCTGGTCGAACTC
AAGTCGAAGGCATGTTAACTGCATTAACTAACTTAGCCGGAGCCGATATCGATTTAAGCGGCGCTTACCCAGGTTGGAAA
CCAGATAACAGCTCACCTGTGATGGCGATAGTACGCGAAACCTATCAAGACATTTACCAAAAAGAGCCAGTGATCATGGT
GATCCATGCGGGTCTTGAGTGTGGTCTATTCAAGAAACCTTACCCAGATATGGATATGGTCTCGATTGGTCCCACGATTC
GTTATCCACACGGACCAGATGAGATGGTGAACATCACCACAGTCGGCCAATACTGGACCTTATTATTAGCCGTACTCGAG
CGTATTCCAGTTAAGGCGTAG

Upstream 100 bases:

>100_bases
AACAAAAGCCTGTGATGCTGAGATTAATTGGCTGCGCAGAATGTGCTAGAATGGCCGCAAATTTGCCCTATACCCACAAG
ACCTTATGAGGGACACTTCT

Downstream 100 bases:

>100_bases
CGCCGAATGTTAGCCTAGCTAACTCAATTGGCACTTAATTCAAGGCCACATCTGCTCAAGTCAGATGTGGCCTTATTTTT
TATCGCGCCTTCTATTAGTG

Product: aminoacyl-histidine dipeptidase

Products: NA

Alternate protein names: Beta-alanyl-histidine dipeptidase; Carnosinase; Cysteinylglycinase; Peptidase D; Xaa-His dipeptidase; X-His dipeptidase [H]

Number of amino acids: Translated: 486; Mature: 485

Protein sequence:

>486_residues
MTALSQLYPQPLWQWFEQICAIPHPSKHEQALSQHIQAWAKSKQLAVVEDAVGNLIIRKPATPGMEDRKIVVIQAHIDMV
PQKNADKVHDFTQDPIEAYVDGDWVKAKGTTLGSDNGIGMASALAILGSDDIKHGPLEVLLTIDEEAGMTGAFGLQAGML
DAEILINTDSEQEGEIYMGCAGGVDAQITLPMVWQASEQSYSAFSLHLSGLKGGHSGVNIHLGRGNANKLLARFLFENAD
DLALELTQFSGGSLRNAIPREANISFMLPEENISALNEKVAEFEALIRTELTIADPDMRLVLNNIPTPKRVMSENSQNTL
IDLLHVCPNGVIRMSDEVEGVTETSLNVGVISTDDEQVTILCLIRSLIDSGRTQVEGMLTALTNLAGADIDLSGAYPGWK
PDNSSPVMAIVRETYQDIYQKEPVIMVIHAGLECGLFKKPYPDMDMVSIGPTIRYPHGPDEMVNITTVGQYWTLLLAVLE
RIPVKA

Sequences:

>Translated_486_residues
MTALSQLYPQPLWQWFEQICAIPHPSKHEQALSQHIQAWAKSKQLAVVEDAVGNLIIRKPATPGMEDRKIVVIQAHIDMV
PQKNADKVHDFTQDPIEAYVDGDWVKAKGTTLGSDNGIGMASALAILGSDDIKHGPLEVLLTIDEEAGMTGAFGLQAGML
DAEILINTDSEQEGEIYMGCAGGVDAQITLPMVWQASEQSYSAFSLHLSGLKGGHSGVNIHLGRGNANKLLARFLFENAD
DLALELTQFSGGSLRNAIPREANISFMLPEENISALNEKVAEFEALIRTELTIADPDMRLVLNNIPTPKRVMSENSQNTL
IDLLHVCPNGVIRMSDEVEGVTETSLNVGVISTDDEQVTILCLIRSLIDSGRTQVEGMLTALTNLAGADIDLSGAYPGWK
PDNSSPVMAIVRETYQDIYQKEPVIMVIHAGLECGLFKKPYPDMDMVSIGPTIRYPHGPDEMVNITTVGQYWTLLLAVLE
RIPVKA
>Mature_485_residues
TALSQLYPQPLWQWFEQICAIPHPSKHEQALSQHIQAWAKSKQLAVVEDAVGNLIIRKPATPGMEDRKIVVIQAHIDMVP
QKNADKVHDFTQDPIEAYVDGDWVKAKGTTLGSDNGIGMASALAILGSDDIKHGPLEVLLTIDEEAGMTGAFGLQAGMLD
AEILINTDSEQEGEIYMGCAGGVDAQITLPMVWQASEQSYSAFSLHLSGLKGGHSGVNIHLGRGNANKLLARFLFENADD
LALELTQFSGGSLRNAIPREANISFMLPEENISALNEKVAEFEALIRTELTIADPDMRLVLNNIPTPKRVMSENSQNTLI
DLLHVCPNGVIRMSDEVEGVTETSLNVGVISTDDEQVTILCLIRSLIDSGRTQVEGMLTALTNLAGADIDLSGAYPGWKP
DNSSPVMAIVRETYQDIYQKEPVIMVIHAGLECGLFKKPYPDMDMVSIGPTIRYPHGPDEMVNITTVGQYWTLLLAVLER
IPVKA

Specific function: Dipeptidase with broad substrate specificity. Requires dipeptide substrates with an unblocked N-terminus and the amino group in the alpha or beta position. Non-protein amino acids and proline are not accepted in the C-terminal position, whereas some dipep

COG id: COG2195

COG function: function code E; Di- and tripeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20C family [H]

Homologues:

Organism=Escherichia coli, GI1786432, Length=485, Percent_Identity=58.9690721649485, Blast_Score=596, Evalue=1e-171,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002933
- InterPro:   IPR011650
- InterPro:   IPR001160 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.4.13.3 [H]

Molecular weight: Translated: 53002; Mature: 52871

Theoretical pI: Translated: 4.42; Mature: 4.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
3.7 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
3.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTALSQLYPQPLWQWFEQICAIPHPSKHEQALSQHIQAWAKSKQLAVVEDAVGNLIIRKP
CCCHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEHHHHCCEEEECC
ATPGMEDRKIVVIQAHIDMVPQKNADKVHDFTQDPIEAYVDGDWVKAKGTTLGSDNGIGM
CCCCCCCCEEEEEEEEECCCCCCCCHHHHHCCCCCHHHHCCCCEEEECCCCCCCCCCCCH
ASALAILGSDDIKHGPLEVLLTIDEEAGMTGAFGLQAGMLDAEILINTDSEQEGEIYMGC
HHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEE
AGGVDAQITLPMVWQASEQSYSAFSLHLSGLKGGHSGVNIHLGRGNANKLLARFLFENAD
CCCCCCEEEEEEEEECCCCCCEEEEEEEECCCCCCCCEEEEECCCCHHHHHHHHHHCCCC
DLALELTQFSGGSLRNAIPREANISFMLPEENISALNEKVAEFEALIRTELTIADPDMRL
CCEEEEEECCCCCHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHEEEEECCCCEE
VLNNIPTPKRVMSENSQNTLIDLLHVCPNGVIRMSDEVEGVTETSLNVGVISTDDEQVTI
EECCCCCCHHHHCCCCCHHHHHHHHHCCCCEEEECCCCCCCEECCEEEEEEECCCCCCHH
LCLIRSLIDSGRTQVEGMLTALTNLAGADIDLSGAYPGWKPDNSSPVMAIVRETYQDIYQ
HHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHC
KEPVIMVIHAGLECGLFKKPYPDMDMVSIGPTIRYPHGPDEMVNITTVGQYWTLLLAVLE
CCCEEEEEECCCCCCCCCCCCCCCCEEECCCEEECCCCCCCEEEEEEHHHHHHHHHHHHH
RIPVKA
HCCCCC
>Mature Secondary Structure 
TALSQLYPQPLWQWFEQICAIPHPSKHEQALSQHIQAWAKSKQLAVVEDAVGNLIIRKP
CCHHHHCCHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHCCCCEEEEHHHHCCEEEECC
ATPGMEDRKIVVIQAHIDMVPQKNADKVHDFTQDPIEAYVDGDWVKAKGTTLGSDNGIGM
CCCCCCCCEEEEEEEEECCCCCCCCHHHHHCCCCCHHHHCCCCEEEECCCCCCCCCCCCH
ASALAILGSDDIKHGPLEVLLTIDEEAGMTGAFGLQAGMLDAEILINTDSEQEGEIYMGC
HHHHHHHCCCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEEEEEECCCCCCCCEEEEE
AGGVDAQITLPMVWQASEQSYSAFSLHLSGLKGGHSGVNIHLGRGNANKLLARFLFENAD
CCCCCCEEEEEEEEECCCCCCEEEEEEEECCCCCCCCEEEEECCCCHHHHHHHHHHCCCC
DLALELTQFSGGSLRNAIPREANISFMLPEENISALNEKVAEFEALIRTELTIADPDMRL
CCEEEEEECCCCCHHHCCCCCCCEEEEECCHHHHHHHHHHHHHHHHHHHEEEEECCCCEE
VLNNIPTPKRVMSENSQNTLIDLLHVCPNGVIRMSDEVEGVTETSLNVGVISTDDEQVTI
EECCCCCCHHHHCCCCCHHHHHHHHHCCCCEEEECCCCCCCEECCEEEEEEECCCCCCHH
LCLIRSLIDSGRTQVEGMLTALTNLAGADIDLSGAYPGWKPDNSSPVMAIVRETYQDIYQ
HHHHHHHHHCCHHHHHHHHHHHHHHCCCCEEECCCCCCCCCCCCCHHHHHHHHHHHHHHC
KEPVIMVIHAGLECGLFKKPYPDMDMVSIGPTIRYPHGPDEMVNITTVGQYWTLLLAVLE
CCCEEEEEECCCCCCCCCCCCCCCCEEECCCEEECCCCCCCEEEEEEHHHHHHHHHHHHH
RIPVKA
HCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1695895; 9278503; 2651887 [H]